Molecular pathological approach to mechanism of cell invasion In pituitary adenoma
| Project/Area Number |
18390405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TERAMOTO Akira Nippon Medical School, 大学院・医学研究科, 教授 (60231445)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Daizo 日本医科大学, 医学部, 准教授 (30210701)
KIM Kyonsong 日本医科大学, 医科部, 助教 (30339387)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥17,840,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | 下垂体腺腫 / 細胞浸潤 / 3-D invasion assay / RECK / SDF-1 / siRNA / 血管新生 / 免疫染色 / DDR1 / tissue microarray / MMP / 3D invasion assay / peptide gel |
|---|
| Research Abstract |
研究代表者による下垂体腺腫の手術標本と培養下垂体腺腫細胞を用いた。低酸素状態に陥った状態での研究を行った。その結果細胞表面に発現するRECK蛋白が低酸素刺激によりMMPへの刺激を介在し、その発現を促進させることで細胞浸潤を亢進させていることが明らかになった。さらに血管内皮細胞の前駆細胞を骨髄から呼び寄せる因子SDF-1も低酸素刺激によって産生され、浸潤傾向の強い下垂体腺腫ほど高く発現していることが明らかとなった。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Cushing's disease complicated with thrombosis in a dog2008
Author(s)
Teshima T, Hara Y, Taoda T, Koyama H, Takahashi K, Nezu Y, Harada Y, Yogo T, Nishida K, Osamura RY, Teramoto A, Tagawa M
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Journal Title
J Vet Med Sci 70(5)
Pages: 487-91
NAID
Related Report
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[Journal Article] mmunohistochemical detection of somatostatin receptor(SSTR)subtypes 2A and 5 in pituitary adenoma from acromegalic patients : good correlation with preoperative response to octreotide2007
Author(s)
Takei M, Suzuki M, Kajiya H, Ishii Y, Tahara S, Miyakoshi T, Egashira N, Takekoshi S, Sanno N, Teramoto A, Osamura RY
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Journal Title
Endocr Pathol(Winter) 18(4)
Pages: 208-16
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[Journal Article] Analyses of the mechanism of intracellular transport and secretion of pituitary hormone, with an insight of the subcellular localization of pituitary hormone and its mRNA2006
Author(s)
Matsuno A, Mizutani A, Takekoshi S, Itoh J, Okinaga H, Nishina Y, Takano K, Nagashima T, Osamura RY, Teramoto A
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Journal Title
Brain Tumor Pathol 23(1)
Pages: 1-5
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