Studies on the mechanisms of dyspnea in terminal cancer patients and for establishment of a new therapy for dyspnea

• Project/Area Number: 18390425
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Chiba University
• Principal Investigator: NISHNIO Takashi Chiba University, 大学院・医学研究院, 教授 (80009703)
• Co-Investigator(Kenkyū-buntansha): NAHO Iiyori 千葉大学, 医学部付属病院, 助教 (10400970)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥9,900,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥1,500,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2006: ¥3,400,000 (Direct Cost: ¥3,400,000)
• Keywords: 呼吸困難 / 末期がん患者 / トロメタモール / 性差 / 疼痛 / 呼吸負荷 / 熱疼痛閾値 / 呼吸困難感 / 咳 / 迷走神経 / THAM / 呼吸ドライブ / 吸気粘性抵抗負荷 / 呼気粘性抵抗負荷

Research Abstract

呼吸困難感に影響を与えると考えられている様々な要因に検討を加え、以下の結論を得た.1)呼吸困難感の質を識別するものとは別に量的な差を識別できる中枢機構が存在する.2)トロメタモール(THAM)は呼吸性アシドーシスを是正すると同時に呼吸困難感を緩和し、呼吸困難緩和に有用である.3)呼吸困難と痺痛が同時に存在する場合、呼吸困難が痔痛に及ぼす影響には性差が存在し、この性差に吸気努力に伴う呼吸系力学変化が関与する.

Research Products

• [Journal Article] Aggravation of dyspnea by cough-Vagal mechanisms (2009)
  • Author(s): Nishino T
  • Journal Title: Pulm Pharmacol Ther 22 Pages: 102-107
  • Peer Reviewed
• [Journal Article] THAM improves an experimentally-induced severe dyspnea (2009)
  • Author(s): Nishino T, Iiyori N, Isono S, Shinozuka N, Taguchi N, Ishikawa T.
  • Journal Title: J Pain Symptom Manage 37 Pages: 212-219
  • Peer Reviewed
• [Journal Article] Aggravation of dyspnea by coughing-Vagal mechanisms (2009)
  • Author(s): Nishino T
  • Journal Title: Pulm Pharmacol Ther 22 Pages: 102-107
  • Peer Reviewed
• [Journal Article] Coughing induced by airway irritation modulates the sensation of air hunger (2008)
  • Author(s): Nishino T, Isono S, Shinozuka N, Ishikawa T
  • Journal Title: J Physiol 586.2 Pages: 649-658
  • Peer Reviewed
• [Journal Article] Sex differences in the effect of dyspnea on thermal pain threshold in young healthy subjects (2008)
  • Author(s): Nishino T, Isono S, Ishikawa T, Shinozuka N
  • Journal Title: Anesthesiology 109 Pages: 1100-1106
  • Peer Reviewed
• [Journal Article] Pathophysiology of dyspnea evaluated by breath-holding test (2008)
  • Author(s): Nishino T
  • Journal Title: studies of furosemide treatment Respiratory Physiology & Neurobiol
  • Peer Reviewed
• [Journal Article] 呼吸生理の基礎と臨床 (2008)
  • Author(s): 西野卓
  • Journal Title: 日本臨床麻酔学会誌 28 Pages: 711-721
  • NAID: 10024299789
  • Peer Reviewed
• [Journal Article] Sex differences in the effect of dyspnea on thermal pain thresh old in young healthy subjects. (2008)
  • Author(s): Nishino T, Isono S, Ishikawa T, Shinozuka N
  • Journal Title: Anesthesiology 109 Pages: 1100-1106
  • Peer Reviewed
• [Journal Article] Coughing induced by airway irritation modulates the sensation of air hunger (2008)
  • Author(s): Nishino T, et. al.
  • Journal Title: Journal of Physiology 586:2 Pages: 649-658
  • Peer Reviewed
• [Journal Article] An additive interaction between different qualities of dyspnea produced in normal human subjects (2007)
  • Author(s): Nishino T, Isono S, Ishikawa T, Shinozuka N
  • Journal Title: Respir Physiol & Neurobiol 155 Pages: 14-21
  • Peer Reviewed
• [Journal Article] Lung volume and collapsibility of the passive pharynx in patients with sleep-disordered breathing (2007)
  • Author(s): Tagaito Y, Nishino T, et. al.
  • Journal Title: Journal of Applied Physiology 103 Pages: 1379-1385
  • Peer Reviewed
• [Journal Article] Dynamic interaction of craniofacial structures during head positioning and direct laryngoscopy in anesthetized patients with and without difficult laryngoscopy (2007)
  • Author(s): Kitamura Y, Nishino T, et. al.
  • Journal Title: Anesthesiology 107 Pages: 875-883
  • Peer Reviewed
• [Journal Article] Submandible angle in nonobese patients with diffieult tracheal intubation (2007)
  • Author(s): Suzuki N, Nishino T, et. al.
  • Journal Title: Anesthesiology 106 Pages: 916-923
  • Peer Reviewed
• [Journal Article] An additive interaction between different qualities of syspnea produced in normal human subjects. (2007)
  • Author(s): Nishino T, et al.
  • Journal Title: Respir Physiol Neurobiol 155 Pages: 14-21
• [Journal Article] CHDF(Continuous Hemodiafiltration)持続的血液濾過透析 (2006)
  • Author(s): 中村達雄, 西野 卓
  • Journal Title: 臨床麻酔 30 Pages: 205-209
• [Journal Article] 上気道に対する麻酔薬の影響 (2006)
  • Author(s): 西野 卓
  • Journal Title: 日医雑誌 135 Pages: 784-784
• [Journal Article] 安全な気道管理 (2006)
  • Author(s): 西野 卓
  • Journal Title: 麻酔 55 Pages: 2-4
• [Presentation] 呼吸困難の生理 (2008)
  • Author(s): 西野卓
  • Organizer: 第28回日本臨床麻酔学会臨床麻酔学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-20
• [Presentation] Cough and dyspnea (2008)
  • Author(s): Nishino T
  • Organizer: 5th International Symposium on cough.
  • Place of Presentation: London
  • Year and Date: 2008-06-27
• [Presentation] Cough and dyspnea (2008)
  • Author(s): Nishino T
  • Organizer: 5th International Symposium on cough
  • Place of Presentation: London
• [Presentation] 呼吸生理の基礎と臨床 (2007)
  • Author(s): 西野卓
  • Organizer: 第27回日本臨床麻酔学会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] だから呼吸は面白い (2007)
  • Author(s): 西野卓
  • Organizer: 日本麻酔科学会リフレシャーコース
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-02
• [Presentation] 上気道反射の役割 (2006)
  • Author(s): 西野卓
  • Organizer: 国際歯科麻酔学会
  • Place of Presentation: 横浜
  • Year and Date: 2006-10-05
• [Book] 最新整形外科体系第9巻周術期管理, リスク管理, 疼痛管理(呼吸系モニタリング, 糸満盛憲, 外須美夫) (2008)
  • Author(s): 西野卓、篠塚典弘
  • Publisher: 中山書店
• [Book] 全身麻酔中の換気、麻酔実践テキスト(武田純三, 森田茂穂) (2008)
  • Author(s): 西野卓
  • Publisher: 南江堂
• [Book] 周術期の呼吸管理 (2007)
  • Author(s): 西野卓
  • Total Pages: 263
  • Publisher: 克誠堂出版社
• [Book] 周術期の呼吸管理 (2007)
  • Author(s): 西野 卓
  • Total Pages: 263
  • Publisher: 克誠堂出版
• [Book] 上気道の調節(有田秀徳)(呼吸の事典) (2006)
  • Author(s): 西野 卓
  • Publisher: 朝倉書店
• [Book] 低体温麻酔 脳神経外科大系3巻 1章麻酔(山浦 彰総編集) (2006)
  • Author(s): 田垣内祐吾, 西野 卓
  • Publisher: 中山書店
• [Book] 血液ガス 検査値のみかた・改訂3版(中井利昭編集代表) (2006)
  • Author(s): 篠塚典弘, 西野 卓
  • Publisher: 中外医学社