Development of a novel diagnostic method for male infertility

• Project/Area Number: 18390435
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka University
• Principal Investigator: MIYAGAWA Yasushi Osaka University, 医学系・研究科, 助教 (70362704)
• Co-Investigator(Kenkyū-buntansha): TSIJIMURA Akira 大阪大学, 医学系・研究科, 講師 (40294053) ; OKUYAMA Akihiko 大阪大学, 医学系・研究科, 教授 (20093388) ; 田中 宏光 大阪大学, 微生物研究科, 助教 (10263310)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Hiromitu 長崎国際大学, 薬学部, 准教授 (10263310)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥21,240,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥3,240,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2006: ¥7,200,000 (Direct Cost: ¥7,200,000)
• Keywords: 不妊症 / 生殖医療 / 少子化対策 / 遺伝子 / 蛋白質 / 男性不妊症 / 精子 / 臨床診断 / 生殖細胞 / 抗体 / 精巣 / 生検 / ゲノム

Research Abstract

新たな男性不妊症診断開発のために、我々が独自にクローニングした精子細胞特異的遺伝子を中心に、これらがコードする14の精巣タンパク質について17抗体を作成、準備し、男性不妊患者における精巣、精液の微量コード蛋白の検出を行った。17抗体のうち1抗体のみ微量蛋白検出に優れ、無精子症患者の精巣におけるコードタンパク質検出と顕微鏡下精巣内精子採取術による精子検出成績に関連性が見出された。精液中の微量蛋白の検出は多くの抗体で不可能・不安定であった。今後、精子検出技術改善と精液への分泌蛋白などの新たなマーカー開発が望まれる。

Research Products

• [Journal Article] Nucleotide Polymorphisms in PRDM9 (MEISETZ) in Patients with Nonobstructive Azoospermia (2009)
  • Author(s): Irie S, Tsujimura A, Miyagawa Y, Ueda T, Matsuoka Y, Matsui Y, Okuyama A, Nishimune Y, Tanaka H. Single
  • Journal Title: J Androl (In press)
  • Peer Reviewed
• [Journal Article] Characterizing mouse male germ cell-specific actin capping protein alpha3 (CPalpha3) : dynamic patterns of expression in testicular and epididymal sperm (2008)
  • Author(s): Tokuhiro K, Miyagawa Y, Tanaka H
  • Journal Title: Asian J Androl 10 Pages: 711-8
  • Peer Reviewed
• [Journal Article] Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis (2008)
  • Author(s): Tokuhiro K, Hirose M, Miyagawa Y, Tsujimura A, Irie S, Isotani A, Okabe M, Toyama Y, Ito C, Toshimori K, Takeda K, Oshio S, Tainaka H, Tsuchida J, Okuyama A, Nishimune Y, Tanaka H
  • Journal Title: J Biol Chem 283 Pages: 19039-48
  • Peer Reviewed
• [Journal Article] Relationship between substances in seminal plasma and Acrobeads Test results (2008)
  • Author(s): Komori K, Tsujimura A, Okamoto Y, Matsuoka Y, Takao T, Miyagawa Y, Takada S, Nonomura N, Okuyama A
  • Journal Title: Fertil Steril 91 Pages: 179-84
  • Peer Reviewed
• [Journal Article] Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein (2008)
  • Author(s): Matsuoka Y, Miyagawa Y, Tokuhiro K, Kitamura K, Iguchi N, Maekawa M, Takahashi T, Tsujimura A, Matsumiya K, Okuyama A, Nishimune Y, Tanaka H
  • Journal Title: Mol Reprod Dev 75 Pages: 967-75
  • Peer Reviewed
• [Journal Article] Androgen decline in patients with nonobstructive azoospemia after microdissection testicular sperm extraction (2008)
  • Author(s): Takada S, Tsujimura A, Ueda T, Matsuoka Y, Takao T, Miyagawa Y, Koga M, Takeyama M, Okamoto Y, Matsumiya K, Fujioka H, Nonomura N, Okuyama A
  • Journal Title: Urology 72 Pages: 114-8
  • Peer Reviewed
• [Journal Article] 男性不妊症に対するマイクロサージェリー、顕微鏡下精巣内精子採取術 (2008)
  • Author(s): 宮川康、辻村晃、高尾徹也、岡本吉夫、奥山明彦
  • Journal Title: 臨床泌尿器科 91 Pages: 575-580
• [Journal Article] 男性不妊症と染色体異常 : Klinefelter症候群・ロバートソン型転座 (2008)
  • Author(s): 宮川康、辻村晃、奥山明彦
  • Journal Title: Urology View 10 Pages: 72-76
• [Journal Article] 精子をめぐる最近の進歩 ARTにおけるmicrodissection TESE (2008)
  • Author(s): 辻村晃、宮川康、奥山明彦
  • Journal Title: 産婦人科治療 96 Pages: 400-405
• [Journal Article] 男性不妊症に対する非内分泌療法 (2008)
  • Author(s): 辻村晃、宮川康
  • Journal Title: Modern Physician 28 Pages: 584-584
• [Journal Article] Klinefelter症候群の妊孕性について (2008)
  • Author(s): 辻村晃、松岡庸洋
  • Journal Title: Modern Physician 10 Pages: 939-939
• [Journal Article] 生殖補助医療をめぐる諸問題 ARTにおける精子の評価 (2008)
  • Author(s): 辻村晃
  • Journal Title: 産科と婦人科 75 Pages: 1236-1240
• [Journal Article] Characterizing mouse male germ cell-specific actin capping protein a3 (cpa3) : Dynamic patterns of expression in testicular and epididymal sperm. (2008)
  • Author(s): Tokuhiro K, Miyagawa Y, Tanaka H
  • Journal Title: Asian J Androl. 10 Pages: 711-718
  • Peer Reviewed
• [Journal Article] Meichroacidin containing the MORN motif is essential for spermatozoa morphogenesis. (2008)
  • Author(s): Tokuhiro K, Miyagawa Y, Tsujimura A, Okuyama A, Nishimune Y, Tanaka H
  • Journal Title: J Biol Chem. 283 Pages: 19039-19048
  • Peer Reviewed
• [Journal Article] Isolation and Characterization of the Haploid Germ Cell-Specific Smrpl Gene for a Novel Manchette Protein in the Mouse. (2008)
  • Author(s): Matsuoka Y, Miyagawa Y, Tsujimura A, Okuyama A, Nishimune Y, Tanaka H
  • Journal Title: Mol Reprod Dev. 75 Pages: 967-975
  • Peer Reviewed
• [Journal Article] Androgen decline in patients with non-obstructive azoospermia after microdissection testicular sperm extraction. (2008)
  • Author(s): Takada S, Tsujimura A, Miyagawa Y., Okuyama A
  • Journal Title: Urology 72 Pages: 114-118
  • Peer Reviewed
• [Journal Article] Relationship between substances in seminal plasma and Acrobeads Test results. (2008)
  • Author(s): Komori K, Tsujimura A, Miyagawa Y, Takada S, Okuyama A
  • Journal Title: Fertil Steril. 91 Pages: 179-184
  • Peer Reviewed
• [Journal Article] 男性不妊症に対するマイクロサージェリー、顕微鏡下精巣内精子採取術. (2008)
  • Author(s): 宮川 康, 辻村 晃, 高尾徹也, 岡本吉夫, 奥山明彦
  • Journal Title: 臨泌 62 Pages: 575-580
• [Journal Article] 男性不妊症と染色体異常 : Klinefelter症候群・ロバートソン型転座. (2008)
  • Author(s): 宮川 康, 辻村 晃, 奥山明彦
  • Journal Title: Urology View 10 Pages: 72-76
• [Journal Article] 精子をめぐる最近の進歩 ARTにおけるmicrodissection TESE. (2008)
  • Author(s): 辻村 晃, 宮川 康, 奥山明彦
  • Journal Title: 産婦人科治療 96 Pages: 400-405
• [Journal Article] 男性不妊症に対する非内分泌療法 (2008)
  • Author(s): 辻村 晃, 宮川 康
  • Journal Title: Modern Physician 28 Pages: 584-584
• [Journal Article] Klinefelter症候群の妊孕性について (2008)
  • Author(s): 辻村 晃, 松岡庸洋
  • Journal Title: Modern Physician 28 Pages: 939-939
• [Journal Article] 生殖補助医療をめぐる諸問題 ARTにおける精子の評価 (2008)
  • Author(s): 辻村 晃
  • Journal Title: 産科と婦人科 75 Pages: 1236-1240
• [Journal Article] Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein. (2008)
  • Author(s): Matsuoka Y, Miyagawa Y, Tsujimura A, Okuyama A, Tanaka H
  • Journal Title: Mol Reprod Dev. (In press)
  • Peer Reviewed
• [Journal Article] Relationship between the substances in seminal plasma and the Acrobeads test. (2008)
  • Author(s): Komori K, Tsujimura A, Miyagawa Y, Okuyama A
  • Journal Title: Fertil Steril. (In press)
  • Peer Reviewed
• [Journal Article] The 193-base pair Gsg2 (haspin) promoter region regulates germ cell-specific expression bidirectionally and synchronously (2007)
  • Author(s): Tokuhiro K, Miyagawa Y, Yamada S, Hirose M, Ohta H, Nishimune Y, Tanaka H
  • Journal Title: Biol Reprod 76 Pages: 407-14
  • Peer Reviewed
• [Journal Article] Clinical comparison of successful and failed microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome (2007)
  • Author(s): Koga M, Tsujimura A, Takeyama M, Kiuchi H, Takao T, Miyagawa Y, Takada S, Matsumiya K, Fujioka H, Okamoto Y, Nonomura N, Okuyama A.
  • Journal Title: Urology 70 Pages: 341-5
  • Peer Reviewed
• [Journal Article] Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules (2007)
  • Author(s): Kita K, Watanabe T, Ohsaka K, Hayashi H, Kubota Y, Nagashima Y, Aoki I, Taniguchi H, Noce T, Inoue K, Miki H, Ogonuki N, Tanaka H, Ogura A, Ogawa T
  • Journal Title: Biol Reprod 76 Pages: 211-7
  • Peer Reviewed
• [Journal Article] Microdissection testicular sperm extraction : prediction, outcome, and complications (2007)
  • Author(s): Tsujimura A
  • Journal Title: Int J Urol 14 Pages: 883-9
  • NAID: 10019947540
  • Peer Reviewed
• [Journal Article] nucleotide polymorphisms : discovery of the genetic causes of male infertility (2007)
  • Author(s): Tanaka H, Hirose M, Tokuhiro K, Matsuoka Y, Miyagawa Y, Tsujimura A, Okuyama A, Nishimune Y. Single
  • Journal Title: Soc Reprod Fertil Suppl 65 Pages: 531-4
• [Journal Article] Molecular biological features of male germ cell differentiation (2007)
  • Author(s): Tanaka H, Miyagawa Y, Tsujimura A, Okuyama A
  • Journal Title: Reprod Med Biol 6 Pages: 1-9
  • NAID: 10018849469
  • Peer Reviewed
• [Journal Article] The 193-Base Pair Gsg2 (Haspin) Promoter Region Regulates Germ Cell-Specific Expression Bidirectionally and Synchronously. (2007)
  • Author(s): Tokuhiro K, Miyagawa Y, Tanaka H
  • Journal Title: Biol. Reprod. 76 Pages: 407-414
  • Peer Reviewed
• [Journal Article] Clinical comparison of successful and failed microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome. (2007)
  • Author(s): Koga M, Tsujimura A, Miyagawa Y, Okuyama A
  • Journal Title: Urology 70 Pages: 341-345
  • Peer Reviewed
• [Journal Article] Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules. (2007)
  • Author(s): Kita K, Tanaka H
  • Journal Title: Biol. Reprod. 76 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Microdissection testicular sperm extraction: prediction, outcome, and complication. (2007)
  • Author(s): Tsujimura A
  • Journal Title: Int. J. Urol 14 Pages: 883-889
  • NAID: 10019947540
  • Peer Reviewed
• [Journal Article] Molecular biological features of male germ cell differentiation. (2007)
  • Author(s): Tanaka H, Miyagawa Y, Tsujimura A, Okuyama A
  • Journal Title: Reprod. Med. Biol. 6 Pages: 1-9
  • NAID: 10018849469
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms: discovery of the genetic causes of male infertility. (2007)
  • Author(s): Tanaka H, Miyagawa Y, Tsujimura A, Okuyama A
  • Journal Title: Soc Reprod Fertil Suppl. 65 Pages: 531-534
• [Journal Article] Mitochondria-related male infertility (2006)
  • Author(s): Nakada K, Sato A, Yoshida K, Morita T, Tanaka H, Inoue S, Yonekawa H, Hayashi J
  • Journal Title: Proc Natl Acad Sci USA 103 Pages: 15148-53
  • Peer Reviewed
• [Journal Article] Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein (2006)
  • Author(s): Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y
  • Journal Title: Int J Androl 29 Pages: 353-9
  • Peer Reviewed
• [Journal Article] Isolation of germ cells from leukemia and lymphoma cells in a human in vitro model : potential clinical application for restoring human fertility after anticancer therapy (2006)
  • Author(s): Fujita K, Tsujimura A, Miyagawa Y, Kiuchi H, Matsuoka Y, Takao T, Takada S, Nonomura N, Okuyama A
  • Journal Title: Cancer Res 66 Pages: 11166-71
  • Peer Reviewed
• [Journal Article] Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia (2006)
  • Author(s): Tsujimura A, Miyagawa Y, Takao T, Takada S, Koga M, Takeyama M, Matsumiya K, Fujioka H, Okuyama A
  • Journal Title: J Urol 175 Pages: 15148-53
  • Peer Reviewed
• [Journal Article] Infertility caused by polymorphisms or mutations in spermatogenesis-specific genes (2006)
  • Author(s): Nishimune Y, Tanaka H
  • Journal Title: J Androl 27 Pages: 326-34
  • Peer Reviewed
• [Journal Article] Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia (2006)
  • Author(s): Tsujimura A, Fujita K, Komori K, Tanjapatkul P, Miyagawa Y, Takada S, Matsumiya K, Sada M, Katsuyama Y, Ota M, Okuyama A
  • Journal Title: Asian J Androl 8 Pages: 213-8
  • Peer Reviewed
• [Journal Article] A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis (2006)
  • Author(s): Fraisl P, Tanaka H, Forss-Petter S, Lassmann H, Nishimune Y, Berger J
  • Journal Title: Arch Biochem Biophys 451 Pages: 23-33
  • Peer Reviewed
• [Journal Article] Expression of Mina53, a product of a Myc target gene in mouse testis (2006)
  • Author(s): Tsuneoka M, Nishimune Y, Ohta K, Teye K, Tanaka H, Soejima M, Iida H, Inokuchi T, Kimura H, Koda Y
  • Journal Title: Int J Androl 29 Pages: 323-30
  • Peer Reviewed
• [Journal Article] Mitochondria-related male infertility. (2006)
  • Author(s): Nakata K, Tanaka H
  • Journal Title: Proc Natl Acad Sci USA. 103 Pages: 15148-15148
• [Journal Article] Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (2006)
  • Author(s): Tanaka H, Miyagawa Y, Tsujimura A, Okuyama A
  • Journal Title: Int J Androl. 29 Pages: 353-353
• [Journal Article] Isolation of germ cells from leukemia and lymphoma cells in a human in vitro model : potential clinical application for restoring human fertility after anticancer therapy. (2006)
  • Author(s): Fujita K, Tsujimura A, Miyagawa Y, Okuyama A
  • Journal Title: Cancer Res. 66 Pages: 11166-11166
• [Journal Article] Salvage microdissection testicular sperm extraction after failed conventional TESE for patients with non-obstructive azoospermia. (2006)
  • Author(s): Tsujimura A, Miyagawa Y, Okuyayama A
  • Journal Title: J. Urol. 175 Pages: 1446-1446
• [Journal Article] Infertility Caused by Polymorphisms or Mutations in Spermatogenesis-Specific Genes. (2006)
  • Author(s): Nishimune Y, Tanaka H
  • Journal Title: J Androl. 27 Pages: 326-326
• [Journal Article] Association study of homologous RNA-binding motif-gene on X chromosome (RBMX) and like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. (2006)
  • Author(s): Tsujimura A, Miyagawa Y, Okuyama A
  • Journal Title: Asian J. Androl. 8 Pages: 213-213
• [Presentation] シンポジウム : 加齢と生殖機能男加齢の男性生殖機能への影響 (2008)
  • Author(s): 宮川康
  • Organizer: 第53回日本生殖医学会総会・学術講演会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-24
• [Presentation] シンポジウム : 加齢と生殖機能 男加齢の男性生殖機能への影響 (2008)
  • Author(s): 宮川 康
  • Organizer: 第53回日本生殖医学会総会・学術講演会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-24
• [Presentation] 閉塞性無精子症を疑わせる非閉塞性無精子症に対するMD-TESEの検討 (2008)
  • Author(s): 辻村晃、宮川康、奥山明彦
  • Organizer: 第53回日本生殖医学会総会・学術講演会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] 特別講演非閉塞性無精子症に対する取り組み-基礎と臨床- (2008)
  • Author(s): 辻村晃
  • Organizer: 第50回日本生殖医学会北海道地方部会学術講演会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] 閉塞性無精子症を疑わせる非閉塞性無精子症に対するMD-TESEの検討 (2008)
  • Author(s): 辻村 晃, 宮川 康, 奥山明彦
  • Organizer: 第53回日本生殖医学会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-10-23
• [Presentation] シンポジウム男性不妊症患者における精巣生殖細胞特異的遺伝子SNP解析とその臨床応用 (2008)
  • Author(s): 宮川康
  • Organizer: 第27回日本アンドロロジー学会
  • Place of Presentation: 京都市
  • Year and Date: 2008-07-05
• [Presentation] シンポジウム 男性不妊症患者における精巣生殖細胞特異的遺伝子SNP解析とその臨床応用 (2008)
  • Author(s): 宮川 康
  • Organizer: 第27回日本アンドロロジー学会
  • Place of Presentation: 京都市
  • Year and Date: 2008-07-05
• [Presentation] 特別講演 非閉塞性無精子症に対する取り組み-基礎と臨床- (2008)
  • Author(s): 辻村 晃
  • Organizer: 第50回日本生殖医学会北海道地方部会学術講演会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-03-01
• [Presentation] TESEを300例以上行った私の手技とコツを大公開. 男性不妊手術手技フォーラム (2007)
  • Author(s): 辻村晃
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-27
• [Presentation] 男性不妊症、生殖医療指導医認定試験講習 (2007)
  • Author(s): 辻村晃
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-27
• [Presentation] Sertoli cell only syndromeに対する顕微鏡下精巣内精子採取術 (2007)
  • Author(s): 宮川康
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-27
• [Presentation] TESEを300例以上行った私の手技とコツを大公開、男性不妊手術手技フォーラム (2007)
  • Author(s): 辻村 晃
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-27
• [Presentation] シンポジウム3「胚発生における精子の関与」 精巣内精子を用いた体外受精-胚発生への影響 (2007)
  • Author(s): 辻村晃
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-26
• [Presentation] 精巣内精子を用いた体外受精-胚発生への影響 (2007)
  • Author(s): 辻村 晃
  • Organizer: 第52回日本生殖医学会シンポジウム3「胚発生における精子の関与」
  • Place of Presentation: 秋田市
  • Year and Date: 2007-10-26
• [Presentation] セルトリセルオンリー症候群に対する顕微鏡下精巣内精子採取術 (2007)
  • Author(s): 宮川 康
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌市
  • Year and Date: 2007-08-29
• [Presentation] マウス精子形成におけるmeichroacidin (MCA)の機能解析 (2007)
  • Author(s): 徳弘圭造, 宮川康, 辻村晃, 奥山明彦, 田中宏光
  • Organizer: 日本アンドロロジー学会第26回学術大会
  • Place of Presentation: 千葉県
  • Year and Date: 2007-07-06
• [Presentation] マウス精子形成におけるmeichroacidin(MCA)の機能解析 (2007)
  • Author(s): 徳弘圭造, 宮川 康, 辻村 晃, 奥山 明彦, 田中 宏光
  • Organizer: 日本アンドロロジー学会第26回学術大会
  • Place of Presentation: 千葉県
  • Year and Date: 2007-07-06
• [Presentation] ランチョンセミナー 妊孕性を考えた性腺補充療法「低ゴナドトロピン性男性性腺機能低下症の治療」 (2007)
  • Author(s): 辻村晃
  • Organizer: 第80回日本内分泌学会
  • Place of Presentation: 東京都
  • Year and Date: 2007-06-14
• [Presentation] 妊孕性を考えた性腺補充療法「低ゴナドトロピン性男性性腺機能低下症の治療」 (2007)
  • Author(s): 辻村 晃
  • Organizer: 第80回日本内分泌学会ランチョンセミナー
  • Place of Presentation: 東京都
  • Year and Date: 2007-06-14
• [Presentation] THE LEARNING CURVE IN MICRODISSECTION TESTICULAR SPERM EXTRACTION AND ITS IMPACT ON SPERM RETRIEVAL RATE IN 200 CONSECUTIVE CASES OF NON-OBSTRUCTIVE AZOOSPERMIA (2007)
  • Author(s): Miyagawa Y
  • Organizer: American Urological Association 102nd Annual Meeting
  • Place of Presentation: Anaheim, California in USA
  • Year and Date: 2007-05-19
• [Presentation] 顕微鏡下精巣内精子採取術における学習曲線と精子回収率に関する検討 (2007)
  • Author(s): 宮川康
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-16
• [Presentation] ワークショップ「患者さんの目線に立った生殖医療の最前線」無精子症に対するMD-TESE : 最近の動向~精子回収率予測と今後の課題~ (2007)
  • Author(s): 宮川康
  • Organizer: 第95回日本泌尿器科学会総会, 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-16
• [Presentation] ケーススタディー3「Andrology・不妊・性機能」 (2007)
  • Author(s): 辻村晃
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-16
• [Presentation] ワークショップ「患者さんの目線に立った生殖医療の最前線」無精子症に対するMD-TESE:最近の動向〜精子回収率予測と今後の課題〜 (2007)
  • Author(s): 宮川 康
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-16
• [Presentation] 精子細胞核Kinase Haspinのpromoterは排卵後の卵でタンパク質発現を誘導する (2007)
  • Author(s): 田中宏光
  • Organizer: 文部科学省 科学研究補助金 特定領域研究「生殖細胞の発生プロセス・再プログラム化とエピジェネティクス」公開シンポジウム
  • Place of Presentation: 東京都
• [Presentation] 精子細胞特異的遺伝子群の解析とその臨床応用 (2007)
  • Author(s): 田中宏光
  • Organizer: 大阪大学イノベーションセンター研究シーズ発表
  • Place of Presentation: 大阪府
• [Presentation] 精子細胞特異的遺伝子群の解析とその臨床応用 (2007)
  • Author(s): 田中宏光
  • Organizer: 大阪大学 イノベーションセンター 研究シーズ発表の場
  • Place of Presentation: 大阪府
• [Book] 生殖医療ガイドライン2007 (2007)
  • Author(s): 辻村晃、奥山明彦
  • Publisher: 金原出版
• [Book] 生殖医療ガイドライン2007(日本生殖医学会編) (2007)
  • Author(s): 辻村 晃、奥山明彦
  • Total Pages: 384
  • Publisher: 金原出版社
• [Book] 蛋白質核酸酵素 「生殖細胞の発生・エピジェネティクスと再プログラム化」 (2007)
  • Author(s): 田中宏光
  • Total Pages: 2006
  • Publisher: 共立出版
• [Book] 精子学(新編) (2006)
  • Author(s): 辻村晃、奥山明彦
  • Publisher: 東京大学出版会
• [Book] 新編 精子学 (森沢正昭・星 和彦・岡部 勝(編))(毛利英雄・星 元紀(監修)) (2006)
  • Author(s): 田中宏光, 西宗義武, 辻村 晃, 奥山明彦
  • Total Pages: 489
  • Publisher: 東京出版
• [Patent(Industrial Property Rights)] ALDOA遺伝子のSNP診断及びその治療法の選択 (2009)
  • Inventor(s): 辻村晃
  • Industrial Property Rights Holder: 国立大学法人 大阪大学
  • Filing Date: 2009-01-28
• [Patent(Industrial Property Rights)] PGAM4遺伝子のSNP診断及びその治療法の選択 (2009)
  • Inventor(s): 辻村晃
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Filing Date: 2009-01-28
• [Patent(Industrial Property Rights)] MCAのSNPについて (2007)
  • Inventor(s): 田中宏光、奥山明彦、辻村晃、宮川康
  • Industrial Property Rights Holder: 田中宏光、奥山明彦、辻村晃、宮川康
  • Industrial Property Number: 2007-184946
  • Filing Date: 2007-07-13