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Fundamental research for new molecular mechanism of anticancer resistance in urogenital cancer

Research Project

Project/Area Number 18390437
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionOkayama University

Principal Investigator

NASU Yasutomo  Okayama University, 大学院・医歯薬学総合研究科, 准教授 (20237572)

Co-Investigator(Kenkyū-buntansha) SAKAGUCHI Masakiyo  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
SAIKA Takashi  岡山大学, 医学部・歯学部付属病院, 講師 (10314676)
EBARA Shin  岡山大学, 医学部・歯学部附属病院, 助手 (70379741)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥14,120,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2006: ¥3,200,000 (Direct Cost: ¥3,200,000)
Keywords腫瘍学 / 遺伝子治療学 / 薬剤耐性 / ストレス応答分子 / JNK / REIC / DKK3 / P-glycoprotein / Dkk3 / Dkk-3 / HSP70
Research Abstract

抗がん剤による治療を行った場合に、徐々にその効果が低下することは臨床上しばしば認めることであり、そのメカニズムを解明しその結果に基づき新たな治療法を開発することは極めて重要なことである.がん細胞に対してアポトーシス(細胞死)誘導するREIC/Dkk-3が耐性獲得抑制、耐性克服もしくは感受性増強のための標的となることを明らかにした.特に、REIC/Dkk-3により抗がん剤耐性獲得におけるkey moleculeであるP-glycoproteinの発現が低下することを突き止めた.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (19 results)

All 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 13 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] REIC/Dkk-3overexpression downregulates P-glycoprotein in multidrug-resistant MCF7 /ADR cells and induces apoptosis in breast cancer2008

    • Author(s)
      Kawasaki K., Watanabe M., Sakaguchi M., Ogasawara Y., Ochiai K., Nasu Y., Doihara H., Kashiwakura Y., Huh N-h., Kumon H., Date H.
    • Journal Title

      Cancer Gene Therapy 16

      Pages: 65-75

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis2008

    • Author(s)
      Abarzua F., Kashiwakura Y., Takaoka M., Watanabe M., Ochiai K., Sakaguchi M., Iwawaki T., Tanimoto R., Nasu Y., Huh NH., Kumon H.
    • Journal Title

      Biochem Biophys Res Commun 375

      Pages: 614-618

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-h.Mechanistic Analysis of Resistance to REIC/Dkk-3-induced Apoptosis in Human Bladder Cancer Cells2008

    • Author(s)
      Kobayashi, T., Sakaguchi M., Tanimoto R., Abarzua, F., Takaishi M., Kaku, H. Kataoka, , K., Saika T.,Nasu Y., Miyazaki M., Kumon H., Huh
    • Journal Title

      Acta Med Okayama 62

      Pages: 379-384

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer2008

    • Author(s)
      Kawasaki K., Nasu Y
    • Journal Title

      Cancer Gene Therapy 16

      Pages: 65-75

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An N-terninal 78 amino acid truncation of REIC/Dkk-3 effect ively induces apoptosis2008

    • Author(s)
      Abarzua F., Nasu Y
    • Journal Title

      Biochem Biophys Res Commun 375

      Pages: 614-618

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic Analysis of Resistance to REIC/Dkk-3-induced Apoptosis in Human Bladder Cancer Cells2008

    • Author(s)
      Kobayashi T., Nasu Y
    • Journal Title

      Ada Med Okayama 62

      Pages: 379-384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer2007

    • Author(s)
      Tanimoto R, Abarzua F, Sakaguchi M, Takaishi M, Nasu Y, Kumon H, Huh NH
    • Journal Title

      Int J Mol Med. 19

      Pages: 363-368

    • NAID

      10019918537

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-32007

    • Author(s)
      Abarzua F, Sakaguchi M, Tanimoto R, Sonegawa H, Li DW, Edamura K, Kobayashi T, Watanabe M, Kashiwakura Y, Kaku H, Saika T, Nakamura K, Nasu Y, Kumon H, Huh NH
    • Journal Title

      Int J Mol Med. 20

      Pages: 37-43

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumo growth and metastasis in an orthotopic prostate cancer model2007

    • Author(s)
      Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh NH, Kumon H
    • Journal Title

      Cancer Gene Ther. 14

      Pages: 765-772

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients withlocal recurrence of prostate cancer after hormonal therapy2007

    • Author(s)
      Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson T.C, Kumon H
    • Journal Title

      Mol Ther. 15

      Pages: 834-840

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer2007

    • Author(s)
      Tanimoto R. Abarzua F, Sakaguchi M, Takaishi M, Nasu Y, Kumon H, Huh NH
    • Journal Title

      Int J Mol Med 19

      Pages: 363-368

    • NAID

      10019918537

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy2007

    • Author(s)
      Nasu Y, Saika T, Ebara S, Kusaka N, Kaku H, Abarzua F, Manabe D, Thompson T.C, Kumon H
    • Journal Title

      Mol Ther 15

      Pages: 834-840

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model2007

    • Author(s)
      Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh N.H. Kumon H
    • Journal Title

      Cancer Gene Ther 14

      Pages: 765-772

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌-基礎・臨床研究のアップデート-II.臨床研究 治療 遺伝子治療自殺遺伝子・サイトカイン遺伝子を用いた遺伝子治療2007

    • Author(s)
      賀来春紀, 那須保友, 雑賀隆史, 公文裕巳
    • Journal Title

      日本臨牀 65

      Pages: 522-527

    • Related Report
      2007 Annual Research Report
  • [Journal Article] REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer2007

    • Author(s)
      Tanimoto R, Nasu Y et al.
    • Journal Title

      Int J Mol Med 19

      Pages: 363-8

    • NAID

      10019918537

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-32007

    • Author(s)
      Abarzua F, Nasu Y et al.
    • Journal Title

      Int J Mol Med (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suicide gene therapy with adenoviral vector delivery of HSV-tk gene and the intravnous administration of ganciclovir for patients with local recurrence of prostate cancer after hormonal therapy2007

    • Author(s)
      Nasu Y, Saika T et al.
    • Journal Title

      Molecular Therapy (In press)

    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗癌剤耐性癌において抗癌剤増強作用を有する癌細胞死誘導剤2007

    • Inventor(s)
      公文裕巳、那須保友、渡部昌実、柏倉祐司、川崎賢祐
    • Industrial Property Rights Holder
      国立大学法人岡山大学、桃太郎源株式会社産業財産権の種類
    • Industrial Property Number
      2007-287373
    • Filing Date
      2007-11-05
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 抗癌剤耐性癌において抗癌剤増強作用を有する癌細胞死誘導剤。2007

    • Inventor(s)
      公文 裕巳
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      2007-287373
    • Filing Date
      2007-11-05
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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