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Development of regenerative therapy for corneal endothelial diseases

Research Project

Project/Area Number 18390468
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

NISHIDA Koji  Tohoku University, 医学系研究科, 教授 (40244610)

Co-Investigator(Kenkyū-buntansha) 前田 直之  大阪大学, 大学院・医学系研究科・寄附講座, 教授 (00273623)
田野 保雄  大阪大学, 大学院・医学系研究科, 教授 (80093433)
大和 雅之  東京女子医科大学, 先端生命医科学研究所, 准教授 (40267117)
中澤 徹  東北大学, 大学院・医学系研究科, 講師 (30361075)
横倉 俊二  東北大学, 病院, 助教 (30400378)
金久保 佐和子  東北大学, 病院・医員 (90436113)
Co-Investigator(Renkei-kenkyūsha) MAEDA Naoyuki  大阪大学, 大学院・医学系研究科, 寄附講座教授 (00273623)
TANO Yasuo  大阪大学, 大学院・医学系研究科, 教授 (80093433)
YAMATO Masayuki  東京女子医科大学, 先端生命研究所, 教授 (40267117)
NAKAZAWA Toru  東北大学, 大学院・医学系研究科, 講師 (30361075)
YOKOKURA Syunji  東北大学, 病院, 助教 (30400378)
KUBOTA Akira  東北大学, 病院, 助教 (50451589)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,080,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
Keywords移植・再生医療 / 再生医学 / 細胞・組織 / トランスレーショナルリサーチ / 臨床
Research Abstract

ヒト角膜内皮から作製したヒト培養角膜内皮細胞シートは、機能的に角膜内皮機能を補完できた。さらに、spheroid培養することで自己複製可能な未分化細胞を得ることに成功した。また移植用キャリアシートとして、アテロコラーゲンおよび新規開発シートを選定した。さらにトランスジェニックマウスを用いた解析によって、眼組織中に内皮細胞源となる未分化かつ多分化能を有する細胞を単離することに成功した。マイクロアレイ解析によって、複数の角膜内皮細胞増殖因子候補を絞り込むことに成功した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (88 results)

All 2009 2008 2007

All Journal Article (43 results) (of which Peer Reviewed: 42 results) Presentation (33 results) Patent(Industrial Property Rights) (12 results)

  • [Journal Article] Analysis of soluble vascular endothelial growth factor receptor-1 secreted from cultured corneal and oral mucosal epithelial cell sheets in vitro.2009

    • Author(s)
      Kanayama S, Nishida K, Yamato M, Hayashi R, Maeda N, Okano T, Tano Y
    • Journal Title

      Br J Ophthalmol 93

      Pages: 263-267

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of soluble vascular endothelial growth factor receptor-1 secreted from cultured corneal and oral mucosal epithelial cell sheets in vitro2009

    • Author(s)
      Kanayama S, et.al.
    • Journal Title

      Br J Ophthalmol. 93

      Pages: 263-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal degeneration2008

    • Author(s)
      Oie Y, Maeda N, Kosaki R, Suzaki A, Hirohara Y, Mihashi T, Hori Y, Inoue T, Nishida K, Fujikado T, Tano Y,
    • Journal Title

      J Cataract Refract Surg 34

      Pages: 928-934

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transportation of transplantable cell sheets fabricated with temperature-responsive culture surfaces for regenerative medicine2008

    • Author(s)
      Nozaki T, Yamato M, Inuma T, Nishida K, Okano T
    • Journal Title

      J Tissue Eng Regen Med. 2

      Pages: 190-195

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous transplantation of autologous oral mucosal epithelial cell sheets fabricated on temperature-responsive culture dishes.2008

    • Author(s)
      Obokata H, Yamato M, Yang J, Nishida K, Tsuneda S, Okano T
    • Journal Title

      J Biomed Mater Res A 86

      Pages: 1088-1096

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Collagen Hydrogel with High Mechanical Strength by a Simple Molecular Orientation Method for Triple-Helix2008

    • Author(s)
      Hongo C, Matsusaki M, Nishida K, Akashi M
    • Journal Title

      Chem. Lett 37

      Pages: 1254-1255

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose tissue-derived mesenchymal stem cells as a novel feeder layer for epithelial cells. Journal of engineering and regenerative medicine2008

    • Author(s)
      Sugiyama H, Maeda K, Yamato M, Hayashi R, Soma T , Hayashida Y, Yang J, Shirakabe M, Matsuyama A, Kikuchi A, Sawa Y, Okano T, Tano Y, Nishida K,
    • Journal Title

      Journal of engineering and regenerative medicine 2

      Pages: 445-449

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of MUC16 in human oral mucosal epithelium and cultivated epithelial sheets2008

    • Author(s)
      Y. Hori Y, Nishida K, Yamato K, Sugiyama H, Soma T, Inoue T, Maeda N, Okano T, Tano Y
    • Journal Title

      Experimental Eye Research 87

      Pages: 1-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Vasohibin, an Antiangiogenice Factor, in Human Choroidal Neovascular Membranes2008

    • Author(s)
      Wakusawa R, Abe T, Sato H, Yoshida M, Kunikata H, Sato Y, Nishida K
    • Journal Title

      Am J Ophthalmol 146

      Pages: 235-243

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Keratocytes and Stromal Inflammation in Chronic Phase of Severe Ocular Surface Diseases with Corneal Stem Cell Deficiencies.2008

    • Author(s)
      Saito T, Nishida K, Sugiyama H, Yamato M, Maeda N, Okano T, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 404-410

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation2008

    • Author(s)
      Tanaka T, Sato H, Tada A, Moriya T, Wada Y, Nishida K
    • Journal Title

      Jpn J Ophthalmol 52

      Pages: 344-345

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topica doxycycline can induce expression of BDNF in transduced retinal pigment epithelial cells transplanted into the subretinal space2008

    • Author(s)
      Abe T, Wakusawa R, Seto H, Asai N, Saito T, Nishida K
    • Journal Title

      Invest Ophthalmol Vis Sci 48

      Pages: 3631-3639

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese2008

    • Author(s)
      Fuse N, Miyazawa A, Nakazawa T, Mengkegale M, Otomo T, Nishida K
    • Journal Title

      Mol Vis 14

      Pages: 1388-1343

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema.2008

    • Author(s)
      Shimura M, Nakazawa T, Yasuda K, Shiono T, Iida T, Sakamoto T, Nishida K
    • Journal Title

      Am J Ophthalmol 145

      Pages: 854-861

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema2008

    • Author(s)
      Shimura M, Nakazawa T, Yasuda K, Kunikata H, Shiono T, Nishida K
    • Journal Title

      Acta Ophthalmol 86

      Pages: 377-384

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of corneal epithelial stem/progenitor cells using cell surface markers, integrin α6 and CD712008

    • Author(s)
      Hayashi R, Yamato M, Sugiyama H, Sumide T, Yang J, Okano T, Tano Y, Nishida K
    • Journal Title

      Biochemical and Biophysical Research Communications 367

      Pages: 256-263

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal degeneration2008

    • Author(s)
      Oie Y, et.al.
    • Journal Title

      J Cataract Refract Surg. 2

      Pages: 928-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transportation of transplantable cell sheets fabricated with temperature-responsive culture surfaces for regenerative medicine2008

    • Author(s)
      Nozaki T, et.al.
    • Journal Title

      J Tissue Eng Regen Med. 2

      Pages: 190-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous transplantation of autologous oral mucosal epithelial cell sheets fabricated on temperature-responsive culture dishes2008

    • Author(s)
      Obokata H, et.al.
    • Journal Title

      J Biomed Mater Res A. 86

      Pages: 1088-96

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Collagen Hydrogel with High Mechanical Strength by a Simple Molecular Orientation Method for Triple-Helix2008

    • Author(s)
      Hongo C, et.al.
    • Journal Title

      Chem. Lett. 37

      Pages: 1254-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose tissue-derived mesenchymal stem cells as a novel feeder layer for epithelial cells. Journal of engineering and regenerative medicine2008

    • Author(s)
      Sugiyama H, et.al.
    • Journal Title

      Journal of engineering and regenerative medicine. 2

      Pages: 445-449

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of MUC16 in human oral mucosal epithelium and cultivated epithelial sheets2008

    • Author(s)
      Y. Hori, et.al.
    • Journal Title

      Experimental Eye Research 87

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Vasohibin, an Antiangiogenice Factor, in Human Choroidal Neovascular Membranes2008

    • Author(s)
      Wakusawa R, et.al.
    • Journal Title

      Am J Ophthalmol. 146

      Pages: 235-243

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Keratocytes and Stromal Inflammation in Chronic Phase of Severe Ocular Surface Diseases with Corneal Stem Cell Deficiencies2008

    • Author(s)
      Saito T, et.al.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 404-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation2008

    • Author(s)
      Tanaka T, et.al.
    • Journal Title

      Jpn J Ophthalmol. 52

      Pages: 344-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical doxycycline can induce expression of BDNF in transduced retinal pigment epithelial cells transplanted into the subretinal space2008

    • Author(s)
      Abe T, et.al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 49

      Pages: 3631-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese2008

    • Author(s)
      Fuse N, et.al.
    • Journal Title

      Mol Vis. 14

      Pages: 1388-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema2008

    • Author(s)
      Shimura M, et.al.
    • Journal Title

      Am J Ophthalmol. 145

      Pages: 854-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema2008

    • Author(s)
      Shimura M, et.al.
    • Journal Title

      Acta Ophthalmol. 86

      Pages: 377-84

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of corneal epithelial stem/progenitor cells using cell surface markers, integrin α6 and CD71.2008

    • Author(s)
      Hayashi R
    • Journal Title

      Biochemical and Biophysical Research Communications. 367

      Pages: 256-263

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of angiogenesis induced by cultured corneal and oral mucosal epithelial cell sheets in vitro2007

    • Author(s)
      Kanayama S, Nishida K, Yamato M, Hayashi R, Sugiyama H, Soma T, Maeda N, Okano T, Tano Y
    • Journal Title

      Exp Eye Res 85

      Pages: 772-781

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche2007

    • Author(s)
      Hayashi R, Yamato M, Sugiyama H, Sumide T, Yang J, Okano T, Tano Y, Nishida K
    • Journal Title

      Stem Cells 25

      Pages: 289-296

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of membrane-associated mucins in cultivated human oral mucosal epithelial cells2007

    • Author(s)
      Hori Y, Sugiyama H, Soma T, Nishida K
    • Journal Title

      Cornea 9

      Pages: 65-69

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans2007

    • Author(s)
      Kitayama K, Hayashida Y, Nishida K, Akama TO
    • Journal Title

      J Biol Chem 282

      Pages: 30085-30096

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progress in the development of tissue engineering of the cornea in Japan2007

    • Author(s)
      Koizumi N, Nishida K, Amano S, Kinoshita S
    • Journal Title

      Nippon Ganka Gakkai Zasshi 111

      Pages: 493-503

    • NAID

      10019576777

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of transplantable genetically modified corneal epithelial cell sheets for gene therapy. Biomaterials2007

    • Author(s)
      Watanabe K, Yamato M, Hayashida Y, Yang J, Kikuchi A, Okano T, Tano Y, Nishida K
    • Journal Title

      Biomaterials 28

      Pages: 745-749

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of angiogenesis induced by cultured corneal and oral mucosal epithelial cell sheets in vitro.2007

    • Author(s)
      Kanayama S
    • Journal Title

      Exp Eye Res. 85

      Pages: 772-781

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche.2007

    • Author(s)
      Hayashi R
    • Journal Title

      Stem Cells. 25

      Pages: 289-296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of membrane-associated mucins in cultivated human oral mucosal epithelial cells.2007

    • Author(s)
      Hori Y
    • Journal Title

      Cornea 9

      Pages: 65-69

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans2007

    • Author(s)
      Kitayama K
    • Journal Title

      J Biol Chem. 282

      Pages: 30085-30096

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progress in the development of tissue engineering of the cornea in Japan.2007

    • Author(s)
      Koizumi N
    • Journal Title

      Nippon Ganka Gakkai Zasshi. 111

      Pages: 493-503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of transplantable genetically modified corneal epithelial cell sheets for gene therapy.2007

    • Author(s)
      Watanabe K
    • Journal Title

      Biomaterials 28

      Pages: 745-749

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-Cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche.2007

    • Author(s)
      Hayashi R, Yamato M, Sugiyama H, Sumide T, Yang J, Okano T, Tano Y, Nishida K
    • Journal Title

      Stem Cells Feb;25 (2)

      Pages: 289-296

    • Related Report
      2006 Annual Research Report
  • [Presentation] Tears and Ocular Surface2008

    • Author(s)
      西田幸二
    • Organizer
      The 14th Annual Meeting of Kyoto Cornea Club Symposium I
    • Place of Presentation
      ウェンスティン都ホテル京都
    • Year and Date
      2008-12-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Tears and Ocular Surface2008

    • Author(s)
      西田幸二
    • Organizer
      The 14th Annual Meeting of Kyoto Cornea Club Symnnsium I
    • Place of Presentation
      ウェンステイン都ホテル京都
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] CORNEAL EPITHELIAL STEM CELL AND REGENERATIVE MEDICINE2008

    • Author(s)
      西田幸二
    • Organizer
      Adult Stem Cells - Biology and Clinical Applications Meeting
    • Place of Presentation
      Griffith University, Australia
    • Year and Date
      2008-11-25
    • Related Report
      2008 Final Research Report
  • [Presentation] CORNEAL EPITHELIAL STEM CELL AND REGENERATIVE MEDICINE2008

    • Author(s)
      西田幸二
    • Organizer
      Adult Stem Cells-Biology and Clinical Applications Meeting
    • Place of Presentation
      Griffith University, Australia
    • Year and Date
      2008-11-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再生医療の話題2008

    • Author(s)
      西田幸二
    • Organizer
      堺市眼科医会総会学術講演会
    • Place of Presentation
      リーガロイヤルホテル堺
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 角膜再生医療の標準化に向けて2008

    • Author(s)
      西田幸二
    • Organizer
      第2回再生医療テクノロジー・イノベーション研究会
    • Place of Presentation
      東京女子医科大学
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 徹底解剖!角膜内皮移植術(DSAEK)2008

    • Author(s)
      西田幸二
    • Organizer
      第62回臨床眼科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 角膜上皮ジストロフィーの治療戦略2008

    • Author(s)
      西田幸二
    • Organizer
      第62回臨床眼科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 徹底解剖! 角膜内皮移植術(DSAEK)2008

    • Author(s)
      西田幸二
    • Organizer
      第62回臨床眼科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結膜炎症と眼表面疾患2008

    • Author(s)
      西田幸二
    • Organizer
      第9回眼炎症セミナー
    • Place of Presentation
      九州大学
    • Year and Date
      2008-10-08
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Corneal epithelial stem cell2008

    • Author(s)
      西田幸二
    • Organizer
      ICER2008
    • Place of Presentation
      Crown Plaza Hotel Wuzhow、北京
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Translational Research2008

    • Author(s)
      西田幸二
    • Organizer
      JST スイスワークショップ
    • Place of Presentation
      スイス連邦工科大学チューリヒ校
    • Year and Date
      2008-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Translational Research2008

    • Author(s)
      西田幸二
    • Organizer
      JSTスイスワークショップ
    • Place of Presentation
      スイス連邦工科大学チューリヒ校
    • Year and Date
      2008-09-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 角膜上皮の再生医療2008

    • Author(s)
      西田幸二
    • Organizer
      東京大学平成20年度基礎・臨床・社会学統合講義
    • Place of Presentation
      東京大学医学部
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 角膜治療のアップデート2008

    • Author(s)
      西田幸二
    • Organizer
      函館眼科医会学術講演会
    • Place of Presentation
      函館国際ホテル
    • Year and Date
      2008-07-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Corneal tissue engineering2008

    • Author(s)
      西田幸二
    • Organizer
      9th International Symposium of Ophthalmology
    • Place of Presentation
      中国青島
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] DALK Combined with Ocular Surface Reconstruction2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008Symposium
    • Place of Presentation
      Hong KongConvention&Exhibition Centre
    • Year and Date
      2008-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] DALK Combined with Cataract Surgery2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008 Symposium
    • Place of Presentation
      Hong Kong Convention&Exhibition Centre
    • Year and Date
      2008-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] DALK Combined with Ocular Surface Reconstruction2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008 Symposium
    • Place of Presentation
      Hong Kong Convention & Exhibition Centre
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] DALK Combined with Cataract Surgery2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008 Symposium
    • Place of Presentation
      Hong Kong Convention & Exhibition Centre
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell Sheet Transplantation for Ocular Surface Reconstruction2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008 Symposium
    • Place of Presentation
      Hong Kong Convention&Exhibition Centre
    • Year and Date
      2008-06-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell Sheet Transplantation for Ocular Surface Reconstruction2008

    • Author(s)
      西田幸二
    • Organizer
      WOC 2008 Symposium
    • Place of Presentation
      Hong Kong Convention & Exhibition Centre
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 角膜手術の進歩2008

    • Author(s)
      西田幸二
    • Organizer
      第94回沖縄眼科集談会
    • Place of Presentation
      琉球大学医学部
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Method for the Validation of Tissue-Engineered Epithelial Cell Sheet2008

    • Author(s)
      林竜平
    • Organizer
      ARVO
    • Place of Presentation
      GREATER FORT LAUDERDALE/BROWARD COUNTY CONCENTION CENTER
    • Year and Date
      2008-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Method for the Validation of Tissue-Engineered Epithelial Cell Sheet2008

    • Author(s)
      林竜平
    • Organizer
      ARVO
    • Place of Presentation
      GREATER FORT LAUD ERDALE / BROWARD COUNTY CONCENTION CENTER
    • Year and Date
      2008-05-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Validation of Human and Rabbit Cultured Corneal Epithelial Cell Sheets by Full-Field Optical Coherence Tomography2008

    • Author(s)
      久保田享
    • Organizer
      ARVO
    • Place of Presentation
      GREATER FORT LAUDERDALE/BROWARD COUNTY CONCENTION CENTER
    • Year and Date
      2008-04-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Validation of Human and Rabbit Cultured Corneal Epithelial Cell Sheets by Full-Field Optical Coherence Tomography2008

    • Author(s)
      久保田享
    • Organizer
      ARVO
    • Place of Presentation
      GREATER FORT LAUD ERDALE / BROWARD COUNTY CONCENTION CENTER
    • Year and Date
      2008-04-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 角膜疾患の外科的治療の進歩2007

    • Author(s)
      西田幸二
    • Organizer
      東京都眼科医会学術講演会
    • Place of Presentation
      丸の内マイプラザホール
    • Year and Date
      2007-11-17
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 再生角膜移植の現状と課題2007

    • Author(s)
      西田幸二
    • Organizer
      国際人工臓器学会
    • Place of Presentation
      仙台国際交流センター
    • Year and Date
      2007-10-30
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 角膜の再生医療2007

    • Author(s)
      西田幸二
    • Organizer
      オキュラーサーフェスシンポジウム東京
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2007-09-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 角膜の再生医療2007

    • Author(s)
      西田幸二
    • Organizer
      オキュラーサーフェスシンポジウム 東京
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2007-09-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 角膜内皮の診かた2007

    • Author(s)
      西田幸二
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-22
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 上皮再生・内皮2007

    • Author(s)
      西田幸二
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-19
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 積層コラーゲンゲルの製造方法、配向方法およびそれらの方法により製造された積層コラーゲンゲル2008

    • Inventor(s)
      明石満、西田幸二、松崎典弥、大道正明
    • Industrial Property Rights Holder
      大阪大学、東北大学
    • Industrial Property Number
      2008-330579
    • Filing Date
      2008-12-25
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 強膜透明化による角膜移植材料調製方法2008

    • Inventor(s)
      西田幸二、田中佑治、久保田享
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2008-141043
    • Filing Date
      2008-05-29
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 組織幹細胞/組織前駆細胞からの角膜内皮細胞の生成方法2008

    • Inventor(s)
      西田幸二、林竜平、菊地未来、大隅典子
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2008-123562
    • Filing Date
      2008-05-09
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 非共有結合型コラーゲン架橋剤2008

    • Inventor(s)
      明石満、西田幸二、松崎典弥、久保田享
    • Industrial Property Rights Holder
      大阪大学、東北大学
    • Industrial Property Number
      2008-121073
    • Filing Date
      2008-05-07
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 上皮系細胞シートの作製のための同種上皮系細胞シートの作製のための同種2008

    • Inventor(s)
      西田幸二、大家義則
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2008-071677
    • Filing Date
      2008-03-19
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 積層コラーゲンゲルの製造方法、配向方法およびそれらの方法により製造された積層コラーゲンゲル2008

    • Inventor(s)
      明石満、西田幸二、松崎典弥、大道正明
    • Industrial Property Rights Holder
      大阪大学・東北大学
    • Filing Date
      2008-12-25
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 強膜透明化による角膜移値材料調製方法2008

    • Inventor(s)
      西田幸二、田中佑治、久保田享
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織幹細胞/組織前駆細胞からの角膜内皮細胞の生成方法2008

    • Inventor(s)
      西田幸二、林竜平、菊地未来、大隅典子
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 非共有結合型コラーゲン架橋剤2008

    • Inventor(s)
      明石満、西田幸二、松崎典弥、久保田享
    • Industrial Property Rights Holder
      大阪大学東北大学
    • Filing Date
      2008-05-07
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 上皮系細胞シートの作製のための同種皮膚由来フィーダー細胞2008

    • Inventor(s)
      西田幸二、大家義則
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2008-071677
    • Filing Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 積層コラーゲンゲルの作製方法及び積層コラーゲンゲル2007

    • Inventor(s)
      明石満、西田幸二、松崎典弥、本郷千鶴、田中佑治、久保田享
    • Industrial Property Rights Holder
      大阪大学、東北大学
    • Industrial Property Number
      2007-339635
    • Filing Date
      2007-12-28
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 積層コラーゲンゲルの作製方法及び積層コラーゲンゲル2007

    • Inventor(s)
      明石 満、西田幸二、松崎典弥 本郷千鶴、田中佑治、久保田享
    • Industrial Property Rights Holder
      東北大学大阪大学
    • Industrial Property Number
      2007-339635
    • Filing Date
      2007-12-28
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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