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Isolation of maltipotent stem cells from keloids

Research Project

Project/Area Number 18390477
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionKyoto University

Principal Investigator

SUZUKI Shigehiko  Kyoto University, 医学研究科, 教授 (30187728)

Co-Investigator(Kenkyū-buntansha) UTANI Atsushi  京都大学, 医学研究科, 准教授 (10292707)
NAITOH Motoko  京都大学, 医学研究科, 講師 (30378723)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,430,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywordsケロイド / 創傷治癒 / 幹細胞 / 組織再生 / 遺伝子
Research Abstract

We obtained multipotent precursor cells derived from keloid tissues. We found that gene B over-expressed in keloid derived precursor cells, plays a crucial role in keloid pathogenesis, because this gene is closely concerned with up-regulation of collagen gene expression. We propose that both of keloid derived precursor cells and gene B may be a good target for a novel therapy.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Book (5 results)

  • [Journal Article] Keloids can be forced into remission with surgical excision and radiation followed by adjuvant therapy2011

    • Author(s)
      山脇聖子、鈴木茂彦, 他
    • Journal Title

      Ann Plast Surg in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Keloids can be forced into remission with surgical excision and radiation followed by adjuvant therapy.2011

    • Author(s)
      山脇聖子、鈴木茂彦, 他
    • Journal Title

      Ann Plast Surg.

      Volume: (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非典型的部位に生じたケロイドに対する切除と放射線治療の結果について2008

    • Author(s)
      山脇聖子、鈴木茂彦, 他
    • Journal Title

      瘢痕・ケロイド治療ジャーナル 2巻

      Pages: 84-87

    • Related Report
      2010 Final Research Report
  • [Journal Article] 幹細胞の基礎研究と臨床の進歩臨床応用再生医療の実際-皮膚2008

    • Author(s)
      鈴木茂彦、森本尚樹、内藤素子
    • Journal Title

      日本臨床 66巻5号

      Pages: 961-965

    • Related Report
      2010 Final Research Report 2008 Self-evaluation Report
  • [Journal Article] 非典型的部位に生じたケロイドに対する切除と放射線治療の結果について2008

    • Author(s)
      山脇聖子、内藤素子、石河利広、池田実香、吉川勝宇、鈴木茂彦
    • Journal Title

      瘢痕・ケロイド治療ジャ-ナル 2巻

      Pages: 84-87

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] 非典型的部位に生じたケロイドに対する切除と放射線療法の結果について2008

    • Author(s)
      山脇聖子
    • Journal Title

      瘢痕・ケロイド治療ジャーナル 2号

      Pages: 84-87

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 非典型的部位に生じたケロイドに対する切除と放射線治療の結果について2008

    • Author(s)
      山脇 聖子
    • Journal Title

      瘢痕・ケロイド治療ジャーナル 2

      Pages: 84-87

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 皮膚・軟部組織の再生2007

    • Author(s)
      鈴木茂彦
    • Journal Title

      治療 89巻

      Pages: 2681-2687

    • Related Report
      2010 Final Research Report
  • [Journal Article] 「皮膚・軟部組織の再生」治療2007

    • Author(s)
      鈴木茂彦、森本尚樹、内藤素子
    • Journal Title

      89巻

      Pages: 2681-2687

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] 肥厚生瘢痕・ケロイドすぐに役立つ日常皮膚神陵における私の工夫2007

    • Author(s)
      鈴木 茂彦
    • Journal Title

      Monthly Book Dermatology 89

      Pages: 2681-2687

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Factor XIII a-positive dermal dendritic cells in keloids and hypertrophic and mature scars2007

    • Author(s)
      Onodera, M.
    • Journal Title

      Pathology International 57

      Pages: 337-342

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of the intralesional injection of triamcinolone acetonide for the treatment of keloids in Orientals2006

    • Author(s)
      Gan Muneuchi、Shigehiko Suzuki, 他
    • Journal Title

      Surg.Hand.Surg. Vol.40 No.2

      Pages: 111-776

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients2006

    • Author(s)
      Muneuchi G, Suzuki S, Onodera M, Ito O, Hata Y, Igawa HH
    • Journal Title

      Scand J Plast Reconstr Surg Hand Surg 40(2)

      Pages: 111-6

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of the intralesional injection of triamcinolone acetonide for the treatment of keloids in Orientals.2006

    • Author(s)
      Gan Muneuchi
    • Journal Title

      Surg. Hand. Surg. 40(2)

      Pages: 111-116

    • Related Report
      2006 Annual Research Report
  • [Presentation] Adult Human Skin-derived Precursor Cellsの採取部位による相違点2010

    • Author(s)
      吉川勝宇、鈴木茂彦, 他
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Adult Human Skin-derived Precursor Cellsの採取部位による相違点2010

    • Author(s)
      吉川勝宇、鈴木茂彦, 他
    • Organizer
      第18回 日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons2010

    • Author(s)
      北岡志保、鈴木茂彦, 他
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons)2010

    • Author(s)
      北岡志保、鈴木茂彦, 他
    • Organizer
      第33回 日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立と脊髄運動ニューロンへの分化2010

    • Author(s)
      北岡志保、鈴木茂彦, 他
    • Organizer
      日本神経科学学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 変異SOD1を有するALS患者由来iPS細胞の樹立と脊髄運動ニューロンへの分化2010

    • Author(s)
      北岡志保、鈴木茂彦, 他
    • Organizer
      第51回 日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adult Human Skin-derived Precursor Cellsの採取部位による差異の検討2009

    • Author(s)
      吉川勝宇、鈴木茂彦
    • Organizer
      第17回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Adult Human Skin-derived Precursor Cellsの採取部位による差異の検討2009

    • Author(s)
      吉川勝宇、鈴木茂彦, 他
    • Organizer
      第17回 日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] ケロイド術後成績評価の点数化への試み2008

    • Author(s)
      山脇聖子, 内藤素子, 石河利広, 吉川勝宇, 鈴木茂彦
    • Organizer
      第3回瘢痕・ケロイド治療研究会
    • Place of Presentation
      長崎
    • Year and Date
      2008-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] ケロイド術後成績評価の点数化への試み2008

    • Author(s)
      山脇聖子、内藤素子、石河利広、吉川勝宇、鈴木茂彦
    • Organizer
      第3回瘢痕・ケロイド治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-30
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] ケロイド術後成績評価の点数化への試み2008

    • Author(s)
      山脇聖子
    • Organizer
      第3回瘢痕・ケロイド治療研究会
    • Place of Presentation
      神戸
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of cultured keloid cells and application to in vivo keloid models.2007

    • Author(s)
      E. Araki
    • Organizer
      The 37th Annual ESDR
    • Place of Presentation
      Swiss
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Management of scar and scar contructure using local flaps2007

    • Author(s)
      鈴木茂彦
    • Organizer
      2^<nd> Shanghai International plastic Surgery Conference
    • Place of Presentation
      Shanghai
    • Year and Date
      2007-04-17
    • Related Report
      2010 Final Research Report 2008 Self-evaluation Report
  • [Presentation] Management of scar and scar contructure using local flaps.2007

    • Author(s)
      Shigehiko Suzuki
    • Organizer
      2nd Shanghai International plastic Surgery Conference
    • Place of Presentation
      China (Shanghai)
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tissue Engineering of skin.2007

    • Author(s)
      Shigehiko Suzuki
    • Organizer
      2nd Shanghai International plastic Surgery Conference
    • Place of Presentation
      China (Shanghai)
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Book] 標準形成外科学2008

    • Author(s)
      鈴木 茂彦
    • Total Pages
      6
    • Publisher
      瘢痕
    • Related Report
      2007 Annual Research Report
  • [Book] 標準形成外科学2008

    • Author(s)
      鈴木 茂彦
    • Total Pages
      4
    • Publisher
      ケロイド
    • Related Report
      2007 Annual Research Report
  • [Book] すぐに役立つ日常皮膚診療における私の工夫:肥厚性瘢痕・ケロイド2007

    • Author(s)
      鈴木茂彦
    • Total Pages
      309
    • Publisher
      全日本病院出版会
    • Related Report
      2010 Final Research Report
  • [Book] すぐに役立つ日常皮膚診療における私の工夫 : 肥厚性瘢痕・ケロイド(全日本病院出版会)2007

    • Author(s)
      鈴木茂彦
    • Total Pages
      309
    • Related Report
      2008 Self-evaluation Report
  • [Book] すぐに役立つ日常皮膚診療における私の工夫 : 肥厚性瘢痕・ケロイド2007

    • Author(s)
      鈴木 茂彦
    • Total Pages
      309
    • Publisher
      全日本病院出版会
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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