A new therapeutic concept for the treatment against sepsis using a functional material, 1,5-anhydrofructose

• Project/Area Number: 18390481
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kagoshima University
• Principal Investigator: ABEYAMA Kazuhiro Kagoshima University, 大学院・医歯学総合研究科, 特任准教授 (30284897)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Ikurou 鹿児島大学, 大学院・医歯学総合研究科, 教授 (20082282) ; ITO Yuji 鹿児島大学, 工学部, 准教授 (60223195) ; ABE Junichi 鹿児島大学, 農学部, 教授 (80128404)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,730,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,730,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2006: ¥5,900,000 (Direct Cost: ¥5,900,000)
• Keywords: 1,5-AF / 1,5-AG / Ascopyrone-P (APP) / HMGB1蛋白 / 敗血症・多臓器不全 / 低酸素・嫌気代謝 / 炎症 / APP / HMGB1 / 嫌気 / HMGBI

Research Abstract

HMGB1蛋白の細胞の放出・分泌は「炎症の拡大・遷延化因子あるいは個体レベルでの疾患の予後増悪因子」として作用する。今回の研究において、我々は、新規機能性単糖1,5-D-アンヒドロフルクトース(1,5-AF)が、(1)炎症性転写因子NF-kBの制御と(2)HMGB1蛋白の機能制御、(3)細胞内糖代謝系の機能修飾などの3つの作用を介し、抗炎症作用を発揮するユニークな創薬シーズとなり得ることを証明した。

Research Products

• [Journal Article] Gene expression profile during rat mammary carcinogenesis induced by 7,12- dimethylbenz[a]anthracene (2009)
  • Author(s): Souda M, Umekita Y, Abeyama K, Yoshida H
  • Journal Title: Int J Cancer(IF : 4.555) (in press)
  • Peer Reviewed
• [Journal Article] Gene expression profile during rat mammary carcinogenesis induced by 7, 12-dimethylbenz[a]anthracene. (2009)
  • Author(s): Souda M, Umekita Y, Abeyama K, et al
  • Journal Title: Int J Cancer. (印刷中)
  • Peer Reviewed
• [Journal Article] A novel function of the receptor for advanced glycation end products (RAGE) in association with tumorigenesis and tumor differentiation of HCC (2008)
  • Author(s): Hiwatashi K, Ueno S, Abeyama K, Kubo F, Sakoda M, Maruyama I, Hamanoue M, Natsugoe S, Aikou T
  • Journal Title: Ann Surg Oncol(IF : 3.917) 15(3) Pages: 923-933
  • Peer Reviewed
• [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF alpha-mediated proinflammatory events (2008)
  • Author(s): Tancharoen S, Matsuyama T, Abeyama K, Matsushita K. Kawahara K , Sangalungkarm V, Tokuda M, Hashiguchi T, Maruyama I, Izumi Y
  • Journal Title: Implication in periodontal inflammation(IF : 3.643) 217(2) Pages: 338-349
  • Peer Reviewed
• [Journal Article] Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis (2008)
  • Author(s): Hamada T, Torikai M, Kuwazuru A, Tanaka M, Horai N, Fukuda T, Yamada S, Nagayama S, Hashiguchi K, Sunahara N, Fukuzaki K, Nagata R, Komiya S, Maruyama I, Fukuda T, Abeyama K
  • Journal Title: Arthritis Rheum(IF : 7.677) 58(9) Pages: 2675-2685
  • Peer Reviewed
• [Journal Article] Extracellular high mobility group box chromosomal protein l is acoupling factor for hypoxia and inflammation in arthritis. (2008)
  • Author(s): Hamada T, Abeyama K., et al
  • Journal Title: Arthritis Rheum. 58(9) Pages: 2675-2685
  • Peer Reviewed
• [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events : Implication in periodontal inflammation. (2008)
  • Author(s): Tancharoen S, Matsuyama T, Abeyama K, et al
  • Journal Title: J Cell Physiol. 217(2) Pages: 338-349
  • Peer Reviewed
• [Journal Article] Extracellular high mobility group box 1 protein is a coupling factor for hypoxia and detrimental inflammation in arthritis. (2008)
  • Author(s): Hamada T, Abeyama K., et. al.
  • Journal Title: Arthritis Rheum.「掲載確定」 (印刷中)
  • Peer Reviewed
• [Journal Article] A novel function of the receptor for advanced glycation end-products (RAGE) in association with tumorigenesis and tumor differentiation of HCC. (2008)
  • Author(s): Hiwatashi K, Abeyama K., et. al.
  • Journal Title: Ann Surg Oncol. 15(3) Pages: 923-933
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats (2007)
  • Author(s): Ito T, Kawahara K, Nakamura T, Yamada S, Nakamura T, Abeyama K, Hashiguchi T, Maruyama I
  • Journal Title: J Thromb Haemost(IF : 5.947) 5(1) Pages: 109-1116
  • Peer Reviewed
• [Journal Article] Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification (2007)
  • Author(s): Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H
  • Journal Title: Mol Cell Biol(IF : 6.42) 27(16) Pages: 5650-5663
  • Peer Reviewed
• [Journal Article] Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification (2007)
  • Author(s): Taniguchi N, Abeyama K., et. al.
  • Journal Title: Mol Cell Biol. 27(16) Pages: 5650-5663
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. (2007)
  • Author(s): Ito T., Abeyama K., et. al.
  • Journal Title: J Thromb Haemost. 5(1) Pages: 109-116
• [Journal Article] 炎症隔離分子としてのトロンボモジュリン (2006)
  • Author(s): 阿辺山和浩、吉元 寧、丸山征郎
  • Journal Title: 血管医学((特集 : 血管炎のオムニバス)) vol. 7.No.3 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Hydroxyapatite formed on/in agarose gel induces activation of blood coagulation and platelets aggregation. (2006)
  • Author(s): Arimura SI., Abeyama K., et. al.
  • Journal Title: J Biomed Mater Res B Appl Biomater. 81B(2) Pages: 456-461
• [Journal Article] 炎症隔離分子としてのトロンボモジュリン (2006)
  • Author(s): 阿辺山 和浩、丸山 征郎
  • Journal Title: 血管医学(メディカルレビュー社) 7(3) Pages: 19-25
• [Presentation] Arthritis- associated myopathy", a characteristic pathology of primate models (2009)
  • Author(s): Horai N, Abeyama K., et.al.
  • Organizer: Society of Toxicology 48th Annual Meeting
  • Place of Presentation: Baltimore USA
• [Presentation] 新しい理論に基づいたサイトプロテクションと疾病の予防・治療法開発 (2009)
  • Author(s): 阿辺山和浩
  • Organizer: 株式会社新日本科学、遺伝子解析ミーティング
  • Place of Presentation: 鹿児島
• [Presentation] カニクイザル (Cynomolgus Monkey) コラーゲン誘発性関節炎モデルにおける骨格筋の病理組織学的検討 (2009)
  • Author(s): 松田みゆき, 阿邊山 和浩, 他5名
  • Organizer: 第25回日本毒性病理学会
  • Place of Presentation: 静岡
• [Presentation] "Arthritis-associated myopathy", a characteristic pathology of primate models. (2009)
  • Author(s): Horai N, Abeyama K., et al
  • Organizer: Society of Toxicology 48th Annual Meeting & ToxExpo
  • Place of Presentation: Baltimore USA
• [Presentation] Sequential Changes in Oleic Acid-Induced Lung Injury in Dogs (2007)
  • Author(s): Nagaoka T, Abeyama K, et.al.
  • Organizer: The Society of Toxicologic Pathology 26th Annual Meeting
  • Place of Presentation: Puerto Rico
• [Presentation] Therapeutic efficacy of oral miconazole administration for the treatment of neonatal intestinal disorders, and its possible mechanism (2007)
  • Author(s): Torikai M, Abeyama K, et.al.
  • Organizer: The 40th Annual Scientifc Meeting of the Pacific Association of Paediatric Surgeons
  • Place of Presentation: Queenstown, New Zealand
• [Presentation] 血清薬理学的ファーマコゲノミクスを用いた生薬薬効の解析 (2007)
  • Author(s): 鈴東昌也、阿辺山和浩
  • Organizer: トミーデジタルバイオロジー社主催Ingenuity pathway analysis ユーザーミーティング
  • Place of Presentation: 東京
• [Presentation] Prophylactic Efficacy of Oral Miconazole Administration for Neonatal Intestinal Perforation, and Its Possible Mechanism. (2007)
  • Author(s): Torikai M, Abeyama K., et. al.
  • Organizer: The 40th Annual Meeting of The Pacific Association of Paediatric Surgeons
  • Place of Presentation: Queenstown, New Zealand
• [Presentation] Sequential Histologic Changes of Oleic Acid-Induced Lung Injury in Cynomolgus Monkeys (2006)
  • Author(s): Yang X, Abeyama K, et.al.
  • Organizer: The Society of Toxicologic Pathology 25th Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] Non-invasive Assessment of Pulmonary Disorder using Computed Tomography (CT)-Imaging in a Non-Human Primate (2006)
  • Author(s): Horai N, Abeyama K, et.al.
  • Organizer: Society of Toxicology 45th Annual Meeting
  • Place of Presentation: San Diego CA USA
• [Presentation] カニクイザルにおけるコンピュータ断層撮影法(CT)を用いた肺傷害の診断 (2006)
  • Author(s): 寳来直人、阿邉山和浩, 他8名
  • Organizer: 第33回日本トキシコロジー学会学術年会
  • Place of Presentation: 名古屋
• [Presentation] カニクイザルにおけるコンピュータ断層撮影法(CT)を用いた肺傷害の診断 (2005)
  • Author(s): 坂東崇志、阿邉山和浩, 他7名
  • Organizer: 第3回日本予防医学会
  • Place of Presentation: 北九州
• [Patent(Industrial Property Rights)] アディポネクチン産生増強剤 (2007)
  • Inventor(s): 阿邉山 和浩, ら
  • Industrial Property Rights Holder: 鹿児島大学・日本澱粉工業
  • Industrial Property Number: 2007-030146
  • Filing Date: 2007-02-09