| Project/Area Number |
18390483
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHIDA Shigemitsu Hokkaido University, 名誉教授 (80174928)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
DOMON Takanori 北海道大学, 大学院・歯学研究科, 教授 (50217618)
ASHIKAGA Yuichi 北海道大学, 大学院・歯学研究科, 助教 (70372258)
INOUE Kiichiro 北海道大学, 大学院・歯学研究科, 助教 (30168439)
KUROSHIMA Shinichiro 北海道大学, 大学院・歯学研究科, 助教 (40443915)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SAWA Yoshihiko 福岡歯科大学, 歯学部, 教授 (70271666)
|
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| Project Period (FY) |
2006 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥17,560,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥9,500,000 (Direct Cost: ¥9,500,000)
|
|---|
| Keywords | リンパ管内皮細胞 / 白血球接着因子 / ケモカイン / 口腔組織 / 毛細リンパ管 / Toll様受容体 / 転写因子 / リンホトキシン / 口腔健常組織 / 口腔炎症組織 |
|---|
| Research Abstract |
We investigated some proteins which play an important role in the immune system to clarify immune mechanisms via intraoral and extraoral lymphatic vessels. We showed that intraoral lymphatic vessels may differently play site-specific roles in immune systems, and extraoral lymphatic vessels have intracellular networks through these proteins. We discovered that systemic lymphatic vessels contribute to not only substance transport, but also immune mechanisms.
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