Establishment of organ culture system for tooth regeneration using pharyngeal teeth of medaka and its use for the exploration of dental stem cells

• Project/Area Number: 18390485
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKANO Yoshiro Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (90126425)
• Co-Investigator(Kenkyū-buntansha): TABATA Makoto 東京医科歯科大学, 大学院・医歯学総合研究学科, 准教授 (20243248) ; BABA Otto 東京医科歯科大学, 大学院・医歯総合研究学科, 助教 (90251545) ; ISEKI Hachiro 東京医科歯科大学, 技術専門, 職員 (00401373) ; 寺島 達夫 東京医科歯科大学, 大学院医歯学総合研究科, 助教授 (20114770)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,500,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥2,100,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2006: ¥8,400,000 (Direct Cost: ¥8,400,000)
• Keywords: メダカ / 咽頭歯 / 器官培養 / 歯の再生 / 実験モデル / 歯の交換 / 硬組織 / 組織化学 / 幹細胞

Research Abstract

本研究は常時脱落と交換を繰り返すメダカ咽頭歯を用いた歯の再生実験モデルの確立を目的に計画されたものであり、咽頭歯骨部の構造基盤と歯の発生・発達・交換の全容を初めて光顕、電顕レベルで明らかにした。更に同部の器官培養系を立ち上げて歯胚とその関連細胞の分化・機能維持が可能な培養条件を決定した。本メダカ咽頭歯骨部器官培養系は歯の発生・発達に伴う機能分子の消長とvivoでの確認が困難な咽頭歯脱落・交換のリアルタイム観察が可能であり、歯の再生研究への活用が期待される。

Research Products

• [Journal Article] Phosphatase actions at the site of appositional mineralization in bisphosphonate-affected bones of the rat (2008)
  • Author(s): Yi Li, Hiroto Nakayama, Takuya Notani, Masud Ahmad, Makoto J. Tabata and Yoshiro Takano
  • Journal Title: J Medical and Dental Sciences 55(3,4) Pages: 255-265
  • NAID: 120006409973
  • Peer Reviewed
• [Journal Article] An immunohistochemical and ultrastructural study of the pericellular matrix ofuneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice (2008)
  • Author(s): Shunichi Shibata, Otto Baba, Tsuyoshi Oda, Tamaki Yokohama-Tamaki, Chunlin Qin, William T. Butler, Yasunori Sakakura and Yoshiro Takano
  • Journal Title: Arch Oral Biol 53(3) Pages: 220-230
  • Peer Reviewed
• [Journal Article] E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro (2008)
  • Author(s): Ken-ichi Katsube, Naruhito Matsuda, Kazuo Kishi, Yoshiro Takano, Hachiro Iseki, Yuko Katsuki, Akira Yamaguchi, Hideo Nakajima, Shuji Mikami, Makio Mukai, Tatsuo Nakajima
  • Journal Title: J Dermatol Sci
  • Peer Reviewed
• [Journal Article] Development and terminal differentiation of pulp and periodontal nerve elements in subcutaneous transplants of molar tooth germs and incisors of the rat (2008)
  • Author(s): Kazunori Higuchi
  • Journal Title: European Journal of Oral Sciences 116 Pages: 324-333
  • Peer Reviewed
• [Journal Article] Phosphatase actions at the site of appositional mineralization in bisphosphonate-affected bones of the rat (2008)
  • Author(s): Li Yi
  • Journal Title: Journal of Medical and Dental Science 55 Pages: 255-265
  • Peer Reviewed
• [Journal Article] "Fluorescent glycogen" for in vivo and in vitro detection. (2008)
  • Author(s): Luozao MC
  • Journal Title: Glycoconjugates Journal 25 Pages: 503-510
  • Peer Reviewed
• [Journal Article] An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice (2008)
  • Author(s): Shinichi Shibata
  • Journal Title: Archives of Oral Biology 53 Pages: 220-230
  • Peer Reviewed
• [Journal Article] Aggregation and amyloid fibril formation of the prion protein is accelerated in presence of glycogen (2008)
  • Author(s): Panza G
  • Journal Title: Rejuvenation Research 11 Pages: 365-369
  • Peer Reviewed
• [Journal Article] E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro (2008)
  • Author(s): Kenichi Katsube
  • Journal Title: Journal of Dermatological Science 51 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Multinucleated osteoclasts in medaka as evidence of active bone remodeling (2007)
  • Author(s): Nemoto Y, Higuchi K, Baba O, Kudo A, Takano Y
  • Journal Title: Bone 40 Pages: 399-408
  • Peer Reviewed
• [Journal Article] Diverse effects of C-src deficiency on molar tooth development and eruption in mice (2007)
  • Author(s): Miyata A, Baba O, Oda T, Ishikawa I, Takano Y
  • Journal Title: Arch Histol Cytol 70 Pages: 63-78
  • NAID: 130004780522
  • Peer Reviewed
• [Journal Article] Glycogen Phosphorylase in Glycogen-Rich Cells Is Involved in Energy Supply for Ion Regulation in Fish Gill Epithelia (2007)
  • Author(s): Tseng Y-C, Huang C-J, Chang J, Teng W-Y, Baba O, Fann M-J, Hwang P-P
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 293 Pages: 482-491
  • Peer Reviewed
• [Journal Article] Regulation of glycogen metabolism in gills and liver of the euryhaline tilapia(Oreochromis mossambicus)during acclimation to seawater (2007)
  • Author(s): Chang J C-H, Wu S-M, Tseng Y-C, Lee Y-C, Baba O, Hwang P-P
  • Journal Title: J Exp Biol 210 Pages: 3494-3504
  • Peer Reviewed
• [Journal Article] The teleost intervertebral region acts asa growth center of the centrum : in vivo visualization of osteoblasts and their progenitors in transgenic fish (2007)
  • Author(s): Inohaya K, Takano Y, Kudo A
  • Journal Title: Dev Dyn 236 Pages: 3031-3046
  • Peer Reviewed
• [Journal Article] Effect of vibration on osteoblastic and osteoclastic activities : Analysis of bone metabolism using goldfish scale as a model for bone (2007)
  • Author(s): Suzuki N, Kitamura, K, Nemoto T Shimizu N, Wada S, Kondo T, Tabata MJ, Sodeyama F, Ijiri K, Hattori A
  • Journal Title: Adv Space Res 40 Pages: 1711-1721
  • Peer Reviewed
• [Journal Article] 魚鱗 (2007)
  • Author(s): 田畑 純, 鈴木信雄, 服部淳彦
  • Journal Title: 硬組織研究と再生研究のフロンティア細胞 39(2) Pages: 55-57
• [Journal Article] Diverse effects of C-src deficiency on molar tooth development and eruption in mice (2007)
  • Author(s): Atsushi Miyata
  • Journal Title: Archives of Histology and Cytology 70 Pages: 63-78
  • Peer Reviewed
• [Journal Article] The teleost intervertebral region acts as a growth center of the centrum: in vivo visualization of osteoblasts and their progenitors in transgenic fish (2007)
  • Author(s): Keiji Inohaya
  • Journal Title: Developmental Dynamics 236 Pages: 3031-3046
  • Peer Reviewed
• [Journal Article] Regulation of glycogen metabolism in gills and liver of the euryhaline tilapia (Oreochromis mossambicus) during acclimation to seawater (2007)
  • Author(s): Chang J C-H
  • Journal Title: Journal of Experimental Biology 210 Pages: 3494-3504
  • Peer Reviewed
• [Journal Article] Glycogen Phosphorylase in Glycogen-Rich Cells Is Involved in Energy supply for Ion Regulation in Fish Gill Epithelia. (2007)
  • Author(s): Tseng Y-C
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 11 Pages: 34-40
  • Peer Reviewed
• [Journal Article] Expression of bone type l PTH receptor in rats with chronic renal failure (2007)
  • Author(s): Kuwahara M
  • Journal Title: Clinical Experimental Nephrology 210 Pages: 3494-3504
  • Peer Reviewed
• [Journal Article] Topographical representation of motoneurons innervating the transverse mandibular muscle in the trigeminal motor nucleus, with special reference to rats (2007)
  • Author(s): Uemura M
  • Journal Title: J Oral Biosci 49 Pages: 136-142
  • Peer Reviewed
• [Journal Article] 魚鱗:硬組織研究と再生研究のフロンティア (2007)
  • Author(s): 田畑 純
  • Journal Title: 細胞 39 Pages: 55-57
  • Peer Reviewed
• [Journal Article] Multinucleated osteoclasts in medaka as evidence of active bone remodeling (2007)
  • Author(s): Yoshiyuki Nemoto
  • Journal Title: Bone 40 Pages: 399-408
• [Journal Article] Remodeling of Acellular Bone in Japanese Medaka (Oryzias latipes) and its Possible Contribution to Mineral Regulation of the Body (2007)
  • Author(s): Yoshiro Takano
  • Journal Title: Proceedings of 8^<th> ICCBMT Pages: 13-15
• [Journal Article] Remodeling of Acellular Bone in Japanese Medaka(Oryzias latipes)and its Possible Contribution to Mineral Regulation of the Body (2006)
  • Author(s): Takano Y, Nakano Y, Katogi R, Nemoto Y, Kudo A
  • Journal Title: Proceedings of 8th International Conference of the Chemistry and Biology of Mineralized Tissues Pages: 13-15
  • Peer Reviewed
• [Journal Article] Immunoloclization of dentprotein 1(DMP1)fragments in rat molar (2006)
  • Author(s): Baba 0, Qin C, Brunn JC, Terashima T, Bonewald L, Butler WT
  • Journal Title: Proceedings of 8th International Conference ofChemistry and Biology of MineralizTissues Pages: 143-146
  • Peer Reviewed
• [Journal Article] Unique Similarities between Dentin Matrix Protein 1 and Dentin Sialophosphoprotein (2006)
  • Author(s): Qin C, Baba O, Brunn JC, McKee MD, Bonewald L, Butler WT
  • Journal Title: Proceedings of 8th International Conference of the Chemistry and Biology of Mineralized Tissues Pages: 174-177
  • Peer Reviewed
• [Journal Article] Proteolysis on maturing enamel surface as shown by gel coating methods (2006)
  • Author(s): Takano Y, Nakano Y, Yamamoto-Shuda Y, Baba O, Terashima T
  • Journal Title: Eur J Oral Sci 114 Pages: 52-58
  • Peer Reviewed
• [Journal Article] Formation of acellular cementum-like layers with and without extrinsic fiber insertion along inert bone surfaces of aging c-Src gene knockout mice (2006)
  • Author(s): Baba O, Miyata A, Abe T, Shibata S, Nakano Y, Terashima T, Oda T, Kudo A, Takano Y
  • Journal Title: Eur J Oral Sci 114 Pages: 524-534
  • Peer Reviewed
• [Journal Article] 宇宙におけるメダカ骨代謝 (2006)
  • Author(s): 工藤明, 石岡憲昭, 内田智子, 大森克徳, 河野靖, 高野吉郎, 永松愛子, 夏井坂誠, 西川和香, 藤本信義, 益川充代, 村上敬司
  • Journal Title: Space Utiliz Res 22 Pages: 241-243
  • NAID: 120006830940
  • Peer Reviewed
• [Journal Article] A Nerve-epithelium Interrelation in the Periodontal Ligament of Guinea pig Teeth (2006)
  • Author(s): Jayawardena CK, Takano Y
  • Journal Title: Arch Oral Biol 51 Pages: 587-595
  • Peer Reviewed
• [Journal Article] Structural features of incremental line-oike striations in mandibular condylar cartilage of c-src-deficient mice (2006)
  • Author(s): Shibata S, Oda T, Abe T, Yamashita Y, Takano Y
  • Journal Title: Arch Oral Biol 51 Pages: 951-959
  • Peer Reviewed
• [Journal Article] The existence of CD11c' sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties (2006)
  • Author(s): Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M
  • Journal Title: International Immunol 18 Pages: 1375-1384
  • NAID: 10018773673
  • Peer Reviewed
• [Journal Article] フリーフライヤー等の早期飛行手段を利用した小型魚類の宇宙生物学研究 (2006)
  • Author(s): 大森克徳
  • Journal Title: 第22回宇宙利用シンポジウム・プロシーディング Pages: 261-263
• [Journal Article] 宇宙におけるメダカ骨代謝 (2006)
  • Author(s): 工藤 明
  • Journal Title: Space Utiliz Res 22 Pages: 241-243
• [Journal Article] Proteolysis on Maturing Enamel Surface as Shown by Gel Coating Methods. (2006)
  • Author(s): Yoshiro Takano
  • Journal Title: Eur J Oral Scie 114 Suppl 1 Pages: 52-58
• [Journal Article] A Nerve-epithelium Interrelation in the Periodontal Ligament of Guinea pig Teeth (2006)
  • Author(s): Chantha Jayawardena
  • Journal Title: Arch Oral Biol 51 Pages: 587-595
• [Journal Article] Development and Innervation of Subcutaneously Transplanted Molar Tooth Germs in the Rat
  • Author(s): Higuchi K, Peerapong S, Terashima T, Nakayama H, Notani T, Iseki H, Baba O and Takano Y
  • Journal Title: Eur J Oral Sci 116 Pages: 324-333
  • Peer Reviewed
• [Presentation] Teeth in Edar deficient medaka fish : an animal model of anhidrotic ectodermal dysplasia (2009)
  • Author(s): A.D.S. ATUKORALA, Kazunori HIGUCHI, Masayuki YOSHIMI, Makoto J TABATA, Otto BABA, Yoshiro TAKANO
  • Organizer: 114^<th> Japanese Association of Anatomists
  • Place of Presentation: Okayama
  • Year and Date: 2009-05-28
• [Presentation] Cement lines and bone quality-A lesson from studies of long-lasting cement lines in osteopetrotic bones of aging c-src deficient mice (2009)
  • Author(s): Yoshiro Takano
  • Organizer: Invited lecture, Material Research Society Spring Meeting 2009
  • Place of Presentation: San Francisco
  • Year and Date: 2009-04-14
• [Presentation] エナメル上皮細胞と歯髄細胞を用いた三次元・重層培養にける組織再構築と細胞相互誘導 (2009)
  • Author(s): 田畑純、野谷拓也、井関八郎、中山博登、馬場麻人、高野吉郎
  • Organizer: 第114回日本解剖学会シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-30
• [Presentation] Histological evaluation of osteoconductivity and fate of anorganic bovine bone fragments(Bio-Oss[○!R]) applied for sinus augmentation preceding implant (2009)
  • Author(s): Tamaki Hitoshi, Nakayama Hiroto, Takano Yoshiro
  • Organizer: Academy of Osseointegration Annual Meeting
  • Place of Presentation: San Diego, CA
• [Presentation] Cell Dynamics in Calcium Regulating Epithelium of the Enamel Organ during Tooth Enamel Formation (2008)
  • Author(s): Takano Yoshiro
  • Organizer: 7^<th> Federation Meeting of Korean Basic Dental Scientists
  • Place of Presentation: Soul, Korea
  • Year and Date: 2008-12-03
• [Presentation] Impaired Tooth Development In Reduced Scale Medaka Mutant (2008)
  • Author(s): Atukorala ADS
  • Organizer: 56^<th> General Session of the JADR
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-29
• [Presentation] Three-dimensional & layered culture method for tooth induction and development (2008)
  • Author(s): Notani Takuya
  • Organizer: 56^<th> General Session of the JADR
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-29
• [Presentation] Provisional mineralization layer in the predentin of murine teeth (2008)
  • Author(s): Ahmad Masud
  • Organizer: 56^<th> General Session of the JADR
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-29
• [Presentation] Amelogenin is a Potent Inhibitor of Odontoclastic Root Resorption (2008)
  • Author(s): Yagi Yuko
  • Organizer: 56^<th> General Session of the JADR
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-29
• [Presentation] ラット歯髄におけるFGF18の発現 : in situ RT-PCRによる検出 (2008)
  • Author(s): 馬場麻人
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-23
• [Presentation] 長期間器官培養法と皮下移植法を用いたマウス歯胚の多根歯形成について (2008)
  • Author(s): 寺島達夫
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-23
• [Presentation] Amelogeninはin vivoにおいて歯根吸収を抑制する (2008)
  • Author(s): 八木優子
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-23
• [Presentation] Enamel matrix derivative (EMD)の歯根吸収抑制活性はアメロゲニンが担う (2008)
  • Author(s): 八木優子
  • Organizer: 第67回日本矯正歯科学会大会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-17
• [Presentation] Cell Dynamics in Calcium Regulating Epithelium of the Enamel Organ during Tooth Enamel Formation (2008)
  • Author(s): Takano Yoshiro
  • Organizer: Water and Salt Institute Seminar
  • Place of Presentation: Aarhus, Denmark
  • Year and Date: 2008-09-16
• [Presentation] 脊椎骨融合を示すダルマメダカ変異体の原因遺伝子の解明 (2008)
  • Author(s): 猪早敬二
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-06
• [Presentation] Matrix Vesicles-Induced Mineralization and Phosphatase Actions in Bisphosphonate-Affected Bones (2008)
  • Author(s): Li Yi
  • Organizer: 86^<th> IADR General Session
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-03
• [Presentation] Cell Dynamics in Calcium Regulating Epithelium of the Enamel Organ during Tooth Enamel Formation (2008)
  • Author(s): Takano Y
  • Organizer: The 7th Federation Meeting of Korean Basic Dental Scientists
  • Place of Presentation: Seoul, Korea
• [Presentation] 石灰化機構から象牙芽細胞と骨芽細胞の異同を探る、日本解剖学会シンポジウム象牙芽細胞と骨芽細胞の違いを考える (2008)
  • Author(s): 高野吉郎
  • Organizer: 第113回日本解剖学会学術大会
  • Place of Presentation: 大分大学
• [Presentation] Analysis of the Dharma-medaka mutant, which shows a defect in formation and/or maintenance of intervertebral region (2008)
  • Author(s): Inohaya K, Takano Y, Kudo A
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] 脊椎骨融合を示すダルマメダカ変異体の原因遺伝子のAT FA Analysis of the Dharma- medaka mutant, which shows a defect in formation of vertebral column (2008)
  • Author(s): 猪早敬二、高野吉郎、工藤明
  • Organizer: 日本動物学会第79回大会
  • Place of Presentation: 福岡大学
• [Presentation] Enamel matrix derivative(EMD)の歯根吸収抑制活性はアメロゲニンが担う (2008)
  • Author(s): 八木優子、須田直人、森山啓司、山越康雄、馬場麻人
  • Organizer: 第67回日本矯正歯科学会大会
  • Place of Presentation: 千葉
• [Presentation] ラット歯髄におけるFGF18の発現 : 加読召RT-PCRによる検出 (2008)
  • Author(s): 馬場麻人、太田正人、寺島達夫、田畑純、高野吉郎
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 東京
• [Presentation] Impaired Tooth Development In Reduced Scale Medaka Mutant (2008)
  • Author(s): Atukorala ADS, Higuchi K, Tabata MJ, Baba O, Mitani H , Takano Y
  • Organizer: 56th General Session of the JADR
  • Place of Presentation: Nagoya,Japan
• [Presentation] Three-dimensional & layered culture method for tooth induction and development (2008)
  • Author(s): Notani T, Tabata MI, Baba O, Takano Y
  • Organizer: 56th General Session of the JADR
  • Place of Presentation: Nagoya, Japan
• [Presentation] Provisional mineralization layer in the predentin of murine teeth (2008)
  • Author(s): Ahmad M, Iseki H, Baba O, Tabata MJ, Takano Y
  • Organizer: 56th General Session of the JADR
  • Place of Presentation: Nagoya, Japan
• [Presentation] Displacement of Orthodontic Microscrews under Retractive Force in the Rat Maxilla (2008)
  • Author(s): Winarakwong L
  • Organizer: 7^<th> world Implant Orthodontic Conference
  • Place of Presentation: Soul, Korea
• [Presentation] 長期飼育c-src遺伝子欠損マウス下顎頭における肥大軟骨細胞の運 (2007)
  • Author(s): 柴田俊一
  • Organizer: 第2回Biomineralization Symposium
  • Place of Presentation: 東京大学
  • Year and Date: 2007-12-01
• [Presentation] Cellular Regulation of Mineralization Process of Dental Hard Tissues (2007)
  • Author(s): Takano Y
  • Organizer: 国際歯科研究学会韓国部会学術大会
  • Place of Presentation: ソウル
  • Year and Date: 2007-11-29
• [Presentation] Evaluation of Cementlines-in Aging Bones of c-Src Deficient Mice (2007)
  • Author(s): Nakayama H
  • Organizer: 国際歯科研究学会日本部会学術大会
  • Place of Presentation: 鶴見大学
  • Year and Date: 2007-11-17
• [Presentation] エナメル質の基質形成と石灰化の細胞性制御 (2007)
  • Author(s): 高野吉郎
  • Organizer: 2007年度エナメル質比較発生学懇話会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2007-09-21
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体の解析 (2007)
  • Author(s): 猪早敬二
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前大学
  • Year and Date: 2007-09-20
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体の解析 (2007)
  • Author(s): 猪早敬二
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-16
• [Presentation] 破骨細胞特異的トランスジェニックメダカを用いたin-vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷 昌宏
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-16
• [Presentation] 命 (2007)
  • Organizer: 第49歯科基礎医学会学術大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2007-08-30
• [Presentation] Phosphatases of matrix vesicles in the bones of bisphosphonate- induced hypocalcaemic animal model (2007)
  • Author(s): Li Y
  • Organizer: 第49回歯科基礎医学会学術犬会
  • Place of Presentation: 北海道大学
  • Year and Date: 2007-08-30
• [Presentation] ラット臼歯歯冠形成期から歯根形成期における歯髄細胞増殖活性の変化 (2007)
  • Author(s): 馬場麻人
  • Organizer: 第49回歯科基礎医学会学術犬会
  • Place of Presentation: 北海道大学
  • Year and Date: 2007-08-30
• [Presentation] 長期間器官培養法を用いたマウス歯胚における歯周組織の形成について (2007)
  • Author(s): 寺島達夫
  • Organizer: 第49回歯科基礎医学会学術犬会
  • Place of Presentation: 北海道大学
  • Year and Date: 2007-08-30
• [Presentation] ATPをリン酸供給源とする骨石灰化の可能性 (2007)
  • Author(s): 中野裕紀子
  • Organizer: 第49回歯科基礎医学会学術犬会
  • Place of Presentation: 北海道大学
  • Year and Date: 2007-08-29
• [Presentation] 破骨細胞が特異的に光るトランスジェニックメーダカを用いたin-vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷昌宏
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-07-21
• [Presentation] The Dharma-medaka mutant is defective in formation and/or maintenance of intervertebral region (2007)
  • Author(s): Keiji Inohaya
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会 合同大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-28
• [Presentation] 東京医科歯科大学大学院硬組織構造生物学分野 : 小型硬骨魚メダカ無細胞骨格系における骨形成と骨吸収 (2006)
  • Author(s): 高野吉郎
  • Organizer: 第114回日本解剖学会シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2006-03-28
• [Book] 新・う蝕の科学(浜田茂幸, 大島隆) (2006)
  • Author(s): 高野吉郎
  • Publisher: 医歯薬出版
• [Book] 口腔組織・発生学 (2006)
  • Author(s): 高野吉郎
  • Publisher: 医歯薬出版
• [Book] 染色・バイオイメージングの実験ハンドブック (2006)
  • Author(s): 高野吉郎
  • Publisher: 羊土社
• [Book] リープコット歯科学のための解剖学 (2006)
  • Author(s): 高野吉郎
  • Publisher: 西村書店
• [Book] 新・う蝕の科学 (2006)
  • Author(s): 高野吉郎
  • Total Pages: 232
  • Publisher: 医歯薬出版