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Studies on the control mechanism of osteoclast differentiation by non-coding RNA

Research Project

Project/Area Number 18390497
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SHIMOKAWA Hitoyata  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 准教授 (80014257)

Co-Investigator(Kenkyū-buntansha) 青木 和広  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40272603)
Research Collaborator WANTIDA Sriarj  東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥15,360,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2006: ¥9,900,000 (Direct Cost: ¥9,900,000)
Keywords発生・分化 / 発現制御 / マイクロアレイ / 破骨細胞 / miRNA / 発現製御
Research Abstract

19年度は共存培養による破骨細胞の分化誘導系を用いて得られた十数種類のmiRNAについて個々に解析を行った。そのうちの数種類について変化が確かめられた。
20年度は骨髄細胞を用いた破骨細胞形成系により確かめることと、個々のmiRNAについての解析を行った。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (9 results)

  • [Journal Article] Inhibition of the classical NF-kB pathway prevents osteoclast bone-resorbing activity2009

    • Author(s)
      Soysa N, Alles N, Shimokawa H, Jimi E, Aoki K, Ohya K
    • Journal Title

      J Bone Mrtab Vol.27(2)

      Pages: 131-139

    • Related Report
      2008 Final Research Report
  • [Journal Article] Bovine dentine organic matrix down-regulates osteoclast activity2009

    • Author(s)
      Wantida S, Aoki K, Ohya K, Takagi Y, Shimokawa H
    • Journal Title

      J Bone Miner Metab Vol.27

      Pages: 315-323

    • NAID

      10025337365

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibition of the classical NF-kappaB pathway prevents osteoclast bone-resorbing activity.2009

    • Author(s)
      Soysa, N. S., Alles. Shimokawa, H., Jimi, E., Aoki, K., Ohya, K.
    • Journal Title

      J Bone Miner Metab 27

      Pages: 131-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bovine dentine organic matrix down-regulates osteoclast activity.2009

    • Author(s)
      Sriarj, W., Aoki, K., Ohya, K., Takagi, Y., Shimokawa, H.
    • Journal Title

      J Bone Miner Metab 27

      Pages: 315-23

    • NAID

      10025337365

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like Growth Factor I Regulates Apoptosis in Condylar Cartilage2008

    • Author(s)
      Yokota T, Shipmokawa H, Shibata S, Itoh K, Baba Y, Ohya K, Ohyama K, Suzuki S
    • Journal Title

      J Dent Res Vol.87(2)

      Pages: 159-163

    • Related Report
      2008 Final Research Report
  • [Journal Article] Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo2008

    • Author(s)
      Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K
    • Journal Title

      J Bone Miner Metab Vol.26

      Pages: 469-477

    • NAID

      10024459458

    • Related Report
      2008 Final Research Report
  • [Journal Article] Bone Morphogenetic Protein-2(BMP-2)and Vascular Endothelial Growth Factor(VEGF)Transfection to Human Periosteal Cells Enhances Osteoblast Differentiation and Bone Formation2008

    • Author(s)
      Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S
    • Journal Title

      J Pharmacol Sci Vol.108

      Pages: 18-31

    • NAID

      10024322237

    • Related Report
      2008 Final Research Report
  • [Journal Article] Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo.2008

    • Author(s)
      Hussain Mian, A., Saito, H., Alles, N., Shimokawa, H., Aoki, K., Ohya, K.
    • Journal Title

      J Bone Miner Metab 26

      Pages: 469-77

    • NAID

      10024459458

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis.2007

    • Author(s)
      Saito H. Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K.
    • Journal Title

      Arthritis and rheumatism 56

      Pages: 1164-1174

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small GTPase Ras and Rho Expression in Rat Osteoblasts during Spaceflight.2007

    • Author(s)
      Kumei Y, Shimokawa H. Ohya K, Katano H. Akiyama H, Hirano M, Morita S.
    • Journal Title

      Annals of the New York Academy of Sciences 1095

      Pages: 292-299

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The control release of TNF-α is necessary to mimic the LPS-induced bone resorption on calvaria2009

    • Author(s)
      Nagano K, Aoki K, Mian H, Alles N, Shimokawa H, Morimoto N, Akiyoshi K, Ohya K
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of Dentine Organic Matrices on Osteoclastogenesis.2008

    • Author(s)
      Sriarj, W., Aoki, K., Ohya, K., Takagi, Y., Shimokawa, H.
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Non-canonical NF-κB pathway regulates osteoclast formation and function2008

    • Author(s)
      Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K
    • Organizer
      The 81^<th> Annual Meeting of the Japanese Pharmacological Society(81回日本薬理学会年会)
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] NIK MUTATION IN ALY/ALY MICE CAUSES OSTEOPETROSIS AND REDUCE RANKL INDUCED OSTEOCLASTOGENESIS2008

    • Author(s)
      Soysa N, Alles N, Mian MD, Yasuda H, Jimi E, Shimokawa H, Aoki K, Ohya K
    • Organizer
      2^<nd> International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodes(Greece)
    • Related Report
      2008 Final Research Report
  • [Presentation] Defective Alternative Pathway of NF-κB Causes Mild Osteopetrosis in Mice2008

    • Author(s)
      Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of Dentin Organic Matrices on Osteoclastogenesis2008

    • Author(s)
      Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Related Report
      2008 Final Research Report
  • [Presentation] LPS投与による抜歯後骨新生の抑制はTNF-α依存的である2008

    • Author(s)
      友松伸允, 青木和広, Mian MD, 下川仁彌太, 天笠光雄, 大谷啓一
    • Organizer
      第28回日本骨形態計測学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] LPS-induced Inhibition of Osteogenesis is TNF-α Dependent2008

    • Author(s)
      Tomomatsu N, Aoki K, Hussain MA, Alles N, Shimokawa H, Amagasa T, Ohya K
    • Organizer
      30^<th> ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Related Report
      2008 Final Research Report
  • [Presentation] 破骨細胞機能抑制ペプチドによる臨床応用の可能性2008

    • Author(s)
      青木和広, Alles N, Soysa N, 自見英治郎, 下川仁彌太, 大谷啓一
    • Organizer
      第50回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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