Development of the osteoinductive devices using magnetostatic stimulus

• Project/Area Number: 18390511
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Tohoku University
• Principal Investigator: TAKADA Yukyo Tohoku University, 大学院・歯学研究科, 准教授 (10206766)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Masafumi 東北大学, 大学院・歯学研究科, 助教 (50250791) ; TAKAHASHI Masatoshi 東北大学, 大学院歯学研究科, 助教 (50400255) ; 奥野 攻 東北大学, 大学院・歯学研究科, 教授 (50014080)
• Co-Investigator(Renkei-kenkyūsha): OKUNO Osamu 東北大学, 大学院・歯学研究科, 教授 (50014080)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,090,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
• Keywords: 静磁場 / 磁石構造体 / 骨組織 / 動物実験 / 骨誘導 / 歯科用磁性アタッチメント / 仮骨 / 骨様組織 / 軟骨性内骨化 / ウサギ / in vivo

Research Abstract

本研究課題では、骨誘導デバイスの開発を前提に、永久磁石を用いた歯科用磁性アタッチメントの静磁場をウサギの骨形成過程で付与し、静磁場の骨形成に及ぼす影響を調べた。その結果、磁性アタッチメントによる静磁場は、骨形成の初期において、骨形成速度の向上に寄与し、その現象は骨の成長を促す骨牙細胞の増殖と分化の加速に起因することが明らかになった。これより、永久磁石を利用した骨誘導デバイスの可能性が示唆された。

Research Products

• [Journal Article] Galvanic corrosion of ferritic stainless steels used for dental magnetic attachments in contact with an iron-platinum magnet (2008)
  • Author(s): Keisuke Nakamura, Yukyo Takada, Masanobu Yoda, Kohei Kimura, Osamu Okuno
  • Journal Title: Dent MaterJ 27 Pages: 203-210
  • NAID: 110006649449
  • Peer Reviewed
• [Journal Article] Galvanic corrosion between dental precious alloys and magnetic stainless steels used for dental magnetic attachments (2008)
  • Author(s): Noriko Takahashi, Yukyo Takada, Osamu Okuno
  • Journal Title: Dent Mater J 27 Pages: 237-242
  • NAID: 110006649454
  • Peer Reviewed
• [Journal Article] Corrosion characteristics of magnetic assemblies composing dental magnetic attachments (2008)
  • Author(s): Yukyo Takada, Noriko Takahashi, Osamu Okuno
  • Journal Title: Interface Oral Health Science 2007 Pages: 343-344
  • Peer Reviewed
• [Journal Article] Galvanic corrosion of ferritic stainless steels used for dental magnetic attachments in contact with an iron-platinum magnet (2008)
  • Author(s): Keisuke Nakamura, Yukyo Takada, Masanobu Yoda, Kohei Kimura, Osamu Okuno
  • Journal Title: Dent Mater J 27 Pages: 203-210
  • NAID: 110006649449
  • Peer Reviewed
• [Journal Article] 白金鉄磁石合金の骨形成への影響 (2007)
  • Author(s): 向山泰泉, 高田雄京, 奥野 攻, 越後成志
  • Journal Title: 歯科材料・器械 26 Pages: 256-265
  • NAID: 110006279266
  • Peer Reviewed
• [Journal Article] Electrochemical behavior and released ions of the stainless steels used for dental magnetic attachments (2007)
  • Author(s): Yukyo Takada, Noriko Takahashi, Osamu Okuno
  • Journal Title: J J Mag Dent 16 Pages: 49-52
• [Journal Article] 白金鉄磁石合金の骨形成への影響 (2007)
  • Author(s): 向山泰泉, 高田雄京, 奥野攻, 越後成志
  • Journal Title: 歯科材料・器械 26 Pages: 256-265
  • NAID: 110006279266
  • Peer Reviewed
• [Presentation] 永久磁石を用いた静磁場刺激による骨誘導 (2009)
  • Author(s): 高田雄京
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 北海道
  • Year and Date: 2009-01-24
• [Presentation] Corrosion resistance of precious casting alloys and magnetic stainless steels used for dental magnetic attachments (2007)
  • Author(s): N. Takahashi, Y. Takada, O. Okuno
  • Organizer: 49th General Session of the Japanese Society for Dental Materials and Devices
  • Place of Presentation: Hokkaido
  • Year and Date: 2007-05-12
• [Presentation] Bone compatibility of dental magnetic attachments with static magnetic field (2007)
  • Author(s): Yukyo TAKADA and Osamu OKUNO
  • Organizer: IADR
  • Place of Presentation: New Orleans USA
• [Presentation] Electrochemical behavior and released ions of the stainless steels used for dental magnetic attachments (2007)
  • Author(s): Y. Takada, N. Takahashi and O. Okuno
  • Organizer: 6th International Conference on MagneticApplications in Dentistry(JSMAD)
  • Place of Presentation: Web
• [Presentation] Corrosion Characteristics of Magnetic Assemblies Composing Dental Magnetic Attachments (2007)
  • Author(s): Yukyo TAKADA Noriko TAKAHASHI and Osamu OKUNO
  • Organizer: 2nd International Symposium for Interface Oral Health Science in SENDAI
  • Place of Presentation: Sendai