| Project/Area Number |
18390515
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAZAKI Masayuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (30107073)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Isao 広島大学, 大学院・医歯薬学総合研究科, 助教 (40346507)
赤川 安正 広島大学, 大学院・医歯薬学総合研究科, 教授 (00127599)
野村 雄二 広島大学, 大学院・医歯薬学総合研究科, 助教 (80218370)
小原 政信 広島大学, 大学院・理学研究科, 准教授 (60132479)
松浦 成昭 大阪大学, 大学院・医学研究科, 教授 (70190402)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAGAWA Yasumasa 広島大学, 大学院・医歯薬学総合研究科, 教授 (00127599)
NOMURA Yuji 広島大学, 大学院・医歯薬学総合研究科, 助教 (80218370)
OBARA Masanobu 広島大学, 大学院・理学研究科, 准教授 (60132479)
MATSUURA Nariaki 大阪大学, 大学院・医学研究科, 教授 (70190402)
MATSUMOTO Takuya 大阪大学, 大学院・歯学研究科, 講師 (40324793)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,550,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2006: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | 炭酸アパタイト / スカフォールド / 骨再生 / 化学修飾 / 機能制御 |
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| Research Abstract |
To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO_3Ap) were synthesized and CO_3Ap-collagen scaffolds were created. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 wks' implantation. Furthermore, when the CO_3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells as well as prominent angiogenesis inside the graft could be detected after 1 week. Thus, the modification of higher function such as cytokine and angiogenesis factors is effective for low regeneration region as tissue engineering biomaterials.
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