Photo-catalytic superhydrophilicity enhances Osseointegration

• Project/Area Number: 18390520
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Nagasaki University
• Principal Investigator: SAWASE Takashi Nagasaki University, 医歯薬学総合研究科, 教授 (80253681)
• Co-Investigator(Kenkyū-buntansha): SHIBATA Yasuaki 長崎大学, 医歯薬学総合研究科, 教授 (80253673) ; IKEDA Tohru 長崎大学, 医歯薬学総合研究科, 教授 (00211029) ; KAMADA Koji 長崎大学, 医歯薬学総合研究科, 助教 (60264256) ; YOSHIDA Keiichi 長崎大学, 医学部・歯学部附属病院, 講師 (70230729) ; ATSUTA Mitsuru 長崎大学, 医歯薬学総合研究科, 教授 (60002135)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥14,910,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
• Keywords: 歯科インプラント学 / 生体材料 / 光触媒活性 / 生体親和性 / 親水性 / オッセオインテグレーション / 細胞親和性

Research Abstract

骨組織内に埋入されるインプラント表面改質により, 光触媒超親水性効果を付与することで, インプラント表面での細胞接着を促進し, ひいては骨形成(オッセオインテグレーション)を亢進するとの仮説を立て, 細胞培養試験ならびに動物実験により検証を行った. その結果超親水性インプラントにおいては, 早期からの細胞接着, 伸展, 増殖が向上し, さらにオッセオインテグレーションの指標である骨接触率の有意な向上を認めた.

Research Products

• [Journal Article] Accelerated photo-induced hydrophilicity promotes osseointegration : an animal study (2009)
  • Author(s): Jimbo R, Ono D, Hirakawa Y, Odatsu T, Tanaka T, Sawase T
  • Journal Title: Clin Implant Dent Relat Res 10
• [Journal Article] Accelerated photo-induced hydrophilicity promotes osseointegration : an animal study (2009)
  • Author(s): Jimbo R, Sawase T
  • Journal Title: Clinical Implant Dentistry and Related Reseach 11(印刷中)
  • Peer Reviewed
• [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium (2008)
  • Author(s): Jimbo R, Sawase T, Baba K, Kurogi T, Shibata Y, Atsuta M
  • Journal Title: Clin Implant Dent Relat Res 10 Pages: 55-61
  • NAID: 120006984724
• [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition (2008)
  • Author(s): Sawase T, Jimbo R, Baba K, Shibata Y, Ikeda T, Atsuta M
  • Journal Title: Clin Oral Implants Res 19 Pages: 491-496
• [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition (2008)
  • Author(s): Sawase T, Jimbo R, Baba K, Shibata Y, Ikeda T, Atsuta M
  • Journal Title: Clinical Oral Implants Research 19 Pages: 491-496
  • Peer Reviewed
• [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium. (2008)
  • Author(s): Jimbo R, Sawase T, Baba K, Kurogi T, Suketa N, Shibata Y, Atsuta M
  • Journal Title: Clinical Implant Dentistry and Related Research 10 Pages: 55-61
  • NAID: 120006984724
  • Peer Reviewed
• [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells (2007)
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Bessho K, Ikeda T, Atsuta M
  • Journal Title: Biomaterials 28 Pages: 3469-3477
  • NAID: 120006984664
• [Journal Article] A novel characteristic of porous titanium oxide implants (2007)
  • Author(s): Sawase T, Jimbo R, Wennerberg A, Suketa N, Tanaka Y, Atsuta M
  • Journal Title: Clin Oral Implants Res 18 Pages: 680-685
• [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells. (2007)
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Bessho K, Ikeda T, Atsuta M
  • Journal Title: Biomateials 28 Pages: 3469-3477
  • NAID: 120006984664
  • Peer Reviewed
• [Journal Article] A novel characteristic of porous titanium oxide implants. (2007)
  • Author(s): Sawase T, Jimbo R, Wennerberg A, Suketa N, Tanaka Y, Atsuta M
  • Journal Title: Clinical Oral Implants Research 18 Pages: 680-685
  • Peer Reviewed
• [Journal Article] A novel characteristic of porous titanium implant (2007)
  • Author(s): Sawase T, Jimbo R, Wnnerberg A, Suketa N, Atsuta M, Tanaka Y
  • Journal Title: Clinical Oral Implant Research (印刷中)
• [Presentation] 親水性チタン表面への血清タンパク質の吸着 (2009)
  • Author(s): 平川祐子, 柴田恭明, 尾立哲郎, 神保 良, 池田 通, 澤瀬 隆
  • Organizer: 第26回日本口腔インプラント学会九州支部学術大会
  • Place of Presentation: 沖縄
  • Year and Date: 2009-02-22
• [Presentation] Lateral bone augmentation with a newly developed beta tri-calcium phosphate block (2008)
  • Author(s): Ono D, Sawase T, Jimbo R, Asahina I, Ioku, Ikeda T
  • Organizer: 4th Asian Academy of Osseointegration
  • Place of Presentation: 広島
  • Year and Date: 2008-07-19
• [Presentation] Lateral bone augmentation with a newly developed beta tri-calcium phosphate block (2008)
  • Author(s): Ono D, Sawase T, Jimbo R, Asahina I, Ioku K, Ikeda T
  • Organizer: 4th Asian Academy of Osseointegration
  • Place of Presentation: Hiroshima
• [Presentation] 光触媒活性超親水性効果によるオッセオインテグレーション促進効果 (2007)
  • Author(s): 澤瀬 隆, 神保 良, 熱田 充
  • Organizer: 日本歯科理工学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-05-12
• [Presentation] Improved photo-induced hydrophilic surface enhances cell behavior and bone apposition (2007)
  • Author(s): 神保 良, 澤瀬 隆, 熱田 充
  • Organizer: International Association for Dental Research
  • Place of Presentation: 札幌
  • Year and Date: 2007-05-12
• [Presentation] Fibronectin induces marrow stromal cells chemotaxis to the implant surface (2007)
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Tanaka Y, Ikeda T, Atsuta M
  • Organizer: 85th IADR(Program, #2537, 2007)
  • Place of Presentation: IADR, New Orleans, USA
• [Presentation] Improved photo-induced hydrophilic surface enhances cell behavior and bone apposition (2007)
  • Author(s): Jimbo R, Sawase T, Atsuta M
  • Organizer: European Association for Osseointegration 16th Annual Scientific Meeting(Program, #310, 2007)
  • Place of Presentation: Barcelona, Spain
• [Presentation] 光触媒活性超親水性効果によるオッセオインテグレーション促進効果 (2007)
  • Author(s): 澤瀬隆, 神保良, 熱田充
  • Organizer: 第49回日本歯科理工学会学術講演会(歯材器, 26, 演題番号P-109, p.253, 2007)
  • Place of Presentation: 札幌
• [Presentation] 光触媒超親水性効果による, 陽極酸化チタンインプラントのオッセオインテグレーション促進効果 (2007)
  • Author(s): 澤瀬隆, 神保良, 尾立哲郎, 平川祐子, 鎌田幸治, 添野光洋, 熱田充
  • Organizer: 第37回日本口腔インプラント学会学術大会(抄録集, 演題番号T-4-7, p.202, 2007)
  • Place of Presentation: 熊本
• [Presentation] Photo-induced hydrophilic surface enhance cell attachment (2006)
  • Author(s): Sawase T, Jimbo R, Shibata Y, Suketa N,Baba K, Ikeda T, Atsuta M
  • Organizer: European Association for Osseointegration 15th Annual Scientific Meeting(Program #288, 2006)
  • Place of Presentation: Zurich, Switzerland
• [Presentation] Fibronectin regulates osteoprogenitor cells migration and bone formation around implants (2006)
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Ikeda T, Atsuta M
  • Organizer: European Association for Osseointegration 15th Annual Scientific Meeting(Program #57, 2006)
  • Place of Presentation: Zurich, Switzerland
• [Presentation] Efficacy of titanium-coated aclylic rods for in situ detection of molecules account for peri-implant bone healing (2006)
  • Author(s): Jimbo R, Sawase T, Tanaka Y, Hirata K, Hishikawa Y, Shibata Y, Ikeda T, Atsuta M
  • Organizer: International Microscopy Congress Annual Meeting(Program #B-10, 2006)
  • Place of Presentation: Sapporo, Japan
• [Presentation] チタン薄膜コーティングインプラントによるオッセオインテグレーション微細構造解析について (2006)
  • Author(s): 神保良, 澤瀬隆, 柴田恭明, 平田一成, 馬場直樹, 祐田尚紀, 池田通, 熱田充
  • Organizer: 第23回日本口腔インプラント学会九州支部学術大会(日本口腔インプラント学会誌, 19, p.65, 2006)
  • Place of Presentation: 小倉
• [Presentation] 光触媒活性親水性効果による, 陽極酸化チタンへの細胞接着, 増殖の亢進 (2006)
  • Author(s): 澤瀬隆, 神保良, 柴田恭明, 祐田尚紀, 鎌田幸治, 添野光洋, 池田通, 熱田充
  • Organizer: 第36回日本口腔インプラント学会総会(抄録集演題番号T-3-3, p.151, 2006)
  • Place of Presentation: 新潟
• [Presentation] 血清ファイブロネクチンのオッセオインテグレーション促進効果 (2006)
  • Author(s): 神保良, 澤瀬隆, 柴田恭明, 平田一成, 池田通, 熱田充
  • Organizer: 第36回日本口腔インプラント学会総会(抄録集演題番号T-3-4, p.151, 2006)
  • Place of Presentation: 新潟
• [Presentation] Fibronectin Induces Marrow Stromal Cells Chemotaxis to the Implant Surface
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Ikeda T, Atsuta M
• [Presentation] 親水性チタン表面への血清タンパク質の吸着
  • Author(s): 平川祐子, 柴田恭明, 尾立哲郎, 神保 良, 池田通, 澤瀬隆
  • Organizer: 第26回日本口腔インプラント学会九州支部学術大会
  • Place of Presentation: 沖縄
• [Patent(Industrial Property Rights)] インプラント (2007)
  • Inventor(s): 澤瀬隆, 馬場恒明, 神保良
  • Industrial Property Rights Holder: 長崎大学, 長崎県
  • Industrial Property Number: 2007-110741
  • Filing Date: 2007-04-27
• [Patent(Industrial Property Rights)] インプラント (2007)
  • Inventor(s): 澤瀬 隆, 馬場 恒明, 神保 良
  • Industrial Property Rights Holder: 長崎大学・長崎県
  • Industrial Property Number: 2007-110741
  • Filing Date: 2007-04-27
• [Patent(Industrial Property Rights)] 特許 (2006)
  • Inventor(s): 澤瀬 隆, 神保 良, 馬場恒明
  • Industrial Property Rights Holder: 長崎大学, 長崎県
  • Industrial Property Number: 2006-232291
  • Filing Date: 2006-08-29