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Photo-catalytic superhydrophilicity enhances Osseointegration

Research Project

Project/Area Number 18390520
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionNagasaki University

Principal Investigator

SAWASE Takashi  Nagasaki University, 医歯薬学総合研究科, 教授 (80253681)

Co-Investigator(Kenkyū-buntansha) SHIBATA Yasuaki  長崎大学, 医歯薬学総合研究科, 教授 (80253673)
IKEDA Tohru  長崎大学, 医歯薬学総合研究科, 教授 (00211029)
KAMADA Koji  長崎大学, 医歯薬学総合研究科, 助教 (60264256)
YOSHIDA Keiichi  長崎大学, 医学部・歯学部附属病院, 講師 (70230729)
ATSUTA Mitsuru  長崎大学, 医歯薬学総合研究科, 教授 (60002135)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥14,910,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywords歯科インプラント学 / 生体材料 / 光触媒活性 / 生体親和性 / 親水性 / オッセオインテグレーション / 細胞親和性
Research Abstract

骨組織内に埋入されるインプラント表面改質により, 光触媒超親水性効果を付与することで, インプラント表面での細胞接着を促進し, ひいては骨形成(オッセオインテグレーション)を亢進するとの仮説を立て, 細胞培養試験ならびに動物実験により検証を行った. その結果超親水性インプラントにおいては, 早期からの細胞接着, 伸展, 増殖が向上し, さらにオッセオインテグレーションの指標である骨接触率の有意な向上を認めた.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 2006 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (17 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Accelerated photo-induced hydrophilicity promotes osseointegration : an animal study2009

    • Author(s)
      Jimbo R, Ono D, Hirakawa Y, Odatsu T, Tanaka T, Sawase T
    • Journal Title

      Clin Implant Dent Relat Res 10

    • Related Report
      2008 Final Research Report
  • [Journal Article] Accelerated photo-induced hydrophilicity promotes osseointegration : an animal study2009

    • Author(s)
      Jimbo R, Sawase T
    • Journal Title

      Clinical Implant Dentistry and Related Reseach 11(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium2008

    • Author(s)
      Jimbo R, Sawase T, Baba K, Kurogi T, Shibata Y, Atsuta M
    • Journal Title

      Clin Implant Dent Relat Res 10

      Pages: 55-61

    • NAID

      120006984724

    • Related Report
      2008 Final Research Report
  • [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition2008

    • Author(s)
      Sawase T, Jimbo R, Baba K, Shibata Y, Ikeda T, Atsuta M
    • Journal Title

      Clin Oral Implants Res 19

      Pages: 491-496

    • Related Report
      2008 Final Research Report
  • [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition2008

    • Author(s)
      Sawase T, Jimbo R, Baba K, Shibata Y, Ikeda T, Atsuta M
    • Journal Title

      Clinical Oral Implants Research 19

      Pages: 491-496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium.2008

    • Author(s)
      Jimbo R, Sawase T, Baba K, Kurogi T, Suketa N, Shibata Y, Atsuta M
    • Journal Title

      Clinical Implant Dentistry and Related Research 10

      Pages: 55-61

    • NAID

      120006984724

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells2007

    • Author(s)
      Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Bessho K, Ikeda T, Atsuta M
    • Journal Title

      Biomaterials 28

      Pages: 3469-3477

    • NAID

      120006984664

    • Related Report
      2008 Final Research Report
  • [Journal Article] A novel characteristic of porous titanium oxide implants2007

    • Author(s)
      Sawase T, Jimbo R, Wennerberg A, Suketa N, Tanaka Y, Atsuta M
    • Journal Title

      Clin Oral Implants Res 18

      Pages: 680-685

    • Related Report
      2008 Final Research Report
  • [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells.2007

    • Author(s)
      Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Bessho K, Ikeda T, Atsuta M
    • Journal Title

      Biomateials 28

      Pages: 3469-3477

    • NAID

      120006984664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel characteristic of porous titanium oxide implants.2007

    • Author(s)
      Sawase T, Jimbo R, Wennerberg A, Suketa N, Tanaka Y, Atsuta M
    • Journal Title

      Clinical Oral Implants Research 18

      Pages: 680-685

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel characteristic of porous titanium implant2007

    • Author(s)
      Sawase T, Jimbo R, Wnnerberg A, Suketa N, Atsuta M, Tanaka Y
    • Journal Title

      Clinical Oral Implant Research (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 親水性チタン表面への血清タンパク質の吸着2009

    • Author(s)
      平川祐子, 柴田恭明, 尾立哲郎, 神保 良, 池田 通, 澤瀬 隆
    • Organizer
      第26回日本口腔インプラント学会九州支部学術大会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-02-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lateral bone augmentation with a newly developed beta tri-calcium phosphate block2008

    • Author(s)
      Ono D, Sawase T, Jimbo R, Asahina I, Ioku, Ikeda T
    • Organizer
      4th Asian Academy of Osseointegration
    • Place of Presentation
      広島
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lateral bone augmentation with a newly developed beta tri-calcium phosphate block2008

    • Author(s)
      Ono D, Sawase T, Jimbo R, Asahina I, Ioku K, Ikeda T
    • Organizer
      4th Asian Academy of Osseointegration
    • Place of Presentation
      Hiroshima
    • Related Report
      2008 Final Research Report
  • [Presentation] 光触媒活性超親水性効果によるオッセオインテグレーション促進効果2007

    • Author(s)
      澤瀬 隆, 神保 良, 熱田 充
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Improved photo-induced hydrophilic surface enhances cell behavior and bone apposition2007

    • Author(s)
      神保 良, 澤瀬 隆, 熱田 充
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Fibronectin induces marrow stromal cells chemotaxis to the implant surface2007

    • Author(s)
      Jimbo R, Sawase T, Shibata Y, Hirata K, Tanaka Y, Ikeda T, Atsuta M
    • Organizer
      85th IADR(Program, #2537, 2007)
    • Place of Presentation
      IADR, New Orleans, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Improved photo-induced hydrophilic surface enhances cell behavior and bone apposition2007

    • Author(s)
      Jimbo R, Sawase T, Atsuta M
    • Organizer
      European Association for Osseointegration 16th Annual Scientific Meeting(Program, #310, 2007)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] 光触媒活性超親水性効果によるオッセオインテグレーション促進効果2007

    • Author(s)
      澤瀬隆, 神保良, 熱田充
    • Organizer
      第49回日本歯科理工学会学術講演会(歯材器, 26, 演題番号P-109, p.253, 2007)
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] 光触媒超親水性効果による, 陽極酸化チタンインプラントのオッセオインテグレーション促進効果2007

    • Author(s)
      澤瀬隆, 神保良, 尾立哲郎, 平川祐子, 鎌田幸治, 添野光洋, 熱田充
    • Organizer
      第37回日本口腔インプラント学会学術大会(抄録集, 演題番号T-4-7, p.202, 2007)
    • Place of Presentation
      熊本
    • Related Report
      2008 Final Research Report
  • [Presentation] Photo-induced hydrophilic surface enhance cell attachment2006

    • Author(s)
      Sawase T, Jimbo R, Shibata Y, Suketa N,Baba K, Ikeda T, Atsuta M
    • Organizer
      European Association for Osseointegration 15th Annual Scientific Meeting(Program #288, 2006)
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2008 Final Research Report
  • [Presentation] Fibronectin regulates osteoprogenitor cells migration and bone formation around implants2006

    • Author(s)
      Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Ikeda T, Atsuta M
    • Organizer
      European Association for Osseointegration 15th Annual Scientific Meeting(Program #57, 2006)
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2008 Final Research Report
  • [Presentation] Efficacy of titanium-coated aclylic rods for in situ detection of molecules account for peri-implant bone healing2006

    • Author(s)
      Jimbo R, Sawase T, Tanaka Y, Hirata K, Hishikawa Y, Shibata Y, Ikeda T, Atsuta M
    • Organizer
      International Microscopy Congress Annual Meeting(Program #B-10, 2006)
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] チタン薄膜コーティングインプラントによるオッセオインテグレーション微細構造解析について2006

    • Author(s)
      神保良, 澤瀬隆, 柴田恭明, 平田一成, 馬場直樹, 祐田尚紀, 池田通, 熱田充
    • Organizer
      第23回日本口腔インプラント学会九州支部学術大会(日本口腔インプラント学会誌, 19, p.65, 2006)
    • Place of Presentation
      小倉
    • Related Report
      2008 Final Research Report
  • [Presentation] 光触媒活性親水性効果による, 陽極酸化チタンへの細胞接着, 増殖の亢進2006

    • Author(s)
      澤瀬隆, 神保良, 柴田恭明, 祐田尚紀, 鎌田幸治, 添野光洋, 池田通, 熱田充
    • Organizer
      第36回日本口腔インプラント学会総会(抄録集演題番号T-3-3, p.151, 2006)
    • Place of Presentation
      新潟
    • Related Report
      2008 Final Research Report
  • [Presentation] 血清ファイブロネクチンのオッセオインテグレーション促進効果2006

    • Author(s)
      神保良, 澤瀬隆, 柴田恭明, 平田一成, 池田通, 熱田充
    • Organizer
      第36回日本口腔インプラント学会総会(抄録集演題番号T-3-4, p.151, 2006)
    • Place of Presentation
      新潟
    • Related Report
      2008 Final Research Report
  • [Presentation] Fibronectin Induces Marrow Stromal Cells Chemotaxis to the Implant Surface

    • Author(s)
      Jimbo R, Sawase T, Shibata Y, Hirata K, Ikeda T, Atsuta M
    • Related Report
      2008 Final Research Report
  • [Presentation] 親水性チタン表面への血清タンパク質の吸着

    • Author(s)
      平川祐子, 柴田恭明, 尾立哲郎, 神保 良, 池田通, 澤瀬隆
    • Organizer
      第26回日本口腔インプラント学会九州支部学術大会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] インプラント2007

    • Inventor(s)
      澤瀬隆, 馬場恒明, 神保良
    • Industrial Property Rights Holder
      長崎大学, 長崎県
    • Industrial Property Number
      2007-110741
    • Filing Date
      2007-04-27
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] インプラント2007

    • Inventor(s)
      澤瀬 隆, 馬場 恒明, 神保 良
    • Industrial Property Rights Holder
      長崎大学・長崎県
    • Industrial Property Number
      2007-110741
    • Filing Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許2006

    • Inventor(s)
      澤瀬 隆, 神保 良, 馬場恒明
    • Industrial Property Rights Holder
      長崎大学, 長崎県
    • Industrial Property Number
      2006-232291
    • Filing Date
      2006-08-29
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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