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Mandibular Reconstruction Using Tissue-engineered Distraction Osteogenesis

Research Project

Project/Area Number 18390536
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNagoya University

Principal Investigator

HIBI Hideharu  Nagoya University, 大学院・医学系研究科, 准教授 (90345885)

Co-Investigator(Kenkyū-buntansha) 上田 実  名古屋大学, 大学院・医学系研究科, 教授 (00151803)
山田 陽一  名古屋大学, 医学部附属病院, 助教 (20345903)
Co-Investigator(Renkei-kenkyūsha) UEDA Minoru  名古屋大学, 大学院・医学系研究科, 教授 (00151803)
YAMADA Yoichi  名古屋大学, 医学部・附属病院, 助教 (20345903)
KINOSHITA Kazuhiko  名古屋大学, 医学部・附属病院, 医員 (40467296)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥8,910,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywords口腔外科学一般 / 再生医学 / 歯学 / 移植・再生医療
Research Abstract

下顎骨に生じた欠損を形態回復するための創内型骨延長装置を開発し, 臨床応用に成功した. また骨延長部に骨形性を得るには数か月間を要するが, これを短縮する方法として骨延長部への骨形成性細胞・多血小板血漿複合体の注入が有効であることを明らかにした. これは自己骨髄液から間葉系幹細胞を分離し培養して増殖させた後に骨形成性細胞に分化誘導したものに, 自己多血小板血漿を複合させたものであり, 注入に適したゲルである.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (62 results)

All 2009 2008 2007 2006

All Journal Article (24 results) (of which Peer Reviewed: 14 results) Presentation (19 results) Book (19 results)

  • [Journal Article] Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation: clinical application report from a 2-6-year follow-up2008

    • Author(s)
      Yamada Y, Hibi H, Ueda M(他4名, 5番目)
    • Journal Title

      Tissue Engineering Part A 14

      Pages: 1699-1707

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material2008

    • Author(s)
      Kinoshita K, Hibi H, Yamada Y, Ueda M
    • Journal Title

      J Craniofac Surg 19

      Pages: 80-87

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Injectable bone applied for ridge augmentation and dental implant placement: human progress study2008

    • Author(s)
      Ueda M, Yamada Y, Kagami H, Hibi H
    • Journal Title

      Implant Dent 17

      Pages: 82-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Injectable bone applied for ridge augmentation and dental implant placement : human progress study2008

    • Author(s)
      Ueda M
    • Journal Title

      Implant Dentistry 17

      Pages: 82-90

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Titanium implant in a vasculari sed scapular bone graft after a 6-year loading period2008

    • Author(s)
      Hibi H
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery 20

      Pages: 148-151

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material2008

    • Author(s)
      Kinoshita K
    • Journal Title

      Journal of Craniofacial Surgery 19

      Pages: 80-87

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral and Maxillofacial Surgery and Periodontics, Quintessence Publishing2008

    • Author(s)
      Jensen OT
    • Journal Title

      Tissue Engineering: Applications

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Distraction Osteogenesis of Facial Skeleton2007

    • Author(s)
      Hibi H
    • Journal Title

      BC Decker

    • Related Report
      2007 Annual Research Report
  • [Journal Article] New internal transport distraction device for reconstructing segmental defects of the mandible2006

    • Author(s)
      Hibi H, Ueda M
    • Journal Title

      Br J Oral Maxillofac Surg 44

      Pages: 382-385

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distraction osteogenesis assisted by tissue engineering in an irradiated mandible : a case report2006

    • Author(s)
      Hibi H, Yamada Y, Kagami H, Ueda M
    • Journal Title

      Int J Oral Maxillofac Implants 21

      Pages: 141-147

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alveolar cleft osteoplasty using tissue-engineered osteogenic material : technical note2006

    • Author(s)
      Hibi H, Yamada Y, Ueda M, Endo Y
    • Journal Title

      Int J Oral Maxillofac Surg 35

      Pages: 551-555

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration method using mesenchymal stem cells(MSCs)and platelet-rich plasma PRP)complexes for sinus floor elevation in rabbits2006

    • Author(s)
      Ohya M, Yamada Y, Hibi H, Ueda M(他3名, 6番目)
    • Journal Title

      Dentistry in Japan 42

      Pages: 61-64

    • NAID

      10019595404

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology : a clinical case report2006

    • Author(s)
      Yamada Y, Ueda M, Hibi H, Baba S
    • Journal Title

      Int J Periodontics Restorative Dent 26

      Pages: 363-369

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 名古屋大学における遺伝子・再生医療センターの現状と展望 : 特にISOとセンター再整備を中心に2006

    • Author(s)
      吉田純, 若林俊彦, 日比英晴, 夏目敦至
    • Journal Title

      現代医学 54

      Pages: 31-38

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞移植による顎骨の再生2006

    • Author(s)
      日比英晴, 上田実
    • Journal Title

      医学のあゆみ 217

      Pages: 281-282

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cluster analysis and gene expression profiles : a cDNA microarray system-based comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells(hMSCs)for tissue engineering cell therapy2006

    • Author(s)
      Yamada Y, Ueda M(他3名, 1番目)
    • Journal Title

      Biomaterials 27

      Pages: 3766-3781

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] New internal transport distraction device for reconstructing segmental defects of the mandible2006

    • Author(s)
      Hibi, H
    • Journal Title

      British Journal of Oral and Maxillofacial Surgery 44・5

      Pages: 382-385

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Orthodontic anchorage system using a locking plate and self-drilling screws2006

    • Author(s)
      Hibi, H
    • Journal Title

      Journal of Oral and Maxillofacial Surgery 64・7

      Pages: 1173-1175

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distraction osteogenesis assisted by tissue engineering in an irradiated mandible : a case report2006

    • Author(s)
      Hibi, H
    • Journal Title

      International Journal of Oral and Maxillofacial Implants 21・1

      Pages: 141-147

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alveolar cleft osteoplasty using tissue-engineered osteogenic material : technical note2006

    • Author(s)
      Hibi, H
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery 35・6

      Pages: 551-555

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 細胞移植による顎骨の再生2006

    • Author(s)
      日比英晴
    • Journal Title

      医学のあゆみ 217・3

      Pages: 281-282

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone regeneration method using mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) complexes for sinus floor elevation in rabbits2006

    • Author(s)
      Ohya, M
    • Journal Title

      Dentistry in Japan 42

      Pages: 61-64

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology : a clinical case report2006

    • Author(s)
      Yamada, Y
    • Journal Title

      The International Journal of Periodontics & Restorative Dentistry 26・4

      Pages: 363-369

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 名古屋大学における遺伝子・再生医療センターの現状と展望 : 特にISOとセンター再整備を中心に2006

    • Author(s)
      吉田純
    • Journal Title

      現代医学 54・1

      Pages: 31-38

    • Related Report
      2006 Annual Research Report
  • [Presentation] 下顎区域切除後の骨延長法による下顎再建2009

    • Author(s)
      日比英晴
    • Organizer
      第27回日本口腔腫瘍学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-01-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 下顎区域切除後の骨延長法による下顎再建2009

    • Author(s)
      日比英晴
    • Organizer
      第27回目本口腔腫瘍学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] インプラントを目的とした再建下顎骨の骨延長法による形態改善2008

    • Author(s)
      日比英晴
    • Organizer
      第12回日本顎顔面インプラント学会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-07
    • Related Report
      2008 Final Research Report
  • [Presentation] インプラントを目的とした再建下顎骨の骨延長法による形態改善2008

    • Author(s)
      日比英晴
    • Organizer
      第12回日本顎顔面インフラント学会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Internal transport distraction for mandibular reconstruction2008

    • Author(s)
      Hibi H
    • Organizer
      19th Congress of the European Association for Cranio-Maxillofacial Surgery
    • Place of Presentation
      Italy
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Internal transport distraction for reconstructing segmental defects of the mandible2008

    • Author(s)
      Hibi H
    • Organizer
      86th General Session & exhibition of the International Association of Dental Research
    • Place of Presentation
      Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 骨再生とインプラント2008

    • Author(s)
      日比英晴
    • Organizer
      第7回日本再生医療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Tissue-engineered osteoplasty for alveolar2007

    • Author(s)
      Hibi H
    • Organizer
      cleft18th International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      India
    • Year and Date
      2007-11-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Experimental study on rapid maxillary distraction osteogenesis using tissue-engineered osteogenic material2007

    • Author(s)
      Kinoshita K
    • Organizer
      89th Annual Meeting, Scientific Sessions and Exhibition, American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      USA
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Experimental study on rapid maxillary distraction osteogenesis using tissue-engineered osteogenic material2007

    • Author(s)
      Kinoshita K
    • Organizer
      89th Annual Meeting, Scientific Sessions and Exhibition, American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      アメリカ
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨形成性細胞多血小板血漿複合体の注入をくみあわせた顎骨延長法についての実験的研究2007

    • Author(s)
      木下一彦
    • Organizer
      第52回日本口腔外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-29
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 顎顔面領域の再生医療2007

    • Author(s)
      日比英晴
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-02
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 骨形成性細胞注入をくみあわせた顎骨延長法についての実験的研究2007

    • Author(s)
      木下一彦
    • Organizer
      第61回日本口腔科学会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Alveolar cleft osteoplasty using tissue-engineered osteogenic material2006

    • Author(s)
      Hibi H
    • Organizer
      18th Congress of the European Association for Cranio-Maxillofacial Surgery
    • Place of Presentation
      Spain
    • Year and Date
      2006-09-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Internal transport distraction for reconstructing the segmental defect from the mandibular body to condyle2006

    • Author(s)
      Hibi H
    • Organizer
      The 1st International and the 19th Annual Meeting of the Japanese Society for the Temporomandibular Joint
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Distraction osteogenesis assisted with engineering technology2006

    • Author(s)
      Hibi H
    • Organizer
      5th International Congress of Maxillofacial and Craniofacial Distraction
    • Place of Presentation
      France
    • Year and Date
      2006-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Internal transport distraction for reconstructing segmental defects of the mandible2006

    • Author(s)
      Hibi H
    • Organizer
      5th International Congress of Maxillofacial and Craniofacial Distraction
    • Place of Presentation
      France
    • Year and Date
      2006-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 顎裂部への培養骨形成性細胞移植2006

    • Author(s)
      日比英晴
    • Organizer
      第60回日本口腔科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] ウサギ上顎骨延長モデルの検討2006

    • Author(s)
      木下一彦
    • Organizer
      第60回日本口腔科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-05-12
    • Related Report
      2008 Final Research Report
  • [Book] 顎骨の再生 ; 臨床再生誘導治療2009

    • Author(s)
      日比英晴, 上田実
    • Publisher
      メディカルドゥ
    • Related Report
      2008 Final Research Report
  • [Book] ティッシュエンジニアリング ; 炎症・再生医学事典2009

    • Author(s)
      日比英晴, 上田実
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 臨床再生誘導治療2009

    • Author(s)
      日比英晴
    • Publisher
      メディカルドウ(印刷中)
    • Related Report
      2008 Annual Research Report
  • [Book] Alveolar distraction osteogenesis and tissue engineering ; Tissue Engineering2008

    • Author(s)
      Jensen OT, Laster Z, Hibi H, Yamada Y, Ueda M
    • Publisher
      Quintessence Publishing
    • Related Report
      2008 Final Research Report
  • [Book] Tissue Engineering: Applications in Oral and Maxillofacial Surgery and Periodontics2008

    • Author(s)
      Jensen OT
    • Total Pages
      312
    • Publisher
      Quintessence Publishing
    • Related Report
      2007 Annual Research Report
  • [Book] Multidirectional bone transport using internal distraction device ; Distraction Osteogenesis of the Facial Skeleton2007

    • Author(s)
      Hibi H, Yamada Y, Ueda M
    • Publisher
      BC Decker
    • Related Report
      2008 Final Research Report
  • [Book] Use of tissue-engineered osteogenic material for alveolar cleft osteoplasty ; Distraction Osteogenesis of the Facial Skeleton2007

    • Author(s)
      Hibi H, Yamada Y, Ueda M
    • Publisher
      BC Decker
    • Related Report
      2008 Final Research Report
  • [Book] 補綴治療における審美性 ; 再生医療と美容2007

    • Author(s)
      日比英晴
    • Publisher
      南山堂
    • Related Report
      2008 Final Research Report
  • [Book] 歯槽骨再生の概念と概要 ; 再生医療とインプラント2007

    • Author(s)
      日比英晴
    • Publisher
      クインテッセンス出版
    • Related Report
      2008 Final Research Report
  • [Book] 注入型培養骨における歯槽骨再生の適応症と治療計画 ; 再生医療とインプラント2007

    • Author(s)
      八島明弘, 山田陽一, 日比英晴
    • Publisher
      クインテッセンス出版
    • Related Report
      2008 Final Research Report
  • [Book] Distraction Osteogenesis of Facial Skeleton2007

    • Author(s)
      Hibi H
    • Publisher
      BC Decker
    • Related Report
      2007 Annual Research Report
  • [Book] 組織再建用材料 ; 臨床歯科理工学2006

    • Author(s)
      日比英晴, 上田実
    • Publisher
      医歯薬出版
    • Related Report
      2008 Final Research Report
  • [Book] 歯科における再生医療/骨造成の観点から ; 歯科臨床における再生療法2006

    • Author(s)
      日比英晴, 山田陽一, 上田実
    • Publisher
      医歯薬出版
    • Related Report
      2008 Final Research Report
  • [Book] Use of tissue-engineered bone cells for sinus augmentation with simultaneous implant placement ; The Sinus Bone Graft2006

    • Author(s)
      Ueda M, Yamada Y, Ohya M, Hibi H
    • Publisher
      Quintessence Publishing
    • Related Report
      2008 Final Research Report
  • [Book] 抗体結合型マグネトリポソームを用いた間葉系幹細胞の濃縮培養法 ; 診断・治療システムと化学工業2006

    • Author(s)
      清水一憲, 山田陽一, 日比英晴, 上田実(他4名, 6番目)
    • Publisher
      化学工学会
    • Related Report
      2008 Final Research Report
  • [Book] 臨床歯科理工学2006

    • Author(s)
      日比英晴
    • Total Pages
      406
    • Publisher
      医歯薬出版
    • Related Report
      2006 Annual Research Report
  • [Book] 歯科臨床における再生療法2006

    • Author(s)
      日比英晴
    • Total Pages
      164
    • Publisher
      医歯薬出版
    • Related Report
      2006 Annual Research Report
  • [Book] The Sinus Bone Graft2006

    • Author(s)
      Jensen, OT
    • Total Pages
      366
    • Publisher
      Quintessence Publishing
    • Related Report
      2006 Annual Research Report
  • [Book] Distraction Osteogenesis of the Facial Skeleton2006

    • Author(s)
      Bell, WH
    • Total Pages
      600
    • Publisher
      DC Becker
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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