Control of invasion and metastasis of oral cancer via clarification of the epithelial-mesenchymal transition

• Project/Area Number: 18390541
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: KAMATA Nobuyuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (70242211)
• Co-Investigator(Kenkyū-buntansha): HIGASHIKAWA Koichiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (80363084) ; ONO Shigehiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (70379882) ; SHIGEISHI Hideo 広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943) ; TAKI Masayuki 広島大学, 病院, 助教 (00403551)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥17,930,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,430,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2006: ¥7,400,000 (Direct Cost: ¥7,400,000)
• Keywords: 口腔癌 / 浸潤転移 / 上皮間葉移行 / 発現遺伝子 / 転写因子 / Snail / p63 / 扁平上皮癌 / 上皮・間葉移行 / 遺伝子発現 / 浸潤・転移

Research Abstract

Epithelial-Mesenchymal Transition (EMT) is a phenomenon that epithelial cells lose their polarity and change into mesenshymal cells possessing active migration. In this study, we aimed to clarify the molecular mechanism of acquisition of highly invasive phenotype through EMT in oral cancer. We identified the genes being regulated accompanied with EMT using micro-array analysis and analyzed the functions of these gene products and the regulatory mechanisms of gene expression. We found that p63 was one of the target gene of EMT and had the important function in invasion of squamous cell carcinoma.

Research Products

• [Journal Article] Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. (2009)
  • Author(s): Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
  • Journal Title: American Journal of Pathology 175(5) Pages: 2235-2248
  • Peer Reviewed
• [Journal Article] Amphiregulin induces proliferative activities in osseous dysplasia. (2009)
  • Author(s): Shigeishi H, Yamaguchi S, Mizuta K, Nakakuki K, Fujimoto S, Amagasa T, Kamata N
  • Journal Title: J Dent Res 88(6) Pages: 563-568
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (2009)
  • Author(s): Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N
  • Journal Title: Int J Oncol 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
  • Journal Title: Int J Cancer 124(12) Pages: 2837-2844
  • Peer Reviewed
• [Journal Article] Oncogenic role of nuclear accumulated Aurora-A. (2009)
  • Author(s): Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T
  • Journal Title: Mol Carcinog 48(9) Pages: 810-820
  • Peer Reviewed
• [Journal Article] Expression of TPX2 in salivary gland carcinomas. (2009)
  • Author(s): Shigeishi H, Ohta K, Hiraoka M, Fujimoto S, Minami M, Higashikawa K, Kamata N
  • Journal Title: Oncol Rep 21(2) Pages: 341-344
  • Peer Reviewed
• [Journal Article] Nodal lymphangiogenesis and metastasis : Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease (2009)
  • Author(s): Hirakawa S, et al.
  • Journal Title: American Journal of Pathology 175(5) Pages: 2235-2248
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas (2009)
  • Author(s): Shigeishi H, et al.
  • Journal Title: International Journal of Oncology 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma (2009)
  • Author(s): Higashikawa K, et al.
  • Journal Title: International Journal of Cancer 124(12) Pages: 2837-4284
  • Peer Reviewed
• [Journal Article] Oncogenic role of nuclear accumulated Aurora-A (2009)
  • Author(s): Tatsuka M, et al.
  • Journal Title: Molecular Carcinogenesis 48(9) Pages: 810-820
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh, M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N.
  • Journal Title: Int J Cancer 124 Pages: 2837-44
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. (2009)
  • Author(s): Higashikawa K
  • Journal Title: Int J Cancer 124(12) : Pages: 2837-2844
  • Peer Reviewed
• [Journal Article] Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts. (2008)
  • Author(s): Ohta K, Shigeishi H, Taki M, Nishi H, Higashikawa K, Takechi M, Kamata N
  • Journal Title: J Dent Res 87(12) Pages: 1160-1165
  • Peer Reviewed
• [Journal Article] Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. (2008)
  • Author(s): Shigeishi H, Higashikawa K, Hiraoka M, Fujimoto S, Mitani Y, Ohta K, Takechi M, Kamata N
  • Journal Title: Oncol Rep 19(6) Pages: 1557-1564
  • Peer Reviewed
• [Journal Article] Up-regulation of stromal cell-derived factor-1alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma. (2008)
  • Author(s): Taki M, Higashikawa K, Yoneda S Ono S, Shigeishi H, Nagayama M, Kamata N
  • Journal Title: Oncol Rep 19(4) Pages: 993-998
  • Peer Reviewed
• [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition. (2008)
  • Author(s): Higashikawa K, Yoneda S, Taki M, Shigeishi H, Ono S, Tobiume K, Kamata N
  • Journal Title: Cancer Lett 264(2) Pages: 256-264
  • Peer Reviewed
• [Journal Article] 東川晃一郎EMTを介した癌の高度浸潤能獲得の分子機構 (2008)
  • Author(s): 鎌田伸之
  • Journal Title: 細胞工学 27(4) Pages: 359-362
• [Journal Article] Up-regulation of stromal cell-derived factor-1 alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma (2008)
  • Author(s): Taki M, Higashikawa K, Yoneda S, Ono S, Shigeishi H, Nagayama M, Kamata N.
  • Journal Title: Oncol Rep 19(4) Pages: 993-8
  • Peer Reviewed
• [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition (2008)
  • Author(s): Higashikawa K, Yoneda S, Taki M, Shigeishi, H, Ono S, Tobiume K, Kamata N.
  • Journal Title: Cancer Lett 264(2) Pages: 256-64
  • Peer Reviewed
• [Journal Article] EMT を介した癌の高度浸潤能獲得の分子機構【EMT 研究がいま面白い 発生・癌・病態研究から見えてきた接点】 (2008)
  • Author(s): 鎌田伸之, 東川晃一郎
  • Journal Title: 細胞工学 27(4) Pages: 359-62
• [Journal Article] Up-regulation of stromal cell-derived factor-1 alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma. (2008)
  • Author(s): Taki M
  • Journal Title: Oncol Rep 19(4) : Pages: 993-998
  • Peer Reviewed
• [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition. (2008)
  • Author(s): Higashikawa K
  • Journal Title: Cancer Lett. 264(2) : Pages: 256-264
  • Peer Reviewed
• [Journal Article] Expression of epiregulin, a novel epidermal growth factor ligand, associatedwith prognosis in human oral squamous cell carcinomas. . (2008)
  • Author(s): Shigeishi H
  • Journal Title: Oncol Rep 19 Pages: 1557-1564
  • Peer Reviewed
• [Journal Article] EMTを介した癌の高度浸潤能獲得の分子機構【EMT研究がいま面白い発生・癌・病態研究から見えてきた接点】. . (2008)
  • Author(s): 鎌田伸之
  • Journal Title: 細胞工学 27(4) Pages: 359-362
• [Journal Article] Up-regulation of stromal cell-derived factor-1 alpha and its receptor CXCR4 expression accompanied with epitherilal-mesenchymal transition in human oral squamous cell carcinoma. (2008)
  • Author(s): Masayuki Taki
  • Journal Title: Oncology Report. 19・4 Pages: 993-998
  • Peer Reviewed
• [Journal Article] Gene expression profiling to identily genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to mesenchymal transition. (2008)
  • Author(s): Koichiro Higashikawa
  • Journal Title: Cancer Lett. er (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Increased expression of CENP-H gene in Human salivary gland carcinomas. (2008)
  • Author(s): Hideo Shigeishi
  • Journal Title: Oral Science International (in print)
  • NAID: 10024185909
  • Peer Reviewed
• [Journal Article] Interaction of E2F-Rb family members with corepressors binding to the adjacent E2F site. (2007)
  • Author(s): Nakajima Y, Yamada S, Kamata N, Ikeda MA
  • Journal Title: Biochem Biophys Res Commun 364(4) Pages: 1050-1055
  • Peer Reviewed
• [Journal Article] Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma. (2007)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Taki M, Shigeishi H, Kamata N
  • Journal Title: Cancer Res 67(19) Pages: 9207-9213
  • Peer Reviewed
• [Journal Article] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. (2007)
  • Author(s): Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, et al.
  • Journal Title: Oncogene 26(57) Pages: 7921-7932
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. (2007)
  • Author(s): Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N, Yasui W
  • Journal Title: Oncogene 26(30) Pages: 4383-4393
  • NAID: 120000875405
  • Peer Reviewed
• [Journal Article] Snail-induced downregulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma (2007)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Taki, M, Shigeishi H, Kamata N.
  • Journal Title: Cancer Res 67(19) Pages: 9207-13
  • Peer Reviewed
• [Journal Article] Snail-induced down-regulation of {delta} Np63{alpha} acquires invasive phenotype of human squamous cell carcinoma. (2007)
  • Author(s): Koichiro Higashikawa
  • Journal Title: Cancer Research 67・19 Pages: 9207-9213
  • Peer Reviewed
• [Journal Article] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. (2007)
  • Author(s): Emina Suzuki
  • Journal Title: Oncogene 26・57 Pages: 7921-7932
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. (2007)
  • Author(s): Yoshitugu Mitani
  • Journal Title: Oncogene 26・30 Pages: 4383-4393
  • Peer Reviewed
• [Journal Article] Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia. (2007)
  • Author(s): Kuniko Mizuta
  • Journal Title: Biochem Biophys Res Commun. 357・1 Pages: 126-132
  • Peer Reviewed
• [Journal Article] Human papillomavirus-16 in oral squamous cell carcinoma : Clinical correlates and 5-year survival. (2007)
  • Author(s): Masaru Sugiyama
  • Journal Title: Br J Oral Maxillofac Surg. 45・2 Pages: 116-122
• [Journal Article] Comparison of genes expressed in cell lines derived from a primary lesion and metastasized lymph nodes of tongue squamous cell carcinoma -a trial study of identifying metastasis-related genes- (2007)
  • Author(s): Takeshi Nobumori
  • Journal Title: Dentistry in Japan 48 Pages: 64-69
• [Journal Article] Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. (2006)
  • Author(s): Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, Taki M, Kamata N
  • Journal Title: OncolRep 16(5) Pages: 1071-1075
  • Peer Reviewed
• [Journal Article] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. (2006)
  • Author(s): Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N
  • Journal Title: Oncol Rep 15(4) Pages: 933-938
  • Peer Reviewed
• [Journal Article] Involvement of Ets-1 transcription factor in inducing matrix metallo-proteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. (2006)
  • Author(s): Taki M, Verschueren K, Yokoyama K, Nagayama M, Kamata N
  • Journal Title: Int J Oncol 28(2) Pages: 487-496
  • Peer Reviewed
• [Journal Article] Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. (2006)
  • Author(s): Masayuki Taki
  • Journal Title: Int J Oncology 28・2 Pages: 487-496
• [Journal Article] Correlation of Bub1 expression with tumor-proliferating activity in human salivary gland tumors. (2006)
  • Author(s): Hideo Shigeishi
  • Journal Title: Oncology Report 15・4 Pages: 933-937
• [Journal Article] Increased expression of CENP-H gene in human oral squamous cell carcinomas with tumor-proliferating activity. (2006)
  • Author(s): Hideo Shigeishi
  • Journal Title: Oncology Report 16・5 Pages: 1071-1075
• [Journal Article] 扁平上皮癌細胞におけるSnailによる上皮・間葉移行を介した遺伝子発現制御の解析 (2006)
  • Author(s): 瀧 雅行
  • Journal Title: 口腔組織培養学会誌 15・2 Pages: 1-10
• [Presentation] EMT型口腔扁平上皮癌細胞におけるgamma-secretase inhibitor抵抗性の解析 (2009)
  • Author(s): 東川晃一郎, 田中扶美, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 口腔扁平上皮癌細胞における高度浸潤能獲得機構の解析 (2009)
  • Author(s): 田中扶美, 東川晃一郎, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 口腔粘膜上皮細胞、歯肉線維芽細胞におけるToll-like Receptorの発現と機能 (2009)
  • Author(s): 福井暁子, 太田耕司, 西裕美, 武知正晃, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] EMT型口腔扁平上皮癌細胞における gamma-secretase inhibitor 抵抗性の解析 (2009)
  • Author(s): 東川晃一郎, 田中扶美, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 口腔粘膜上皮癌細胞、歯肉線維芽細胞における Toll-like Receptor の発現と機能 (2009)
  • Author(s): 福井暁子, 太田耕司, 西裕美, 武知正晃, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] Snailによる転写調節とEMTの誘導 (2009)
  • Author(s): 鎌田伸之, 東川晃一郎, 飛梅圭
  • Organizer: 第68回日本癌学会学術総会・シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 扁平上皮癌細胞においてSnailが発現抑制するdeltaNp63αの機能解析 (2009)
  • Author(s): 東川晃一郎, 飛梅圭, 田中扶美, 鎌田伸之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 口腔扁平上皮癌細胞における高度浸潤能獲得へのSnail標的分泌型タンパクの関与 (2009)
  • Author(s): 田中扶美, 東川晃一郎, 飛梅圭, 小野重弘, 重石英生, 鎌田伸之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Snail による転写調節とEMTの誘導 (2009)
  • Author(s): 鎌田伸之, 東川晃一郎, 飛梅圭
  • Organizer: 第68回日本癌学会学術総会・シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 扁平上皮癌細胞において Snail が発現抑制する deltaNp63αの機能解析 (2009)
  • Author(s): 東川晃一郎, 飛梅圭, 田中扶美, 鎌田伸之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 口腔扁平上皮癌細胞における高度浸潤能獲得への Snail 標的分泌型タンパクの関与 (2009)
  • Author(s): 田中扶美, 東川晃一郎, 飛梅圭, 小野重弘, 重石英生, 鎌田伸之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 皮膚悪性腫瘍のリンパ行性転移機構:がん組織におけるリンパ管新生の役割 (2009)
  • Author(s): 平川聡史, 松尾恵太郎, 東川晃一郎, 鎌田伸之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 口腔粘膜上皮・歯肉線維芽細胞における炎症性サイトカインによるJAK/STATシグナル伝達経路の解析 (2009)
  • Author(s): 西裕美, 太田耕司, 福井暁子, 武知正晃, 鎌田伸之
  • Organizer: 第19回日本口腔粘膜学会・総会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-06-06
• [Presentation] Candida albicansによる歯肉線維芽細胞のFractalkine(CX3CL1)発現誘導と機能 (2009)
  • Author(s): 太田耕司, 西裕美, 福井暁子, 重石英生, 武知正晃, 鎌田伸之
  • Organizer: 第19回日本口腔粘膜学会・総会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-06-06
• [Presentation] 口腔粘膜上皮細胞, 歯肉線維芽細胞におけるToll-like Receptorの発現と機能 (2009)
  • Author(s): 福井暁子, 太田耕司, 西裕美, 武知正晃, 鎌田伸之
  • Organizer: 第19回日本口腔粘膜学会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-06-06
• [Presentation] 歯肉線維芽細胞における炎症性サイトカインによるJAK/STATシグナル伝達経路の解析 (2009)
  • Author(s): 西裕美, 太田耕司, 福井暁子, 武知正晃, 鎌田伸之
  • Organizer: 第63回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2009-04-17
• [Presentation] Candida albicans感染による口腔粘膜上皮細胞、線維芽細胞におけるFractalkine(CX3CL1)の発現の検討 (2009)
  • Author(s): 太田耕司, 西裕美, 福井暁子, 瀧雅行, 重石英生, 武知正晃, 鎌田伸之
  • Organizer: 第63回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2009-04-17
• [Presentation] EMT型口腔扁平上皮癌細胞の浸潤抑制因Id3の解析 (2008)
  • Author(s): 東川晃一郎, 米田進吾, 飛梅圭, 瀧雅行, 三谷佳嗣, 小野重弘, 重石英生, 鎌田伸之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 口腔扁平上皮癌におけるEMT関連遺伝子VEGF-Cの役割と発現機構 (2008)
  • Author(s): 小野重弘, 三谷佳嗣, 東川晃一郎, 重石英生, 米田進吾, 瀧雅行, 北台靖彦, 鎌田伸之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 扁平上皮癌細胞における上皮・間葉移行を介したWnt-5aによる高度浸潤能獲得機構 (2008)
  • Author(s): 瀧雅行, 東川晃一郎, 米田進吾, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] h-pruneの高発現は扁平上皮癌のアノイキスや細胞運動に関与する (2008)
  • Author(s): 三谷佳嗣, 瀧雅行, 小野重弘, 東川晃一郎, 菊池章, 鎌田伸之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 悪性腫瘍で過剰発現するオーロラAは細胞核を標的として機能する (2008)
  • Author(s): 達家雅明, 神田暁史, 鎌田伸之, 北島正二朗, 工藤保誠, 高田隆, 嶋本文雄, 太田隆英
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] EMT 型口腔扁平上皮癌細胞の浸潤抑制因子Id3 の解析 (2008)
  • Author(s): 東川晃一郎, 米田進吾, 飛梅圭, 瀧雅行, 三谷佳嗣, 小野重弘, 重石英生, 鎌田伸之
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 口腔扁平上皮癌におけるEMT 関連遺伝子VEGF-Cの役割と発現機構 (2008)
  • Author(s): 小野重弘, 三谷佳嗣, 東川晃一郎, 重石英生, 米田進吾, 瀧雅行, 北台靖彦, 鎌田伸之
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 扁平上皮癌細胞における上皮・間葉移行を介したWnt-5aによる高度浸潤能獲得機構 (2008)
  • Author(s): 瀧雅行, 東川晃一郎, 米田進吾, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] EMT型口腔扁平上皮癌細胞の浸潤抑制因子Id3の解析 (2008)
  • Author(s): 東川晃一郎
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 口腔扁平上皮癌におけるEMT関連遺伝子VEGF-Cの役割と発現機構 (2008)
  • Author(s): 小野重弘
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 口腔扁平上皮癌におけるRHAMM遺伝子の発現解析 (2008)
  • Author(s): 重石英生, 藤本伸一, 瀧雅行, 小野重弘, 三谷佳嗣, 東川晃一郎, 鎌田伸之
  • Organizer: 第53回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 扁平上皮癌細胞におけるWnt-5aによる高度浸潤能獲得機構の解析 (2008)
  • Author(s): 瀧雅行, 東川晃一郎, 米田進吾, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第53回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 口腔扁平上皮癌におけるEMT関連遺伝子VEGF-Cの役割と発現機構 (2008)
  • Author(s): 小野重弘, 三谷佳嗣, 東川晃一郎, 重石英生, 米田進吾, 瀧雅行, 鎌田伸之
  • Organizer: 第53回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] EMT型口腔扁平上皮癌細胞の浸潤を抑制するId3の解析 (2008)
  • Author(s): 東川晃一郎, 米田進吾, 瀧雅行, 田中扶美, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第53回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 口腔扁平上皮癌におけるEMT標的遺伝子VEGF-Cの発現と病期進展との関連 (2007)
  • Author(s): 小野重弘, 三谷佳嗣, 重石英生, 米田進吾, 瀧雅行, 東川晃一郎, 北台靖彦, 鎌田伸之
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 口腔癌におけるh-pruneの発現と浸潤・転移との関連 (2007)
  • Author(s): 三谷佳嗣, 米田進吾, 瀧雅行, 小野重弘, 東川晃一郎, 鎌田伸之
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Expressions of the EMT target gene VEGF-C and disease progression in Oral Squamous Cell Carcinomas (2007)
  • Author(s): 小野重弘
  • Organizer: 第66回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] 口腔癌におけるh-pruneの発現と浸潤・転移との関連 (2007)
  • Author(s): 三谷善嗣
  • Organizer: 第52回 (社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2007-09-29
• [Presentation] 上皮・間葉移行を介した扁平上皮癌細胞におけるΔNp63αの発現依存的な浸潤能の変化 (2007)
  • Author(s): 米田進吾
  • Organizer: 第80回 日本組織培養学会総会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2007-05-14
• [Presentation] 扁平上皮癌細胞におけるEMT標的遺伝子ΔNp63αの発現依存的な浸潤能の変化 (2007)
  • Author(s): 米田進吾, 東川晃一郎, 瀧雅行, 重石英生, 小野重弘, 三谷佳嗣, 鎌田伸之
  • Organizer: 第61回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-20
• [Presentation] 扁平上皮癌細胞におけるEMT標的遺伝子ΔNp63αの発現依存的な浸潤能の変化 (2007)
  • Author(s): 米田進吾
  • Organizer: 第61回 NPO法人日本口腔科学会総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2007-04-19
• [Presentation] 口腔扁平上皮癌におけるEMT標的遺伝子VEGF-Cの発現と病期進展との関連 (2006)
  • Author(s): 小野重弘, 重石英生, 米田進吾, 瀧雅行, 東川晃一郎, 鎌田伸之
  • Organizer: 第51回(社)日本口腔外科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2006-10-12
• [Presentation] 上皮・間葉移行を介した扁平上皮癌の高度浸潤能の獲得における△Np63αの役割 (2006)
  • Author(s): 東川晃一郎, 瀧雅行, 米田進吾, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第51回(社)日本口腔外科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2006-10-12
• [Presentation] 口腔扁平上皮癌におけるEMT標的遺伝子VEGF-C発現の臨床病理学的意義に関する検討 (2006)
  • Author(s): 小野重弘, 重石英生, 米田進吾, 瀧雅行, 東川晃一郎, 鎌田伸之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔癌におけるh-pruneの発現と浸潤・転移との関連 (2006)
  • Author(s): 三谷佳嗣, 重石英生, 小野重弘, 米田進吾, 瀧雅行, 東川晃一郎, 鎌田伸之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔癌におけるBAC-arrayを用いたDNAメチル化領域の網羅的探索 (2006)
  • Author(s): 中川貴之, 横井左奈, 井上純, 鈴木江美奈PimkhaokhamAtiphan, 鎌田伸之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 上皮・間葉移行を介したp63の発現消失による扁平上皮癌の高度浸潤能の獲得 (2006)
  • Author(s): 東川晃一郎, 米田進吾, 瀧雅行, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔扁平上皮癌におけるCENP-Hの発現解析 (2006)
  • Author(s): 重石英生, 東川晃一郎, 小野重弘, 瀧雅行, 鎌田伸之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔粘膜上皮細胞と線維芽細胞における炎症性ケモカイン発現の検討 (2006)
  • Author(s): 太田耕司, 重石英生, 瀧雅行, 西裕美, 鎌田伸之
  • Organizer: 第16回日本口腔粘膜学会総会・学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2006-06-30
• [Presentation] 扁平上皮癌における上皮・間葉移行を介したp63の発現消失 (2006)
  • Author(s): 東川晃一郎, 瀧雅行, 米田進吾, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第51回(社)日本口腔外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-05-12
• [Book] 細胞工学 特集EMT研究がいま面白い-分子・癌・病態研究から見えてきた接点-EMTを介した癌の高度浸潤獲得の分子機構 (2008)
  • Author(s): 鎌田伸之
  • Total Pages: 4
  • Publisher: 秀潤社