Usefulness as gnathic bone reconstruction material of a carbonate apatite form with continuous porous

• Project/Area Number: 18390542
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yamaguchi University
• Principal Investigator: UEYAMA Yoshiya Yamaguchi University, 大学院・医学系研究科, 教授 (00168668)
• Co-Investigator(Kenkyū-buntansha): UDOH Kouichi 山口大学, 大学院・理工学研究科, 准教授 (60145266) ; MANO Takamitsu 山口大学, 医学部・附属病院, 講師 (80325125) ; 石川 邦夫 九州大学, 大学院・歯学研究科, 教授 (90202952)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Kunio 九州大学, 大学院・歯学研究院, 教授 (90202952)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,250,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,250,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2006: ¥7,500,000 (Direct Cost: ¥7,500,000)
• Keywords: 顎骨再建 / 連続気孔性 / 炭酸アパタイト / 生体材料

Research Abstract

本研究は骨再生のために必要な足場として炭酸アパタイトを, さらに細胞として骨髄間質性細胞を用いてその有用性を検討した.炭酸アパタイトには骨芽細胞が侵入するために連続気孔性を付与し, 実験動物に埋入すると4 週間で気孔内に骨の形成を認め炭酸アパタイトの吸収も確認できた.しかし24 週後でも炭酸アパタイトは完全に骨に置換していなかった.さらにこの炭酸アパタイトに骨髄間質性細胞を分化誘導させた細胞を注入すると骨再生の時期は少し早まったが, 完全な骨への置換は認めなかった.

Research Products

• [Journal Article] Fabrication of macroporous carbonate apatite foam by hydrothermal conversion of α-tricalcium phosphate in carbonate solutions (2009)
  • Author(s): Wakae H
  • Journal Title: Journal of Biomedioal Materials Research Part A 88A Pages: 957-963
  • Peer Reviewed
• [Journal Article] Fabrication of low-crystallinity hydroxyapatite foam based on the setting react ion of α-tricalcium phosphate foam (2009)
  • Author(s): Karashima S
  • Journal Title: Journal of Biomedical Materials Research Part A 88A Pages: 628-633
  • Peer Reviewed
• [Journal Article] Fabrication of low-crystallinity hydroxyapatite foam based on the setting reaction of α-tricalcium phosphate foam (2008)
  • Author(s): Karashima S, Takeuchi A, Matsuya S, Udou K, Koyano K, Ishikawa K
  • Journal Title: Biomed Mater Res A 88 Pages: 628-633
  • Peer Reviewed
• [Journal Article] Fablication of macroporous carbonate apatite foam by hydrothermal conversion of α-tricalcium phosphate in carbonate solutions (2008)
  • Author(s): Wakae H, Takeuchi A, Udoh K, Matsuya S, Munar M, LeGeros RZ, Nakasima A, Ishikawa K
  • Journal Title: J Biomed Mater Res A 87 Pages: 957-963
  • Peer Reviewed
• [Journal Article] Fabrication of porous low crystalline calcite block by carbonation of calcium hydroxide compact (2007)
  • Author(s): Matsuya S, Lin X, Udoh K, Nakagawa M, Shimogoryo R, Terada Y, Ishikawa K
  • Journal Title: J Mater Sci : Mater Med 18 Pages: 1361-1367
  • Peer Reviewed
• [Journal Article] Effects of sintering temperature over 1, 300°C on the physical and structural properties of porous hydroxyapatite foam (2006)
  • Author(s): Munar ML, Udoh K, Ishikawa K, Matsuya S, Nakagawa M
  • Journal Title: Dent Mater J 25 Pages: 51-58
  • Peer Reviewed
• [Journal Article] Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration (2006)
  • Author(s): Ueyama Y, Koyama T, Ishikawa K, Mano T, Ogawa Y, Nagatsuka H, Suzuki K
  • Journal Title: J Mater Sci Mater Med 17 Pages: 281-288
  • Peer Reviewed
• [Journal Article] Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guide bone regeneration (2006)
  • Author(s): Ueyama Y
  • Journal Title: Journal of Materials Science : Materials in Medicine 17 Pages: 281-288
• [Presentation] 炭酸カルシウム-第二リン酸カルシウム混合物の水熱処理による炭酸アパタイトブロックの調製-第2報- (2009)
  • Author(s): 大東文和, 竹内あかり, 都留寛治, 松家茂樹, 寺田善博, 石川邦夫
  • Organizer: 第53回日本歯科理工学会学術講演会タワーホール船掘
  • Place of Presentation: 東京都江戸川区
• [Presentation] Development of synthetic bone replacement (2008)
  • Author(s): Ishikawa K
  • Organizer: University of Phillipine Biomaterials Seminor
  • Place of Presentation: University of Philipine, Manila, Philippines
  • Year and Date: 2008-09-09
• [Presentation] The relationship between jaw deformity and scoliosis (2008)
  • Author(s): Mano T, Mori Y, Uchida K, Horinaga D, Ueyama Y
  • Organizer: The 19th Congress of the European Association for Cranio-Maxillofacia Surgery
  • Place of Presentation: Bologna, Italy
• [Presentation] Identificationof sentinel lymph node using computed tomographic lymphography in oral cancer (2007)
  • Author(s): Ueyama K
  • Organizer: The 46th Congress of Korean Association of Maxillofacial Plastic and JReconstructive Surgery
  • Place of Presentation: Inter-Burgo Hotel, Daegu, Korea