• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diagnostic and therapeutic application of cell-cycle checkpoint genes for oral squamous cell cancer.

Research Project

Project/Area Number 18390545
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionSapporo Medical University

Principal Investigator

TOKINO Takashi  Sapporo Medical University, School of Medicine Cancer Research Inst, Dept Molecular Biology, Professor (40202197)

Co-Investigator(Kenkyū-buntansha) HIRATSUKA Hiroyoshi  Sapporo Medical University, School of Medicine, Dept Oral Surgery, Professor (50165180)
OGI Kazuhiro  Sapporo Medical University, School of Medicine, Dept Oral Surgery, Instructor (40433114)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,750,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordsdrug sensitivity / microtubule inhibitor / cell cycle / ubiquitinliease / checkpoint / translationalresearch / トランスレーショナル リサーチ
Research Abstract

CHFR which contains a RING domain and has ubiquitin ligase activity, a novel mitotic checkpoint gene delays chromosome condensation in cells treated with microtubule poisons. CHFR is inactivated by promoter methylation, and cancer cells lacking CHFR are sensitive to microtubule inhibitors.
(1) Proteins interacting with CHFR, mitotic-checkpoint ubiquitin ligase.
In this study, we isolated cellular proteins capable of interacting with CHFR using yeast two-hybrid method to clarify the function of CHFR. As a result of the screening, we isolated canonical and noncanonical E2 ubiquitin conjugating enzymes as CHFR interacting proteins, which are involved in proteolytic and non-proteolytic ubiquitination respectively. This raises the possibility that CHFR is switching canonical and noncanonical ubiquitination depending on the situation of cells.On the other hand, we isolated gadd34 which interacted with the FHA domain of CHFR. Furthermore, CHFR moved in part from nucleus to cytoplasm in the pres … More ence of microtubule inhibitor docetaxel, which enabled colocalization of CHFR and gadd34 in cytoplasm. This colocalization was followed by cell death. These suggest that gadd34 and CHFR cooperate to mediate cell death in response to mitotic stress.
(2) CHFR mitotic checkpoint protein inhibits the transcriptional activity of NF-kB.
To clarify the molecular mechanisms by which CHFR modulates tumor growth, our analysis focused on transcriptional regulation mediated by CHFR. Using microarray analysis, we found that CHFR downregulated NF-kB signaling. NF-kB-dependent luciferase assay demonstrated that overexpression of CHFR inhibited NF-kB signaling. Moreover, knockdown of CHFR activated the NF-kB activity. Furthermore, we found that IL-8, one of the NF-kB target genes, was regulated by CHFR. mRNA and protein levels of IL-8 were significantly repressed by overexpression of CHFR. Altogether, our findings reveal a novel function of CHFR as a regulator of NF-kB signaling, and which might account for tumor suppression by CHFR. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (88 results)

All 2008 2007 2006 Other

All Journal Article (75 results) (of which Peer Reviewed: 39 results) Presentation (11 results) Book (2 results)

  • [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer2008

    • Author(s)
      Kawamura YI
    • Journal Title

      Gastroenterology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpGisland methylation in colorectal cancer2008

    • Author(s)
      Toyota M
    • Journal Title

      Cancer Research (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A requirement for DICER to maintain full promoter CpG island Hypermethylation in human cancer cells2008

    • Author(s)
      Ting AH
    • Journal Title

      Cancer Research 68

      Pages: 2570-2575

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer2008

    • Author(s)
      Maruyama R
    • Journal Title

      Carinogenesis (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Molecular Cancer Therapeutics 7

      Pages: 779-787

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of flotillin-2,a major protein on lipid rafts,as a novel target of the p53 family members2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Molecular Cancer Research 6

      Pages: 395-406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer2008

    • Author(s)
      Suzuki H
    • Journal Title

      British J Cancer 98

      Pages: 1147-1156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma2008

    • Author(s)
      Imai T
    • Journal Title

      Cancer Science 99

      Pages: 958-966

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma2008

    • Author(s)
      Sogabe Y
    • Journal Title

      Int J Oncology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A requirement for DICER to maintain full promoter CpG island Hypermethylation in human cancer cells2008

    • Author(s)
      Tingm, Allm, et. al.
    • Journal Title

      Cancer Research 68

      Pages: 2570-2575

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models2008

    • Author(s)
      Sasaki, Y, et. al.
    • Journal Title

      Molecular Cancer Therapeutics 7

      Pages: 779-787

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of flotillin-2,a major protein on lipid rafts,as a novel target of the p53 family members2008

    • Author(s)
      Sasaki, Y, et. al.
    • Journal Title

      Molecular Cancer Research 6

      Pages: 395-406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer2008

    • Author(s)
      Suzuki, H, et. al.
    • Journal Title

      British J Cancer 98

      Pages: 1147-1156

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma2008

    • Author(s)
      Imai, T, et. al.
    • Journal Title

      Cancer Science 99

      Pages: 958-966

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Molecular Cancer Research 6

      Pages: 395-406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI
    • Journal Title

      Gastroenterology (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Molecular Cancer Therapeutics (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H
    • Journal Title

      British J Cancer (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R
    • Journal Title

      Carcinogenesis (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T
    • Journal Title

      Cancer Science (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.2008

    • Author(s)
      Sogabe Y
    • Journal Title

      Int J Oncology (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reauction of TRAILinduced Mcl-1 and cIAP2 by c・Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death2007

    • Author(s)
      Ricci MS
    • Journal Title

      Cancer Cell 12

      Pages: 66-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene amplification and overexpression of PRDM14 in breast cancers2007

    • Author(s)
      Nishikawa N
    • Journal Title

      Cancer Research 67

      Pages: 9649-9657

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ku70 and poly(ADP-ribose)polymerase-1 competitively regulate beta-catenine and T-cell factor-4-mediated gene transactivation:possible linkage of DNA damage recognition and Wnt signaling2007

    • Author(s)
      Idogawa M
    • Journal Title

      Cancer Research 67

      Pages: 911-918

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer2007

    • Author(s)
      Nojima M
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer2007

    • Author(s)
      Watanabe Y
    • Journal Title

      Clinical Cancer Research 13

      Pages: 4786-4794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors2007

    • Author(s)
      Sato H
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer2007

    • Author(s)
      Akino K
    • Journal Title

      Cancer Science 98

      Pages: 88-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma celllines2007

    • Author(s)
      Oshima Y
    • Journal Title

      Cancer Biology & Therapy 6

      Pages: 1058-1066

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death2007

    • Author(s)
      Ricci, MS, et. al.
    • Journal Title

      Cancer Cell 12

      Pages: 66-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene amplification and overexpression of PRDM14 in breast cancers.2007

    • Author(s)
      Nishikawa, N, et. al.
    • Journal Title

      Cancer Research 67

      Pages: 9649-9657

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenine and T-cell factor-4-mediated gene transactivation : possible linkage of DNA damage recognition and Wnt signaling.2007

    • Author(s)
      Idogawa, M, et. al.
    • Journal Title

      Cancer Research 67

      Pages: 911-918

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima, M, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression pro filing of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer2007

    • Author(s)
      Watanabe, Y, et. al.
    • Journal Title

      Clinical Cancer Research 13

      Pages: 4786-4794

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato, H, et. al.
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation ingastric cancer2007

    • Author(s)
      Akino, K, et. al.
    • Journal Title

      Cancer Science 98

      Pages: 88-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      Oshima, Y, et. al.
    • Journal Title

      Cancer Biology Therapy 6

      Pages: 1058-1066

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafbnib Sensitizes resistant human cancer cells to TRAIL-induced death.2007

    • Author(s)
      Ricci MS
    • Journal Title

      Cancer Cell 12

      Pages: 66-80

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ku70 and poly (ADP-ribose) polymerase-1 competitively regulate beta-catenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.2007

    • Author(s)
      Idogawa M
    • Journal Title

      Cancer Research 67

      Pages: 911-918

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Amplification and overexpression of PRDM14 in breast cancers.2007

    • Author(s)
      Nishikawa N
    • Journal Title

      Cancer Research 67

      Pages: 9649-9657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007

    • Author(s)
      Watanabe Y
    • Journal Title

      Clinical Cancer Research 13

      Pages: 4786-4794

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato H
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K
    • Journal Title

      Cancer Science 98

      Pages: 88-95

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      Oshima Y
    • Journal Title

      Cancer Biology & Therapy 6

      Pages: 1058-1066

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      K.Akino
    • Journal Title

      Cancer Science 98・1

      Pages: 88-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      M.Nojima
    • Journal Title

      Oncogene (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenine and T-cell factor-4-mediated gene transactivation : possible linkage of DNA damage recognition and Wnt signaling.2007

    • Author(s)
      M.Idogawa
    • Journal Title

      Cancer Research 67・3

      Pages: 911-918

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Proteins interacting with CHFR,mitotic-checkpoint ubiqutin ligase2006

    • Author(s)
      Mita H
    • Journal Title

      Tumor Research 41

      Pages: 23-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparative genome analysis identifies the vitamin Dreceptor gene as a direct target of p53-mediated transcriptional activation2006

    • Author(s)
      Maruyama R
    • Journal Title

      Cancer Research 66

      Pages: 4574-4583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB 13 in human renal cell carcinoma2006

    • Author(s)
      Okuda H
    • Journal Title

      Oncogene 25

      Pages: 1733-1742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis2006

    • Author(s)
      King KE
    • Journal Title

      Carcinogenesis 27

      Pages: 53-63

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic,epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barrvirus2006

    • Author(s)
      Kusano M
    • Journal Title

      Cancer 106

      Pages: 1467-1479

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines2006

    • Author(s)
      Terasawa K
    • Journal Title

      British J Cancer 94

      Pages: 914-921

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Antiangiogenic potency of BAIl in vivo: Implications for gene therapy treatment of human glioblastomas2006

    • Author(s)
      Kang K
    • Journal Title

      Cancer Gene Therapy 13

      Pages: 385-392

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer2006

    • Author(s)
      Kobayasbi T
    • Journal Title

      International J Molecular Medicine 18

      Pages: 161-170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Proteins interacting with CHFR, mitotic-checkpoint ubiqutin ligase2006

    • Author(s)
      Mita, H, et. al.
    • Journal Title

      Tumor Research 40

      Pages: 23-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation2006

    • Author(s)
      Maruyama, R, et. al.
    • Journal Title

      Cancer research 66

      Pages: 4574-4583

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma2006

    • Author(s)
      Okuda, H, et. al.
    • Journal Title

      Oncogene 25

      Pages: 1733-1742

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis2006

    • Author(s)
      King, KE, et. al.
    • Journal Title

      Carcinogenesis 27

      Pages: 53-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic,epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus2006

    • Author(s)
      Kusano, M, et. al.
    • Journal Title

      Cancer 106

      Pages: 1467-1479

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines2006

    • Author(s)
      Terasawa, K, et. al.
    • Journal Title

      British J Cancer 94

      Pages: 914-921

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy2006

    • Author(s)
      Kang, K, et. al.
    • Journal Title

      Cancer Gene Therapy 13

      Pages: 385-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer2006

    • Author(s)
      Kobayashi, T, et. al.
    • Journal Title

      Int J Molecular Medicine 18

      Pages: 161-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      R.Maruyama
    • Journal Title

      Cancer Research 66・9

      Pages: 4574-4583

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006

    • Author(s)
      M.Kusano
    • Journal Title

      Cancer 106・7

      Pages: 1467-1479

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      K.Terasawa
    • Journal Title

      British J Cancer 94・6

      Pages: 914-921

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama.2006

    • Author(s)
      H.Okuda
    • Journal Title

      Oncogene 25・12

      Pages: 1733-1742

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.2006

    • Author(s)
      T.Kobayashi
    • Journal Title

      Int J Molecular Medicine 18・1

      Pages: 161-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas.2006

    • Author(s)
      X.Kang
    • Journal Title

      Cancer Gene Therapy 13・4

      Pages: 385-392

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.2006

    • Author(s)
      K.E.King
    • Journal Title

      Carcinogenesis 27・1

      Pages: 53-63

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer

    • Author(s)
      Kawamura, YI, et. al.
    • Journal Title

      Gastroenterology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.

    • Author(s)
      Toyota, M, et. al.
    • Journal Title

      Cancer Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer

    • Author(s)
      Maruyama, R, et. al.
    • Journal Title

      Carcinogenesis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma

    • Author(s)
      Sogabe, Y, et. al.
    • Journal Title

      Int J Oncology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CHFR mitotic chechpoint protein inhibits the transcriptional activity of NF-kB2007

    • Author(s)
      鹿島 理沙
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CHFR mitotic chechpoint protein inhibits the transcriptional activity of NF-kB2007

    • Author(s)
      Lisa, Kashima, et. al.
    • Organizer
      JCA (Japanese Cancer Association) Annual Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      Takashi Tokino
    • Organizer
      米国癌学会年会
    • Place of Presentation
      ロサンゼルス
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007

    • Author(s)
      Takashi, Tokino, et. al.
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      時野 隆至
    • Organizer
      米国癌学会(American Association of Cancer Research)
    • Place of Presentation
      米国ロサンゼルス
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] CHFR(checkpoint with FHA and RING domain)によるNF-kBシグナ.リング制御2006

    • Author(s)
      鹿島 理沙
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CHFR(checkpoint with FHA and RING domain) inhibit NF-kB signaling2006

    • Author(s)
      Lisa, Kashima, et. al.
    • Organizer
      JCA (Japanese Cancer Association) Annual Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of mitotic checkpoint ligase CHFR interacting proteins2006

    • Author(s)
      Hiroaki Mita
    • Organizer
      米国癌学会年会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2006-04-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of mitotic checkpoint ligase CHFR interacting proteins2006

    • Author(s)
      Hiroaki, Mita, et. al.
    • Organizer
      AACR (American Association for Cancer Research) Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2006-04-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes2006

    • Author(s)
      Takashi Tokino
    • Organizer
      米国癌学会年会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2006-04-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes2006

    • Author(s)
      Lisa, Kashima, et. al.
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2006-04-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Checkpoint responses in cancer therapy(共著)2008

    • Author(s)
      Minoru Toyota
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Checkpoint Responses in Cancer Therapy

    • Author(s)
      Minoru, Toyota, et. al.
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi