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Analysis of mechanisms of oral cancer metastasis via chemokine signals and molecular target therapy for inhibition of metastasis

Research Project

Project/Area Number 18390549
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHyogo College of Medicine

Principal Investigator

URADE Masahiro  Hyogo College of Medicine, 医学部, 教授 (70104883)

Co-Investigator(Kenkyū-buntansha) SAKURAI Kazunari  兵庫医科大学, 医学部, 講師 (30129118)
KISHIMOTO Hiromitsu  兵庫医科大学, 医学部, 講師 (30291818)
NOGUCHI Kazuma  兵庫医科大学, 医学部, 講師 (50309473)
HASHITANI Susumu  兵庫医科大学, 医学部, 助教 (00330449)
Research Collaborator TAKAOKA Kazuki  兵庫医科大学, 医学部, 助教 (60373122)
TANAKA Noriaki  兵庫医科大学, 医学部, 助教 (70412012)
SEGAWA Emi  兵庫医科大学, 医学部, 病院助手
ZUSHI Yuusuke  兵庫医科大学, 大学院
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,230,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywords口腔癌 / 腺様嚢胞癌 / 浸潤 / 転移 / ケモカインレセプター / CXCR4 / 予後
Research Abstract

本研究は、口腔癌の転移機構をケモカインシグナルの観点から解析することを目的とし、口腔癌臨床材料、口腔癌培養細胞およびヌードマウスに移植した口腔癌細胞のリンパ節転移および血行転移モデルを用いて、ケモカインおよびケモカインレセプター発現を免疫組織学的、細胞・遺伝子工学的に検索した結果、代表的なケモカインレセプターであるCXCR4は、口腔扁平上皮癌、腺様嚢胞癌の転移や予後に、さらに悪性線維性組織球腫の転移にも深く関与していることが示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007 2006

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (16 results)

  • [Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck2009

    • Author(s)
      Yusuke Zushi, et al.
    • Journal Title

      International Journal of Oncology 33

      Pages: 1133-1139

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck.2008

    • Author(s)
      Sakurai K, Segawa E, Takaoka K, Toyohara Y, Tanaka N, Kishimoto H, Urade M.
    • Journal Title

      Int J Oncol 33

      Pages: 1133-1139

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA.2008

    • Author(s)
      Takaoka K, Kishimoto H, Segawa E, Otsu N, Zushi Y, Hashitani S, Noguchi K, Urade M.
    • Journal Title

      Oncol Rep 20

      Pages: 645-649

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung.2008

    • Author(s)
      Maeda T, Hashitani S, Zushi Y, Segawa E, Tanaka N, Sakurai K, Urade M.
    • Journal Title

      J Cancer Res Clin 134

      Pages: 1005-1011

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of cyclooxygenase-2 and DNA topoisomerase II α in precancerous and cancerous lesions of the oral mucosa.2008

    • Author(s)
      Segawa E, Sakurai K, Kishimoto H, Takaoka K, Noguchi K, Hashitani S, Hirota S, Urade M.
    • Journal Title

      Oral Oncol 44

      Pages: 664-671

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of cyclooxygenase-2 and DNA topoisomerase IT α in precancerous and cancerous lesions of the oral mucosa2008

    • Author(s)
      Emi Segawa, et al.
    • Journal Title

      Oral Oncology 44

      Pages: 664-671

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung2008

    • Author(s)
      Tsunenari Maeda, et al.
    • Journal Title

      Journal of Cancer Reserch and Clinical Oncology 134

      Pages: 1005-1011

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA2008

    • Author(s)
      Kazuki Takaoka, et al.
    • Journal Title

      Oncology Reports 20

      Pages: 645-649

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of cyclooxygenase-2 and DNA topoisomerase II α expression in oral carcinoma.2007

    • Author(s)
      Sakurai K, Urade M, Noguchi K, Hashitani S, Takaoka K, Segawa E, Kishimoto H.
    • Journal Title

      Head Neck 29

      Pages: 1002-1009

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice.2007

    • Author(s)
      Tanaka N, Urabe K, Hashitani S, Sakurai K, Urade M.
    • Journal Title

      Oncol Rep 17

      Pages: 335-340

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastases to lymph node and lung.2007

    • Author(s)
      Hashitani S, Urade M, Zushi Y, Sagawa E, Okui S, Sakurai K.
    • Journal Title

      Oncol Rep 17

      Pages: 67-72

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and trans plantable in nude mice2007

    • Author(s)
      Noriaki Tanaka, et. al.
    • Journal Title

      Oncology Reports 17

      Pages: 335-340

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of gyclooxygenase-2 and DNA topoisomerase IIα expresstion in oral carcinoma2007

    • Author(s)
      Kazunari Sakurai, et. al.
    • Journal Title

      Head and Neck 29

      Pages: 1002-1009

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung2007

    • Author(s)
      Susumu Hashitani, et al.
    • Journal Title

      Oncology Reports 17・1

      Pages: 67-72

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA.2006

    • Author(s)
      Takaoka K, Kishimoto H, Segawa E, Hashitani S, Zushi Y, Noguchi K, Sakurai K, Urade M.
    • Journal Title

      Int J Oncol 29

      Pages: 1095-1101

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated cell migration, invasion and tumorigenesis in human KB carcinoma cells transfected with COX-s cDNA2006

    • Author(s)
      Kazuki Takaoka, et al.
    • Journal Title

      International Journal of Oncology 29・5

      Pages: 1095-1101

    • Related Report
      2006 Annual Research Report
  • [Presentation] ヌードマウス心腔内移植によるCOX-2高発現ヒトKB癌細胞の転移能およびsiRNAによる転移抑制効果2008

    • Author(s)
      瀬川英美, 他
    • Organizer
      第62回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      博多、北九州市
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prognostic significance of cyclooxygenase-2 in oral cancer2008

    • Author(s)
      Urade M, Kishimoto H, Takaoka K, Segawa E, Noguchi K, Hashitani S, Sakurai K
    • Organizer
      XIX Congress of the European Association for Cranio-Maxillo-Facial Surgery
    • Place of Presentation
      Bologna, Italy)
    • Related Report
      2008 Final Research Report
  • [Presentation] ヌードマウス心腔内移植におけるCOX-2高発現ヒトKB癌細胞の転移能およびsiRNA による転移抑制効果2008

    • Author(s)
      瀬川英美、岸本裕充、高岡一樹、橋谷 進、野口一馬、浦出雅裕
    • Organizer
      第32回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Prognostic significance of cyclooxygenase-2 in oral cancer2008

    • Author(s)
      Masahiro Urade, et al.
    • Organizer
      XIX Congress of the European Association for Cranio-Maxillo-Facial Surgery
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] COX-2遺伝子を導入したヒトKB癌細胞の転移能およびsiRNAによる抑制効果の検討2007

    • Author(s)
      瀬川 英美, ほか
    • Organizer
      第44回日本口腔組織培養学会
    • Place of Presentation
      松山市、愛媛
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] In vitro susceptibility to anticancer agents of human KB carcinoma cell line transfected with COX-2 cDNA.2007

    • Author(s)
      Takaoka K, Urade M, Kishimoto H, Hashitani S, Toyohara Y, Noguchi K
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Establishment and characterization of a human malignant fibrous histiocytoma of the mandible transplantable in nude mice.2007

    • Author(s)
      Hashitani S, Toyohara Y, Takaoka K, Noguchi K, Kishimoto H, Sakurai K, Urade M
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Relationship between expression of CXCR4 and histological type in adenoid cystic carcinoma of the head and neck.2007

    • Author(s)
      Sakurai K, Takaoka K, Tanaka N, Kishimoto H, Urade M.
    • Organizer
      The European Cancer Conference 14th (ECCO14)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Relationship between expression of CXCR4 and histological type in adenoid cystic carcinoma of the head and neck2007

    • Author(s)
      Yusuke Zushi, et. al.
    • Organizer
      The European Cancer Conference 14th
    • Place of Presentation
      Barcelona,Spain
    • Related Report
      2007 Annual Research Report
  • [Presentation] 3次元培養可能な上顎腺様嚢胞癌由来培養細胞株の細胞特性2006

    • Author(s)
      田中徳昭、橋谷 進、櫻井一成、浦出雅裕
    • Organizer
      第43回日本口腔組織培養学会
    • Place of Presentation
      大阪
    • Year and Date
      2006-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma showing metastases to the lymph node and lung.2006

    • Author(s)
      Hashitani S, Noguchi K, Zushi Y, Okui S, Tanaka N, Sakurai K, Urade M.
    • Organizer
      7^<th> Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Final Research Report
  • [Presentation] COX-2遺伝子導入によるヒトKB癌細胞の増殖能と浸潤能の亢進2006

    • Author(s)
      高岡一樹、浦出雅裕、岸本裕充、橋谷進、豊原幸代、野口一馬、櫻井一成
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト口底腺様嚢胞癌のヌードマウスにおける転移モデルの樹立とその細胞生物学的特性2006

    • Author(s)
      橋谷進、野口一馬、豊原幸代、高岡一樹、岸本裕充、櫻井一成、浦出雅裕
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヌードマウス可移植性ヒト腺様嚢胞癌の移植継代による転移モデルの樹立2006

    • Author(s)
      橋谷進、野口一馬、奥井 森、瀬川英美、頭司雄介、櫻井一成、浦出雅裕
    • Organizer
      第60回日本口腔科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 3次元培養可能な腺様嚢胞癌細胞株の樹立とその細胞特性について2006

    • Author(s)
      田中徳昭、占部一彦、橋谷進、櫻井一成、浦出雅裕
    • Organizer
      第60回日本口腔科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] COX-2高発現ヒトKB癌細胞の増殖および浸潤能における一酸化窒素の影響2006

    • Author(s)
      高岡一樹、岸本裕充、瀬川英美、頭司雄介、萬野幸代、橋谷進、野口一馬、櫻井一成、浦出雅裕
    • Organizer
      第60回日本口腔科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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