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An investigation on the neural network for impaired articulation using non-invasive functional brain imaging

Research Project

Project/Area Number 18390553
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ONO Takashi  Tokyo Medical and Dental University, Graduate School Maxillofacial Orthognathics, Lecturer (30221857)

Co-Investigator(Kenkyū-buntansha) HONDA Ei-ichi  University of Tokushima, Graduate School Oral/Maxillofacial Radiobgy, Professor (30192321)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,350,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥11,800,000 (Direct Cost: ¥11,800,000)
Keywordsimpaired speech / covert speech / overt speech / cleft lip and palate / velar plosive / fMRI / central nervous system / 脳賦活 / 代償性構音 / 構音点 / 破裂音 / 脳賦活パタン / 小脳
Research Abstract

Neural networks for speech may be subdivided into two stages, such as the imaginary and executive stages, and products from these stages are called covert and overt speech, respectively. On the other hand, subjects with cleft lip and palate (CLP) axe known to show impaired speech, or compensatory misarticulation. Previous studies showed that these were significant differences between subjects with and without CLP in 1) the activated pattern in the brain during articulation (Shinagawa, et al., 2006), and 2) the movement pattern of the articulators (Sato-Wakabayashi, et al., 2008). However, the responsible stage for the difference in articulation between those with and without CLP was unknown. Adult subjects with [unilateral (UCLP) and bilateral (BCLP)l and without CLP were recruited. We used a 1.5 T MR apparatus. Functional MRI data were taken while the subject repeated the velar plosive, /ka/, at 1.5 Hz for either covert (C) or overt (O) speech in the block design SPM2 was used for analysis. It was shown that the premotor area was activated during C speech in subjects with and without CLP. During O speech, the premotor area, the primary motor cortex and the cerebellum were activated in subjects with UCLP and those without CLP,. On the other hand, these areas were not activated but the posterior cingulate gyrus was activated in the subject with BCLP. These findings suggest that there seems to be little difference in the imaginary stage, but there are differences in the executive stage for articulation between subjects with and without CLP. It appears that several factors including types of the cleft, the difference in the motor outputs and sensory inputs, the types and severity of misarticulation and the timing and effect of speech therapy maybe involved in the difference.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (53 results)

All 2008 2007 2006

All Journal Article (26 results) (of which Peer Reviewed: 14 results) Presentation (26 results) Book (1 results)

  • [Journal Article] Combined fMRI and MRI movie in the evaluation of articulation in subjects with and without cleft lip and palate2008

    • Author(s)
      Sato-Wakabayashi M, et. al.
    • Journal Title

      Cleft Palate CraniofacialJ 45

      Pages: 309-314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Short-term changes in temporomandibular joint function in subjects with cleft lip and palate treated with maxillary distraction osteogenesis2008

    • Author(s)
      Hashimoto K, et. al.
    • Journal Title

      Orthod Craniofac Res 11

      Pages: 74-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Changes in horizontal jaw position and intraoral pressure2008

    • Author(s)
      Takada J, et. al.
    • Journal Title

      Angle Orthod 78

      Pages: 254-261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Combined fMRI and MRI movie in the evaluation of articulation in subjects with and without cleft lip and palate. Cleft2008

    • Author(s)
      Sato-Wakabayashi M, Inoue MS, Ono T, Honda E, Kurabayashi T, Moriyama K.
    • Journal Title

      Palate Craniofacial J. 45

      Pages: 309-314

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Short-term changes in temporomandibular joint function in subjects with cleft lip and palate treated with maxillary distraction osteogenesis2008

    • Author(s)
      Hashimoto K, Otsuka R, Minato A, Sato-Wakabayashi M, Takada J, Inoue-Arai MS, Miyamoto JJ, Ono T, Ohyama K, Moriyama K.
    • Journal Title

      Orthod Craniofac Res 11

      Pages: 74-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes in horizontal jaw position and intraoral pressure2008

    • Author(s)
      Takada J, Ono T, Takahashi S, Honda E, Kurabayashi T.
    • Journal Title

      Angle Orthod 78

      Pages: 254-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes in horizontal j aw position and intraoral pressure2008

    • Author(s)
      Takada J, Ono T, Takahashi S, Honda E, Kurabayashi T
    • Journal Title

      Angle Orthod. 78

      Pages: 254-261

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Qombined fMRI and MRI movie in the evaluation of articulation in subjects with and without c1eft 1ip and pa1ate2008

    • Author(s)
      Sato-Wakabayashi M, Inoue MS, Ono T, Honda E, Kurabayashi T, Moriyama K.
    • Journal Title

      Cleft Palate Craniofacial J. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mandibular distraction osteogenesis in a skeletal Class II patient with obstructive sleep apnea2007

    • Author(s)
      Hamada T, et. al.
    • Journal Title

      AmJ Orthod Dentofacial Orthop 131

      Pages: 415-425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characteristics of movement of the lips, tongue and velum during a bilabial plosive2007

    • Author(s)
      Inoue MS et a1.
    • Journal Title

      Angle Orthod 77

      Pages: 612-618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mandibular distraction osteogenesis in a skeletal Class II patient with obstructive sleep apnea. Am J Orthod2007

    • Author(s)
      Hamada T, Ono T, Otsuka R, Honda E, Harada K, Kurabayashi T, Ohyama K.
    • Journal Title

      Dentofacial Orthop 131

      Pages: 415-425

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characteristics of movement of the lips, tongue and velum during a bilabial plosive2007

    • Author(s)
      Inoue MS, Ono T, Honda E, Kurabayashi T.
    • Journal Title

      Angle Orthod 77

      Pages: 612-618

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characteristics of movement of the lips, tongue and velum during a bilabial plosive2007

    • Author(s)
      Inoue MS, Ono T, Honda E, Kurabavashi T
    • Journal Title

      Angle Orthod. 77

      Pages: 612-618

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of movement of the lips, tongue and velum during a bilabial2007

    • Author(s)
      Inoue MS, et al.
    • Journal Title

      Angle Orthod. 77(4)

      Pages: 612-618

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of the anterior cingulate cortex in volitional swallowing: an electromyographic and functional magnetic resonance imaging study2006

    • Author(s)
      Maeda K, et. al.
    • Journal Title

      J Med Dent Sci 53

      Pages: 149-157

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distinctive cortical articulatory representation in cleft lip and palate. a preliminary functional magnetic resonance imagingstudy2006

    • Author(s)
      Shinagawa H, et. al.
    • Journal Title

      Cleft Palate Craniofacial J 43

      Pages: 620-624

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Application of magnetic resonance imaging movie to assess articulatory movement2006

    • Author(s)
      Inoue MS, et. al.
    • Journal Title

      Orthod Craniofac Res 9

      Pages: 157-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The representation of the human oral area in the somatosensory cortex: afunctional MRI study2006

    • Author(s)
      Miyamoto JJ, et. al.
    • Journal Title

      Cereb Cortex 16

      Pages: 669-675

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study2006

    • Author(s)
      Hashimoto K, et. al.
    • Journal Title

      J Appl Physiol 100

      Pages: 579-586

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Changes in nasorespiratory function in association with maxillary distraction osteogenesis in subjects with cleft lip and palate2006

    • Author(s)
      Saito K, et. al.
    • Journal Title

      Cleft Palate Craniofacial J 43

      Pages: 75-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the anterior cingulate cortex in volitional swallowing : an electromyographic and functional magnetic resonance imaging study2006

    • Author(s)
      Maeda K, Ono T, Shinagawa H, Honda E, Kurabayashi T, Ohyama K.
    • Journal Title

      J Med Dent Sci 53

      Pages: 149-157

    • NAID

      110006318484

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distinctive cortical articulatory representation in cleft lip and palate : a preliminary functional magnetic resonance imaging study2006

    • Author(s)
      Shinagawa H, Ono T, Honda E, Kurabayashi T, Iriki A, Ohyama K.
    • Journal Title

      Cleft Palate Craniofacial J. 43

      Pages: 620-624

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Application of magnetic resonance imaging movie to assess articulatory movement2006

    • Author(s)
      Inoue MS, Ono T, Honda E, Kurabayashi T, Ohyama K.
    • Journal Title

      Orthod Craniofac Res 9

      Pages: 157-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The representation of the human oral area in the somatosensory cortex : a functional MRI study2006

    • Author(s)
      Miyamoto JJ, Honda M, Saito DN, Okada T, Ono T, Ohyama K, Sadato N.
    • Journal Title

      Cereb Cortex 16

      Pages: 669-675

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects : a functional magnetic resonance imaging study2006

    • Author(s)
      Hashimoto K, Ono T, Honda E, Maeda K, Shinagawa H, Tsuiki S, Hiyama S, Kurabayashi T, Ohyama K.
    • Journal Title

      J Appl Physiol 100

      Pages: 579-586

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes in nasorespiratory function in association with maxillary distraction osteogenesis in subjects with cleft lip and palate2006

    • Author(s)
      Saito K, Ono T, Mochida M, Ohyama K.
    • Journal Title

      Cleft Palate Craniofacial J. 43

      Pages: 75-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 上顎骨延長法を応用して咬合の再構成を行った口唇口蓋裂症例2007

    • Author(s)
      片岡恵一, 他
    • Organizer
      第66回東京矯正歯科学会大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Brain activation in plosives in subjects with and without cleft lip and palate2007

    • Author(s)
      Sato-Wakabayashi M, et. al.
    • Organizer
      80th Scientific Meeting of the German Orthodontic Society
    • Place of Presentation
      Berlin
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of changes in horizontal jaw position on intraoral pressure2007

    • Author(s)
      Takada J, et. al.
    • Organizer
      83rd Congress of the European Orthodontic Society
    • Place of Presentation
      Berlin
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Movement of articulators using three-dimensional MRI movie2007

    • Author(s)
      Ittoue MS, et. al.
    • Organizer
      83rd Congress of the European Orthodontic Society
    • Place of Presentation
      Berlin
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case report of chromosome 18 ring syndrome2007

    • Author(s)
      Hamada T, et. al.
    • Organizer
      64th American Cleft Palate Association Annual Meeting
    • Place of Presentation
      Broomfield
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Short-term changes in symptoms of the temporomandibular joint inpatients with cleft lip and palate treated with maxillary distraction osteogenesis2007

    • Author(s)
      Hashimoto K, et. al.
    • Organizer
      64th American Cleft Palate Association Annual Meeting
    • Place of Presentation
      Broomfield
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Short-term changes in symptoms of the temporomandibular joint in patients with cleft lip and palate treated with maxillary distraction osteogenesis2007

    • Author(s)
      Hashimoto K, Otsuka R, Minato A, Sato M, Takada J, Inoue MS, Miyamoto J, Matsubara M, Saito K, Hiyama S, Ono T.
    • Organizer
      64th American Cleft Palate Association Annual Meeting
    • Place of Presentation
      Broomfield
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Short-term changes in symptoms of the temporomandibular joint in patients with cleft lip and palate treated with maxillary distraction osteogenesis2007

    • Author(s)
      Hashimoto K, Otsuka R, Minato A. Sato M, et. al.
    • Organizer
      64th American Cleft Palate Association Annual Meeting
    • Place of Presentation
      Broomfield, CO, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] A case report of chromosome 18 ring syndrome2007

    • Author(s)
      Hamada T, Okuma M, Motohashi N, Ono T
    • Organizer
      64th American Cleft Palate Association Annual Meeting
    • Place of Presentation
      Broomfield, CO, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Movement of articulators using three-dimensional MRI movie2007

    • Author(s)
      Inoue, MS, Ono T, Honda E, Kurabayashi T
    • Organizer
      83rd Congress of the European Orthodontic Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of changes in horizontal jaw position on intraoral pressure2007

    • Author(s)
      Takada J, Ono T, Honda E, Miyamoto J, Kurabayashi T
    • Organizer
      83rd Congress of the European Orthodontic Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Brain activation in plosives in subjects with and without cleft lip and palate2007

    • Author(s)
      Sato-Wakabayashi M, Hashimoto K, Honda E, Mivamoto J. Ono T
    • Organizer
      80th Scientific Meeting of the German Orthodontic Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] 著しい下顎骨左側偏位を伴う下顎前突症患者に対し外科的矯正治療を施行した1例2006

    • Author(s)
      橋本幸治, 他
    • Organizer
      第65回東京矯正歯科学会大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Kinematic analysis of coordinative articulatory movement during bilabial plosives using magnetic resonance imaging (MRI) movie2006

    • Author(s)
      井上マリステラ小百合, 他
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chromosome 18 ring syndromeの一治験例2006

    • Author(s)
      濱田俊, 他
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional magnetic resonance imaging(fMRI)を用いた破裂音発音時の小脳賦活部位のマッピング2006

    • Author(s)
      佐藤みちる, 他
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 下顎の側方偏位が口腔内圧に与える影響2006

    • Author(s)
      高田潤一, 他
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 上顎骨骨延長術を施行した口唇口蓋裂患者の顎関節症状の短期的変化2006

    • Author(s)
      橋本幸治, 他
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mandibular distraction osteogenesis in obstructive sleep apnea: a case report2006

    • Author(s)
      Hamada T, et. al.
    • Organizer
      84th International Association for Dental Research
    • Place of Presentation
      Brisbane
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oral cortical representation in humans: a functional MRI study2006

    • Author(s)
      Miyamoto JJ, et. al.
    • Organizer
      84th International Association for Dental Research
    • Place of Presentation
      Brisbane
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 下顎骨骨切り術により治療した下顎骨線維性骨異形成症による顔面非対称の1例2006

    • Author(s)
      新井直也, 他
    • Organizer
      第16回日本顎変形症学会総会
    • Place of Presentation
      千葉
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 上顎骨延長術と顎裂部骨移植を同時に行った唇顎口蓋裂患者4例の検討2006

    • Author(s)
      山本庸介, 他
    • Organizer
      第16回日本顎変形症学会総会
    • Place of Presentation
      千葉
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The tactile representation of human oral area in the primary and secondary somatosensory cortex: a functional MRI study2006

    • Author(s)
      Miyamoto JJ, et. al.
    • Organizer
      12th Human Brain Mapping
    • Place of Presentation
      Florence
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mandibular distraction osteogenesis in obstructive sleep apnea : a case report2006

    • Author(s)
      Hamada T, Ono T, Honda E, Ohyama K.
    • Organizer
      84th International Association for Dental Research
    • Place of Presentation
      Brisbane
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oral cortical representation in humans : a functional MRI study2006

    • Author(s)
      Miyamoto JJ, Honda M, Saito DN, Okada T, Ono T, Ohyama K, Sadato N.
    • Organizer
      84th International Association for Dental Research
    • Place of Presentation
      Brisbane
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The tactile representation of human oral area in the primary and secondary somatosensory cortex : a functional MRI study2006

    • Author(s)
      Miyamoto JJ, Honda M, Saito DN, Okada T, Ono T, Ohyama K, Sadato N.
    • Organizer
      12th Human Brain Mapping
    • Place of Presentation
      Florence
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 不正咬合の原因:後天的原因、歯科矯正学(第5版)2008

    • Author(s)
      小野卓史、森山啓司
    • Total Pages
      390
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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