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Investigation into mechanism of development of stomatognathic function using knock-out mice accompanied by oral motor disorders

Research Project

Project/Area Number 18390555
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIDA Noriaki  Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40230750)

Co-Investigator(Kenkyū-buntansha) 古賀 義之  長崎大学, 医学部・歯学部附属病院, 講師 (50175329)
岡安 一郎  長崎大学, 医学部・歯学部附属病院, 助教 (80346923)
ゼレド ジョージ  長崎大学, 医歯薬学総合研究科, 助教 (10363459)
山田 好秋  新潟大学, 医歯学総合研究科, 教授 (80115089)
北浦 英樹  長崎大学, 医歯薬学総合研究科, 助教 (60295087)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,030,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2006: ¥6,200,000 (Direct Cost: ¥6,200,000)
Keywords顎運動 / 筋電図 / 顎口腔機能 / 摂食・嚥下機能 / 軟食化 / 咀嚼機能 / 臨界期 / 無歯顎モデルマウス / op / opマウス / 歯根膜機械受容器
Research Abstract

本研究では、離乳後に固形飼料と液状飼料でそれぞれ飼育したマウスの咀嚼機能の変化を解析し、軟食化が咀嚼機能の発達を妨げるという仮説を検証した。軟食を日常摂取すると、吸啜から咀嚼への転換は行われるものの、顎口腔機能を司る中枢機構の発達が阻害される可能性が示唆された。また、歯のないマウスを用いて、歯および歯根膜の存在が咀嚼機能の発達にどのような役割を果たすかを検証した。歯根膜機械受容器からの入力が閉口筋活動の末梢性調節に重要な役割を果たしており、適度な食刺激が正常な咀嚼機能の獲得をもたらすと考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 2006

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (8 results) Book (4 results)

  • [Journal Article] Mastication-induced modulation of the jaw-opening reflex during different periods of mastication in awake rabbits2009

    • Author(s)
      Mostafeezur R, Yamamura K, Kurose M, Yamada Y
    • Journal Title

      Brain Res 1254

      Pages: 28-37

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible effects of periodontal inputs on the masticatory function2008

    • Author(s)
      Sanefuji K, Zeredo JL, Kurose M, Tanaka M, Koga Y, Yamada Y, Yoshida N
    • Journal Title

      J Jpn Soc Stomatognath Funct 14

      Pages: 89-95

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An anti-c-Fms antibody inhibits orthodontic tooth movement2008

    • Author(s)
      Kitaura H, Yoshimatsu M, Fujimura Y, Eguchi T, Kohara H, Yamaguchi A, Yoshida N
    • Journal Title

      J Dent Res 87

      Pages: 396-400

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in physiological responses to sound stimulation in subjects with and without fear of dental treatments2008

    • Author(s)
      Kudo T, Mishima R, Yamamura K, Mostafeezur R, Zakir HM, Kurose M, Yamada Y
    • Journal Title

      Odontology 96

      Pages: 44-49

    • NAID

      10024565136

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emotional stress-and pain-related behaviors evoked by experimental tooth movement2008

    • Author(s)
      Yozgatian JH, Zeredo JL, Hotokezaka H, Koga Y, Toda K, Yoshida N
    • Journal Title

      Angle Orthod 78

      Pages: 487-494

    • NAID

      120006985641

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible effects of periodontal inputs on the masticatory function.2008

    • Author(s)
      Kyoko Sanefuji
    • Journal Title

      J Jpn Soc Stomatognath Funct 14(2)

      Pages: 89-95

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of heat shock protein 47 in the periodontal ligament during orthodontic tooth movement.2008

    • Author(s)
      Masako Yoshimatsu
    • Journal Title

      Arch Oral Biol 53(9)

      Pages: 890-895

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emotional stress- and pain-related behaviors evoked by experimental tooth movement.2008

    • Author(s)
      Joseph Yozgatian
    • Journal Title

      Angle Orthod 78(3)

      Pages: 487-494

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional changes of the temporomandibular joint mechanoreceptors induced by a lateralmandibular shift in rats2007

    • Author(s)
      Kokai S, Yabushita T, Zeredo JL, Toda K, Soma K
    • Journal Title

      Angle Orthod 77

      Pages: 436-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible effects of periodontal inputs on the masticatory function2007

    • Author(s)
      Kyoko Sanefuji
    • Journal Title

      J Jpn Soc Stomatognath Funct

      Pages: 999-1003

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan2007

    • Author(s)
      Hitoshi Hotokezaka
    • Journal Title

      J Cell Biochem 101(1)

      Pages: 122-134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of a patient with metal hypersensitivity after orthodontic surgery2007

    • Author(s)
      Hideki Kitaura
    • Journal Title

      Angle Orthod (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of soft diet feeding on development of masticatory function2006

    • Author(s)
      Yamada M, Koga Y, Okayasu I, Sanefuji K, Yamada Y, Oi K, Yoshida N
    • Journal Title

      J Jpn Soc Stomatognath Funct 12

      Pages: 118-125

    • NAID

      110006153924

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 成長期における咀嚼機能の発達と学習のメカニズム解明に向けた実験的アプローチについて2006

    • Author(s)
      吉田教明
    • Journal Title

      顎機能誌 13

      Pages: 2-10

    • NAID

      110006153939

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of soft diet feeding on development of masticatory function2006

    • Author(s)
      Masahiko Yamada
    • Journal Title

      J Jpn Soc Stomatognath Funct 12・2

      Pages: 118-125

    • NAID

      110006153924

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The hemoglobin receptor protein of Porphyromonas gingivalis inhibits receptor activator NF-_KB ligand-induced osteoclastogenesis from bone marrow macrophages.2006

    • Author(s)
      Yuji Fujimura
    • Journal Title

      Infect Immun 74・5

      Pages: 2544-2551

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of amphotericin B-induced cell signaling with chemical inhibitors of signaling molecules2006

    • Author(s)
      Kenichiro Matsuo
    • Journal Title

      Microbiol Immunol 50・4

      Pages: 337-347

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Experimental model of tooth movement by orthodontic force in mice and its application to tumor necrosis factor receptor-deficient mice.2006

    • Author(s)
      Masako Yoshimatsu
    • Journal Title

      J Bone Miner Metab 24・1

      Pages: 20-27

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 成長期における咀嚼機能の発達と学習のメカニズム解明に向けた実験的アプローチについて2006

    • Author(s)
      吉田 教明
    • Journal Title

      顎機能誌 13・2

      Pages: 2-10

    • NAID

      110006153939

    • Related Report
      2006 Annual Research Report
  • [Presentation] Recombinant mouse M-CSF receptor c-fms inhibits TNF-α-induced osteoclastogenesis2008

    • Author(s)
      Kitaura H、Yoshida N(他5名)
    • Organizer
      The 30th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Biting behavior induced by acute stress in the rat during experimental tooth movement2008

    • Author(s)
      Zeredo JL、Yoshida N(他4名)
    • Organizer
      6th International Conference on Methods and Techniques in Behavioral Research
    • Place of Presentation
      Maastricht, Netherlands
    • Year and Date
      2008-08-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 自由運動下のマウスを用いた咀嚼運動パターンの解析2007

    • Author(s)
      黒瀬雅之、吉田教明、山田好秋(他5名)
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 顎口腔機能の発達を解明するための実験計画の立案2007

    • Author(s)
      吉田教明
    • Organizer
      第5回口腔機能セミナー
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 遺伝子改変マウスに応用可能な咀嚼運動様式の基礎データの収集2007

    • Author(s)
      黒瀬雅之、山田好秋(他4名)
    • Organizer
      第1回三叉神経領域の感覚-運動統合機構研究会
    • Place of Presentation
      松本
    • Year and Date
      2007-01-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 自由運動下のマウスを用いた咀噛運動パターンの解析2007

    • Author(s)
      黒瀬 雅之
    • Organizer
      第49回 歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 咀嚼機能獲得に果たす歯の役割-無歯顎op/opマウスを実験モデルとした機能解析-2006

    • Author(s)
      實藤恭子、岡安一郎、ゼレドジョージ、古賀義之、吉田教明(他3名)
    • Organizer
      第65回日本矯正歯科学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Daily of soft food influences development of masticatory function2006

    • Author(s)
      Yamada M、Koga Y, Okayasu I, Zeredo JL, Yoshida N(他2名)
    • Organizer
      84th IADR
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2006-06-28
    • Related Report
      2008 Final Research Report
  • [Book] マウスにおける咀嚼運動研究のための慢性実験系(日本顎口腔機能学会編)2008

    • Author(s)
      岡安一郎, 山田好秋, 吉田教明, 大井久美子
    • Publisher
      顎運動および筋電図検査法
    • Related Report
      2008 Final Research Report
  • [Book] 顎口腔機能の発達を解明するための実験計画の立案(日本顎口腔機能学会編)2008

    • Author(s)
      吉田教明, 古賀義之, 松尾恭子
    • Publisher
      顎運動および筋電図検査法
    • Related Report
      2008 Final Research Report
  • [Book] 下顎側方限界運動量の左右差と咀嚼筋活動量の相関について(日本顎口腔機能学会編)2008

    • Author(s)
      久保圭, 岡野耕大, 倉田知香, 武元嘉彦, 松岡なつき, 窪田直子, 増田裕次, 吉田教明, 山崎要一, 三浦宏之
    • Publisher
      顎運動および筋電図検査法
    • Related Report
      2008 Final Research Report
  • [Book] 問診・ガム咀嚼・ロールワッテ試験による主咀嚼側判定結果と筋活動に関する検討(日本顎口腔機能学会編)2008

    • Author(s)
      塙総司, 内海大, 安村真一, 山田千晶, 寺部やよひ, 谷岡款相, 松田慎平, 小川徹, 荒川一郎, 岡安一郎, 志賀博
    • Publisher
      顎運動および筋電図検査法
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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