• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation and reguration of the periodontal disease progression mechanism based on new inflammation adjustments(ANA and HMGB-1)

Research Project

Project/Area Number 18390561
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionTokyo Medical and Dental University (2007-2008)
Kagoshima University (2006)

Principal Investigator

IZUMI Yuichi  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60159803)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  鹿児島大学, 医歯(薬)学総合研究科, 教授 (20082282)
MACHIGASHIRA Miho  鹿児島大学, 医学部・歯学部附属病院, 講師 (80253897)
NAKAMURA Toshiaki  鹿児島大学, 医歯(薬)学総合研究科, 助教 (60381183)
KOBAYASHI Hiroaki  東京医科歯科大学, 大学院・医歯学総合研科, 助教 (50396967)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,450,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥7,700,000 (Direct Cost: ¥7,700,000)
Keywords歯周病 / HMGB-1 / アナンダマイド / 炎症 / HMGB1 / 歯肉線維芽細胞 / アポトーシス / ネクローシス / 歯根膜細胞 / IL-6 / IL-11 / 歯肉上皮細胞 / 炎症性細胞浸潤 / 歯肉線維牙細胞 / 炎症抑制 / 歯肉溝滲出液 / 内因性カンナビノイド / レセプター / 歯周炎 / エンドトキシン
Research Abstract

歯周炎の疾患進行における、新規炎症メディエーターであるアナンダマイド(ANA)とHigh Mobility Group Box-1(HMGB-1)に関する研究を行った。ANAは神経性物質であり、神経末端から放出される。このANAは歯周炎局所で発現が亢進しており、歯周炎疾患進行において神経機構が関与している可能性が示唆された。HMGB-1は核内では転写因子として働き、細胞外では起炎性物質として働く。HMGB-1の歯周組織での発現が認められ、疾患進行に関与している可能性が示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (89 results)

All 2009 2008 2007 2006 Other

All Journal Article (49 results) (of which Peer Reviewed: 16 results) Presentation (40 results)

  • [Journal Article] Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1α-stimulated human periodontal ligament cells2009

    • Author(s)
      Bando Y, Noguchi K, Kobayashi H, Yoshida N, Ishikawa I, Izumi Y
    • Journal Title

      J Periodont Res 44(3)

      Pages: 395-401

    • Related Report
      2008 Final Research Report
  • [Journal Article] Significant Association Between Score of Periodontal Disease and Coronary Artery Disease.2009

    • Author(s)
      Y. Oe
    • Journal Title

      Heart and Vessels (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1α-stimulated human periodontal ligament cells.2009

    • Author(s)
      Bando Y.
    • Journal Title

      J Periodontal Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human gingival fibroblasts release HMGB-1 through active and passive pathways.2009

    • Author(s)
      Feghali K.
    • Journal Title

      Oral Microbiol and Immunol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal status and Prevotella intermedia antibody in acute coronary syndrome2008

    • Author(s)
      Soejima H., Oe Y.,Nakayama, H., Matsuo K., Fukunaga T., Sugamura K., Kawano H., Sugiyama S., Shinohara M., Izumi Y., Ogawa H.
    • Journal Title

      Int J Cardiol, 2008,doi 10, 1016(/j.ijcard)

      Pages: 57-57

    • Related Report
      2008 Final Research Report
  • [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events : Implication in periodontal inflammation2008

    • Author(s)
      S. Tancharoen, T. Matsuyama, K. Abeyama, K. Matsushita, K. Kawahara, V. Sangalungkarn, M. Tokuda, T. Hashiguchi, I. Maruyama, Y. Izumi
    • Journal Title

      J Cell Physiol 217

      Pages: 338-349

    • Related Report
      2008 Final Research Report
  • [Journal Article] IL-6 induces osteoblastic differentiation of periodontal ligament cells2008

    • Author(s)
      K. Iwasaki, M. Komaki, K. Mimori, E. Leon, Y. Izumi, I. Ishikawa
    • Journal Title

      J Dent Res 87

      Pages: 937-942

    • Related Report
      2008 Final Research Report
  • [Journal Article] Changes in serum interleukin-6, C-reactive protein and thrombomodulin levels under periodontal ultrasonic debridement2008

    • Author(s)
      Y. Ushida, G. Koshy, Y. Kawashima, M. Kiji, M. Umeda, H. Nitta, T. Nagasawa, I. Ishikawa, Y. Izumi
    • Journal Title

      J Clin Periodontol 35

      Pages: 969-975

    • Related Report
      2008 Final Research Report
  • [Journal Article] Molecular mimicry of Aggregatibacter actinomycetemcomitans with b2 glycoprotein I2008

    • Author(s)
      D. Wang, T. Nagasawa, Y. Chen, Y. Ushida, H. Kobayashi, Y. Takeuchi, M. Umeda, Y. Izumi
    • Journal Title

      Oral Microbiol Immunol 23

      Pages: 401-405

    • Related Report
      2008 Final Research Report
  • [Journal Article] Injectable growth/differentiation factor-5/recombinant human collagen composite induces endochondral ossification via sox9 expression and angiogenesis in murine calvariae2008

    • Author(s)
      Kadomatsu, H., Matsuyama, T., Yoshimoto, T., Negishi, Y., Sekiya, H., Yamamoto, M. Izumi, Y.,
    • Journal Title

      J. Periodontal Res 43

      Pages: 483-489

    • Related Report
      2008 Final Research Report
  • [Journal Article] Significance of thrombomodulin release from gingival epithelial cells in periodontitis patients2008

    • Author(s)
      Matsuyama, T., Tokuda, M., Izumi, Y.
    • Journal Title

      J Periodontal Res 43

      Pages: 379-385

    • Related Report
      2008 Final Research Report
  • [Journal Article] Tumor necrosisi factor-alpha stimulates gingival epithelial cells to release high mobility-group box 12008

    • Author(s)
      Morimoto, Y., Kawahara, K-I., Tancharoen, S., Kikuchi, K., Matsuyama, T., Hashiguchi, T., Izumi, Y., Maruyama, I.
    • Journal Title

      J Periodontal Res. 43

      Pages: 76-83

    • Related Report
      2008 Final Research Report
  • [Journal Article] Periodontitis may increase the risk of peripheral arterial disease2008

    • Author(s)
      Yi-Wen Chen, Makoto Umeda, Toshiuki Nagasawa, Yasuo Takeuchi, Yi Huang, Yoshinori Inoue, Takehisa Iwai, Yuichi Izumi, Isao Ishikawa
    • Journal Title

      European Journal of Vascular and Endovascular Surgery 35

      Pages: 153-158

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparison of injectable calcium phosphate bone cement grafting and open flap debridement in periodontal intrabony defects A randomized clinical trial2008

    • Author(s)
      Shirakata, Y., Setoguchi, T., Machigashira, M., Matsuyama, T., Furuichi, Y., Hasegawa, K., Nakamura, T. and Izumi, Y.
    • Journal Title

      J. Periodontol. 79

      Pages: 25-32

    • Related Report
      2008 Final Research Report
  • [Journal Article] Surface properties and biocompatibility of acid-etched titanium2008

    • Author(s)
      Iwaya Y, Machigashira M, Kanbara K, Miyamoto M, Noguchi K, Izumi Y, Ban S
    • Journal Title

      Dent Mater J 27

      Pages: 415-421

    • NAID

      110006742425

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effect of rhBMP-2 with PLGA/gelatin sponge type(PGS)carrier on alveolar ridge augmentation in dogs2008

    • Author(s)
      Kawakatsu N, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Akizuki T,Hayashi C, Kokubo S, Ishikawa I, Izumi Y.
    • Journal Title

      Journal of Oral Rehabilitation 35

      Pages: 647-655

    • Related Report
      2008 Final Research Report
  • [Journal Article] The effect of chemical and/or mechanical conditioning on the Er : YAG laser treated root cementum : analysis of surface morphology and periodontal ligament fibroblast attachment2008

    • Author(s)
      Maruyama H, Aoki A, Sasaki KM, Takasaki AA, Iwasaki K, Ichinose S, Oda S, Ishikawa I, Izumi Y.
    • Journal Title

      Lasers Surg Med 40(3)

      Pages: 211-222

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hydrogen sulfide inhibits cell proliferation and induces cell cycle arrest via an elevated p21Cip1 level in Ca9-22 cells2008

    • Author(s)
      Takeuchi H, Setoguchi T, Machigashira M, Kanbara K, Izumi Y.
    • Journal Title

      J Periodontal Res 43

      Pages: 90-95

    • Related Report
      2008 Final Research Report
  • [Journal Article] IL-6 induces osteoblastic differentiation of periodontal ligament cells.2008

    • Author(s)
      Iwasaki K.
    • Journal Title

      J Dent Res 87

      Pages: 937-942

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of thrombomodulin release from gingival epithelial cells in periodontitis patients.2008

    • Author(s)
      Matsuyama, T.
    • Journal Title

      J Periodontal Res 43

      Pages: 379-385

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events : Implication in periodontal inflammation.2008

    • Author(s)
      Tancharoen S.
    • Journal Title

      J Cell Physiol 217

      Pages: 338-349

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes of serum IL-6, CRP, and thrombomodulin levels under periodontal ultrasonic debridement. J Clin Periodontol2008

    • Author(s)
      Ushida Y.
    • Journal Title

      J Clin Periodontol 35

      Pages: 969-975

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mimicry of Aggregatibacter acttinomycetemcomitans with β2glycoprotein 1.2008

    • Author(s)
      Wang D.
    • Journal Title

      Oral Microbiol Immnol 23

      Pages: 401-405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Mobility Group Box 1 (HMGB1)が培養ヒト歯根膜細胞に与える影響2008

    • Author(s)
      長谷川奈美
    • Journal Title

      口病誌 75

      Pages: 13-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.2008

    • Author(s)
      Kawahara K.
    • Journal Title

      Cardiovascular pathology 17

      Pages: 129-138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRP induces High Mobility Group Box-1 Protein Release Through activation of p38MAPK in macrophage cell line-RAW264.7 cells.2008

    • Author(s)
      Ko-ichi Kawahara
    • Journal Title

      Cardiovascular pathology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-a Stimulates Gingival Epithelial Cells to Actively Release High Mobility Group Box 1.2008

    • Author(s)
      Yoko Morimoto
    • Journal Title

      J Periodontal Bes 43

      Pages: 76-83

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis May Increase the Risk of Peripheral Arterial Disease.2008

    • Author(s)
      Y-W. Chen
    • Journal Title

      Eur J Vasc Endovasc Surg 35

      Pages: 153-158

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide inhibits cell proliferation and induces cell cycle arrest via an elevated p21Cip1 level in Ca9-22 cells.2008

    • Author(s)
      Takeuchi, H
    • Journal Title

      J Periodontal Res 43

      Pages: 90-95

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human gingival fibroblasts release HMGB1through active and passive pathways2007

    • Author(s)
      Feghali K, Iwasaki K, Tanaka K, Komaki M, Machigashira M, Ishikawa I, Izumi Y
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 1-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] High incidence of actinobacillus actinomycetemcomitans infection in acute coronary syndrome2007

    • Author(s)
      Sakurai K, Wang D, Suzuki J, Umeda M, Nagasawa T, Izumi Y, Ishikawa I, Isobe M.
    • Journal Title

      Int Heart J 48

      Pages: 663-675

    • NAID

      130000068979

    • Related Report
      2008 Final Research Report
  • [Journal Article] Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments2007

    • Author(s)
      M. Ibi, A. Ishisaki, M. Yamamoto, A. Wada, T. Kozakai, A. Nakashima, J. Iida, S. Takao, Y. Izumi, A. Yokoyama, M. Tamura,
    • Journal Title

      Arch Oral Biol 52

      Pages: 1002-1008

    • NAID

      120000970795

    • Related Report
      2008 Final Research Report
  • [Journal Article] Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese2007

    • Author(s)
      Gunji, T., Onouchi, Y., Nagasawa, T., Katagiri, S., Watanabe, H., Kobayashi, H., Arakawa, S., Noguchi, K., Hata, A., Izumi, Y., Ishikawa, I.
    • Journal Title

      Biophys. Res. Commun 364

      Pages: 7-13

    • Related Report
      2008 Final Research Report
  • [Journal Article] Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative : A pilot study with canine mandibles2007

    • Author(s)
      Shirakata, Y., Yoshimoto, T., Goto, H., Yonamine, Y., Kadomatsu, H., Miyamoto, M., Nakamura, T., Hayashi, C. and Izumi, Y.
    • Journal Title

      J. Periodontol 78

      Pages: 889-898

    • Related Report
      2008 Final Research Report
  • [Journal Article] High incidence of actinobacillus actinomycetemcomitans infection in a cute coronary syndrome.2007

    • Author(s)
      Sakurai K
    • Journal Title

      Int Heart J. 48

      Pages: 663-675

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphisms of the FPRI gene and aggressive periodontitis in Japanese2007

    • Author(s)
      Gunji, T.
    • Journal Title

      Biochem. Biophys. Res. Commun 364

      Pages: 7-13

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-rich plasma/osteoblasts complex induces bone formation via osteoblastic differentiation following subcutaneous transplantation2006

    • Author(s)
      H. Goto, T. Matsuyama, M. Miyamoto, Y. Yonamine, Y. Izumi
    • Journal Title

      J Periodont Res 41

      Pages: 455-462

    • Related Report
      2008 Final Research Report
  • [Journal Article] B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease2006

    • Author(s)
      Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seicho Makihira, Makoto Seki, Nadeem Y. Karimbux, Reginaldo B. Goncalves, Paloma Valverde, Serge Dibart, Yi-Ping Li, Leticia A. Miranda, Cory W.O. Ernst, Yuichi Izumi, Martin A. Taubman
    • Journal Title

      Am J Pathol 169

      Pages: 987-998

    • Related Report
      2008 Final Research Report
  • [Journal Article] Gene Transfer to Corneal Epithelium and Keratocytes Mediated by Ultrasound with Microbubbles2006

    • Author(s)
      Shozo Sonoda, Katsuro Tachibana, Eisuke Uchino, Akiko Okubo, Matsuo Yamamoto, Kenji Sakoda, Toshio Hisatomi, Koh-Hei Sonoda, Yoichi Negishi, Yuichi Izumi, Sonshin Takao, Taiji Sakamoto
    • Journal Title

      Invest Ophthalmol Vis Sci 47

      Pages: 558-564

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kB pathway inhibition2006

    • Author(s)
      Yumiko Nakajima, Yasushi Furuichi, Kamal Krishna Biswas, Teruto Hashiguchi, Ko-ichi Kawahara, Kazuyo Yamaji, Tomonori Uchimura, Yuichi Izumi, Ikuro Maruyama
    • Journal Title

      FEBS Letters 580

      Pages: 613-619

    • Related Report
      2008 Final Research Report
  • [Journal Article] Simvastatin Decreases IL-6 and IL-8 Production in Epithelial Cells2006

    • Author(s)
      K. Sakoda, M. Yamamoto, Y. Negishi, J.K. Liao, K. Node, Y. Izumi
    • Journal Title

      J Dent Res 85

      Pages: 520-523

    • Related Report
      2008 Final Research Report
  • [Journal Article] Recombinant human growth/differentiation factor-5 induced bone formation on murine calvariae2006

    • Author(s)
      T. Yoshimoto, M. Yamamoto, H. Kadomatsu, K. Sakoda, Y. Yonamine, Y. Izumi
    • Journal Title

      J Periodont Res 41

      Pages: 140-147

    • Related Report
      2008 Final Research Report
  • [Journal Article] Early cellular responses of osteoblast-like cells on acid- etching and alkaline treated titanium2006

    • Author(s)
      M. Miyamoto, H. Kono, A. Yuda, H. Goto, M. Machigashira, S. Ban, Y. Izumi
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 403-406

    • Related Report
      2008 Final Research Report
  • [Journal Article] Arginine-specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leukocyte protease inhibitor in periodontal tissue2006

    • Author(s)
      T. Into, M. Inomata, Y. Kanno, T.Matsuyama, M.Machigashira, Y.Izumi, T. Imamura, M. Nakashima, T. Noguchi and K. Matsushita
    • Journal Title

      Clin Exp Immunol 145(3)

      Pages: 545-554

    • Related Report
      2008 Final Research Report
  • [Journal Article] Arginie-specific gingipains from porphyromonas gingivalis deprive protective functions of secretory leukocyte protease inhibitor in periodontal tissue.2006

    • Author(s)
      T.Into
    • Journal Title

      Clin Exp Immunol 145・3

      Pages: 545-554

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition.2006

    • Author(s)
      Yumiko Nakajima
    • Journal Title

      FEBS Letters 580・2

      Pages: 613-619

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Periodontal tissue regeneration using fibroblast growth factor-2

    • Author(s)
      Kitamura M., Nakashima K., Kowashi Y., Fujii T., Shimauchi H., Sasano T., Furuuchi T., Fukuda M., Noguchi T., Shibutani T., Iwayama Y., Takashiba S., Kurihara H., Ninomiya M., Kido J., Nagata T., Hamachi T., Maeda K., Hara Y., Izumi Y., Hirofuji T., Imai E., Omae M., Watanuki M., Murakami S.
    • Journal Title

      Randomized controlled phase II clinical trial PLos ONE 3(7)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibition of HMGB1 by Deep Ocean Water Attenuates Endotoxin-Induced Sepsis

    • Author(s)
      Kawahara KI
    • Journal Title

      Medical Hypotheses. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tumor necrosis factor-a Stimulates Gingival Epithelial Cells to Actively Release High Mobility Group Box1.

    • Author(s)
      Yoko Morimoto
    • Journal Title

      Journal of Periodontal Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 軟骨細胞においてBMP2の誘導するRANKL活性化はRANKL promoterのRunx2 binding sitesを介する2009

    • Author(s)
      臼井通彦
    • Organizer
      第50回春季日本歯周病学会
    • Place of Presentation
      横須賀
    • Year and Date
      2009-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 腹部大動脈瘤でのRANKL発現と歯周病原細菌の検出との関連2008

    • Author(s)
      須田智也
    • Organizer
      口腔病学会第73回学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-16
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 歯周炎患者と健常者における歯肉溝滲出液中の抗FDF抗体価の比較2008

    • Author(s)
      大西英知
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 超音波スケーラーによる full-mouth debridement後の血清IL-6, CRPおよび可溶性トロンボモジュリンの変動2008

    • Author(s)
      牛田由佳
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 超音波スケーラーによる full-mouth debridement 後の血清IL-6, CRP および可溶性トロンボモジュリンの変動2008

    • Author(s)
      牛田由佳
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] High Mobility Group Box 1は歯根膜細胞のIL-8産生を増強する2008

    • Author(s)
      長谷川奈美
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル
    • Year and Date
      2008-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Mobility Group Box 1は歯根膜細胞のIL-8産生を増強する2008

    • Author(s)
      長谷川奈美
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gingival Epithelial Cells Potently Release HMGB1 : Implication in Periodontitis2008

    • Author(s)
      Morimoto Y
    • Organizer
      The 86^<th> General session of international association of dental Research
    • Place of Presentation
      Toronto
    • Related Report
      2008 Final Research Report
  • [Presentation] Human gingival fibroblasts release HMGB1 after stimulation with LPS2008

    • Author(s)
      Feghali K
    • Organizer
      The 86^<th> General session of international association of dental Research
    • Place of Presentation
      Toronto
    • Related Report
      2008 Final Research Report
  • [Presentation] RANKL expression in abdominal aortic aneurysms might be associated with periodontopathic bacteria2008

    • Author(s)
      Suda T
    • Organizer
      94^<th> Annual Meetimg of the American Academy of Periodontology
    • Place of Presentation
      Seattle
    • Related Report
      2008 Final Research Report
  • [Presentation] Human gingival fibroblasts release HMGB1 through active and passive pathways2008

    • Author(s)
      Feghali K
    • Organizer
      56^<th> Annual meeting of Japanese Association of Dental Research
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯周創傷治癒に内因性カンナビノイドが関与している2008

    • Author(s)
      小薗清香
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] β-2 glycoprotein Iと相同性を有する歯周病原細菌由来ペプチドに対する歯周炎患者の抗体反応2008

    • Author(s)
      長澤敏行
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Final Research Report
  • [Presentation] High Mobility Group Box 1(HMGB1)がヒト歯根膜に与える影響2008

    • Author(s)
      長谷川奈美
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 歯周炎患者由来の歯肉溝滲出液中に存在するForsythia detaching factor : FDFに対する抗体価と歯周炎の病態との関連性の解析2008

    • Author(s)
      大西英知
    • Organizer
      第50回歯科基礎医学学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Gingival Epithelial Cells Potently Release HMGB1 : Implication in Periodontitis.2008

    • Author(s)
      Morimoto Y.
    • Organizer
      The 86^<th> General session of international association of dental Research
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Human gingival fibroblasts release HMGB1 after stimulation with LPS.2008

    • Author(s)
      Feghali K.
    • Organizer
      The 86^<th> General session of international association of dental Research
    • Place of Presentation
      Toronto
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANKL expression in abdominal aortic aneurysms might be associated with periodontopathic bacteria.2008

    • Author(s)
      Suda T.
    • Organizer
      94^<th> Annual Meetimg of the American Academy of Periodontology
    • Place of Presentation
      Seattle
    • Related Report
      2008 Annual Research Report
  • [Presentation] Human gingival fibroblasts release HMGB1 through active and passive pathways.2008

    • Author(s)
      Feghali K.
    • Organizer
      56^<th> Annual meeting of Japanese association of dental research.
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report
  • [Presentation] β-2 glycoprotein I と相同性を有する歯周病原細菌由来ペプチドに対する歯周炎患者の抗体反応2008

    • Author(s)
      長澤敏行
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Annual Research Report
  • [Presentation] Production of BMP-2 by Human periodontal fibroblasts stimulated with TGF-β2007

    • Author(s)
      Yashiro R
    • Organizer
      Tissue Engineering International & Regenerative Medicine Society Asia-Pacific Chapter Meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-12-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Production of BMP-2 by Human periodontal fibroblasts stimulated with TGF-β.2007

    • Author(s)
      Yashiro R
    • Organizer
      Tissue Engineering International & Regenerative Medicine Society Asia-Pacific Chapter Meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-12-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 慢性歯周炎患者の歯周病原性細菌に対する血清抗体価に与える喫煙の影響2007

    • Author(s)
      甘美和
    • Organizer
      第50回春季日本歯周病学会
    • Place of Presentation
      横須賀
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of PGE_2 on VEGF production in human periodontal ligament cells2007

    • Author(s)
      Bando Y
    • Organizer
      The 7^<th> Asian Pacific Society of Periodontology Meeting(APSP 2007)
    • Place of Presentation
      Beijing, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Actinobacillus actinomycetemcomitans infection and acute coronary syndrome2007

    • Author(s)
      Wang D
    • Organizer
      The 7th Asian Pacific Society of Periodontology Meeting(APSP 2007)
    • Place of Presentation
      Beijing, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular mimicry of Actinobacillus actinomycetemcomitans with beta-2 glycoprotein I2007

    • Author(s)
      Nagasawa T
    • Organizer
      American Academy of Periodontology 93^<rd> Annualmeeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-23 production from monocytes stimulated with periodontopathic bacteria2007

    • Author(s)
      Kobayashi H
    • Organizer
      American Academy of Periodontology 93^<rd> Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] AP-1 suppresses osteoprotegerin synthesis in periodontal ligament fibroblasts2007

    • Author(s)
      Suda T
    • Organizer
      American Academy of Periodontology 93^<rd> Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] アナンダマイドによる歯周病の炎症制御2007

    • Author(s)
      中島結実子
    • Organizer
      第50回春季日本歯周病学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] ヒト歯肉上皮細胞のIL-8産生に及ぼすHigh Mobility Group Box 1(HMGB1)の影響2007

    • Author(s)
      森元陽子
    • Organizer
      第50回秋季日本歯周病学会50周年記念大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 歯周病がBurger病患者における抗Cardiolipin抗体に与える影響2007

    • Author(s)
      陳イ紋
    • Organizer
      第50回秋季日本歯周病学会50周年記念大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 歯根膜細胞における転写因子AP-1によるOPG抑制効果について2007

    • Author(s)
      須田智也
    • Organizer
      第50回秋季日本歯周病学会50周年記念大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Effect of PGE_2 on VEGF production in human periodontal ligament cells2007

    • Author(s)
      Bando Y
    • Organizer
      The 7th Asian Pacific Society of Periodontology Meeting (APSP2007)
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Actinobacillus actinomycetemcomitans infection and acute coronary syndrome.2007

    • Author(s)
      Wang D
    • Organizer
      The 7th Asian Pacific Society of Periodontology Meeting(APSP 2007)
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular mimicry of Actinobacillus actinomycetemcomitans with beta-2 glycoprotein I.2007

    • Author(s)
      Nagasawa T
    • Organizer
      American Academy of Periodontology 93rdAnnual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-23 production from monocytes stimulated with periodontopathic bacteria.2007

    • Author(s)
      Kobayashi H
    • Organizer
      American Academy of Periodontology 93rdAnnual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] AP-1 suppresses osteoprotegerin synthesis in periodontal ligament fibroblasts.2007

    • Author(s)
      Suda T,
    • Organizer
      American Academy of Periodontology 93rdAnnual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Effectiveness of TACE Inhibitor : New Option for Treating Periodontal Inflammation2006

    • Author(s)
      M. Machigashira
    • Organizer
      Europerio5
    • Place of Presentation
      IFEMA Madrid, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of High Mobility Group Box 1(HMGB1)in gingival epithelial cells2006

    • Author(s)
      Y. Morimoto
    • Organizer
      Europerio 5
    • Place of Presentation
      IFEMA Madrid, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition2006

    • Author(s)
      Y. Nakajima
    • Organizer
      Europerio 5
    • Place of Presentation
      IFEMA Madrid, Spain
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi