Development oforal health pedormance assessment system usingbreath, gingival crevicular fluid and saliva
Project/Area Number |
18390568
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Social dentistry
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Research Institution | Osaka University |
Principal Investigator |
TANAKA Muneo Osaka University, Dental Hospital, Assistant Professor (90263300)
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Co-Investigator(Kenkyū-buntansha) |
SHIZUKUISHI Satoshi Osaka University, Graduate School of Dentistry, Professor (00028789)
OJIMA Miki Osaka University, Graduate School of Dentistry, Research Associate (20263303)
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Project Period (FY) |
2006 – 2007
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Project Status |
Completed (Fiscal Year 2007)
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Budget Amount *help |
¥16,100,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
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Keywords | oral health performance assessment / lifestyle / risk factor / oral malodor / nerindnntal disease / salivary marker / volatile organic compounds / cluster analysis / 臭気指数 / 口腔保健要因 / 歯周病細菌 / 喫煙 / 炎症マーカー |
Research Abstract |
The objective of this study was to develop the oral health performance assessment system by clarification of association between oral malodor, periodontal disease progression. and biomarkers from breath air, gingival crevicular fluid and. saliva. Hydrogen sulfide, methyhmercaptan, ammonia, trimethylamine and butyraldehyde influenced total malodor intensity (MI) value. The clinical parameters, incruding tongue-coating score and plaque index were associated with total MI values. In the multiple logistic model, significant variables were current smoking and hours of sleep in lifestyle-related factors served as independent variables. Additionally, 38.5% of periodontal disease progression was attributable to current smoking. Moreover, pack-years of smoking demonstrated a dose-response relationship with disease progression. These results show that smoking exerted the greatest influence on periodontitis risk among lifestyle factors. Levels of salivary markers including prostaglandin F2, lactoferrin, albumin, aspartate aminotransferase, lactate dehydrogenase and alkaline phosphatase were significantly lower in current smokers. However, no meaningful differences in the proportions of six periodontal pathogens were observed between current and non-current smokers. Based on the malodor-intensity values of seven gases, the halitosis patients were classified into four clusters. These clusters showed different clinical characteristics. Furthermore, in multiple logistic regression analysis of "not improved outcome" as a dependent variable, only one of clusters showed independent association.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Longitudinal Study of the Association between Smoking as a Periodontitis Risk and Salivary Biomarkers Related to Periodontitis
Author(s)
Kibayashi, M, Tanaka, M, Nishida, N, Kuboniwa, M, Kataoka, K, Nagata, H, Nakayama, K, Morimoto, K, Shizukuishi, S.
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Journal Title
Journal of Periodontology (In press)
Related Report
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[Presentation] 職場における口腔保健管理2007
Author(s)
雫石 聰
Organizer
第35回産業医学講習会
Place of Presentation
東京
Year and Date
2007-09-29
Description
「研究成果報告書概要(和文)」より
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