| Project/Area Number |
18406004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHTA Shigeru Hiroshima University, Graduate School of Biomedical Sciences, Professor (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
KOTAKE Yaichiro Hiroshima University, Graduate School of Biomedical Sciences, Assitant Professor (20335649)
SUGIHARA Kazumi Hiroshima University, Graduate School of Biomedical Salances, Assistant Professor (20271067)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥14,340,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Keywords | parkinsonism / tetrahydroisoquinoline / Annonaceae / neurotoxin / Caribbean islands |
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| Research Abstract |
In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. Local inhabitants consume the fruits, and also drink tea made from the leaves.
In the present study, we investigated the mechanism of causing the disease and correlation between the din and the fruits.
In Annonaceae family, there are some tetrahydroisoquinoline derivatives as alkaloids. These compounds showed neurotoxic effects
It seems possible that these neurotoxic tetrahydroisoquinoline derivatives are taken into the human body and accumulated in the brain, and they might be rebind to the pathogenesis of the kcal endemic disease.
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