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Schistosomiasis japonica : a re-emerging disease in China and a new approach for disease monitoring and effective control

Research Project

Project/Area Number 18406012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionTokyo Medical and Dental University

Principal Investigator

OTA Nobuo  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10143611)

Co-Investigator(Kenkyū-buntansha) 熊谷 貴  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40369054)
二瓶 直子  国立感染症研究所, 客員研究員 (70425677)
Co-Investigator(Renkei-kenkyūsha) KUMAGAI Takashi  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40369054)
NIHEI Naoko  国立感染症研究所, 客員研究員 (70425677)
Research Collaborator WEN Liyong  中国浙江省医学アカデミー, 寄生虫病研究所, 所長
LU Shaohong  中国浙江省医学アカデミー, 寄生虫病研究所, 副所長
WAN Tianping  中国安徽省・寄生虫病研究所, 所長
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥14,840,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Keywords日本住血吸虫 / 再興感染症 / DNA診断 / Oncomelania / LAMP法 / PCR / PCR法 / 治療薬 / Oncomelania hupensis / GPS / 28S rDNA-ITS / Sjα1 / EPG
Research Abstract

中国における日本住血吸虫症流行地が低下してきている状況に応じて、中間宿主及び終宿主の感染を簡便で効率的な遺伝子検出によって評価するシステムを構築し、中間宿主貝の生態分布の地理生物学的なモニター、及び中間宿主貝と寄生虫の地理分布による適応の差異に関する情報も併せてリスクマップの作製を進め、流行状況が急速に変化してきている中国国内の日本住血吸虫症流行に対する新規対策スキームの開発と応用の可能性を中国との共同研究として実施した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007 2006

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (21 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but no for nitric oxide2009

    • Author(s)
      Kumagai T, Osada Y, Ohta N, Kanazawa T.
    • Journal Title

      Molecular and Biochemical Parasitology 164

      Pages: 26-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spacial analysis and remote sensing for monitoring systems of Oncomelania nosophora following the eradication of schistosomiasis japonica in Yamanashi Prefecture2009

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Saitoh Y, Mochizuki K, Nakamura S.
    • Journal Title

      Journal of Infectious Diseases 19

      Pages: 125-132

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators2009

    • Author(s)
      Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
    • Journal Title

      International Journal for Parasitology 39

      Pages: 457-464

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A win-win collaboration to combat neglected tropical diseases in Southeast Asia2009

    • Author(s)
      Zhou XN, Ohta N, Utzinger J, Berquist R,Olveda RM. RNAS(+)
    • Journal Title

      Parasityology International 57

      Pages: 243-245

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not for nitric oxide.2009

    • Author(s)
      Kumagai T, Osada Y, Ohta N, Kanazawa T.
    • Journal Title

      Molecular and Biochemical Parasitolot 164

      Pages: 26-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spacial analysis and remote sensing for monitoring systems of Oncomelania nosophora following the eradication of schistosomiasis japonica in Ymanashi Prefecture.2009

    • Author(s)
      Nihei N, Komagata O, Kobayashi M. Saitoh Y, Mochizuki K, Nakamura S.
    • Journal Title

      Journal of Infectious Diseases 62

      Pages: 125-132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 国内問題としてのNeglected diseases2008

    • Author(s)
      太田伸生
    • Journal Title

      Clinical Parasitology 19

      Pages: 17-20

    • Related Report
      2008 Final Research Report
  • [Journal Article] RNAS (+) : A win-win collaboration to combat neglected tropical diseases in Southeast Asia.2008

    • Author(s)
      Zhou XN, Ohta N, Utzinger J, Berquist R, Olveda RM
    • Journal Title

      Parasitology International 57

      Pages: 243-245

    • NAID

      10025328241

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 国内問題としてのNeglected Diseases2008

    • Author(s)
      太田伸生
    • Journal Title

      Clinical Parasitology 19

      Pages: 17-20

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Disease burden and epidemiology of soil-transmitted helminthiases and schistosomiasis in Asia : the Japanese perspective2007

    • Author(s)
      Ohta N, Waikagul J
    • Journal Title

      Trends in Parasitology 23

      Pages: 30-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] School-health-based parasite control initiatives : extending successful Japanese policies to Asia and Africa2007

    • Author(s)
      Kojima S, Aoki Y, Ohta N, Tateno S, Takeuchi T
    • Journal Title

      Trends in Parasitology 23

      Pages: 54-57

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disease burden and epidemiology of soil-transmitted helminthisases and schistosomiasis in Asia: the Japanese perspective2007

    • Author(s)
      Ohta N & Waikagul J
    • Journal Title

      Trends in Parasitology 23

      Pages: 30-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] School-health-based parasite control initiatives: extending successful Japanese policies to Asia and Afriac.2007

    • Author(s)
      Kojima S, Aoki Y, Ohta N, Tateno S, Takeuchi T
    • Journal Title

      Trends in Parasitology 23

      Pages: 54-57

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease burden and epidemiology of soil-transmitted helminthisases and schistosomiasis in Asia : the Japanese perspective.2007

    • Author(s)
      Ohta N, Waikagul J.
    • Journal Title

      Trends in Parasitology 23

      Pages: 30-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] School-health-based parasite control initiatives : extending successful Japanese policies to Asia and Africa.2007

    • Author(s)
      Kojima S, Aoki Y, Ohta N, Tateno S, Takeuchi T.
    • Journal Title

      Trends in parasitology 23

      Pages: 54-57

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evaluation of the antihelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols2006

    • Author(s)
      Lu SH, Kumagai T, Ai QH, Yan XL, Ohmae H, Yabu Y, Li SW, Wen LY, Maruyama H, Ohta N
    • Journal Title

      Parasitology International 55

      Pages: 63-68

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols.2006

    • Author(s)
      Lu SH, Kumagai T, Ai QH, Yan XL, Ohmae H, Yabu Y, Li SW, Wen LY, Maruyama H, Ohta N.
    • Journal Title

      Parasitology International 55

      Pages: 63-68

    • NAID

      10017321629

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 住血吸虫感染症におけるTh2シフトとサイトカイン2006

    • Author(s)
      太田伸生
    • Journal Title

      臨床免疫 45

      Pages: 207-211

    • Related Report
      2006 Annual Research Report
  • [Presentation] Therapeutic effects of a synthesized compound on schistostosomiasis mansoni : Two different effects on worm killing and anti-fecundity in murine experimental infection.2008

    • Author(s)
      Ohta N, Taniguchi T, Kumagai T, Shimogawara E, Kim HS, Wataya Y.
    • Organizer
      17^<th> International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Juju, Korea
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] The comparison of susceptibility of Schistosoma japonicum Yamanashi strain against Oncomelania spp. from various area.2008

    • Author(s)
      Shimogawara E, Kumagai T, Itabashi A, Nihei N, Saitoh Y, Ohta N.
    • Organizer
      17^<th> International Congress of Tropical Me dicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] RNAS (+) : A win-win collaboration to combat neglected tropical diseases in Southeast Asia.2008

    • Author(s)
      Zhou XN, Ohta N, Ultzinger J, Berquist R, Olveda R.
    • Organizer
      17^<th> International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Juju, Korea
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Surveillance for schistosomiasis after the interruption of trans mission in Japan2008

    • Author(s)
      Ohta N.
    • Organizer
      WHO Meeting on Schistosomiasis Control, 2008.
    • Place of Presentation
      Salbador, Brazil
    • Year and Date
      2008-08-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 国内問題としてのNeglected diseases2008

    • Author(s)
      太田伸生
    • Organizer
      第19回日本臨床寄生虫学会
    • Place of Presentation
      京都市
    • Year and Date
      2008-06-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 山梨株日本住血吸虫感染に対するOncomelania属中間宿主貝の感染性における地域間比較2008

    • Author(s)
      板橋明子, 熊谷貴, 下河原理江子, 二瓶直子, 斎藤康秀, 太田伸生
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 感染宿主内の日本住血吸虫Peroxiredoxinを標的としたin vitro RNAi法2008

    • Author(s)
      熊谷貴, 長田良雄, 下河原理江子, 板橋明子, 太田伸生
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Therapeutic effects of a synthesized compound on schistosomiasis mansoni : two different effects on worm killing and anti-fecundity in murine experimental infection2008

    • Author(s)
      Ohta N, Taniguchi T, Kumagai T,Shimogawara R, Kim HS, Wataya Y
    • Organizer
      17^<th> International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] A win-win collaboration to combat neglected tropical diseases in Southeast Asia2008

    • Author(s)
      Zhou XN, Ohta N, Ultzinger J, Berquist R, Olveda RM. RNAS(+)
    • Organizer
      17th International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] The comparison of susceptibility of Schistosoma japonicum Yamanashi strain against Oncomelania spp2008

    • Author(s)
      Shimogawara R, Kumagai T, Itagaki A, Nihei N, Saito Y, Ohta N.
    • Organizer
      from various areas
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Direct gene suppression of peroxiredoxins from Schistosoma japonicum in the portal vein by in vivo RNA interference2008

    • Author(s)
      Kumagai T, Shimogawara R, Osada Y,Kanazawa T, Ohta N
    • Organizer
      from various areas
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Surveillance for schistosomiasis after the interruption of transmission in Japan2008

    • Author(s)
      Ohta N
    • Organizer
      WHO Meeting on Schistosomiasis Control 2008
    • Place of Presentation
      Salvador, Brasil
    • Related Report
      2008 Final Research Report
  • [Presentation] ALOS画像を用いた日本住血吸虫症などの感染症の疫学的解析2008

    • Author(s)
      二瓶直子, ほか
    • Organizer
      平成19年度長崎大学熱研合同研究会
    • Place of Presentation
      長崎市
    • Related Report
      2007 Annual Research Report
  • [Presentation] New compound of anti-schistosomal effects Searching a new tool for disease control2007

    • Author(s)
      Ohta N.
    • Organizer
      2^<nd> Nagasaki Symposium on Tropical and Emerging Infectious Diseases
    • Place of Presentation
      Nagasaki, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Epidemiological analysis of infectious diseases and the establishment of a surveillance system hrough remote sensing using ALOS images2007

    • Author(s)
      Nihei N
    • Organizer
      1^<st> Joint PI Symposium of ALOS Data Nodes for ALOS Science Program
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本住血吸虫DNA検出を応用したミヤイリガイ感染率判定法の開発2007

    • Author(s)
      熊谷貴、下河原理江子、板橋明子、谷口斎恵、Wang T、Lu S、Wen L、太田伸生
    • Organizer
      第48回日本熱帯医学会
    • Place of Presentation
      別府
    • Related Report
      2008 Final Research Report
  • [Presentation] New compounds of anti-schistosomal effects-Searching a new tool for disease control2007

    • Author(s)
      Ohta N
    • Organizer
      2nd Nagasaki Symposium on Tropical and Emerging Infectious Diseases
    • Place of Presentation
      Nagasaki
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本住血吸虫ペルオキシレドキシンにおける抗醒化作用2007

    • Author(s)
      熊谷貴、長田良雄、金澤保、太田伸生
    • Organizer
      第18回日本生体防御学会
    • Place of Presentation
      福岡市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本住血吸虫DNA検出を応用したミヤイリガイ感染率判定法の開発2007

    • Author(s)
      熊谷貴、下河原理江子、板橋明子、谷口斎恵、Wang T, Lu S, Wen L, 太田伸生
    • Organizer
      第48回日本熱帯医学会
    • Place of Presentation
      別府市
    • Related Report
      2007 Annual Research Report
  • [Presentation] ペルオキシレドキシンを標的とした日本住血吸虫へのin vitro/in vivo RNAiの検討2007

    • Author(s)
      熊谷貴、下河原理江子、長田良雄、金澤保、太田伸生
    • Organizer
      第30回日本分子生物学会/第80回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epidemiological analysis of infectious diseases and the establishment of a surveillance system through remote sensing using ALOS images.2007

    • Author(s)
      Nihei N, ほか
    • Organizer
      lst joint PI symposium of ALOS data nodes for ALOS science program
    • Place of Presentation
      京都市
    • Related Report
      2007 Annual Research Report
  • [Book] 感染症と生態防御、分担執筆2008

    • Author(s)
      太田伸生
    • Publisher
      NHK出版
    • Related Report
      2008 Final Research Report
  • [Book] 寄生虫のふしぎ2008

    • Author(s)
      太田伸生(分担執筆)
    • Publisher
      科学評論社
    • Related Report
      2008 Annual Research Report
  • [Book] 感染症と生体防御(分担執筆)2008

    • Author(s)
      太田 伸生
    • Total Pages
      21
    • Publisher
      NHK出版
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規抗住血吸虫剤2008

    • Inventor(s)
      綿矢有佑、金恵淑、平本晃子、佐藤聡、太田伸生、熊谷貴、下河原理江子、谷口斎恵
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2008-07-01
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 新規抗住血吸虫剤2008

    • Inventor(s)
      綿矢有佑, 金恵淑, 平本晃子, 佐藤聡, 太田伸生, 熊谷貴, 下河原理江子, 谷口齋恵
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2008-07-01
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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