Dynamics of circulating rotavirus strains after vaccine introduction in Brazil.
| Project/Area Number |
18406016
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAGOMI Toyoko Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (40155693)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Shyoko 長崎大学, 大学院・医歯薬学総合研究科, 教務職員 (80277128)
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| Research Collaborator |
CORREIA JB ブラジル・フィゲイラ教授記念総合医学研究所
MONTENEGRO FM ブラジル・フィゲイラ教授記念総合医学研究所
GERMANO EM ブラジル・フィゲイラ教授記念総合医学研究所
CORREIA NB ブラジル・フィゲイラ教授記念総合医学研究所
PATEL MM アメリカ合衆国疾病管理センター
PARASHAR UD アメリカ合衆国疾病管理センター
CUNLIFFE NA 英国・リバプール大学
CUEVAS LE 英国・リバプール大学
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥14,650,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | ロタウイルス / ワクチン / 血清型 / 有効性 / 異型免疫 / 流行株 / G2P[4] / ブラジル / 分子疫学 / 遺伝子型 / 防御免疫 / ロタウイルスワクチン / 新興株 / 抗原変異 |
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| Research Abstract |
We observed an abrupt increase of G2P[4] strains in Brazil after the introduction of the monovalent G1P[8] rotavirus vaccine. In clinical trials, the effectiveness of the monovalent vaccine against fully-heterotypic G2P[4] strains was not well established because the circulating strains at the time of clinical trials were mainly G1P[8] strains. Thus, this study was undertaken to assess the vaccine effectiveness against G2P[4] strains using the case-control design. Among children aged 6-11 months, the effectiveness of the monovalent vaccine was 77% against severe G2P[4] diarrhoea, and 83-85% against hospitalization. The G1P[8] monovalent vaccine was shown to be effective against severe diarrhoea due to G2P[4] rotavirus strains in an impoverished setting in Latin America.
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Report
(6 results)
Research Products
(38 results)
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[Journal Article] Apparent extinction of non-G2 rotavirus strains from circulation in Recife, Brazil, after the introduction of rotavirus vaccine.2008
Author(s)
Nakagomi T, Cuevas LE, Gurgel RG, Elrokhsi SH, Belkhir YA, Abugalia M, Dove W, Montenegro FM, Correia JB, Nakagomi O, Cunliffe NA, Hart CA
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Journal Title
Arch Virol 153
Pages: 591-593
Related Report
Peer Reviewed
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[Journal Article] Apparent extinction of non-G2 rotavirus strains from circulation in Recife, Brazil, after the introduction of rotavirus vaccine2008
Author(s)
Nakagomi T, Cuevas LE, Gurgel RG, Elrokhsi SH, Belkhir YA, Abugalia M, Dove W, Montenegro FM, Correia JB, Nakagomi O, Cunliffe NA, Hart CA
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Journal Title
Arch Virol 153
Pages: 591-593
Related Report
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[Journal Article] Predominance of rotavirus P[4]G2 in a vaccinated population, Brazil.2007
Author(s)
Gurgel RQ, Cuevas LE, Viera SCF, Barros VCF, Fontes PB, Salustino EF, Nakagomi O, Nakagomi T, Dove W, Cunliffe NA, Hart CA
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Journal Title
Emerg Infect Dis 13
Pages: 1571-1573
Related Report
Peer Reviewed
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[Journal Article] Predominance of rotavirus P[4]G2 in a vaccinated population2007
Author(s)
Gurgel RQ, Cuevas LE, Viera SCF, Barros VCF, Fontes PB, Salustino EF, Nakagomi O, Nakagomi T, Dove W, Cunliffe NA, Hart CA
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Journal Title
Brazil. Emerg Infect Dis 13
Pages: 1571-1573
Related Report
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