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Study of characteristics and prevalence of novel species rotavirus detected in Asia

Research Project

Project/Area Number 18406018
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionSapporo Medical University

Principal Investigator

KOBAYASHI Nobumichi  Sapporo Medical University, 医学部, 教授 (80186759)

Co-Investigator(Kenkyū-buntansha) ISHINO Masaho  札幌医科大学, 医学部, 准教授 (30232325)
SUMI Ayako  札幌医科大学, 医学部, 講師 (10363699)
NAGASHIMA Shigeo  札幌医科大学, 医学部, 助教 (60433116)
MISE Keiji  札幌医科大学, 医学部, 助手 (30200025)
TANIGUCHI Koki  藤田保健衛生大学, 医学部, 教授 (40094213)
Research Collaborator T.N Naik  インド国立コレラ腸管感染症研究所
T Krishnan  インド国立コレラ腸管感染症研究所
M Chawla-sarkar  インド国立コレラ腸管感染症研究所
S.K Paul  マイメンシン医科大学
M.M Alam  バングラデシュ農科大学
T.S Aung  ミャンマー国立保健研究所
Y-H Wang  武漢市CDC
X Zhou  武漢市CDC
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥15,750,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥6,000,000 (Direct Cost: ¥6,000,000)
Keywordsロタウイルス / 新種 / 成人 / 下痢症 / 分子疫学 / アジア / 新興型 / B 群 / B群 / 熱帯地域
Research Abstract

バングラデシュで成人下痢症より検出された非定型的ヒトロタウイルスB219株の全遺伝子配列を決定し、遺伝子解析を行った結果、B219株は従来から知られるA群、B群、C群ロタウイルスとは遺伝学的に異なる新種(群)に属することが判明した。アジアでの成人・小児由来ロタウイルスの疫学調査では新種ロタウイルスは検出されず浸淫度は低いと考えられたが、A群ロタウイルスは小児と成人の間で感染・伝播していることが示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007 2006

All Journal Article (23 results) (of which Peer Reviewed: 17 results) Presentation (23 results) Book (1 results)

  • [Journal Article] Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine to human interspecies transmission2009

    • Author(s)
      Mukherjee A, Dutta D, Ghosh S, Bagchi P, Chattopadhyay S, Nagashima S, Kobayashi N, Dutta P, Krishnan T, Naik TN, Chawla-Sarkar M.
    • Journal Title

      Archives of Virology (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China2009

    • Author(s)
      Wang Y-H, Kobayashi N, Zhou X, Nagashima S, Zhu Z-R Peng J-S, Liu M-Q, Hu Q, Zhou D-J, Watanabe S, Ishino M.
    • Journal Title

      Journal of Medical Virology 81

      Pages: 382-389

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of rotaviruses with genotypes G1, G2, G9 and G12 in Bangladesh : evidence for a close relationship between rotaviruses from children and adults2008

    • Author(s)
      Paul SK, Kobayashi N, Nagashima S, Ishino M, Watanabe S, Alam MM, Ahmed MU, Hossain MA, Naik TN.
    • Journal Title

      Archives of Virology 153

      Pages: 1999-2012

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human group A rotavirus P[8] Hun9-like and rare OP354-like strains are circulating among diarrhoeic children in Eastern India2008

    • Author(s)
      Samajdar S, Ghosh S, Dutta D, Chawla-Sarkar M, Kobayashi N, Naik TN.
    • Journal Title

      Archives of Virology 153

      Pages: 1933-1936

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase in prevalence of human group A rotavirus G9 strains as an important VP7 genotype among children in eastern India2008

    • Author(s)
      Samajdar S, Ghosh S, Chawla-Sarkar M, Mitra U, Dutta P, Kobayashi N, Naik TN.
    • Journal Title

      J Clin Virol 43

      Pages: 334-339

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus2008

    • Author(s)
      Nagashima S, Kobayashi N, Ishino M, Alam MM, Ahmed MU, Paul SK, Ganesh B, Chawla-Sarkar M, Krishnan T, Naik TN, Wang Y-H.
    • Journal Title

      J Med Virol 80

      Pages: 2023-2033

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of rotaviruses2008

    • Author(s)
      Alam MM, Kobayashi N, Ishino M, Nagashima S, Paul SK, Chawla-Sarkar M, Krishnan T, Naik TN.
    • Journal Title

      Arch Virol 153

      Pages: 555-559

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus.2008

    • Author(s)
      Nagashima S, et al.
    • Journal Title

      Journal of Medical Virology 80

      Pages: 2023-2033

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of rotaviruses with genotypes G1, G2, G9 and G12 in Bangladesh : evidence for a close relationship between rotaviruses from children and adults.2008

    • Author(s)
      Paul SK, et al.
    • Journal Title

      Archives of Virology 153

      Pages: 1999-2012

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China.2008

    • Author(s)
      Wang Y, et al.
    • Journal Title

      Journal of Medical Virology 81

      Pages: 382-389

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of rotaviruses.2008

    • Author(s)
      Alam M, et. al.
    • Journal Title

      Archives of Virology 153

      Pages: 555-559

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for bovine origin of VP4 and VP7 genes of human group A rotavirus G6P[14] and G10P[14] strains2007

    • Author(s)
      Ghosh S, Varghese V, Samajdar S, Sinha M, Naik TN, Kobayashi N.
    • Journal Title

      J Clin Microbiol 45

      Pages: 2751-2753

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study of the effect of vaccination on periodic structures of measles epidemics in Japan2007

    • Author(s)
      Sumi A, Kamo K, Ohtomo N, Kobayashi N.
    • Journal Title

      Microbiol Immunol 51

      Pages: 805-814

    • NAID

      10020279045

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular epidemiologic analysis of group A rotaviruses in adults and children with diarrhea in Wuhan city, China, 2000-20062007

    • Author(s)
      Wang Y-H, Kobayashi N, Zhou D-Z, Yang Z-Q, Zhou X, Peng J-S, Zhu Z-R, Zhao D-F, Liu M-Q, Gong J.
    • Journal Title

      Arch Virol 152

      Pages: 669-685

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of an ADRV-N-like rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh2007

    • Author(s)
      Alam MM, Kobayashi N, Ishino M, Ahmed MS, Ahmed MU, Paul SK, Muzumdar BK, Hussain Z, Wang Y-H, Naik TN.
    • Journal Title

      Arch Virol 152

      Pages: 199-208

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular epidemiologic analysis of group A rotaviruses in adults and children with diarrhea in Wuhan city, China,2000-2006.2007

    • Author(s)
      Wang YH, et. al.
    • Journal Title

      Archives of Virology 152

      Pages: 669-685

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for bovine origin of VP4 and VP7 genes of human group A rotavirus G6P [14] and G10P[14] strains.2007

    • Author(s)
      Ghosh S, et. al.
    • Journal Title

      Journal of Clinical Microbiology 45

      Pages: 2751-2753

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of NSP4 protein between group A and B human rotaviruses : detection of novel diarrhea-causing sequence in group BNSP4.2006

    • Author(s)
      Ishino M, et al.
    • Journal Title

      Arch Virol 151

      Pages: 173-182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An outbreak of rotavirus infection among adults in an institution for rehabilitation : long-term residence in a closed community as a risk factor for rotavirus illness.2006

    • Author(s)
      Iijima Y, et al.
    • Journal Title

      Scand J Infect Dis 38

      Pages: 490-496

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains.2006

    • Author(s)
      Varghese V, et al.
    • Journal Title

      Virus Genes 32

      Pages: 241-247

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Changing pattern of human group A rotaviruses : Emergence of G12 as an important pathogen among children in eastern India.2006

    • Author(s)
      Samajdar S, et al.
    • Journal Title

      J Clin Virol 36

      Pages: 183-188

    • Related Report
      2006 Annual Research Report
  • [Journal Article] RT-PCR based diagnosis revealed importance of human group B rotavirus infection in childhood diarrhoea.2006

    • Author(s)
      Barman P, et al.
    • Journal Title

      J Clin Virol 36

      Pages: 222-227

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis on genetic factors related topreferential selection of NSP1 gene segment observed in mixed infection and multiple passage of rotaviruses.2006

    • Author(s)
      Alam MM, et al.
    • Journal Title

      Arch Virol 151

      Pages: 2149-2159

    • Related Report
      2006 Annual Research Report
  • [Presentation] 下利便におけるプロテオーム解析2009

    • Author(s)
      石埜正穂、長嶋茂雄、三瀬敬治、小林宣道
    • Organizer
      第79回日本衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Phylogenetic relatedness of G1, G3, and G9 rotaviruses between children and adults in Wuhan, China2009

    • Author(s)
      Kobayashi N, Wang Y-H, Zhou X, Nagashima S, Peng J-S, Zhu Z-R, Liu M-Q, Hu Q, Zhou D-J.
    • Organizer
      8th Asia Pacific Congress of Medical Virology
    • Place of Presentation
      香港
    • Year and Date
      2009-02-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular epidemiologic study of norovirus in sporadic cases of gastroenteritis in all age groups in Wuhan, China, 20082009

    • Author(s)
      Wang Y-H, Kobayashi N, Peng J-S, Nagashima S, Zhou X, Yang T, Hu Q, Zhou D-J.
    • Organizer
      8th Asia Pacific Congress of Medical Virology
    • Place of Presentation
      香港
    • Year and Date
      2009-02-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Phylogenetic analysis of G4P[6] rotavirus strain R479 isolated in Wuhan, China2009

    • Author(s)
      Kobayashi N, Wang Y-H, Peng J-S, Nagashima S, Zhou X, Hu Q, Zhou D-J.
    • Organizer
      8th Asia Pacific Congress of Medical Virology
    • Place of Presentation
      香港
    • Year and Date
      2009-02-26
    • Related Report
      2008 Final Research Report
  • [Presentation] "Host cellular proteins" : key determinants of rotavirus infection and pathogenesis2008

    • Author(s)
      Chawla-Sarkar M, Dutta D, Bagchi P, Krishnan T, Nagashima S, Kobayashi N.
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections
    • Place of Presentation
      札幌
    • Year and Date
      2008-12-16
    • Related Report
      2008 Final Research Report
  • [Presentation] バングラデシュにおける小児および成人下痢症由来A群ロタウイルスの遺伝子学的解析2008

    • Author(s)
      長嶋茂雄、Paul Shyamal, 渡辺祥二郎、石埜正穂、小林宣道
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] バングラデシュにおける小児および成人下痢症由来A群ロタウイルスの遺伝子学的解析.2008

    • Author(s)
      長嶋茂雄
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      岡山市
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中国・武漢市における成人および小児下痢症由来G1, G3, G9 ロタウイルスの分子疫学的解析2008

    • Author(s)
      小林宣道、長嶋茂雄、石埜正穂、渡辺祥二郎、Wang Yuanhong, Zhou Xuan
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 中国・武漢市における成人および小児下痢症由来G1, G3, G9ロタウイルスの分子疫学的解析.2008

    • Author(s)
      小林宣道
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular epidemiologic analysis of group A rotaviruses in children with diarrhea in Wuhan city, China, 20072008

    • Author(s)
      Zhou X, Kobayashi N, Wang YH, Zhu ZR, Zhou DJ, Sun SH
    • Organizer
      The 13th International Congress on Infectious Diseases
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2008-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Whole sequence analysis of novel group rotavirus B219 and group B rotaviruses2008

    • Author(s)
      Kobayashi N, Nagashima S, Alam M, Wang Y-H, Krishnan T, Chawla-Sarkar M.
    • Organizer
      The 7th Japan-China International Conference of Virology
    • Place of Presentation
      東京
    • Year and Date
      2008-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular epidemiology of rotaviruses in Wuhan, China, Jun. 2006-Feb. 2008 : predominance of variant G3 strains and increase of G9 strains2008

    • Author(s)
      Wang Y-H, Kobayashi N, Zhou X, Nagashima, S, Zhu Z-R, Sun S-H, Liu M-Q, Peng J-S, Hu Q, Zhou D-J.
    • Organizer
      The 7th Japan-China International Conference of Virology
    • Place of Presentation
      東京
    • Year and Date
      2008-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Phylogenetic analysis of predominant G2, emerging G9 and G12 rotaviruses from children and adults in Bangladesh2008

    • Author(s)
      Paul SK, Nagashima S, Kobayashi N, Ishino M, Watanabe S, Alam MM, Ahmed MU.
    • Organizer
      The 42nd Joint Working Conference on Viral Diseases, The U.S.-Japan Cooperative Medical Science Program
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-27
    • Related Report
      2008 Final Research Report
  • [Presentation] バングラデシュ(マイメンシン市)における小児および成人下痢症由来A群ロタウイルスの分子疫学的解析2008

    • Author(s)
      長嶋茂雄、渡辺祥二郎、石埜正穂、小林宣道
    • Organizer
      第78回日本衛生学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] バングラデシュ(マイメンシン市)における小児および成人下痢症由来A群ロタウイルスの分子疫学的解析.2008

    • Author(s)
      長嶋茂雄
    • Organizer
      第78回日本衛生学会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] B群ヒトロタウイルスのVP1およびVP3遺伝子配列の解析2007

    • Author(s)
      長嶋茂雄、石埜正穂、小林宣道
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Whole genome characterization of a human rotavirus strain B219 that belongs to a novel rotavirus group2007

    • Author(s)
      Nagashima S, Ishino M, Kobayashi N, Alam MM, Ahmed MU.
    • Organizer
      The 41st Joint Working Conference on Viral Diseases, The U.S.-Japan Cooperative Medical Science Program
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2007-07-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 成人下痢症由来の新奇なヒトロタウイルスB219 株の分子疫学的解析2007

    • Author(s)
      長嶋茂雄、石埜正穂、小林宣道
    • Organizer
      第77回日本衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 中国・武漢市における成人・小児下痢症由来A 群ロタウイルスの分子疫学的解析2007

    • Author(s)
      小林宣道、石埜正穂、長嶋茂雄、三瀬敬治、鷲見紋子
    • Organizer
      第77回日本衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 中国・武漢市における成人・小児下痢症由来A 群ロタウイルスの分子疫学的解析2006

    • Author(s)
      小林宣道、石埜正穂、長嶋茂雄、三瀬敬治、鷲見紋子
    • Organizer
      第54回日本ウイルス学会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 成人下痢症由来の新種ヒトロタウイルスB219 株の遺伝子解析2006

    • Author(s)
      長嶋茂雄、石埜正穂、小林宣道
    • Organizer
      第54回日本ウイルス学会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic and epidemiologic characterization of group A rotavirus among adults and children with diarrhea in Wuhan, China, Dec. 2000-Mar. 20062006

    • Author(s)
      Wang Y-H, Kobayashi N, Zhou D-J, Yang Z-Q, Zhu Z-R, Zhou X, Liu M-Q, Peng J-S, Li Y.
    • Organizer
      The 6th China-Japan International Conference of Virology
    • Place of Presentation
      上海
    • Year and Date
      2006-06-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic analysis of an ADRV-N-like novel human rotavirus detected in a sporadic case of adult diarrhea in Bangladesh2006

    • Author(s)
      Kobayashi N, Wang Y-H, Ishino M, Alam MM, Ahmed MU.
    • Organizer
      The 6th China-Japan International Conference of Virology
    • Place of Presentation
      上海
    • Year and Date
      2006-06-23
    • Related Report
      2008 Final Research Report
  • [Book] Diversity of G-type and P-type of human and animal rotaviruses and its genetic background. In A. Mendez-Vilas, Editor2007

    • Author(s)
      Kobayashi N, Ishino M, Wang Y-H., Chawla-Sarkar M, Krishnan T, Naik T.N.
    • Publisher
      Communicating Current Research and Educational Topics and Trends in Applied Microbiology (Microbiology Book Series-2007 Edition) Formatex, Spain
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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