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Immunogenetic analysis of the resistance to infectious diseases

Research Project

Project/Area Number 18406019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TSUBATA Takeshi  Tokyo Medical and Dental University, Laboratory of Immunology, School of Biomedical Science, Professor (80197756)

Co-Investigator(Kenkyū-buntansha) WATANABE Kozo  Laboratory of Immunology, Medical Research Institute, 難治疾患研究所, Assistant Professor (20376718)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥10,770,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsSARS / polymorphism / CD22 / CD72 / B lymphocyte / infectious diseases / alternative splicing / ER stress / CD7 2 / 多型 / ハプロタイプ
Research Abstract

Both CD22 and CD72 are B lymphocyte membrane molecules that negatively regulate signaling thorough B cell antigen receptor. Both CD22 and CD72 genes are polymorphic. To elucidate whether polymorphisms of these genes are associated with resistance to acute infection, we examined haplotypes of both CD22 and CD72 in SARS patients in China and individuals who were close contact with SARS patients but did not develop SARS. A CD72 haplotype was tend to be increased in patients with severe symptoms although the increase was not significant because of the limited sample numbers. Next, we examined the functional difference of different CD72 haplotypes. The human CD72 gene generates two distinct splicing isoforms, i.e., full length CD72 and CD72 lacking exon 8 (CD72 Δ ex8). We demonstrated that the level of CD72 Δ ex8 but not full length CD72 depends on CD72 haoplotypes. Moreover, CD72 Δ ex8 is accumulated in the endoplastic reticulum (ER), and augments ER stress and apoptosis mediated by ER stress. These results indicate that CD72 polymorphism regulates expression of CD72 Δ ex8 that regulates B lymphocyte apoptosis mediated by ER stress, thereby regulating infection immunity.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (86 results)

All 2009 2008 2007 2006

All Journal Article (37 results) Presentation (46 results) Book (3 results)

  • [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22specific inhibitors.2008

    • Author(s)
      Abdu-Allah, H. H. M., Tamanaka, T., Yu, J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
    • Journal Title

      J. Me. l Chem. 51

      Pages: 6665-6681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The centromerio interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72b coneenic mice.2008

    • Author(s)
      Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Comm. 380

      Pages: 193-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] T Siglec-2 is a key molecule for immune response.2008

    • Author(s)
      Tsubata, T
    • Journal Title

      In Experimental Glycoscience, Glycobiology (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki and S. Hase) (Springer.)

      Pages: 167-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation.2007

    • Author(s)
      Sato, M., Adachi, T., Tsubata, T.
    • Journal Title

      J. Immunol. 178

      Pages: 2901-2907

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.2007

    • Author(s)
      Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 360

      Pages: 759-764

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis.2007

    • Author(s)
      Yan, B. C., Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 365

      Pages: 143-148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interdomain A is crucial for ITAM-dependent and-independent regulation of Syk.2007

    • Author(s)
      Adachi, T, Wienands, J., Tsubata, T., Kurosaki, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 364

      Pages: 111-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response.2007

    • Author(s)
      Onodera, T., Poe, J, C., Tedder, T. F., Tsubata, T.
    • Journal Title

      J. Immunol. 180

      Pages: 907-913

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 achtivated by B lymphocyte stimulation with antigen.2007

    • Author(s)
      Zhu, C., Fujimoto, M., Sato, M., Yanagisawa, T., Tsubata, T.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 1653-1659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] FRET-based Ca^<2+> measurement in B lymphocyte by flow cytometry and confocal microscopy.2007

    • Author(s)
      Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 142

      Pages: 377-382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation.2007

    • Author(s)
      Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Comm. 374

      Pages: 274-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22-specific inhibitors.2007

    • Author(s)
      Abdu-Allah, H. H. M., Tamanaka, T., Yu' J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
    • Journal Title

      J. Me. l Chem. 51

      Pages: 6665-6681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes.2007

    • Author(s)
      Watanabe, K, Tsubata, T.
    • Journal Title

      Autophagy. 5

      Pages: 108-110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells.2007

    • Author(s)
      Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
    • Journal Title

      Biochem J. 417

      Pages: 673-683

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD 72^b congenic mice.2007

    • Author(s)
      Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Comm. 380

      Pages: 193-197

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthetic glycan ligand excludes CD22 from2007

    • Author(s)
      Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., kiso, M., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 360

      Pages: 759-764

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis.2007

    • Author(s)
      Yan, B, C, Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophvs. Res. Commun. 365

      Pages: 143-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interdomain A is crucial for ITAM-dependent and independent regulation of Syk.2007

    • Author(s)
      Adachi, T., Wienands, J., Tsubata, T., Kurosaki, T.
    • Journal Title

      Biochem. Bioohvs. Res. Commun. 364

      Pages: 111-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response.2007

    • Author(s)
      Onodera. T., Poe, J, C, Tedder, T. F., Tsubata, T.
    • Journal Title

      J. Immunol. 180

      Pages: 907-913

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 achtivated by B lymphocyte stimulation with antigen.2007

    • Author(s)
      Zhu, C, Fujimoto, M., Sato, M., Yanagisawa, T., Tsubata, T.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 1653-1659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] FRET-based Ca2+ measurement in B lymphocyte by flow cytometry and confocal microscopy.2007

    • Author(s)
      Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 142

      Pages: 377-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis2007

    • Author(s)
      Yan, B, C., Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 365

      Pages: 143-148

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Interdomain A is crucial for ITAM-dependent and-independent regulation of Syk2007

    • Author(s)
      Adachi, T., Wienands, J., Tsubata, T., Kurosaki, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 364

      Pages: 111-117

    • Related Report
      2007 Annual Research Report
  • [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response2007

    • Author(s)
      Onodera, T., Poe, J, C., Tedder. T. F., Tsubata. T.
    • Journal Title

      J. Immunol. 180

      Pages: 907-913

    • Related Report
      2007 Annual Research Report
  • [Journal Article] FRET-based Ca^<2+> measurement in B lymphocyte by flow cytometry and confocal microscopy2007

    • Author(s)
      Adachi, T., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 142

      Pages: 377-382

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation2007

    • Author(s)
      Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T
    • Journal Title

      Biochem. Biophys. Res. Comm. 374

      Pages: 274-281

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22-specific inhibitors2007

    • Author(s)
      Abdu-Allah, H. H. M., Tamanaka, T., Yu' J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
    • Journal Title

      J. Med. Chem. 51

      Pages: 6665-6681

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes2007

    • Author(s)
      Watanabe, K, Tsubata, T.
    • Journal Title

      Autophagy 5

      Pages: 108-110

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells2007

    • Author(s)
      Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
    • Journal Title

      Biochem J. 417

      Pages: 673-683

    • Related Report
      2007 Annual Research Report
  • [Journal Article] The centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72^b congenic mice2007

    • Author(s)
      Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
    • Journal Title

      Biochem. Biophys. Res. Comm. 380

      Pages: 193-197

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation.2007

    • Author(s)
      Sato, M., Adachi, T. and Tsubata, T.
    • Journal Title

      J. Immunol 178

      Pages: 2901-2907

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2006

    • Author(s)
      Devi, S. S., Hagiyama, H., Adachi, T., Muyasaka, N., Tsubata, T.
    • Journal Title

      Signal Transduction 6

      Pages: 54-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bispecific Abs against modified protein and DNA with oxidized2006

    • Author(s)
      Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Yatnaguchi, S., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
    • Journal Title

      PNAS 103

      Pages: 6160-6165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] B cell abnormality and systemiclupus erythematosus.2006

    • Author(s)
      Tsubata, T.
    • Journal Title

      APLAR J. Rheum 9

      Pages: 372-376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2006

    • Author(s)
      Devi, S. S., Hagiyama, H., Adachi, T., Muyasaka, N. and Tsubata, T.
    • Journal Title

      Signal Transductio 6

      Pages: 54-61

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bispecific Abs against modified protein and DNA with oxidized lipids.2006

    • Author(s)
      Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Yamaguchi, S., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T. and Uchida, K.
    • Journal Title

      PNAS 103

      Pages: 6160-6165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] B cell abnormality and systemic lupus erythematosus.2006

    • Author(s)
      Tsubata, T.
    • Journal Title

      APLAR J. Rheum 9

      Pages: 372-376

    • Related Report
      2006 Annual Research Report
  • [Presentation] Membrane-bound lectins and humoral immunity2009

    • Author(s)
      Tsubata, T.
    • Organizer
      CREST International Symposium "Acquired Immunity and Glycobiology"
    • Place of Presentation
      Kazusa, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Membrane-bound lectins and humoral immunity2009

    • Author(s)
      Tsubata, T.
    • Organizer
      CREST International Symposium “Acquired Immunity and Glycobiology"
    • Place of Presentation
      Kazusa, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫応答と組織細胞ストレス2008

    • Author(s)
      鍔田武志
    • Organizer
      第一回センシングバイオロジー・シンポジウム(第5回IBBフロンティアシンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2008-12-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Functional role of inhibitory BCR co-receptors CD22 and CD722008

    • Author(s)
      Tsubata, T.
    • Organizer
      1^<st> International Singapore Symposium of Immunology
    • Place of Presentation
      Singapore
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endoplasmic reticulum stress and autoimmune diseases2008

    • Author(s)
      Tsubata, T.
    • Organizer
      36. Kongress der Deutschen Gesellschaft fur Rheumatologie
    • Place of Presentation
      Berlin, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cell death, autophagy, cell senescence and their roles in diseases2008

    • Author(s)
      Tsubata, T.
    • Organizer
      7^<th> Surugadai International Symposium
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Antigen receptor tail clue of class-switched memory B cells2008

    • Author(s)
      N. Engels, C. Heemann, L. Koening, Tsubata, T., S. Griep, V. Schrader, J. Wienands.
    • Organizer
      Joint Annual Meeting of Immunology of the Austrian and German Societies
    • Place of Presentation
      Vienna, Austria
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する2008

    • Author(s)
      渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increased tonic B cell antigen receptor signaling but reduced antigen-induced B cell response in transgenic B cells expressing IgG2008

    • Author(s)
      満栄勇, 小野寺大志, 鍔田武志
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] SLE抵抗性を有するヒトCD 2選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する2008

    • Author(s)
      人見祐基, 安達貴弘, 岩井佳子, 土屋尚之, 本田善一郎, 徳永勝士, 鍔田武志
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性2008

    • Author(s)
      渡辺幸造, 安達貴弘, 鍔田武志
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CD22阻害化合物の構造活性相関2008

    • Author(s)
      玉中大智, Hajjaj H. M. Abdu-Allah, Jie Yu, Lu Zhuoyuan, Magesh Sadagopan, 安達貴弘, 鍔田武志, Soerge Kelm, 石田秀治, 木曾眞
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CD22による糖鎖リガンド依存的および非依存的なB細胞抗原受容体シグル伝達制御2008

    • Author(s)
      安達貴弘, 満栄勇, 矢倉英隆, 鍔田武志
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cell death, autophagy, cellsenescence and their roles in diseases2008

    • Author(s)
      Tsubata, T.
    • Organizer
      7th Surugadai International Symposium
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antigen receptor tail clue of class-switched memory B2008

    • Author(s)
      N. Engels, C. Heemann, L. Koening, Tsubata, T., S. Griep, V. Schrader, J. Wienands.
    • Organizer
      Joint Annual Meeting of Immunology of the Austrian and German Societies
    • Place of Presentation
      Vienna, Austria
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B細胞特異的C型レクチン様分子CD72ほオリゴマンノースに対してCa2+非依存性のレクチン活性を有する2008

    • Author(s)
      渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Presentation] SLE抵抗性を有するヒトCD72選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する2008

    • Author(s)
      人見祐基, 安達貴弘, 岩井佳子, 土屋尚之, 本田善一郎, 徳永勝士, 鍔田武志
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bリンパ球の生と死2007

    • Author(s)
      鍔田武志
    • Organizer
      橋本康弘教授就任講演会
    • Place of Presentation
      福島
    • Year and Date
      2007-10-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膜型レクチン分子における液性免疫応答の制御2007

    • Author(s)
      鍔田武志
    • Organizer
      第31回皮膚科免疫セミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-03-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膜型レクチン分子による免疫応答制御2007

    • Author(s)
      鍔田武志
    • Organizer
      理研シンポジウム第10回生体分子の化学
    • Place of Presentation
      和光市
    • Year and Date
      2007-01-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional role of inhibitory BCR Co-receptors CD22 and CD72.2007

    • Author(s)
      Tsubata, T.
    • Organizer
      1^<st> International Singapore Symposium of Immunology.
    • Place of Presentation
      Biopolis, Singapore.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors.2007

    • Author(s)
      Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
    • Organizer
      XIX International Symposium on Glycoconjugates.
    • Place of Presentation
      Cairns, Australia.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 抗原受容体を介するBリンパ球アポトーシスの分子メカニズム2007

    • Author(s)
      鍔田武志
    • Organizer
      平成19年生理学研究会
    • Place of Presentation
      東岡崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors.2007

    • Author(s)
      A, A, H, H, Mohamed., Tsubata, T., Ishida, H., Kiso, M.
    • Organizer
      The 2nd Annual meeting of Japanese society for chemical biology
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖鎖リガンド類似化合物によるBリンパ球活性化制御分子CD22の機能制御2007

    • Author(s)
      Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
    • Organizer
      日本ケミカルバイオロジー研究会第2回年会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The alternatively s pliced isoform of human CD72 that confers resistance against systemic lupus erythematosus regulats B lymphocyte apoptosis.2007

    • Author(s)
      Hitomi, Y., Adachi, T., Tsuchiya, N., Honda, Z., Tokunaga, K., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The kinetics of antibody response is regulated by CD22.2007

    • Author(s)
      Onodera, T., Poe, J, C., Tedder, T, F., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害/Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.2007

    • Author(s)
      Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小胞体ストレスがB細胞抗原受容体を介したアポトーシスに関与する/Unfolded protein response is involved in B cell antgen receptor-mediated apoptosis.2007

    • Author(s)
      Yan, B., Adachi, T., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling.2007

    • Author(s)
      Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白抗原が必要である/CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen.2007

    • Author(s)
      Adachi, T., Yu, J., Ondera, T., Man, R., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells.2007

    • Author(s)
      戸田宗豊, 圓山浩二, 万木肇, 秋田薫, 井上瑞江, 竹内紀子, 安達貴弘, 鍔田武志, 中田博
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional role of inhibitory BCR Co-receptors CD22 and CD72.2007

    • Author(s)
      Tsubata, T.
    • Organizer
      1st International Singapore Symposium of Immunology.
    • Place of Presentation
      Biopolis, Singapore.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Design and synthesis of novel sialosides at : potential CD22-specific inhihibitors.2007

    • Author(s)
      Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
    • Organizer
      XIX International Symposium on Glycoconjugates. (Glyco-19)
    • Place of Presentation
      Cairns, Australia.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors2007

    • Author(s)
      Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
    • Organizer
      XIX International Symposium on Glycoconjugates.
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2007 Annual Research Report
  • [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors2007

    • Author(s)
      A, A, H, H, Mohamed., Tsubata, T., Ishida, H., Kiso, M.
    • Organizer
      The 2nd Annual meeting of Japanese society for chemical biology
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] The alternatively spliced isoform of human CD72 that confers resistance against systemic lupus erythematosus regulats B lymphocyte apoptosis.2007

    • Author(s)
      Hitomi, Y., Adachi, T., Tsuchiya, N., Honda, Z., Tokunaga, K., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] The kinetics of antibody response is regulated by CD222007

    • Author(s)
      Onodera, T., Poe, J, C., Tedder, T, F., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害/ Synthetic glycan Iigand excludes CD22 from antigen receptor-containing lipid rafts.2007

    • Author(s)
      Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling2007

    • Author(s)
      Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白抗原が必要であ/CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen2007

    • Author(s)
      Adachi, T., Yu, J., Ondera, T., Man, R., Tsubata, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells2007

    • Author(s)
      戸田宗豊, 圓山浩二, 万木肇, 秋田薫, 井上瑞江, 竹内紀子, 安達貴弘, 鍔田武志, 中田博
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] B cell tolerance and autoimmunity.2006

    • Author(s)
      Tsubata, T.
    • Organizer
      FMSA/IIS Advanced Course on Immunology
    • Place of Presentation
      New Delhi, India
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunoglobulin isotype-dependent regulation of B cell antigen receptor signaling mediated by Siglec2/CD22.2006

    • Author(s)
      Tsubata, T.
    • Organizer
      The 5^<th> Sialoglycoscience 2006 International Conference.
    • Place of Presentation
      Mishima
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunosuppressive effect of mucin on2006

    • Author(s)
      Toda M, Takeuchi N, Inoue M, Adachi T, Matsubara J, Taketani S, Tsubata T, Murata T, Nakada H.
    • Organizer
      20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress.
    • Place of Presentation
      Kyoto, japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling.2006

    • Author(s)
      Zhu C, Tsubata T, Adachi T.
    • Organizer
      20th IUBMB International Congless of Biochemistry and Molecular Biology and 1lth FAOBMB Congress.
    • Place of Presentation
      Kyoto. Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Siglec-2 is a key molecule for immune response. In "Experimental Glycoscience, Glycobiology" (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki and S. Hase)2008

    • Author(s)
      Tsubata, T
    • Total Pages
      4
    • Publisher
      Springer.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Siglec-2 is a key molecule for immune response. In "Experimental Glycoscience, Glycobiology" (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, S. Hase)2008

    • Author(s)
      Tsubata, T
    • Total Pages
      4
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] B細胞共受容体CD22とCD72の機能と糖鎖リガンドAnnual Review免疫20082007

    • Author(s)
      鍔田武志
    • Total Pages
      8
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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