Immunogenetic analysis of the resistance to infectious diseases

• Project/Area Number: 18406019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Immunology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TSUBATA Takeshi Tokyo Medical and Dental University, Laboratory of Immunology, School of Biomedical Science, Professor (80197756)
• Co-Investigator(Kenkyū-buntansha): WATANABE Kozo Laboratory of Immunology, Medical Research Institute, 難治疾患研究所, Assistant Professor (20376718)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥10,770,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
• Keywords: SARS / polymorphism / CD22 / CD72 / B lymphocyte / infectious diseases / alternative splicing / ER stress / CD7 2 / 多型 / ハプロタイプ

Research Abstract

Both CD22 and CD72 are B lymphocyte membrane molecules that negatively regulate signaling thorough B cell antigen receptor. Both CD22 and CD72 genes are polymorphic. To elucidate whether polymorphisms of these genes are associated with resistance to acute infection, we examined haplotypes of both CD22 and CD72 in SARS patients in China and individuals who were close contact with SARS patients but did not develop SARS. A CD72 haplotype was tend to be increased in patients with severe symptoms although the increase was not significant because of the limited sample numbers. Next, we examined the functional difference of different CD72 haplotypes. The human CD72 gene generates two distinct splicing isoforms, i.e., full length CD72 and CD72 lacking exon 8 (CD72 Δ ex8). We demonstrated that the level of CD72 Δ ex8 but not full length CD72 depends on CD72 haoplotypes. Moreover, CD72 Δ ex8 is accumulated in the endoplastic reticulum (ER), and augments ER stress and apoptosis mediated by ER stress. These results indicate that CD72 polymorphism regulates expression of CD72 Δ ex8 that regulates B lymphocyte apoptosis mediated by ER stress, thereby regulating infection immunity.

Research Products

• [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22specific inhibitors. (2008)
  • Author(s): Abdu-Allah, H. H. M., Tamanaka, T., Yu, J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
  • Journal Title: J. Me. l Chem. 51 Pages: 6665-6681
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The centromerio interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72b coneenic mice. (2008)
  • Author(s): Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Comm. 380 Pages: 193-197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T Siglec-2 is a key molecule for immune response. (2008)
  • Author(s): Tsubata, T
  • Journal Title: In Experimental Glycoscience, Glycobiology (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki and S. Hase) (Springer.) Pages: 167-170
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. (2007)
  • Author(s): Sato, M., Adachi, T., Tsubata, T.
  • Journal Title: J. Immunol. 178 Pages: 2901-2907
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. (2007)
  • Author(s): Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 360 Pages: 759-764
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis. (2007)
  • Author(s): Yan, B. C., Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 365 Pages: 143-148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interdomain A is crucial for ITAM-dependent and-independent regulation of Syk. (2007)
  • Author(s): Adachi, T, Wienands, J., Tsubata, T., Kurosaki, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 364 Pages: 111-117
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response. (2007)
  • Author(s): Onodera, T., Poe, J, C., Tedder, T. F., Tsubata, T.
  • Journal Title: J. Immunol. 180 Pages: 907-913
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 achtivated by B lymphocyte stimulation with antigen. (2007)
  • Author(s): Zhu, C., Fujimoto, M., Sato, M., Yanagisawa, T., Tsubata, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 1653-1659
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] FRET-based Ca^<2+> measurement in B lymphocyte by flow cytometry and confocal microscopy. (2007)
  • Author(s): Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 142 Pages: 377-382
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation. (2007)
  • Author(s): Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Comm. 374 Pages: 274-281
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22-specific inhibitors. (2007)
  • Author(s): Abdu-Allah, H. H. M., Tamanaka, T., Yu' J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
  • Journal Title: J. Me. l Chem. 51 Pages: 6665-6681
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes. (2007)
  • Author(s): Watanabe, K, Tsubata, T.
  • Journal Title: Autophagy. 5 Pages: 108-110
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells. (2007)
  • Author(s): Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
  • Journal Title: Biochem J. 417 Pages: 673-683
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD 72^b congenic mice. (2007)
  • Author(s): Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Comm. 380 Pages: 193-197
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthetic glycan ligand excludes CD22 from (2007)
  • Author(s): Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., kiso, M., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 360 Pages: 759-764
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis. (2007)
  • Author(s): Yan, B, C, Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophvs. Res. Commun. 365 Pages: 143-148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interdomain A is crucial for ITAM-dependent and independent regulation of Syk. (2007)
  • Author(s): Adachi, T., Wienands, J., Tsubata, T., Kurosaki, T.
  • Journal Title: Biochem. Bioohvs. Res. Commun. 364 Pages: 111-117
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response. (2007)
  • Author(s): Onodera. T., Poe, J, C, Tedder, T. F., Tsubata, T.
  • Journal Title: J. Immunol. 180 Pages: 907-913
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 achtivated by B lymphocyte stimulation with antigen. (2007)
  • Author(s): Zhu, C, Fujimoto, M., Sato, M., Yanagisawa, T., Tsubata, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 1653-1659
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FRET-based Ca2+ measurement in B lymphocyte by flow cytometry and confocal microscopy. (2007)
  • Author(s): Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 142 Pages: 377-382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis (2007)
  • Author(s): Yan, B, C., Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 365 Pages: 143-148
• [Journal Article] Interdomain A is crucial for ITAM-dependent and-independent regulation of Syk (2007)
  • Author(s): Adachi, T., Wienands, J., Tsubata, T., Kurosaki, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 364 Pages: 111-117
• [Journal Article] CD22 Regulates Time Course of Both B Cell Division and Antibody Response (2007)
  • Author(s): Onodera, T., Poe, J, C., Tedder. T. F., Tsubata. T.
  • Journal Title: J. Immunol. 180 Pages: 907-913
• [Journal Article] FRET-based Ca^<2+> measurement in B lymphocyte by flow cytometry and confocal microscopy (2007)
  • Author(s): Adachi, T., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 142 Pages: 377-382
• [Journal Article] Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation (2007)
  • Author(s): Watanabe, K., Ichinose, S., Hayashizaki, K., Tsubata, T
  • Journal Title: Biochem. Biophys. Res. Comm. 374 Pages: 274-281
• [Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22-specific inhibitors (2007)
  • Author(s): Abdu-Allah, H. H. M., Tamanaka, T., Yu' J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
  • Journal Title: J. Med. Chem. 51 Pages: 6665-6681
• [Journal Article] Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes (2007)
  • Author(s): Watanabe, K, Tsubata, T.
  • Journal Title: Autophagy 5 Pages: 108-110
• [Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells (2007)
  • Author(s): Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
  • Journal Title: Biochem J. 417 Pages: 673-683
• [Journal Article] The centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72^b congenic mice (2007)
  • Author(s): Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Comm. 380 Pages: 193-197
• [Journal Article] Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. (2007)
  • Author(s): Sato, M., Adachi, T. and Tsubata, T.
  • Journal Title: J. Immunol 178 Pages: 2901-2907
• [Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes. (2006)
  • Author(s): Devi, S. S., Hagiyama, H., Adachi, T., Muyasaka, N., Tsubata, T.
  • Journal Title: Signal Transduction 6 Pages: 54-61
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bispecific Abs against modified protein and DNA with oxidized (2006)
  • Author(s): Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Yatnaguchi, S., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
  • Journal Title: PNAS 103 Pages: 6160-6165
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] B cell abnormality and systemiclupus erythematosus. (2006)
  • Author(s): Tsubata, T.
  • Journal Title: APLAR J. Rheum 9 Pages: 372-376
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes. (2006)
  • Author(s): Devi, S. S., Hagiyama, H., Adachi, T., Muyasaka, N. and Tsubata, T.
  • Journal Title: Signal Transductio 6 Pages: 54-61
• [Journal Article] Bispecific Abs against modified protein and DNA with oxidized lipids. (2006)
  • Author(s): Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Yamaguchi, S., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T. and Uchida, K.
  • Journal Title: PNAS 103 Pages: 6160-6165
• [Journal Article] B cell abnormality and systemic lupus erythematosus. (2006)
  • Author(s): Tsubata, T.
  • Journal Title: APLAR J. Rheum 9 Pages: 372-376
• [Presentation] Membrane-bound lectins and humoral immunity (2009)
  • Author(s): Tsubata, T.
  • Organizer: CREST International Symposium "Acquired Immunity and Glycobiology"
  • Place of Presentation: Kazusa, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Membrane-bound lectins and humoral immunity (2009)
  • Author(s): Tsubata, T.
  • Organizer: CREST International Symposium “Acquired Immunity and Glycobiology"
  • Place of Presentation: Kazusa, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 免疫応答と組織細胞ストレス (2008)
  • Author(s): 鍔田武志
  • Organizer: 第一回センシングバイオロジー・シンポジウム(第5回IBBフロンティアシンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2008-12-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional role of inhibitory BCR co-receptors CD22 and CD72 (2008)
  • Author(s): Tsubata, T.
  • Organizer: 1^<st> International Singapore Symposium of Immunology
  • Place of Presentation: Singapore
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Endoplasmic reticulum stress and autoimmune diseases (2008)
  • Author(s): Tsubata, T.
  • Organizer: 36. Kongress der Deutschen Gesellschaft fur Rheumatologie
  • Place of Presentation: Berlin, Germany
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cell death, autophagy, cell senescence and their roles in diseases (2008)
  • Author(s): Tsubata, T.
  • Organizer: 7^<th> Surugadai International Symposium
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Antigen receptor tail clue of class-switched memory B cells (2008)
  • Author(s): N. Engels, C. Heemann, L. Koening, Tsubata, T., S. Griep, V. Schrader, J. Wienands.
  • Organizer: Joint Annual Meeting of Immunology of the Austrian and German Societies
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する (2008)
  • Author(s): 渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Increased tonic B cell antigen receptor signaling but reduced antigen-induced B cell response in transgenic B cells expressing IgG (2008)
  • Author(s): 満栄勇, 小野寺大志, 鍔田武志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SLE抵抗性を有するヒトCD 2選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する (2008)
  • Author(s): 人見祐基, 安達貴弘, 岩井佳子, 土屋尚之, 本田善一郎, 徳永勝士, 鍔田武志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性 (2008)
  • Author(s): 渡辺幸造, 安達貴弘, 鍔田武志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CD22阻害化合物の構造活性相関 (2008)
  • Author(s): 玉中大智, Hajjaj H. M. Abdu-Allah, Jie Yu, Lu Zhuoyuan, Magesh Sadagopan, 安達貴弘, 鍔田武志, Soerge Kelm, 石田秀治, 木曾眞
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CD22による糖鎖リガンド依存的および非依存的なB細胞抗原受容体シグル伝達制御 (2008)
  • Author(s): 安達貴弘, 満栄勇, 矢倉英隆, 鍔田武志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cell death, autophagy, cellsenescence and their roles in diseases (2008)
  • Author(s): Tsubata, T.
  • Organizer: 7th Surugadai International Symposium
  • Place of Presentation: Tokyo, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Antigen receptor tail clue of class-switched memory B (2008)
  • Author(s): N. Engels, C. Heemann, L. Koening, Tsubata, T., S. Griep, V. Schrader, J. Wienands.
  • Organizer: Joint Annual Meeting of Immunology of the Austrian and German Societies
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] B細胞特異的C型レクチン様分子CD72ほオリゴマンノースに対してCa2+非依存性のレクチン活性を有する (2008)
  • Author(s): 渡辺幸造, 中島権一, 今井有香, 安達貴弘, 佐藤元彦, 林崎浩史, 戸谷希一郎, 伊藤幸成, 鍔田武志
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] SLE抵抗性を有するヒトCD72選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する (2008)
  • Author(s): 人見祐基, 安達貴弘, 岩井佳子, 土屋尚之, 本田善一郎, 徳永勝士, 鍔田武志
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Bリンパ球の生と死 (2007)
  • Author(s): 鍔田武志
  • Organizer: 橋本康弘教授就任講演会
  • Place of Presentation: 福島
  • Year and Date: 2007-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 膜型レクチン分子における液性免疫応答の制御 (2007)
  • Author(s): 鍔田武志
  • Organizer: 第31回皮膚科免疫セミナー
  • Place of Presentation: 東京
  • Year and Date: 2007-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 膜型レクチン分子による免疫応答制御 (2007)
  • Author(s): 鍔田武志
  • Organizer: 理研シンポジウム第10回生体分子の化学
  • Place of Presentation: 和光市
  • Year and Date: 2007-01-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional role of inhibitory BCR Co-receptors CD22 and CD72. (2007)
  • Author(s): Tsubata, T.
  • Organizer: 1^<st> International Singapore Symposium of Immunology.
  • Place of Presentation: Biopolis, Singapore.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors. (2007)
  • Author(s): Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: XIX International Symposium on Glycoconjugates.
  • Place of Presentation: Cairns, Australia.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗原受容体を介するBリンパ球アポトーシスの分子メカニズム (2007)
  • Author(s): 鍔田武志
  • Organizer: 平成19年生理学研究会
  • Place of Presentation: 東岡崎
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors. (2007)
  • Author(s): A, A, H, H, Mohamed., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: The 2nd Annual meeting of Japanese society for chemical biology
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 糖鎖リガンド類似化合物によるBリンパ球活性化制御分子CD22の機能制御 (2007)
  • Author(s): Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The alternatively s pliced isoform of human CD72 that confers resistance against systemic lupus erythematosus regulats B lymphocyte apoptosis. (2007)
  • Author(s): Hitomi, Y., Adachi, T., Tsuchiya, N., Honda, Z., Tokunaga, K., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The kinetics of antibody response is regulated by CD22. (2007)
  • Author(s): Onodera, T., Poe, J, C., Tedder, T, F., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害/Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. (2007)
  • Author(s): Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスがB細胞抗原受容体を介したアポトーシスに関与する/Unfolded protein response is involved in B cell antgen receptor-mediated apoptosis. (2007)
  • Author(s): Yan, B., Adachi, T., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling. (2007)
  • Author(s): Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白抗原が必要である/CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen. (2007)
  • Author(s): Adachi, T., Yu, J., Ondera, T., Man, R., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells. (2007)
  • Author(s): 戸田宗豊, 圓山浩二, 万木肇, 秋田薫, 井上瑞江, 竹内紀子, 安達貴弘, 鍔田武志, 中田博
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional role of inhibitory BCR Co-receptors CD22 and CD72. (2007)
  • Author(s): Tsubata, T.
  • Organizer: 1st International Singapore Symposium of Immunology.
  • Place of Presentation: Biopolis, Singapore.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of novel sialosides at : potential CD22-specific inhihibitors. (2007)
  • Author(s): Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: XIX International Symposium on Glycoconjugates. (Glyco-19)
  • Place of Presentation: Cairns, Australia.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors (2007)
  • Author(s): Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: XIX International Symposium on Glycoconjugates.
  • Place of Presentation: Cairns, Australia
• [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors (2007)
  • Author(s): A, A, H, H, Mohamed., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: The 2nd Annual meeting of Japanese society for chemical biology
  • Place of Presentation: 京都
• [Presentation] The alternatively spliced isoform of human CD72 that confers resistance against systemic lupus erythematosus regulats B lymphocyte apoptosis. (2007)
  • Author(s): Hitomi, Y., Adachi, T., Tsuchiya, N., Honda, Z., Tokunaga, K., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] The kinetics of antibody response is regulated by CD22 (2007)
  • Author(s): Onodera, T., Poe, J, C., Tedder, T, F., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害/ Synthetic glycan Iigand excludes CD22 from antigen receptor-containing lipid rafts. (2007)
  • Author(s): Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling (2007)
  • Author(s): Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白抗原が必要であ/CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen (2007)
  • Author(s): Adachi, T., Yu, J., Ondera, T., Man, R., Tsubata, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells (2007)
  • Author(s): 戸田宗豊, 圓山浩二, 万木肇, 秋田薫, 井上瑞江, 竹内紀子, 安達貴弘, 鍔田武志, 中田博
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] B cell tolerance and autoimmunity. (2006)
  • Author(s): Tsubata, T.
  • Organizer: FMSA/IIS Advanced Course on Immunology
  • Place of Presentation: New Delhi, India
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Immunoglobulin isotype-dependent regulation of B cell antigen receptor signaling mediated by Siglec2/CD22. (2006)
  • Author(s): Tsubata, T.
  • Organizer: The 5^<th> Sialoglycoscience 2006 International Conference.
  • Place of Presentation: Mishima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Immunosuppressive effect of mucin on (2006)
  • Author(s): Toda M, Takeuchi N, Inoue M, Adachi T, Matsubara J, Taketani S, Tsubata T, Murata T, Nakada H.
  • Organizer: 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress.
  • Place of Presentation: Kyoto, japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling. (2006)
  • Author(s): Zhu C, Tsubata T, Adachi T.
  • Organizer: 20th IUBMB International Congless of Biochemistry and Molecular Biology and 1lth FAOBMB Congress.
  • Place of Presentation: Kyoto. Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Siglec-2 is a key molecule for immune response. In "Experimental Glycoscience, Glycobiology" (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki and S. Hase) (2008)
  • Author(s): Tsubata, T
  • Total Pages: 4
  • Publisher: Springer.
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Siglec-2 is a key molecule for immune response. In "Experimental Glycoscience, Glycobiology" (ed by N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, S. Hase) (2008)
  • Author(s): Tsubata, T
  • Total Pages: 4
  • Publisher: Springer
• [Book] B細胞共受容体CD22とCD72の機能と糖鎖リガンドAnnual Review免疫2008 (2007)
  • Author(s): 鍔田武志
  • Total Pages: 8
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より