Genetic and ecologic background and resistance to malaria

• Project/Area Number: 18406025
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Public health/Health science
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIDA Takafumi The University of Tokyo, 大学院・理学系研究科, 准教授 (20184533)
• Co-Investigator(Kenkyū-buntansha): IHARA Yasuo 東京大学, 大学院・理学系研究科, 講師 (90376533) ; SHIMIZU Hana 東京大学, 大学院・理学系研究科, 助教 (80401032)
• Research Collaborator: AUGUSTINUS Soemantri ディポネゴロ大学, 医学部, 教授 ; MARIA Mexitalia ディポネゴロ大学, 医学部, 講師 ; WANNAPA Settheetham-ishida コンケン大学, 医学部, 准教授 ; KASHIMA Taeko 東京大学, 大学院・理学系研究科, 博士課程 ; ISIHARA Shoko 東京大学, 大学院・理学系研究科, 修士課程 ; KITAMURA Yumi 東京大学, 大学院・理学系研究科, 修士課程 ; NOJO Saori 東京大学, 大学院・理学系研究科, 博士課程
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,010,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥2,610,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
• Keywords: スンバ島 / マラリア / JCウイルス / ヘモグロビン異常症 / 卵形赤血球 / 集団生物学 / 社会構造 / 民族移動 / 遺伝的多様性 / 適応 / インドネシア / 民族 / 遺伝的抵抗性

Research Abstract

東南アジア島嶼部(スンバ島)における不完全免疫マラリア感染状態といくつかのマラリア抵抗性遺伝的形質の分布を明らかにした。マラリア抵抗性遺伝形質のうち、バンド3欠失型についてはハプロタイプ解析から、その起源を推定した。また、遺伝的多様性と変異型G6PDの分布から、スンバ島民の来歴について理解を深めた。

Research Products

• [Journal Article] 集団内JCウイルスゲノム型の解析による伝播動態の検討 (2010)
  • Author(s): 石原祥子, 清水華, 石田貴文
  • Journal Title: DNA多型 Vol. 18
  • NAID: 10029668299
  • Peer Reviewed
• [Journal Article] FGFR2, but not EDA, is associated with hair thickness in Asian populations (2009)
  • Author(s): Fujimoto, et al.
  • Journal Title: Journal of Human Genetics 54 Pages: 461-465
  • Peer Reviewed
• [Journal Article] The Pacific Lineage (2E) of JC Polyomavirus is Prevalent in Sumba Island (2008)
  • Author(s): Ikegaya, H., Zhong, S., Shimizu, H., Sekiyama, M., Soemantri, A., Ishida, T., Nakazawa, M., Ohtsuka, R., Takasaka, T., Shibuya, A., Kitamura, T., Yogo, Y.
  • Journal Title: Eastern Indonesia. Anthropological Science 116 Pages: 183-186
  • Peer Reviewed
• [Journal Article] Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection (2008)
  • Author(s): Nagao, Y., Kimura-Sato, M., Chavalitshewinkoon-Petmitr, P., Thongrungkiat, S., Wilairatana, P., Ishida, T., Tan-Ariya, P., Brian de Souza, J., Krudsood, S., Looareesuwan, S.
  • Journal Title: Malaria Journal 7 Pages: 113-120
  • Peer Reviewed
• [Journal Article] TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania (2007)
  • Author(s): Kashima, T., Makino, K., Soemantri, A, Ishida, T.
  • Journal Title: Journal of Human Genetics 52 Pages: 694-697
  • NAID: 10019812955
  • Peer Reviewed
• [Journal Article] TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania (2007)
  • Author(s): Kashima, T., Makino, K., Soemantri, A a
  • Journal Title: Journal of Human Genetics 52 Pages: 694-697
  • NAID: 10019812955
  • Peer Reviewed
• [Journal Article] FTO polymorphisms in Oceanic populations (2007)
  • Author(s): Ohashi, J., Naka, I., Kimura, R., Natsuha
  • Journal Title: Journal of Human Genetics 52 Pages: 1031-1035
  • Peer Reviewed
• [Journal Article] Quantitative analysis of cell-free Epstein-Barr virus DNA in the plasma of patients with peripheral (2007)
  • Author(s): Suwiwat, S., Pradutkanchana, J., Ishida,
  • Journal Title: Journal of Clinical Virology 40 Pages: 277-283
  • Peer Reviewed
• [Journal Article] Ovalocytosis without band 3 gene 27-bp deletion and malaria infection (2006)
  • Author(s): Kimura, M., Soemantri, A., Siswanto, E., Ishida, T.
  • Journal Title: Anthropological Science 114 Pages: 161-164
  • NAID: 10017650838
  • Peer Reviewed
• [Journal Article] Coexistence of five G6PD variants indicates ethnic complexity of Phuket Islanders, southern Thailand (2006)
  • Author(s): Ninokata, A., Kimura, R., Samakkarn, U., Settheetham-Ishida, W., Ishida, T.
  • Journal Title: Journal of Human Genetics 51 Pages: 424-428
  • NAID: 10019167867
  • Peer Reviewed
• [Journal Article] Coexistence of five G6PD variants indicates ethnic complexity of Phuket Islanders, southern Thailand (2006)
  • Author(s): Ninokata, et. al.
  • Journal Title: Journal of Human Genetics 51 Pages: 424-428
• [Journal Article] Ovalocytosis without band 3 gene 27-bp deletion and malaria infection (2006)
  • Author(s): Kimura, et. al.
  • Journal Title: Anthropological Science 114 Pages: 161-164
• [Journal Article] Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity (2006)
  • Author(s): Saechan, et. al.
  • Journal Title: Journal of Clinical Virology 36 Pages: 119-125
• [Presentation] 集団内JCウイルスゲノム型の解析による伝播動態の検討 (2009)
  • Author(s): 石原祥子, 清水華, 石田貴文
  • Organizer: DNA多型学会
  • Place of Presentation: 久留米
  • Year and Date: 2009-11-20
• [Presentation] 東南アジア型卵形赤血球症の原因となるSLC4A1遺伝子27塩基対欠失の起源 (2008)
  • Author(s): 佐藤正子・神田芳郎・木村博司・宝来聰・Nizam Isa・Saturnina C. Halos・Wannapa Settheetham-Ishida・Surin Pookajorn・Danai Tiwawech・Augustinus Soemantri・石田貴文
  • Organizer: 日本人類学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-03
• [Presentation] EBV detection and application in NPC (2007)
  • Author(s): Ishida, T.
  • Organizer: The IX National Cancer Conference
  • Place of Presentation: Bangkok
  • Year and Date: 2007-12-13
• [Presentation] TP53 codon 72 polymorphism in12 populations of insular Southeast Asia and Oceania. (2007)
  • Author(s): Kashima, T., Makino, K., Soemantri, A., Ishida, T.
  • Organizer: Fifth ISABS Conference in Forensic Genetics and Molecular Anthropology
  • Place of Presentation: Split, Croatia
  • Year and Date: 2007-09-11
• [Presentation] Distribution of glucose-6-phosphate dehydrogenase deficiency in Southeast Asia and Oceania (2006)
  • Author(s): Ninokata, A., Ishida, T.
  • Organizer: 11th ICHG Brisbane
  • Place of Presentation: Australia
• [Book] Cervical Cancer in Northeastern Thailand in New Research on Cervical Cancer G. Z. Rolland ed. (2007)
  • Author(s): Settheetham-Ishida, W., Ishida, T.
  • Total Pages: 247
  • Publisher: Nova Science Publishers, Inc., New York