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Genetic and ecologic background and resistance to malaria

Research Project

Project/Area Number 18406025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionThe University of Tokyo

Principal Investigator

ISHIDA Takafumi  The University of Tokyo, 大学院・理学系研究科, 准教授 (20184533)

Co-Investigator(Kenkyū-buntansha) IHARA Yasuo  東京大学, 大学院・理学系研究科, 講師 (90376533)
SHIMIZU Hana  東京大学, 大学院・理学系研究科, 助教 (80401032)
Research Collaborator AUGUSTINUS Soemantri  ディポネゴロ大学, 医学部, 教授
MARIA Mexitalia  ディポネゴロ大学, 医学部, 講師
WANNAPA Settheetham-ishida  コンケン大学, 医学部, 准教授
KASHIMA Taeko  東京大学, 大学院・理学系研究科, 博士課程
ISIHARA Shoko  東京大学, 大学院・理学系研究科, 修士課程
KITAMURA Yumi  東京大学, 大学院・理学系研究科, 修士課程
NOJO Saori  東京大学, 大学院・理学系研究科, 博士課程
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥16,010,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Keywordsスンバ島 / マラリア / JCウイルス / ヘモグロビン異常症 / 卵形赤血球 / 集団生物学 / 社会構造 / 民族移動 / 遺伝的多様性 / 適応 / インドネシア / 民族 / 遺伝的抵抗性
Research Abstract

東南アジア島嶼部(スンバ島)における不完全免疫マラリア感染状態といくつかのマラリア抵抗性遺伝的形質の分布を明らかにした。マラリア抵抗性遺伝形質のうち、バンド3欠失型についてはハプロタイプ解析から、その起源を推定した。また、遺伝的多様性と変異型G6PDの分布から、スンバ島民の来歴について理解を深めた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 2007 2006

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (1 results)

  • [Journal Article] 集団内JCウイルスゲノム型の解析による伝播動態の検討2010

    • Author(s)
      石原祥子, 清水華, 石田貴文
    • Journal Title

      DNA多型 Vol. 18

    • NAID

      10029668299

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] FGFR2, but not EDA, is associated with hair thickness in Asian populations2009

    • Author(s)
      Fujimoto, et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 461-465

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Pacific Lineage (2E) of JC Polyomavirus is Prevalent in Sumba Island2008

    • Author(s)
      Ikegaya, H., Zhong, S., Shimizu, H., Sekiyama, M., Soemantri, A., Ishida, T., Nakazawa, M., Ohtsuka, R., Takasaka, T., Shibuya, A., Kitamura, T., Yogo, Y.
    • Journal Title

      Eastern Indonesia. Anthropological Science 116

      Pages: 183-186

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection2008

    • Author(s)
      Nagao, Y., Kimura-Sato, M., Chavalitshewinkoon-Petmitr, P., Thongrungkiat, S., Wilairatana, P., Ishida, T., Tan-Ariya, P., Brian de Souza, J., Krudsood, S., Looareesuwan, S.
    • Journal Title

      Malaria Journal 7

      Pages: 113-120

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania2007

    • Author(s)
      Kashima, T., Makino, K., Soemantri, A, Ishida, T.
    • Journal Title

      Journal of Human Genetics 52

      Pages: 694-697

    • NAID

      10019812955

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania2007

    • Author(s)
      Kashima, T., Makino, K., Soemantri, A a
    • Journal Title

      Journal of Human Genetics 52

      Pages: 694-697

    • NAID

      10019812955

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FTO polymorphisms in Oceanic populations2007

    • Author(s)
      Ohashi, J., Naka, I., Kimura, R., Natsuha
    • Journal Title

      Journal of Human Genetics 52

      Pages: 1031-1035

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of cell-free Epstein-Barr virus DNA in the plasma of patients with peripheral2007

    • Author(s)
      Suwiwat, S., Pradutkanchana, J., Ishida,
    • Journal Title

      Journal of Clinical Virology 40

      Pages: 277-283

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovalocytosis without band 3 gene 27-bp deletion and malaria infection2006

    • Author(s)
      Kimura, M., Soemantri, A., Siswanto, E., Ishida, T.
    • Journal Title

      Anthropological Science 114

      Pages: 161-164

    • NAID

      10017650838

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of five G6PD variants indicates ethnic complexity of Phuket Islanders, southern Thailand2006

    • Author(s)
      Ninokata, A., Kimura, R., Samakkarn, U., Settheetham-Ishida, W., Ishida, T.
    • Journal Title

      Journal of Human Genetics 51

      Pages: 424-428

    • NAID

      10019167867

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of five G6PD variants indicates ethnic complexity of Phuket Islanders, southern Thailand2006

    • Author(s)
      Ninokata, et. al.
    • Journal Title

      Journal of Human Genetics 51

      Pages: 424-428

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ovalocytosis without band 3 gene 27-bp deletion and malaria infection2006

    • Author(s)
      Kimura, et. al.
    • Journal Title

      Anthropological Science 114

      Pages: 161-164

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity2006

    • Author(s)
      Saechan, et. al.
    • Journal Title

      Journal of Clinical Virology 36

      Pages: 119-125

    • Related Report
      2006 Annual Research Report
  • [Presentation] 集団内JCウイルスゲノム型の解析による伝播動態の検討2009

    • Author(s)
      石原祥子, 清水華, 石田貴文
    • Organizer
      DNA多型学会
    • Place of Presentation
      久留米
    • Year and Date
      2009-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 東南アジア型卵形赤血球症の原因となるSLC4A1遺伝子27塩基対欠失の起源2008

    • Author(s)
      佐藤正子・神田芳郎・木村博司・宝来聰・Nizam Isa・Saturnina C. Halos・Wannapa Settheetham-Ishida・Surin Pookajorn・Danai Tiwawech・Augustinus Soemantri・石田貴文
    • Organizer
      日本人類学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] EBV detection and application in NPC2007

    • Author(s)
      Ishida, T.
    • Organizer
      The IX National Cancer Conference
    • Place of Presentation
      Bangkok
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] TP53 codon 72 polymorphism in12 populations of insular Southeast Asia and Oceania.2007

    • Author(s)
      Kashima, T., Makino, K., Soemantri, A., Ishida, T.
    • Organizer
      Fifth ISABS Conference in Forensic Genetics and Molecular Anthropology
    • Place of Presentation
      Split, Croatia
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Distribution of glucose-6-phosphate dehydrogenase deficiency in Southeast Asia and Oceania2006

    • Author(s)
      Ninokata, A., Ishida, T.
    • Organizer
      11th ICHG Brisbane
    • Place of Presentation
      Australia
    • Related Report
      2008 Final Research Report
  • [Book] Cervical Cancer in Northeastern Thailand in New Research on Cervical Cancer G. Z. Rolland ed.2007

    • Author(s)
      Settheetham-Ishida, W., Ishida, T.
    • Total Pages
      247
    • Publisher
      Nova Science Publishers, Inc., New York
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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