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International corroboration research of effects of development and reproduction in development countries

Research Project

Project/Area Number 18406026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionMie University

Principal Investigator

YOKOYAMA Kazuhito  Mie University, 医学部, 教授 (00158370)

Co-Investigator(Kenkyū-buntansha) KITAMURA Fumihiko  三重大学, 大学院・医学系研究科, 講師 (20301145)
KIDA Hirotaka  三重大学, 大学院・医学系研究科, 助教 (00402678)
CHIBA Momoko  国際医療福祉大学, 大学院・薬科学研究科, 教授 (80095819)
MOHSEN Vigeh  労働安全衛生総合研究所, 国際情報・労働衛生研究振興センター, 研究員 (80455485)
小林 廉毅  東京大学, 大学院・医学系研究科, 教授 (70178341)
駒田 美弘  三重大学, 大学院・医学系研究科, 教授 (80186791)
荒記 俊一  独立行政法人労働安全衛生総合研究所, 理事長 (00111493)
杉山 隆  三重大学, 大学院医学系研究科, 助教授 (10263005)
Co-Investigator(Renkei-kenkyūsha) SUGIYAMA Takashi  三重大学, 大学院・医学系研究科, 准教授 (10263005)
KOMADA Yoshihiro  三重大学, 大学院・医学系研究科, 教授 (80186791)
ARAKI Shunichi  順天堂大学, 医学部, 客員教授 (00111493)
KOBAYASHI Yasuki  東京大学, 大学院・医学系研究科, 教授 (70178341)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2006: ¥5,200,000 (Direct Cost: ¥5,200,000)
Keywords妊婦 / 胎児 / 微量金属 / 生殖機能影響 / 鉛 / 生殖 / 分娩 / 微量元素 / 中国 / イラン / 農薬 / 開発途上国 / 先天異常
Research Abstract

To assess the effects of non-occupationl exposures to trace metals on pregnancy outcome, the level of trace metals in the umbilical cord blood (UCB) and the mother whole blood (MWB) samples were measured in apparently healthy mothers and their newborns in Tehran, Shanghai and Dalian. The study indicated the relationships of lead, antimony and manganese, to preeclampsia to manganese and arsenic of low birth weight child, and of lead to abortion at low level of exposure.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (49 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (30 results) (of which Peer Reviewed: 22 results) Presentation (14 results) Book (4 results) Remarks (1 results)

  • [Journal Article] 四日市公害患者の予後の男女差2010

    • Author(s)
      郭鵬, 横山和仁, 郭琳, 高橋正昭
    • Journal Title

      四日市大学環境情報論集 13

      Pages: 49-54

    • NAID

      130007697008

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The determination of 21 trace elements in maternal blood and cord blood in Dalian region.2009

    • Author(s)
      Li XW, Guan H, Piao FY, Li QJ, Xu L, Yokoyama K
    • Journal Title

      Chinese Journal of Birth Health & Heredity (in Chinese) 17,5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood cadmium levels of pregnant women and influencing factors.2009

    • Author(s)
      uan H, Piao FY, Li XW, Liu XF, Li QJ, Li F, Xu L, Yokoyama K
    • Journal Title

      Journal of Dalian Medical University (in Chinese). 31

      Pages: 534-537

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reliability and validity of Japanese version of the McGill Quality of Life Questionaire assessed by application in palliative care wards2009

    • Author(s)
      Tsujikawa M., Yokoyama K., Urakawa K., Onishi K.
    • Journal Title

      Palliative Medicine 23

      Pages: 659-664

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sense of coherence(SOC)may reduce the effects of occupational stress on mental health status among Japanese factory workers2009

    • Author(s)
      Urakawa K., Yokoyama K.
    • Journal Title

      Industrial Health 47

      Pages: 503-508

    • NAID

      130004483407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Trichlorfon on Maternal Reproduction and Mouse Embryo Development during Organogenesis2009

    • Author(s)
      Ying TIAN, Fei DAI, Li SHEN, Yi FENG, Yu GAO, Lei XU, Song HAN, Xiaoming SHEN
    • Journal Title

      Industrial Health 47

      Pages: 3013-318

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of samarium inhaled by mice : Exposure length and time-dependent change2009

    • Author(s)
      Shinohara, A., Chiba, M., Kumasaka, T.
    • Journal Title

      Journal of Radioanalytical nad Nuclear Chemistry 281

      Pages: 119-122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The determination of 21 trace elements in maternal blood and cord blood in Dalian region2009

    • Author(s)
      Li XW, Guan H, Piao FY, Li QJ, Xu L, Yokoyama K
    • Journal Title

      Chinese Journal of Birth Health & Heredity(in Chinese) 17

      Pages: 55-57

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of concentration of five air pollutants in side citizen accommodation2009

    • Author(s)
      Lu FY, Piao FY, Lu H, Guo P, Yokoyama K, Kamijima M
    • Journal Title

      Journal of Dalian Medical University(in Chinese) 31

      Pages: 204-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood cadmium levels of pregnant women and influencing factors2009

    • Author(s)
      Guan H, Piao FY, Li XW, Liu XF, Li QJ, Li F, Xu L, Yokoyama K
    • Journal Title

      Journal of Dalian Medical University(in Chinese) 31

      Pages: 534-537

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of indoor volatile organic compound concentrations2009

    • Author(s)
      LV H, Piao FY, LV Fy, Guo P, Yokoyama K, Kamijima M
    • Journal Title

      Journal of Environmental Health(in Chinese) 26

      Pages: 514-516

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood manganese concentrations and intrauterine growth restriction2009

    • Author(s)
      Vigeh M., Yokoyama K., Ramezanzadeh F., Dahaghin M., Fakhriazad E., Seyedaghamiri Z., Araki S.
    • Journal Title

      reproductive Toxicology 25

      Pages: 219-223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occupational Medicine in Iran2009

    • Author(s)
      Maria M., Vigeh M.
    • Journal Title

      Occupational Medicine 59

      Pages: 66-66

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      横山和仁(横山和仁, 下光輝一, 野村忍編)
    • Journal Title

      はじめに. 第1章-1. 付録1. 2., 診断・指導に活かすPOMS事例集初版第6刷(金子書房)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Blood manganese concentrations and intrauterine growth restriction.2008

    • Author(s)
      Vigeh M, Yokoyama K, Ramezanzadeh F, Dahaghin M, Fakhriazad E, Seyedaghamiri Z, Araki S
    • Journal Title

      Reproductive Toxicology 25

      Pages: 219-223

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mortality and life expectancy of Yokkaichi Asthma patients, Japan: Late effects of air pollution in 1960-70s.2008

    • Author(s)
      Guo P, Yokoyama K, Suenaga M, Kida H
    • Journal Title

      Environmental Health 7 8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood manganese concentrations and intrauterine growth restriction2008

    • Author(s)
      Vigeh M, Yokoyama K, Ramezanzadeh F, Dahaghin M, Fakhriazad E, Seyedaghamiri Z, Araki S
    • Journal Title

      Reproductive Toxicology 25

      Pages: 219-223

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Blood manganese concentrations and intrauterine growth restriction.2008

    • Author(s)
      Vigeh M, et al
    • Journal Title

      Reproductive Toxicology 25

      Pages: 219-223

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zinc coadministration on lead toxicity in rats2007

    • Author(s)
      Piao, et. al.
    • Journal Title

      Industrial Health 45

      Pages: 546-551

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Our recent experiences with sarin poisoning cases in Japan and pesticide users with reference to some selected chemicals2007

    • Author(s)
      Yokoyama K
    • Journal Title

      Neurotoxicology 28

      Pages: 364-373

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lead and other trace metals in preeclampsia: a case-control study in Tehran, Iran.2006

    • Author(s)
      Vigeh M, Yokoyama K, Ramezanzadeh F, Dahaghin M, Sakai T, Morita Y, Kitamura F, Sato H, Kobayashi Y
    • Journal Title

      Environmental Research 100

      Pages: 268-275

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lead and other trace metals in preeclampsia a case-control study in Tehran, Iran2006

    • Author(s)
      Vigeh, M., Yokoyama, K., Ramezanzadeh, F., Dahaghin, M., Sakai, T., Morita, Y., Kitamura, F., Sato, H., Kobayashi, Y.
    • Journal Title

      Environmental Research 100

      Pages: 268-275

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Relationships of eating disturbances to alexithymia, need for social approval, and gender identity among Japanese female undergraduate students.2006

    • Author(s)
      Kiyotaki, y.
    • Journal Title

      Personality and Individual Differences 41

      Pages: 609-618

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreases in CD8+T, na□ve (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.2006

    • Author(s)
      Nakata, A.
    • Journal Title

      Industtrial Health 44

      Pages: 592-597

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Early Pregnancy Blood Lead levels and the Risk of Premature Rupture of the Membranes.

    • Author(s)
      Vigeh M, Yokoyama K, Shinohara A, Afshinrokh M, Yunesain M
    • Journal Title

      Reproductive Toxicology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase in Blood Lead at Currently Accepted Levels may Cause Preterm Labor.

    • Author(s)
      Vigeh M, Yokoyama K, Seyedaghamiri Z, Shinohara A, Matsukawa T, Chiba M, Yunesain M
    • Journal Title

      Occupational and Environmental Medicine (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxic damage in female resideents exposed to environmental air pollution in Shenyang city, China.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Cancer Letters (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The association between risk factors and low back pain among commercial vehicle drivers in Peninsular Malaysia : a preliminary result.

    • Author(s)
      Tamrin, S.B.M.
    • Journal Title

      Industrial Health (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals.

    • Author(s)
      Yokoyama, K.
    • Journal Title

      Neurotoxicology (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Low-levels of Blood Lead and Abortion.2009

    • Author(s)
      Vigeh M
    • Organizer
      29th International Congress on Occupational Health
    • Place of Presentation
      Cape Town, South.
    • Related Report
      2009 Final Research Report
  • [Presentation] 吸入曝露したサマリウムとセリウムの体内挙動の比較2009

    • Author(s)
      篠原厚子, 松川岳久, 熊坂利夫, 千葉百子
    • Organizer
      第26回希土類討論会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] Simultaneous determination of the enantiomers of selenomethionine and[2H3,82Se]selenomethionine in biological fluid by capillary gas chromatography mass spectrometry2009

    • Author(s)
      Matsukawa T, Hasegawa H, Shinohara Y, Kobayashi J, Shinohara A, Chiba M, Inaba Y, Ichida K, Yokoyama K
    • Organizer
      he 1st International Conference of D-Amino Acid Research
    • Place of Presentation
      Awaji
    • Related Report
      2009 Annual Research Report
  • [Presentation] アラル海東岸地域に住む小児の腎機能と尿中元素濃度の地域差と経年変化2009

    • Author(s)
      篠原厚子, 長岡理恵子, 扇原淳, 下田妙子, 佐々木敏, 千葉百子
    • Organizer
      第20回日本微量元素学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスに吸入曝露した希土類の体内分布と経時変化のICP-MSによる検討2009

    • Author(s)
      篠原厚子, 松川岳久, 千葉百子, 小林淳, 横山和仁
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非精神科一般医の思春期精神病理早期介入への関わり2009

    • Author(s)
      高村光幸, 萩典子, 横山和仁
    • Organizer
      第13回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 労働者メンタルヘルス不調の予防と早期支援のあり方に関する研究2009

    • Author(s)
      谷伊織, 横山和仁, 大久保豪, 鈴木麻揚, 池田若葉
    • Organizer
      日本産業衛生学会産業神経・行動学研究会(第21回)/日本衛生学会脳・神経学研究会/日本神経行動毒性研究会合同企画「環境と脳・神経」
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 上海市における非職業性低濃度微量金属曝露による新生児体重への影響2008

    • Author(s)
      許蕾, 横山和仁, 北村文彦, 木田博隆
    • Organizer
      第23回三重母性衛生学会総会・学術総会
    • Place of Presentation
      津
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトの生殖機能におけるマンガンの毒性:妊娠結果について.2008

    • Author(s)
      モーセンヴィージェ, 斉藤宏之, 横山和仁
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Mortality and life expectancy of Yokkaichi Asthma patients, Japan: Late effects of sulfur oxide air pollution occurred in 1960-1970s.2008

    • Author(s)
      Yokoyama K, Guo P, Suenaga M, Kida H
    • Organizer
      The 20th International Conference on Epidemiology in Occupational Health and 10th International symposium on Neurobehavioral Methods and Effects in Environmental and Occupational Health
    • Place of Presentation
      Costa Rica.
    • Related Report
      2009 Final Research Report
  • [Presentation] 血中の超微量元素測定法の検討と臍帯血への応用.2008

    • Author(s)
      篠原厚子, 千葉百子, 松川岳久, 稲葉裕, Mohsen Vigeh, Elham Fakhriazad, 北村文彦, 横山和仁
    • Organizer
      第19回日本微量元素学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 血中の超微量元素測定法の検討と臍帯血への適用2008

    • Author(s)
      篠原厚子、千葉百子、松川岳久、稲葉裕、Fakhriazad E、Vigeh M、北村文彦、横山和仁
    • Organizer
      第19回日本微量元素学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] Respiratory mortality and life expectancy of Yokkaichi Asthma patients.2007

    • Author(s)
      Guo P, Yokoyama K, Suenaga M, Kida H
    • Organizer
      第7回国際環境シンポジウム「四日市学」三重大学
    • Place of Presentation
      津
    • Related Report
      2009 Final Research Report
  • [Presentation] マレーシアのたばこ作業者の農薬曝露による神経影響2007

    • Author(s)
      北村文彦 ほか
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Book] 診断・指導に活かすPOMS事例集 初版第6刷(はじめに.第1章-1.付録1.2.)2009

    • Author(s)
      横山和仁(横山和仁,下光輝一,野村忍編)
    • Publisher
      金子書房
    • Related Report
      2009 Final Research Report
  • [Book] 病気予防百科2007

    • Author(s)
      北村文彦, 横山和仁:鉛中毒. 渡邊昌, 和田攻(監修)
    • Publisher
      日本医療企画
    • Related Report
      2009 Final Research Report
  • [Book] Progress in Environmental Research(Willis IC(Ed), Epidemiology and environmental pollution: a lesson from Yokkaichi Asthma, Japan)2007

    • Author(s)
      Yoshida K, Morio K, Yokoyama K
    • Publisher
      Nova Science Publishers, Inc
    • Related Report
      2009 Final Research Report
  • [Book] 四日市学講義(朴恵叔(編), 環境問題への疫学的アプローチの意義)2007

    • Author(s)
      横山和仁, 角田弘子
    • Publisher
      風媒社
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.medic.mie-u.ac.jp/pubhealth

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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