| Project/Area Number |
18406032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MATSUO Seiichi Nagoya University, Graduate School of Medicine, Professor (70190410)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINO Yasuhiko Juntendo University, School of Medicine, Professor (60130077)
IMAI Enyu Osaka University, Graduate School of Medicine, Associate Professor (00223305)
HORIO Masaru Osaka University, Graduate School of Medicine, Professor (20273633)
YASUDA Yoshinari Nagoya University, Graduate School of Medicine, Designated Assistant Professor (60432259)
TANIMOTO Mitsuo Juntendo University, School of Medicine, Assistant Professor (00420836)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥12,770,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | chronic kidney disease (CKD) / glomerular filtration rate (GFR) / GFR equation / inulin clearance / 糸球体濾過値(GFR) / 国際情報交換 / 韓国:中国 |
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| Research Abstract |
Glomerular filtration rate (GFR) Project by Japanease Society of Nephrology was carried among 80 collaborating centers all over Japan and new Japanese GFR equations were developed in 413 participants and validated in 350 participants. In our study, GFR was evaluated in 95 Japanese cases.
Protocol of inulin clearance (Cin) was simplified in this study. In the standard method, GFR is evaluated by 3 sets of Cin for 30 minutes, which is not practical in clinical use. GFR evaluated with 2 consecutive Cin for 30 minutes was compared to those with 3 consecutive one in 737 cases. GFR by 2 consecutive Cin showed high correlation coefficients against GFR by 3 Cin tests (r=0.988). Root mean square error (RMSE) was 5.3 ml/min per 1.73 m^2. Therefore, GFR was evaluated by simplified Cin protocol with 2 consecutive Cin tests in this study.
Doctor driven clinical trials of Cin tests were conducted in Korea and Taiwan. Using simplified Cin protocol, GFR was evaluated in 113 Korean and 200 Taiwanese cases and Japanse GFR equation was validated. All samples were assayed in a central laboratory in Japan. No severe adverse event by Cin test was reported. Accuracy within 30% of measured GFR was 74% for Japanese equation, which is greater than that of MDRD or Cockroft-Gault equation.
In conclusion, Japanese GFR equation are more accurate for the Korean and Taiwanese population than the previously reported equations.
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