Studies of mechanisms of theta burst stimulation and other repetitive TMS using non-invasive neuroimaging methods
Project/Area Number |
18500236
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | Fukushima Medical University (2007) The University of Tokyo (2006) |
Principal Investigator |
UGAWA Yoshikazu Fukushima Medical University, DEPF Neurol, Professor (50168671)
|
Co-Investigator(Kenkyū-buntansha) |
TERAO Yasuo Tokyo Univ. Hospital, Dept Neurol, Assistant Professor (20343139)
HANAJIMA Ritsuko Tokyo Univ. Hospital, Dept Neurol, Assistant Professor (80396738)
|
Project Period (FY) |
2006 – 2007
|
Project Status |
Completed (Fiscal Year 2007)
|
Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
Keywords | Renetitive TMS / LTP / LTD / Motor cortex / monophasic stimulation |
Research Abstract |
Effects of theta burst TMS measured by NIRS Cerebral blood flow (CBF) changes induced by TBS over the primary motor cortex were measured by near infrared spectroscopic recording in normal volunteers. TBS over M1 induced CBF decrease at the contralateral motor cortex and increase at the contralateral sensory cortex. They indicate the mutual inhibitory interaction between bilateral motor cortices and between ipsilateral sensori-motor cortices. These interactions may explain some beneficial remote effects in rTMS. treatment. Comparisons of the long lasting after effects between monophasic and biphasic rTMS in humans We compared the after effects induced by monopahsic and biphasic rTMS over the primary motor cortex in humans using several neurophysiological measures. Monophasic rTMS elicited greater and longer facilitatory short lasting after effects on the primary motor cortex as compared with widely used biphasic rTMS. This suggests that rTMS using monophasic pulses may be superior to the w
… More
idely used biphasic rTMS in the treatment of several disorders. The origin of facilitation induced by repetitive paired pulse TMS over the M1 Several measures of cortical and spinal excitability were obtained before and after the repetitive paired pulse TMS (rPPS) of the primary motor cortex. The motor cortical excitability was increased by rPPS of M1 without any changes in the spinal motoneuronal excitability. It indicates that rPPS produces motor cortical facilitation. Physiological results suggest that this facilitation is not due to the membrane excitability changes, but may be due to synaptic efficacy changes at the motor cortex. The repetitive, monophasic quadric-pulse TMS We proposed a brand new repetitive TMS stimulation method to induce a long term after effects. One train consists of four monophasic TMS pulses. We gave a train every five seconds for thirty minutes (total 1440 pulses) (repetitive quadric-pulse TMS (rQPS)) over the primary motor cortex. The after effects induced by rQPS were much greater and lasted much longer than those induced by rPPS. Several physiological parameters to estimate motor cortical excitability and synaptic efficacy were compared between after rPPS and rQPS. These results suggest that QPS had powerful effects on the motor cortical synaptic efficacy. Based on the above results, we conclude that the QPS is the best method of TMS for the treatment for neurological disorders. Less
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Short and long duration transcranial direct current stimulation (tDCS) over the human hand motor area.2008
Author(s)
Furubayashi, T., Terao, Y., Arai, N., Okabe, S., Mochizuki, H, Hanajima, R., Hamada, M., Yugeta, A., Inomata-Terada, S., Ugawa, Y
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Journal Title
Exp Brain Res 185
Pages: 279-286
Description
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[Journal Article] Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation.2008
Author(s)
Iwata, NK., Aoki, S., Okabe, S., Arai, N., Terao, Y., Kwak, S., Abe, O., Kanazawa, I., Tsuji, S., Ugawa, Y
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Journal Title
Neurology 70
Pages: 528-532
Description
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[Journal Article] Origin of facilitation in repetitive,1.5 ms interval,paired pulse transcranial magnetic stimulation (rPPS)of the human motor cortex2007
Author(s)
Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
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Journal Title
Clin Neurophysiol 118
Pages: 1596-1601
Description
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[Journal Article] Quadro-pulse stimulation is more effective than paired pulse stimulation for plasticity induction of the human motor cortex.2007
Author(s)
Hamada, M., Hanajima, R., Terao, Y., Arai, N., Furubayashi, T., Inomata-Terada, S., Yugeta, A., Matsumoto, H., Shiroata, Y., Ugawa, Y
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Journal Title
Clin Neurophysiol 118
Pages: 2672-2682
Description
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[Journal Article] Differences in after-effect between monophasic and biphasic high-frequency rTMS of the human motor cortex.2007
Author(s)
Arai, N., Okabe, S., Furubayashi, T., Mochizuki, H., Iwata, NK., Hanajima, R., Terao, Y., Yuasa, K., Ugawa, Y
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Journal Title
Clin Neurophysiol 118
Pages: 2227-2233
Description
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[Journal Article] Comparison of different methods for estimating motor threshold with transcranial magnetic stimulation.2007
Author(s)
Hanajima, R., Wang, R., Nakatani-Enomoto, S., Hamada, M., Terao, Y., Furubayashi, T., Okabe, S., Inomata-Terada, S., Yugeta, A., Rothwell, JC., Ugawa, Y
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Journal Title
Clin Neurophysiol 118
Pages: 2120-2122
Description
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[Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex2007
Author(s)
Hamada, M., Hanajima, R., Terao, Y., Arai, N., Furubayashi, T., Inomata-Terada, S., Yugeta, A., Matsumoto, H., Shiroata, Y., Ugawa, Y
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Journal Title
Clin Neurophysiol 118
Pages: 1596-1601
Description
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[Journal Article] Modifying the cortical processing for motor preparation by repetitive transcaranikal magnetic stimulation.2007
Author(s)
Terao, Y., Furubayashi, T., Okabe, S., Mochizuki, H., Arai, N., Kobayashi, S., Ugawa, Y
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Journal Title
J Cognitive Neurosci 19
Pages: 1556-1573
Description
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[Journal Article] Hemoglobin concentration changes in the contralateral hemishphere during and after theta burst stimulation of the human motor cortices2007
Author(s)
Mochizuki, H., Furubayashi, T., Hanajima, R., Terao, Y., Okabe, S., Ugawa, Y
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Journal Title
Exp Brain Res 180
Pages: 667-675
Description
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[Journal Article] Median nerve somatosensory evoked potentials and their high-frequency oscillations in amyotrophic lateral sclerosis.2007
Author(s)
Hamada, M., Hanajima, R., Terao, Y., Sato, F., Okano, T., Yuasa, K., Furubayashi, T., Okabe, S., Arai, N., Ugawa, Y
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Journal Title
Olin Neurophysiol 118
Pages: 877-886
Description
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[Journal Article] J Neurol 254 : 442.447, 20072007
Author(s)
Terao, Y., Ugawa, Y., Yamamoto, T., Sakurai, Y., Matsumoto, T., Abe, O., Mtsutani, Y., Aoki, S., Tsuji, S
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Journal Title
J Neurol 254
Pages: 442-447
Description
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[Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex2007
Author(s)
Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
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Journal Title
Clin Neurophysiol 118
Pages: 1596-1601
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[Journal Article] Task-guided selection of the dual neural pathways for reading2006
Author(s)
Nakamura, K., Hara, N., Kouder, S., Takayama, Y., Sakai, K., Ugawa, Y
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[Journal Article] Vocal amusia in a professinal tango singer due to a right superior temporal cortex infarction.2006
Author(s)
Terao, Y., Mizuno, T., Shindoh, M., Sakurai, Y., Ugawa, Y., Kobayashi, S., Nagai, C., Furubayashi, T., Arai, N., Okabe, S., Mochizuki, H., Hanajima, R., Tsuji, S
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Journal Title
Neuropsychologia 44(3)
Pages: 479-488
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[Journal Article] Difference in intracortical inhibition of the motor cortex between cortical myoclonus and focal hand dystonia
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Hanajima, R., Okabe, S., Terao, Y., Furubayashi, T., Inomata-Terada, S., Hamada, M., Yugeta, A., Ugawa, Y
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Journal Title
Clin Neurophysiol (in press)
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[Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex
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Hamada M, Hanajima R, Terao Y, Arai N, Furubaynshi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
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Clin Neurophysiol In press
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[Presentation] Effects of electromagnetic field exposure from mobile phone base stations:Does it differ between subjects with mobile phoen related symptom and those without?-A population-based questionnaire survey and provocation study in Japan2007
Author(s)
Ugawa Y, Terao Y, Furubayashi T, Mizuno Y, Shirasawa K, Kageyama A, Okano T, Nishikawa M, Miyawaki K, Yasuda A, Uchiyama M, Yamashita HK, Ushiyama A, Masuda H, Hirota S, Takahashi M, Sokijima S, Maruyama E, Pongpaibool P, Wake K, Watababe S, Taki M, Oukubo C
Organizer
The Bioelectromagnetics Society 29th Annual Meeting
Place of Presentation
Kanazawa,Japan
Description
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[Presentation] 磁気刺激法の最前線2007
Author(s)
宇川 義一
Organizer
第37回 日本臨床神経生理学会学術大会
Place of Presentation
宇都宮
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[Presentation] Effects of electromagnetic field exposure from mobile phone base stations: Does it differ between subjects with mobile phoen related symptom and those without? - A population - based questionnaire survey and provocation study in Japan.2007
Author(s)
Ugawa Y, Terao Y, Furubayashi T, Mizuno Y, Shirasawa K, Kageyama A, Okano T, Nishikawa M, Miyawaki K, Yasuda A, Uchiyama M, Yamashita HK, Ushiyama A, Masuda H, Hirota S, Takahashi M, Sokijima S, Maruyama E, Pongpaibool P, Wake K, Watababe S, Taki M, Oukubo C
Organizer
The Bioelectromagnetics Society 29th Annual Meeting
Place of Presentation
Kanazawa, Japan
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