Studies of mechanisms of theta burst stimulation and other repetitive TMS using non-invasive neuroimaging methods

• Project/Area Number: 18500236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Fukushima Medical University (2007); The University of Tokyo (2006)
• Principal Investigator: UGAWA Yoshikazu Fukushima Medical University, DEPF Neurol, Professor (50168671)
• Co-Investigator(Kenkyū-buntansha): TERAO Yasuo Tokyo Univ. Hospital, Dept Neurol, Assistant Professor (20343139) ; HANAJIMA Ritsuko Tokyo Univ. Hospital, Dept Neurol, Assistant Professor (80396738)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: Renetitive TMS / LTP / LTD / Motor cortex / monophasic stimulation

Research Abstract

Effects of theta burst TMS measured by NIRS
Cerebral blood flow (CBF) changes induced by TBS over the primary motor cortex were measured by near infrared spectroscopic recording in normal volunteers. TBS over M1 induced CBF decrease at the contralateral motor cortex and increase at the contralateral sensory cortex. They indicate the mutual inhibitory interaction between bilateral motor cortices and between ipsilateral sensori-motor cortices. These interactions may explain some beneficial remote effects in rTMS. treatment.
Comparisons of the long lasting after effects between monophasic and biphasic rTMS in humans
We compared the after effects induced by monopahsic and biphasic rTMS over the primary motor cortex in humans using several neurophysiological measures. Monophasic rTMS elicited greater and longer facilitatory short lasting after effects on the primary motor cortex as compared with widely used biphasic rTMS. This suggests that rTMS using monophasic pulses may be superior to the w idely used biphasic rTMS in the treatment of several disorders.
The origin of facilitation induced by repetitive paired pulse TMS over the M1
Several measures of cortical and spinal excitability were obtained before and after the repetitive paired pulse TMS (rPPS) of the primary motor cortex. The motor cortical excitability was increased by rPPS of M1 without any changes in the spinal motoneuronal excitability. It indicates that rPPS produces motor cortical facilitation. Physiological results suggest that this facilitation is not due to the membrane excitability changes, but may be due to synaptic efficacy changes at the motor cortex.
The repetitive, monophasic quadric-pulse TMS
We proposed a brand new repetitive TMS stimulation method to induce a long term after effects. One train consists of four monophasic TMS pulses. We gave a train every five seconds for thirty minutes (total 1440 pulses) (repetitive quadric-pulse TMS (rQPS)) over the primary motor cortex. The after effects induced by rQPS were much greater and lasted much longer than those induced by rPPS. Several physiological parameters to estimate motor cortical excitability and synaptic efficacy were compared between after rPPS and rQPS. These results suggest that QPS had powerful effects on the motor cortical synaptic efficacy.
Based on the above results, we conclude that the QPS is the best method of TMS for the treatment for neurological disorders.

Research Products

• [Journal Article] Modifying the cortical processing for motor preparation by repetitive transcaranikal magnetic stimulation (2008)
  • Author(s): Terao Y, Furubayashi T, Okabe S, Mochizuki H, Arai N, Kobayashi S, Ugawa Y
  • Journal Title: J Cognitive Neurosci 185 Pages: 279-286
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Short and long duration transcranial direct current stimulation (tDCS) over the human hand motor area. (2008)
  • Author(s): Furubayashi, T., Terao, Y., Arai, N., Okabe, S., Mochizuki, H, Hanajima, R., Hamada, M., Yugeta, A., Inomata-Terada, S., Ugawa, Y
  • Journal Title: Exp Brain Res 185 Pages: 279-286
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation. (2008)
  • Author(s): Iwata, NK., Aoki, S., Okabe, S., Arai, N., Terao, Y., Kwak, S., Abe, O., Kanazawa, I., Tsuji, S., Ugawa, Y
  • Journal Title: Neurology 70 Pages: 528-532
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modifying the cortical processing for motor preparation by repetitive transcaranikal magnetic stimulation. (2008)
  • Author(s): Terao Y, Furubayashi T, Okabe S, Hochizuki H, Arai N, Kobayashi S, Ugawa Y
  • Journal Title: J Cognitive Neurosci 185 Pages: 279-286
  • Peer Reviewed
• [Journal Article] Quadro-pulse stimulation is more effective than paired pulse stimulation for plasticity induction of the human motor cortex (2007)
  • Author(s): Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2672-2682
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Differences in after-effect between monophasic and biphasic high-frequency rTMS of the human motor cortex (2007)
  • Author(s): Arai N, Okabe S, Furubayashi T, Mochizuki H, Iwata NK, Hanajima R, Terao Y, Yuasa K, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2227-2233
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Origin of facilitation in repetitive,1.5 ms interval,paired pulse transcranial magnetic stimulation (rPPS)of the human motor cortex (2007)
  • Author(s): Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 1596-1601
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hemoglobin concentration changes in the contralateral hemishphere during and after theta burst stimulation of the human motor cortices (2007)
  • Author(s): Mochizuki H, Furubayashi T, Hanajima R, Terao Y, Okabe S, Ugawa Y
  • Journal Title: Exp Brain Res 180 Pages: 667-675
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Quadro-pulse stimulation is more effective than paired pulse stimulation for plasticity induction of the human motor cortex. (2007)
  • Author(s): Hamada, M., Hanajima, R., Terao, Y., Arai, N., Furubayashi, T., Inomata-Terada, S., Yugeta, A., Matsumoto, H., Shiroata, Y., Ugawa, Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2672-2682
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differences in after-effect between monophasic and biphasic high-frequency rTMS of the human motor cortex. (2007)
  • Author(s): Arai, N., Okabe, S., Furubayashi, T., Mochizuki, H., Iwata, NK., Hanajima, R., Terao, Y., Yuasa, K., Ugawa, Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2227-2233
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of different methods for estimating motor threshold with transcranial magnetic stimulation. (2007)
  • Author(s): Hanajima, R., Wang, R., Nakatani-Enomoto, S., Hamada, M., Terao, Y., Furubayashi, T., Okabe, S., Inomata-Terada, S., Yugeta, A., Rothwell, JC., Ugawa, Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2120-2122
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex (2007)
  • Author(s): Hamada, M., Hanajima, R., Terao, Y., Arai, N., Furubayashi, T., Inomata-Terada, S., Yugeta, A., Matsumoto, H., Shiroata, Y., Ugawa, Y
  • Journal Title: Clin Neurophysiol 118 Pages: 1596-1601
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characteristics and distribution of somatosensory evoked potentials in the subthalamic region. (2007)
  • Author(s): Kitagawa, M., Murata, J., Vesugi, H., Hanajima, R., Ugawa, Y
  • Journal Title: J Neurosurg 107 Pages: 548-554
  • NAID: 10024369178
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modifying the cortical processing for motor preparation by repetitive transcaranikal magnetic stimulation. (2007)
  • Author(s): Terao, Y., Furubayashi, T., Okabe, S., Mochizuki, H., Arai, N., Kobayashi, S., Ugawa, Y
  • Journal Title: J Cognitive Neurosci 19 Pages: 1556-1573
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hemoglobin concentration changes in the contralateral hemishphere during and after theta burst stimulation of the human motor cortices (2007)
  • Author(s): Mochizuki, H., Furubayashi, T., Hanajima, R., Terao, Y., Okabe, S., Ugawa, Y
  • Journal Title: Exp Brain Res 180 Pages: 667-675
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Median nerve somatosensory evoked potentials and their high-frequency oscillations in amyotrophic lateral sclerosis. (2007)
  • Author(s): Hamada, M., Hanajima, R., Terao, Y., Sato, F., Okano, T., Yuasa, K., Furubayashi, T., Okabe, S., Arai, N., Ugawa, Y
  • Journal Title: Olin Neurophysiol 118 Pages: 877-886
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracortical inhibition of the motor cortex in Segawa's disease (DYT5) (2007)
  • Author(s): Hanajima, R., Nomura, Y., Segawa, M., Ugawa, Y
  • Journal Title: Neurology 68 Pages: 1039-1044
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] J Neurol 254 : 442.447, 2007 (2007)
  • Author(s): Terao, Y., Ugawa, Y., Yamamoto, T., Sakurai, Y., Matsumoto, T., Abe, O., Mtsutani, Y., Aoki, S., Tsuji, S
  • Journal Title: J Neurol 254 Pages: 442-447
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Quadro-pulse stimulation is more effective than paired pulse stimulation for plasticity induction of the human motor cortex. (2007)
  • Author(s): Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2672-2682
  • Peer Reviewed
• [Journal Article] Differences in after-effect between monophasic and biphasic high-frequency rTMS of the human motor cortex. (2007)
  • Author(s): Arai N, Okabe S, Furubayashi T, Mochizuki H, Iwata NK, Hanajima R, Terao Y, Yuasa K, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 2227-2233
  • Peer Reviewed
• [Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex (2007)
  • Author(s): Hamada M, Hanajima R, Terao Y, Arai N, Furubayashi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
  • Journal Title: Clin Neurophysiol 118 Pages: 1596-1601
  • Peer Reviewed
• [Journal Article] Task-guided selection of the dual neural pathways for reading (2006)
  • Author(s): Nakamura, K., Hara, N., Kouder, S., Takayama, Y., Sakai, K., Ugawa, Y
  • Journal Title: Neuron 52 Pages: 557-564
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vocal amusia in a professinal tango singer due to a right superior temporal cortex infarction. (2006)
  • Author(s): Terao, Y., Mizuno, T., Shindoh, M., Sakurai, Y., Ugawa, Y., Kobayashi, S., Nagai, C., Furubayashi, T., Arai, N., Okabe, S., Mochizuki, H., Hanajima, R., Tsuji, S
  • Journal Title: Neuropsychologia 44(3) Pages: 479-488
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cortical hemoglobin concetration changes under the coil induced by single-pulse TMS in humans. A simultaneous redording with near-infrared-spectroscopy. (2006)
  • Author(s): Mochizuki, H., Ugawa, Y., Terao, Y., Sakai, K
  • Journal Title: Exp Brain Res 169 Pages: 302-310
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of thirty minutes mobile phone use on the human sensory cortex. (2006)
  • Author(s): Yuasa K, Arai N, Okabe S, Tarusawa Y, Nojima T, Hanajima R, Terao Y, Ugawa Y
  • Journal Title: Clin Neurophysiol 117 Pages: 900-905
• [Journal Article] Task-guided selection of the dual neural pathways for reading (2006)
  • Author(s): Nakamura K, Hara N, Kouder S, Takayama Y, Sakai K, Ugawa Y
  • Journal Title: Neuron 52 Pages: 557-564
• [Journal Article] Difference in intracortical inhibition of the motor cortex between cortical myoclonus and focal hand dystonia
  • Author(s): Hanajima, R., Okabe, S., Terao, Y., Furubayashi, T., Inomata-Terada, S., Hamada, M., Yugeta, A., Ugawa, Y
  • Journal Title: Clin Neurophysiol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hemoglobin concentration changes in the contralateral hemishphere during and after theta burst stimulation of the human motor cortices
  • Author(s): Mochizuki H, Furubayashi T, Hanajima R, Terao Y, Okabe S, Ugawa Y
  • Journal Title: Exp Brain Res In press
• [Journal Article] Modifying the cortical processing for motor preparation by repetitive transcaranikal magnetic stimulation.
  • Author(s): Terao Y, Furubayashi T, Okabe S, Mochizuki H, Arai N, Kobayashi S, Ugawa Y
  • Journal Title: J Cognitive Neurosci In press
• [Journal Article] Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex
  • Author(s): Hamada M, Hanajima R, Terao Y, Arai N, Furubaynshi T, Inomata-Terada S, Yugeta A, Matsumoto H, Shiroata Y, Ugawa Y
  • Journal Title: Clin Neurophysiol In press
• [Journal Article] Characteristics and distribution of somatosensory evoked potentials in the subthalamic region.
  • Author(s): Kitagawa M, Murata J, Uesugi H, Hanajima R, Ugawa Y
  • Journal Title: J Neurosurg In press
  • NAID: 10024369178
• [Presentation] Regulatory concerns in Japan.Present and future of TMS. Safety and Ethical Guidelines (2008)
  • Author(s): Ugawa Y
  • Organizer: IFCN committee for TMS safety
  • Place of Presentation: Siena,Italy
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulatory concerns in Japan. Present and future of TMS. Safety and Ethical Guidelines (2008)
  • Author(s): Ugawa Y
  • Organizer: IFCN committee for TMS safety
  • Place of Presentation: Siena, Italy
• [Presentation] New Aspects of single pulse TMS and repetitive TMS: from clinical point of view (2007)
  • Author(s): Ugawa Y
  • Organizer: 6th International Conference on Bioelectromagnetics
  • Place of Presentation: Aizu-Wakamatsu,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effects of electromagnetic field exposure from mobile phone base stations:Does it differ between subjects with mobile phoen related symptom and those without?-A population-based questionnaire survey and provocation study in Japan (2007)
  • Author(s): Ugawa Y, Terao Y, Furubayashi T, Mizuno Y, Shirasawa K, Kageyama A, Okano T, Nishikawa M, Miyawaki K, Yasuda A, Uchiyama M, Yamashita HK, Ushiyama A, Masuda H, Hirota S, Takahashi M, Sokijima S, Maruyama E, Pongpaibool P, Wake K, Watababe S, Taki M, Oukubo C
  • Organizer: The Bioelectromagnetics Society 29th Annual Meeting
  • Place of Presentation: Kanazawa,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 磁気刺激法の最前線 (2007)
  • Author(s): 宇川 義一
  • Organizer: 第37回 日本臨床神経生理学会学術大会
  • Place of Presentation: 宇都宮
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ミオクローヌス、ビデオセッション (2007)
  • Author(s): 柴崎 浩、宇川 義一
  • Organizer: 第一回MDSJ学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New Aspects of single pulse TMS and repetitive TMS: from clinical point of view. (2007)
  • Author(s): Ugawa Y
  • Organizer: 6th International Conference on Bioelectromagnetics.
  • Place of Presentation: Aizu-Wakamatsu, Japan
• [Presentation] Effects of electromagnetic field exposure from mobile phone base stations: Does it differ between subjects with mobile phoen related symptom and those without? - A population - based questionnaire survey and provocation study in Japan. (2007)
  • Author(s): Ugawa Y, Terao Y, Furubayashi T, Mizuno Y, Shirasawa K, Kageyama A, Okano T, Nishikawa M, Miyawaki K, Yasuda A, Uchiyama M, Yamashita HK, Ushiyama A, Masuda H, Hirota S, Takahashi M, Sokijima S, Maruyama E, Pongpaibool P, Wake K, Watababe S, Taki M, Oukubo C
  • Organizer: The Bioelectromagnetics Society 29th Annual Meeting
  • Place of Presentation: Kanazawa, Japan
• [Book] Repetitive transcranial magnetic stimulation (rTMS) in monkeys. Functional Neuroscience : Evoked Potentials and Related Techniques. (suppl to Clin Neurophysiol vol 59) (2006)
  • Author(s): Ugawa Y, Okabe S, Hayashi T, Ohnishi T, Nonaka Y
  • Publisher: Elsevier