Human brain mechanism of motor inhibition studied by MEG and TMS

• Project/Area Number: 18500239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Kyoto University
• Principal Investigator: MIMA Tatsuya Kyoto University, 医学研究科, 准教授 (20324618)
• Co-Investigator(Kenkyū-buntansha): 長峯 隆 京都大学, 医学研究科, 助教授 (10231490)
• Co-Investigator(Renkei-kenkyūsha): NAGAMINE Takashi 京都大学, 医学研究科, 准教授 (10231490)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 経頭蓋的磁気刺激 / 運動抑制 / 機能的磁気共鳴画像 / 脳磁図 / fMRI / 経頭蓋的磁気刺激法 / 前頭前野 / stop signal課題

Research Abstract

stop signal 課題を遂行中の脳活動を、事象関連機能的磁気共鳴画像法の計測によって評価し、運動抑制に関わる脳部位を明らかにした.脳磁図による検討は、実験継続中である.次に、解明された脳部位をターゲットとして、事象関連TMS を与えた.その結果、ターゲット筋にかかわらず四肢の運動抑制が認められることを発見した.これらの結果は、運動抑制の脳内局在には、体部位局在がはっきりしないことを示唆する所見である.

Research Products

• [Journal Article] Disordered plasticity in the primary somatosensory cortex in focal hand dystonia (2009)
  • Author(s): Tamura, Y., Ueki, Y., Lin, P., Vorbach, S., Mima, T., Kakigi, R., *Hallett, M
  • Journal Title: Brain 132 Pages: 749-55
• [Journal Article] Social impact of recent advances in neuroscience (2009)
  • Author(s): Mima, T
  • Journal Title: Brain Nerve 61 Pages: 18-26
  • NAID: 40016432629
• [Journal Article] Stimulus-Response Profile during Single-Pulse Transcranial Magnetic Stimulation to the Primary Motor Cortex (2009)
  • Author(s): Hanakawa, T., Mima, T., Matsumoto, R., Abe, M., Inouchi, M., Urayama, S. I., Anami, K., Honda, M., Fukuyama, H
  • Journal Title: Cereb Cortex (in press)
• [Journal Article] Stimulus-Response Profile during Single-Pulse Transcranial Magnetic Stimulation to the Primary Motor Cortex (2009)
  • Author(s): Hanakawa T, Mima T, Matsumoto R, Abe M, Inouchi M, et al.
  • Journal Title: Cereb Cortex
  • Peer Reviewed
• [Journal Article] Disordered plasticity in the primary somatosensory cortex in focal hand dystonia (2009)
  • Author(s): Tamura Y, Ueki Y, Lin P, Vorbach S, Mima T, Kakigi R, et al
  • Journal Title: Brain 132 Pages: 749-55
  • Peer Reviewed
• [Journal Article] A mirror reflection of a hand modulates stimulus-induced 20-Hz activity (2009)
  • Author(s): Tominaga W, Matsubayashi J, Deguchi Y, Minami C, Kinai T, Nakamura M. Nagamine T, Matsuhashi M, Mima T, et al.
  • Journal Title: Neuroimage
  • Peer Reviewed
• [Journal Article] Neural correlates of regional EEG power change (2007)
  • Author(s): Oishi, N., *Mima, T., Ishii, K., Bushara, K.O., Hiraoka, T., Ueki, Y., Fukuyama, H. , Hallett, M
  • Journal Title: Neuroimage 36 Pages: 1301-12
• [Journal Article] The role of left and right intraparietal sulcus in the attentional blink : a transcranial magnetic stimulation study (2007)
  • Author(s): Kihara, K., Hirose, N., Mima, T, Abe, M., Fukuyama, H., Osaka, N
  • Journal Title: Exp. Brain. Res 178 Pages: 135-40
• [Journal Article] Recovery from object substitution masking induced by transient suppression of visual motion processing : a repetitive transcranial magnetic stimulation study (2007)
  • Author(s): Hirose, N., Kihara, K., Mima, T, Ueki, Y,. Fukuyama, H., Osaka, N
  • Journal Title: J Exp Psychol Hum Percept Perform 33 Pages: 1495-503
• [Journal Article] Repetitive transcranial magnetic stimulation of human MT+ reduces apparent motion perception (2007)
  • Author(s): Matsuyoshi, D., Hirose, N., Mima, T., Fukuyama, H., Osaka, N
  • Journal Title: Neurosci Lett 429 Pages: 131-5
• [Journal Article] Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans (2007)
  • Author(s): Osaka, N., Otsuka, Y., Hirose, N., Ikeda, T., Mima, T,. Fukuyama, H. , Osaka, M
  • Journal Title: Neurosci Lett 418 Pages: 232-5
• [Journal Article] Recovery from object substitution masking induced by transient suppression of visual motion processing (2007)
  • Author(s): Hirose N, Kihara K, Mima T, Ueki Y, Fukuyama H, Osaka N
  • Journal Title: Journal of experimental psychology 33 Pages: 1495-1503
  • Peer Reviewed
• [Journal Article] The role of left and right intraparietal sulcus in the attentional blink: a transcranial magnetic stimulation study (2007)
  • Author(s): Kihara K, Hirose N, Mima T, Abe M, Fukuyama H, Osaka N
  • Journal Title: Experimental brain research 178 Pages: 135-140
  • Peer Reviewed
• [Journal Article] Repetitive transcranial magnetic stimulation of human MT+reduces apparent motion perception (2007)
  • Author(s): Matsuyoshi D, Hirose N, Mima T, Fukuyama H, Osaka N
  • Journal Title: Neurosci Lett 429 Pages: 131-135
  • Peer Reviewed
• [Journal Article] The role of left and right intraparietal sulcus in the attentional blink : a transcranial magnetic stimulation study. (2007)
  • Author(s): Kihara, K., Hirose, N., Mima, T., Abe, M., Fukuyama, H., Osaka, N.
  • Journal Title: Exp. Brain. Res 178 Pages: 135-140
• [Journal Article] Altered plasticity of the human motor cortex in Parkinson's disease (2006)
  • Author(s): Ueki, Y., Mima, T., Kotb, M.A., Sawada, H., Saiki, H., Ikeda, A., Begum, T., Reza, F., Nagamine, T. , *Fukuyama, H
  • Journal Title: Ann Neurol 59 Pages: 60-71
• [Journal Article] Transient functional suppression and facilitation of Japanese ideogram writing induced by repetitive transcranial magnetic stimulation of posterior inferior temporal cortex (2006)
  • Author(s): Ueki, Y., Mima, T, Nakamura, K., Oga, T., Shibasaki, H., Nagamine, T., , Fukuyama, H
  • Journal Title: J. Neurosci 26 Pages: 8523-30
• [Journal Article] Transient functional suppression and facilitation of Japanese ideogram writing induced by repetitive transcranial magnetic stimulation of posterior inferior temporal cortex. (2006)
  • Author(s): Ueki, Y., Mima, T., Nakamura, K., Oga, T., Shibasaki, H., Nagamine, T., Fukuyama, H.
  • Journal Title: J. Neurosci 26 Pages: 8523-8530
• [Presentation] Induction of plasticity in the human motor cortex by modified paired associative stimulation through transcallosal tract The 38th Annual Meeting of the Society for Neuroscience (2008)
  • Author(s): Koganemaru S, Mima T, Nakatsuka M, Ueki Y, Fukuyama H, Domen K
  • Organizer: Washington DC
  • Place of Presentation: USA
  • Year and Date: 2008-11-25
• [Presentation] Differential effects of repetitive transcranial magnetic stimulation (rTMS) on the timing of intention and action The 38th Annual Meeting of the Society for Neuroscience (2008)
  • Author(s): Ueki Y, Mima T, Fukuyama H
  • Organizer: Washington DC
  • Place of Presentation: USA
  • Year and Date: 2008-11-25
• [Presentation] 脳波と機能的MRI の同時計測(EEG-fMRI)によるてんかん焦点の同定と関連するネットワークの評価 : 皮質脳波との比較 (2008)
  • Author(s): 井内盛遠、松本理器、澤本伸克、中川朋一、浦山慎一、美馬達哉、三國信啓、穴見公隆、栗屋智就、加藤武雄、福山秀直、高橋良輔、池田昭夫
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-21
• [Presentation] The human motor associative plasticity induced through transcallosal connection The 3rd TMS and tDCS Meeting (2008)
  • Author(s): Koganemaru S, Mima T, Nakatsuka M, Ueki Y, Fukuyama H, Domen K
  • Organizer: Goettingen
  • Place of Presentation: Germany
  • Year and Date: 2008-10-10
• [Presentation] Directional structure of sensorimotor beta rhythm in monkeys (2008)
  • Author(s): Mima T, Tsujimoto T
  • Organizer: The 16th International Conference on Biomagnetism, Sappro
  • Place of Presentation: Japan
  • Year and Date: 2008-08-11
• [Presentation] Effects of human motor inhibition on the excitability of foot motor area studied by stop signal task (2008)
  • Author(s): Mima T, et al.
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Effects of human hand motor inhibition on the excitability of foot motor area studied by stop signal task (2008)
  • Author(s): 美馬達哉、Badry R、麻生俊彦、長峯隆、福山秀直
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Brain representation of human price bidding (2008)
  • Author(s): Votinov M、美馬達哉、阿部十也、麻生俊彦、澤本伸克、篠崎淳、福山秀直
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Increased change in water diffusion MRI following low frequency repetitive transcranial magnetic stimulation (2008)
  • Author(s): Abe M, Mima T, Sawamoto N, Urayama S, Aso T, LeBihan D, Fukuyama H
  • Organizer: The 16th Scientific Meeting of the International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-05-24
• [Presentation] 大脳-次運動野の脳可逆性における加齢の影響-連合性対刺激法による検討- (2008)
  • Author(s): 植木美乃、美馬達哉、小金丸聡子、ディナ・ファティファリ、長峯隆、福山秀直
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-24
• [Presentation] TMSを用いた認知神経科学研究 (2007)
  • Author(s): 美馬達哉
  • Organizer: 第37回日本臨床神経生理学会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2007-11-22
• [Presentation] Laterality of human prefrontal cortex function during motor inhibition (2007)
  • Author(s): Tabu H, Mima T, Aso T, Fukuyama H
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2007-11-13
• [Presentation] 運動抑制における前頭前野機能の側方性 (2007)
  • Author(s): 椨勇人、美馬達哉、麻生俊彦、澤本伸克、福山秀直
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Movement-related field potentials of dystonia recorded in the human pallidum (2006)
  • Author(s): Murase, N., Urushihara, H., Shimazu, H., Matsuzaki, K., Nagahiro, S., Yamada, K., Goto, S., Mima, T., Nagamine, T., Fukuyama, H., Kaji, R
  • Organizer: The 10th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-11
• [Presentation] Effect of tonic and phasic movements on afferent inhibition of the motor cortex excitability studied by TMS (2006)
  • Author(s): Mima, T., Kotb, M., Begum, T., Ueki, Y., Nagamine, T., Fukuyama, H
  • Organizer: The 28th International Congress of Clinical Neurophysiology
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2006-09-21
• [Presentation] 拡散強調画像法を用いた反復経頭蓋磁気刺激後の脳皮質水拡散能の変化 (2006)
  • Author(s): 阿部十也、美馬達哉、浦山慎一、麻生俊彦、澤本伸克、福山秀直
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-07-13
• [Presentation] 経頭蓋磁気刺激による運動野神経活動強度依存性変化の磁気共鳴機能画像的研究 (2006)
  • Author(s): 花川隆、美馬達哉、松本理器、Faruque Reza、井内盛遠、本田学、福山秀直
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-07-12
• [Remarks]
  • URL: http://hbrc.kuhp.kyoto-u.ac.jp/