| Project/Area Number |
18500247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Juntendo University |
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Principal Investigator |
LU Xiaofeng Juntendo University, school of medicine, Associate Professor (20360703)
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| Co-Investigator(Kenkyū-buntansha) |
KITAZAWA Shigeru Juntendo University, school of medicine, Professor (00251231)
TAKADA Masahiko Tokyo Metropolitan Institute for Neuroscience, Physiology, Professor (00236233)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Inferior olive / Cerebello-thalamo-cortical pathway / Cerebellar nuclei / Purkinje cell / Primary motor cortex / Rabies virus / Monkey / 小脳皮質 |
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| Research Abstract |
The inferior olive (IO) is known to project to the primary motor cortex (MI) via the cerebellum and the thalamus. However, there are very few anatomical studies that show the somatotopic organization of IO inputs to the MI. In this study, we used transneuronal transport of rabies virus to examine the labeling of fourth-order neurons in the IO after viral injections into physiologically identified hindlimb, forelimb and orofacial representations of the MI in macaque monkeys. The results showed the neuronal labeling from the hindlimb, forelimb and orofacial representation was located, respectively, in the medial part of dorsal lamella of the principal nucleus of the IO (POdI), the lateral part of the POdI, and the dorsal part of lateral bend of the principal nucleus of the IO (Pobd). This indicates that the IO is somatotopically organized with the medial-lateral arrangement pattern of hindlimb, forelimb and face within the principal nucleus.
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