The effects of stress exposure in weanling mice on cognitive function and neurogenesis: the role of histaminergic neuron systems
| Project/Area Number |
18500286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKURAI Eiko Tohoku University, Tohoku, University, Graduate School of Medicine, Assistant Professor (90153949)
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| Co-Investigator(Kenkyū-buntansha) |
YANAI Kazuhiko Tohoku, University, Graduate School of Medicine, Professor (50192787)
WATANABE Takehiko Tohoku, University, Honor Professor (70028356)
YAMAZAKI Hiromichi Tohoku, University, Cyclotron and Radioisotope Center, Professor (00166654)
OKAMURA Nobuyuki Tohoku, University, Graduate School of Medicine, Assistant Professor (40361076)
KURAMASU Atsuo Tohoku, University, Graduate School of Medicine, Lecture (90302091)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,140,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | histaminergic neuron system / mice / stress / childhood / learning / memory / atypical anti-psychotics / neurogeneses / in-air micro PIXE / 大気マイクロPUXE |
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| Research Abstract |
It is known that childhood stress carries a significant risk for a variety of problems involving cognition and behavior. Early social isolation rearing from the age of wearing (21-28 days) into adulthood has been often used as an appropriate environmental factor to produce animal models with negative symptoms of schizophrenia. Previous studies have shown that both the cholinergic and histaminergic neuron systems are in many physiological functions including learning and memory. However, it is still unclear how and what existent central histaminergic transmission is involved in the phathophysiology of psychiatric diseases. In this study, we examined 6 topics as follows; 1. Whether the blockade of multiple histamine receptors has any significant effects on the survival of life and health? 2. Animal model of the early social isolation and the behavioral change in the mice. 3. The effects of antipsychotic drugs on the mice subjected social isolation. 4. An imaging of neurogenesis in mice brain by in air micro-PIXE method. 5. The measurement of the bromine ions in the brain slices in the social isolation mice. 6. Effects of isolation stress on monoamines and their metabolite contents in the brain. From these experiments, blockade of H1 receptor-mediated neurotransmission attenuates social isolation-induced behavioral changes and the therapeutic effects of atypical anti-psychotics are mediated, at least in part, by interaction with H1 receptors in the brain. BrdU labeling hippocampal neurogeneses were observed in the brain slices of H1KO and WT mice by use of in-air micro PIXE analysis. The amount of bromine in the case of H1KO mice is small compared with WT mice. H1, H2, H3 triple histamine receptors gene deficient mice and HI, H3 double histamine receptors knockout mice were born and alive. However, H2 receptor-related multiple histamine receptors genes knockout mice were difficult to make, although the reasons were unknown.
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Report
(3 results)
Research Products
(59 results)
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[Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
Author(s)
Sakurai E, Yanai k, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K
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Journal Title
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
Author(s)
Sakurai E. Yanai k, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K.
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Journal Title
JAEA-Review 182
Pages: 2007-6
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
Author(s)
Sakurai E, Yanai K, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K
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Journal Title
JAEA-Review 2007-060
Pages: 182-182
Related Report
Peer Reviewed
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[Journal Article] Development of an In-Air ON/OFF Axis STIM System for Quantitative Elemental Mapping.2006
Author(s)
K. Inomata, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Watanabe, A. Ishizaki, R. Oyama, Y. Kawamura, T. Yamaguchi, G. Momose, E. Sakurai, K. Yanai, T. Kamiya, T. Sakai, T. Satoh, M. Oikawa, K. Arakawa,
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Journal Title
International Jounal of PIXE 16(3&4)
Pages: 149-156
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
Author(s)
Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K,
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Journal Title
Neurophamacology, 50(4)
Pages: 404-411
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Development of an In-Air ON/OFF Axis STIM System for Quantitative Elemental Mapping2006
Author(s)
K. Inomata, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Watanabe, A. Ishizaki, R. Oyama, Y. Kawamura, T. Yamaguchi, G Momose, E. Sakurai. K. Yanai, T. Kamiya, T. Sakai, T. Satoh, M. Oikawa, K. Arakawa
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Journal Title
International Jounal of PIXE 16 (3 & 4)
Pages: 149-156
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
Author(s)
Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E. Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K.
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Journal Title
Neurophamacology 50 (4)
Pages: 404-411
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Sakurai E. Yanaik, IshiiK, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Arakawa K, Kamiya T, Oikawa M, Satoh T, Haga J2007
Author(s)
Sakurai E. Yanaik, IshiiK, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Arakawa K, Kamiya T, Oikawa M, Satoh T, Haga J
Organizer
A cooperation important point study panel discussion on the advanced atomic energy technology meeting
Place of Presentation
Tokai
Year and Date
2007-08-20
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Measurement of trace metals in mouse brain slices by in-air micro PIXE analysis2007
Author(s)
Sakurai E, Yanai k, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Arakawa K, Kamiya T, Oikawa M, Satoh T, Haga J
Organizer
2nd Takasaki Advances Radiation Research Symposium
Place of Presentation
Takasaki
Year and Date
2007-06-21
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai2007
Author(s)
Eiko Sakurai, Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai
Organizer
80^<th> Annual Meeting of the Japanese Pharmacological Society
Place of Presentation
Nagoya
Year and Date
2007-03-15
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Elemental analysis of ionic distributions by in-air micro-PIXE in rat basophilic leuckemia cells (2H3) and mouse brain slices2007
Author(s)
Eiko Sakurai, Hongmei Dai, Keiko Mizuma, Shigeru Abe, Ryohei Oyama, Takuro Sakai, Takahiro Satoi, Hiromichi Yamazaki, Keizo Ishii and Kazuhiko Yanai,
Organizer
21COEバイオナノテクノロジー基盤未来医工学プログラム, 第9回国際シンポジウム
Place of Presentation
仙台
Description
「研究成果報告書概要(和文)」より
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[Presentation] Eiko Sakurai. Hongmei Dai, Keiko Mizuma, Shigeru Abe, Ryohei Oyama, Takuro Sakai, Takahiro Satoi, Hiromichi Yamazaki, Keizo Ishii and Kazuhiko Yanai2007
Author(s)
Eiko Sakurai. Hongmei Dai, Keiko Mizuma, Shigeru Abe, Ryohei Oyama, Takuro Sakai, Takahiro Satoi, Hiromichi Yamazaki, Keizo Ishii and Kazuhiko Yanai
Organizer
Future Medical Engineering Based on Bionanotechnology Proceedings of the final Symposium of the Tohoku University 21^<st> Century Center of Excellence Program
Place of Presentation
Sendai
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai2006
Author(s)
Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai
Organizer
10^<th> Japanese histamine research society
Place of Presentation
Okayama
Year and Date
2006-12-15
Description
「研究成果報告書概要(欧文)」より
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