Modulation of light responses by purinergic receptors in the mouse retina
| Project/Area Number |
18500312
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
KANEDA Makoto Keio University, 医学部, 准教授 (30214480)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KANEKO Akimichi 畿央大学, 大学院・健康科学研究科, 教授 (00051491)
霜田 幸雄 東京女子医科大学, 医学部, 准教授 (00051871)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIMODA Yukio 東京女子医科大学, 医学部, 准教授 (00051871)
|
|---|
| Project Period (FY) |
2006 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
|---|
| Keywords | 感覚系神経生理学 / マウス / 網膜 / ATP |
|---|
| Research Abstract |
網膜にはOFF経路とON経路とよばれる二つの並列な情報処理経路が存在する。本研究ではATPで活性化されるP2X2型プリン受容体が、コリン作動性アマクリン細胞のOFF型には多く存在するが、ON型にはほとんど存在しないことを明らかにすることができた。網膜神経節細胞の光応答もON経路とOFF経路でP2X型プリン受容体を介して経路特異的に調節を受けていることが明らかとなった。
|
Report
(4 results)
Research Products
(32 results)
-
-
-
-
-
-
-
[Journal Article] A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy2006
Author(s)
Singh, B., Ogiwara, I., Kaneda, M., Tokonami, N., Mazaki, E., Baba, K., Matsuda, K., Inoue, Y., and Yamakawa, K.
-
Journal Title
Neurobiol. Dis 24
Pages: 245-53
Related Report
Peer Reviewed
-
[Journal Article] A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy2006
Author(s)
Singh, B., Ogiwara, I., Kaneda, M., Tokonami, N., Mazaki, E., Baba, K., Matsuda, K., Inoue, Y, Yamakawa, K.
-
Journal Title
Neurobiol. Dis. 24
Pages: 245-53
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Mutation analysis of the voltage-gated sodium channel・II gene in patients with early childhood intractable epilepsies.2008
Author(s)
Ogiwara, I., Ito, K., Osaka, H., Mazaki, E., Inoue, I., Fuiiwara, T., Inoue, Y., Kaneda, M., Yamakawa, K.
Organizer
38th Annual Meeting of Neuroscience
Place of Presentation
Washington DC, USA
Related Report
-
-
-
-
-
-
-
-
-
