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Temporal Information Processing in Prefrontal-Basal Ganglia Circuit

Research Project

Project/Area Number 18500314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKinki University

Principal Investigator

INASE Masahiko  Kinki University, School of Medicine, Professor (80249961)

Co-Investigator(Kenkyū-buntansha) CHIBA Atsushi  Kinki University, School of Medicine, Assistant Professor (30155311)
OSHIO Ken-ichi  Kinki University, School of Medicine, Assistant Professor (30296751)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsCerebral Cortex / Prefrontal Cortex / Basal Ganglia / Striatum / Duration Discrimination / Visual stimuli / Neuronal Activity / Neurophysiology / 時間弁別課題 / ニューロン活動 / サル / 時間情報処理
Research Abstract

We have been conducting neurophysiological experiments to reveal neuronal mechanisms for temporal information processing in the prefrontal-basal ganglia circuit. Monkeys were trained to perform a duration discrimination task. In the task, two visual cues were presented successively in different duration (0.2〜1.6 sec). Each cue presentation was followed by a 1-sec delay period. The subjects were instructed to choose a longer presented cue after the second delay period. Single-unit activity was recorded from the prefrontal cortex and the striatum while the monkeys were performing the task.
Prefrontal neurons showed phasic activity during the first cue period. The activity had peak time around 800ms that was close to the midpoint between long and short cue duration. This activity might have functioned for filtering cue duration to discriminate between long and short cues. In the first delay period prefrontal neurons exhibited differential activity following long and short cues. In the neurons with preference for long cues the delay activity after longer cues was uniformly high regardless of cue duration, but that after shorter cues was uniformly low. This binary change in the delay activity indicates that the prefrontal cortex could represent cue duration categorically as long or short. Striatal neurons phasically responded during the first and second delay periods. Responses during the first delay period changed depending on the first cue duration. Activity of populations of these neurons correlated with the first cue duration positively or negatively. Responses during the second delay period differed between long-short and short-long trials. These findings suggest that striatal neurons could encode cue duration with monotonically changing responses and discrimination results between the two cue durations.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (14 results)

All 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Delay period activity of monkey prefrontal neurons during duration-discrimination task2006

    • Author(s)
      Oshio, K.
    • Journal Title

      Eur.J.Neurosci. 23

      Pages: 2779-2790

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cue familiarity is represented in monkey medial prefrontal cortex during visuomotor association learning2006

    • Author(s)
      Inase, M.
    • Journal Title

      Exp.Brain Res. 168

      Pages: 281-286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Delay period activity of monkey prefrontal neurons during duration-discriminatiion task.2006

    • Author(s)
      Oshio K, Chiba A, Inase M.
    • Journal Title

      Eur. J. Neurosci. 23

      Pages: 2779-2790

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cue familiarity is represented in monkey medial prefrontal cortex during visuomotor association learning.2006

    • Author(s)
      Inase M. Li B-M, Takashima I, Iijima T
    • Journal Title

      Exp. Brain Res. 168

      Pages: 281-286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Delay period activity of monkey prefrontal neurons during duration-discrimination task.2006

    • Author(s)
      K Oshio, A Chiba, M Inase
    • Journal Title

      Eur. J. Neurosic. 23

      Pages: 2779-2790

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cue familiarity is represented in monkey medial prefrontal cortex during visuomotor association learning.2006

    • Author(s)
      M Inase, B-M Li, I Takashima, T Iijima
    • Journal Title

      Exp. Brain Res. 168

      Pages: 281-286

    • Related Report
      2006 Annual Research Report
  • [Presentation] 時間弁別課題の刺激呈示期間におけるサル前頭前野ニューロンの活動2007

    • Author(s)
      生塩 研一
    • Organizer
      第30回日本神経科学会大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 時間弁別課題中のサル線条体の手がかり期の神経細胞活動2007

    • Author(s)
      千葉 惇
    • Organizer
      第30回日本神経科学会大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cue-period activity of monkey prefrontal neurons during a duration-discrimination task.2007

    • Author(s)
      Oshio, K.
    • Organizer
      30th Annual Meeting of the Japanese Neuroscience Society.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cue response of monkey striatal neurons during a duration discrimination task.2007

    • Author(s)
      Chiba, A.
    • Organizer
      30th Annual Meeting of the Japanese Neuroscience Society.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 時間弁別課題遂行中のサル線条体の遅延期活動2006

    • Author(s)
      千葉 惇
    • Organizer
      第29回日本神経科学会大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cue and delay responses of monkey striatal neurons during a duration discrimination task2006

    • Author(s)
      Chiba, A.
    • Organizer
      36th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Atlanta(USA)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Delay period activity of the monkey striatum in duration discrimination task.2006

    • Author(s)
      Chiba, A.
    • Organizer
      29th Annual Meeting of the Japanese Neuroscience Society.
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cue and delay responses of monkey striatal neurons during a duration discrimination task.2006

    • Author(s)
      Chiba, A.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience.
    • Place of Presentation
      Atlanta(USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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