Activity dependent modulation of corticothalamic synapses onto relay and reticular neurons

• Project/Area Number: 18500316
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Women's Medical University (2008); National Institute for Physiological Sciences (2006-2007)
• Principal Investigator: MIYATA Mariko Tokyo Women's Medical University, 医学部, 教授 (70281631)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥6,580,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 視床 / 皮質視床シナプス / 視床網様体細胞 / カイニン酸受容体 / 視床・網様体細胞 / 視床投射細胞 / 生理学 / 神経科学 / シグナル伝達

Research Abstract

皮質視床シナプスは視床投射細胞に興奮性シナプスを形成すると同時に、その側枝は、抑制性細胞である網様体細胞にシナプスを形成し、網様体細胞から視床投射細胞に抑制性シナプスを作ることで、皮質視床シナプスは視床に対しfeed forward inhibition も与える。我々は、皮質視床シナプスのこれら二つの細胞へのシナプス伝達においてカイニン酸受容体がシナプス前性にそれぞれ相反した作用を持つことを明らかにし、皮質投射細胞へのシナプス伝達にはGluR5が関与していることも明らかになった。さらに、ニコチン受容体も皮質視床シナプスの伝達に寄与していることが明らかになった。

Research Products

• [Journal Article] Contrary roles of kainate receptors in transmitter release at orticothalamic synapses onto thalamic relay and reticular neurons (2009)
  • Author(s): Miyata M. & Imoto K.
  • Journal Title: Journal of Physiology 587 Pages: 999-1012
  • Peer Reviewed
• [Journal Article] Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways Pharmacology (2009)
  • Author(s): Hayashi T Miyata M Nagata T Izawa Y Kawakami Y
  • Journal Title: biochemistry, and behavior 91 Pages: 441-446
  • Peer Reviewed
• [Journal Article] Contrary roles of kainate receptors in transmitter release at corticothalamic synapses onto thalamic relay and reticular neurons (2009)
  • Author(s): Miyata M., Imoto K.
  • Journal Title: Jounal of Physiology 587 Pages: 999-1012
  • Peer Reviewed
• [Journal Article] Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways (2009)
  • Author(s): Hayashi T, Miyata M, et al.
  • Journal Title: Biochemistry and Behavior 91 Pages: 441-446
  • Peer Reviewed
• [Journal Article] Distinct properties of corticothalamic and primary sensory synapses to thalamic neurons (2007)
  • Author(s): Miyata M
  • Journal Title: Neurosci. Res 59 Pages: 377-382
  • NAID: 10024418587
  • Peer Reviewed
• [Journal Article] Distinct properties of corticothalamic and primary sensory synapses to thalamic neurons (2007)
  • Author(s): Mariko Miyata
  • Journal Title: Neurosci. Research 59 Pages: 377-382
  • NAID: 10024418587
  • Peer Reviewed
• [Presentation] Distinct properties and modulation in corticothalamic and primary sensory synapses of thalamic neurons (2008)
  • Author(s): Mariko Miyata
  • Organizer: US-JAPAN Brain Research Collaborative Program
  • Place of Presentation: アメリカ
  • Year and Date: 2008-02-26
• [Presentation] Presynapic roles of kainate recepors on corticothalamic synaptic transmission onto thalamic relay and reiticular neurons Society for Neuroscience (2008)
  • Author(s): Mariko Miyata Kieji Imoto
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington, DC. USA
• [Presentation] Bidiectional roles of kainate receptors on the release at coricothalamic synapses onto thalamic relay and reticular neurons (2008)
  • Author(s): 宮田麻理子、井本敬二
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Neuromodulatory effect of acetylcholine on synaptic transmission in the ventrobasal thalamic nucleusc (2008)
  • Author(s): Nagumo Y Takeuchi Y Kawakami Y Imoto K Miyata M
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Developmental change of lemniscus synapses on the mice ventrobasal thalamus (2008)
  • Author(s): Takeuchi Y. Imoto K. Miyata M.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Remarks] 中日新聞「研究室発 : 痛みの解明、治療に生かす」2008年4月29日朝刊