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Characterization of AEP/Legumain-deficient mice as a model of hemophagocytic syndrome-like disease

Research Project

Project/Area Number 18500325
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKanazawa University

Principal Investigator

HASHIMOTO Noriyoshi  Kanazawa University, 学際科学実験センター, 准教授 (50242524)

Co-Investigator(Kenkyū-buntansha) ASANO Masahide  金沢大学, 学際科学実験センター, 教授 (50251450)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords病態モデル / 血球貪食症候群 / Legumain / AEP / リソソーム蓄積症 / プロテアーゼ / リソソーム病 / 遺伝子改変動物 / 血液疾患 / 疾患モデルマウス / レグマイン / 実験動物
Research Abstract

アスパラギンエンドペプチダーゼ(AEP)遺伝子欠損マウスを解析し, 体温上昇, 貧血, 肝脾腫, 骨髄や脾臓における血球貪食細胞の出現など, ヒト血球貪食症候群(HPS)の病態をよく再現したモデルマウスとして位置づけた。血球貪食細胞はマクロファージであり赤血球貪食能は上昇し, 一部でリソソーム病であるゴーシェ病に特徴的なゴーシェ細胞様の特徴も示した。リソソーム酵素であるAEPの欠損により貪食作用の亢進と血球分解産物の異常な蓄積を生じ, HPS様病態形成に深く関わっていることが示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome2009

    • Author(s)
      Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Chengyun Zheng, Jan-Inge Henter, Marie Meeths, Magnus Nordenskjold, Shi-Yong Li, Ikuko Hara-Nishimura, Masahide Asano, Keqiang Ye
    • Journal Title

      Proc Natl Acad Sci U S A 106(2)

      Pages: 468-473

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.2009

    • Author(s)
      Chan, C. B., Abe, M., Hashimoto, N., et al.
    • Journal Title

      Proceeding of the National Academy of Sciences of the United States of America 106

      Pages: 468-473

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase2008

    • Author(s)
      Zhixue Liu, Sung-Wuk Jang, Xia Liu, Dongmei Cheng, Junmin Peng, Manuel Yepes, Xiao-jiang Li, Steve Matthews, Colin Watts, Masahide Asano, Ikuko Hara-Nishimura, Hongbo R. Luo, Keqiang Ye
    • Journal Title

      Mol Cell 29(6)

      Pages: 665-678

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase2008

    • Author(s)
      Liu Z, et. al.
    • Journal Title

      Molecular Cell 29

      Pages: 665-678

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells2007

    • Author(s)
      Yoshikata Morita, Hisazumi Araki, Toshiro Sugimoto, Keisuke Takeuchi, Takuya Yamane, Toshinaga Maeda, Yoshio Yamamoto, Katsuji Nishi, Masahide Asano, Kanae Shirahama-Noda, Mikio Nishimura, Takashi Uzu, Ikuko Hara-Nishimura, Daisuke Koya, Atsunori Kashiwagi, Iwao Ohkubo
    • Journal Title

      FEBS Lett 581(7)

      Pages: 1417-1424

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells2007

    • Author(s)
      Morita Y, et. al.
    • Journal Title

      FEBS Letter 581

      Pages: 1417-1424

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] AEP/Legumain欠損マウスにおける血球貪食症候群様病態の解析2007

    • Author(s)
      安陪道代、橋本憲佳、宮石理、中尾眞二、西村いくこ、浅野雅秀
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Legumain(AEP)遺伝子欠損マウスは血球貪食症候群様の病態を呈する2006

    • Author(s)
      安陪道代, 橋本憲佳, 宮石理, 西村いくこ, 浅野雅秀
    • Organizer
      第53回日本実験動物学会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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