| Project/Area Number |
18500341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
YUASA Tetsuya Yamagata University, Graduate School of Science and Engineering, 教授 (30240146)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Tohoru University of Tsukuba, Graduate School of Comprehensive Human Sciences, 講師 (10197311)
WU Jin University of Tsukuba, Graduate School of Comprehensive Human Sciences, 講師 (20375512)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,050,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Synchrotron X-Ray / Fluorescent X-Ray / Computed Tomography / Tomoeranhic Imaging / Molecular Imaging |
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| Research Abstract |
Fluorescent x-ray computed tomography (FXCT) that can detect and image a trace of non-radioactive imaging agent, e. g., iodine, in a biomedical subject at a high spatial resolution can be a novel molecular imaging modality. Presently, we are developing an FXCT system using synchrotron radiation as an x-ray source for in-vivo imaging brains of small animals such as mouse, rat, and so on. For the purpose, we must overcome the following two difficulties damaging an image-quality: One difficulty is that the number of projections is remarkably restricted due to the long data-acquisition time. In order to reduce the measurement time, we propose to eliminate unnecessary beam scans by adaptively and efficiently controlling the scanning according to the subject size. The other difficulty is that the measured data are contaminated by inevitable physical factors. Here, we propose data-processing methods to estimate reliable projections from raw data. The efficacies of the proposed methods are demonstrated using physical-phantom images and an in-vivo image of mouse brain, which were reconstructed from experimental data acquired in KEK, Japan.
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