Hydrophilic substance transport via lymphatic wall

• Project/Area Number: 18500356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Nagano National College of Technology
• Principal Investigator: ONO Nobuyuki Nagano National College of Technology, 電子制御工学科, 教授 (60214186)
• Co-Investigator(Renkei-kenkyūsha): ONO Nobuyuki 長野工業高等専門学校, 電子制御工学科, 教授 (60214186)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥690,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: リンパ / リンパ循環 / 水溶性物質 / 透過性 / リンパ管 / リンパ管内皮細胞 / 内皮細胞

Research Abstract

今回リンパ管壁を介する水溶性物質の移動において,水溶性物質の分子量依存性と水溶性物質の移動に対するリンパ管内皮細胞の影響を中心に調査および研究を行った.
その結果,リンパ管壁を介する水溶性物質の移動には分子量依存性があり,さらにリンパ管内腔にTNF-αあるいはY-27632 を作用させると透過する分子量サイズは増加した.
これらの現象は,リンパ管内皮細胞の形態的あるいは機能的な変化が要因である可能性が示唆された.

Research Products

• [Journal Article] Glucose and Glucose Transporters Regulate Lymphatic Pump Activity through Activation of the Mitochondrial ATP-Sensitive K+ Channel (2008)
  • Author(s): Xiangjun Li, Risuke Mizuno, Nobuyuki ONO, Toshio Ohhashi
  • Journal Title: The Journal of Physiological Sciences Vol. 58 No.4 Pages: 249-261
  • NAID: 10023966412
  • Peer Reviewed
• [Journal Article] Glucose and Glucose Transporters Regulate Lymphatic Pump Activity through Activation of the Mitochondrial ATP-Sensitive K+ Channel. (2008)
  • Author(s): Xiangjun LI
  • Journal Title: The Journal of Physiological Sciences 58 Pages: 249-261
  • Peer Reviewed
• [Presentation] Roles of Reactive Oxygen Species (ROS) in the Regulation of Pumping Activity of Isolated Rat Lymphatic Vessels (2008)
  • Author(s): Mizuno, R 他
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] Roles of reactive oxygen species(ROS) in the regulation of pump activity of isolated rat lymph vessels (2008)
  • Author(s): Risuke Mizuno, Nobuyuki Ono, Toshio Ohhashi
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] A novel preparation of isolated rat lymph nodes for selective collection of the intranodal cells (2006)
  • Author(s): Mizuno, R., Kawai, Y., Hosaka, K., Ikomi, F., Kobayashi, M., Nakayama, J., Ono, N. and Ohhashi, T
  • Organizer: Cordon Research Conference
  • Place of Presentation: スイス
• [Presentation] 摘出リンパ節灌流標本からの選択的細胞採取システムの開発 (2006)
  • Author(s): 水野理介,河合佳子,保坂佳代子,伊古美文隆,小野伸幸,大橋俊夫
  • Organizer: 第47回日本脈管学会総会
  • Place of Presentation: 神戸