Evaluation of left ventricular torsion by two dimensional tissue tracking system
| Project/Area Number |
18500378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MURATA Kazuya Yamaguchi University, Division of Laboratory, Associated professor (60314803)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Yasuaki Yamaguchi University, Hospital, Department of medicine and clinical science, Assistant Professor (50448297)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,930,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Ultrasonics / Heart Failure / Echocardiograoh / Physiology / Cardiology |
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| Research Abstract |
Background: The Two-Dimensional Tissue Tracking (2DTT) technique can trace regional myocardial tissue using pattern matching method. The 2DTT has a capability to clinically evaluate the left ventricular (LV) torsion in endocardium (Endo) and epicardium (Epi) separately. Our objective was to characterize the response of LV torsion to low-dose dobutamine (Dob)infusion using 2DTT in idiopathic dilated cardiomyopathy (DCM). Methods: Ten patients with DCM were studied. We acquired LV basal and apical short-axis views both at rest and during Dob infusion (5, 10μg/kg/min) using Hitachi EUB-7500 ultrasound machine equipped with 2DTT software. Eight points were manually placed both at Endo and Epi equally in each basal and apical view. The movements of these points were automatically tracked by the system throughout a cardiac cycle. The center of rotation in each frame was determined by customized software, and rotation angle of each point was calculated and averaged. The LV torsion was defined as net-difference between basal and apical rotation angle. LV end-diastolic volume and LV end-systolic volume (ESV)were assessed by the biplane Simpson's equation. Results: Seven of 10 patients showed more than 10% reduction in ESV after 10μg/kg/min Dob infusion(responder). In responders, both apical Endo and Epi rotation increased at 10μg/kg/min Dob infusion (Endo: 1.2±1.1 to 3.6±1.8°, Epi: 0.8±0.7 to 2.3±1.2, p<0.01, respectively), however, basal rotation angles unchanged throughout of study. Consequently, the LV torsion in Endo and Epi increased after Dob infusion (Endo: 3.1±1.7 to 5.7±1.6°, Epi: 2.4±1.0 to 4.6±1.7, p<0.05, respectively).On the other hand, in patients with poor LV response to Dob infusion, basal and apical rotation angles unchanged during Dob infusion. Conclusions: The augmentation of LV rotation was observed especially in apex by inotropic stimulation, which may reflect myocardial contractile reserve in DCM.
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Report
(3 results)
Research Products
(82 results)
