| Project/Area Number |
18500389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
KAWABATA Masaaki (2007) Hyogo College of Medicine, Faculty of Medicine, Assistant Professor (70411999)
中尾 伸二 (2006) 兵庫医科大学, 医学部, 助手 (80309450)
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| Co-Investigator(Kenkyū-buntansha) |
MASUYAMA Tohru Hyogo College of Medicine, Faculty of Medicine, Professor (70273670)
YUBA Masao Hyogo College of Medicine, Faculty of Medicine, Instructor (60351821)
李 正明 兵庫医科大学, 医学部, 講師 (70411999)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,950,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
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| Keywords | Heart Failure / Chronic Heart Failure / Cardiac Re-synchronization Therapy / Ultrasound / Tissue Characterization / 循環器心不全 / 循環器・心不全 / 超音波 |
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| Research Abstract |
We obtained ultrasonic radio-frequency (RF) signals in the left ventricular posterior wall, in addition to tissue Doppler strain imaging in patients with chronic heart failure based on DCM. The signals were analyzed to determine correlation dimension (CD) which reflects chaotic behavior of RF signals on the basis of chaos theory. We observed the value of CD in patients with DCM is lower than that of normal subjects. We attempted to explore changes in ultrasonic properties of the myocardium following antihypertensive medication (such as calcium channel blocker or angiotensin receptor blocker) in hypertensive patients. The administration of those drugs caused non-uniform changes in the chaotic nature of the ultrasound signals. Though the mean value of CD did not change, distribution of CD values decreased after medication. In patients with CD of lower 2.8 before medication, there was an increase in CD following administration. This change was associated with an increase in E', an index of LV diastolic filling. Possible reduction of myocardial fibrosis is associated with an increase in the value of CD. We also attempt to estimate the chronic effects of cardiac resynchronization therapy in the future research by using this method as well as tissue Doppler strain imaging in patients with chronic heart failure.
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