Development of a new method for transfection to the skin by ultrasound
| Project/Area Number |
18500391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
IRIE Yutaka Fukuoka University, 医学部, 助教 (80352235)
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Katsuro 福岡大学, 医学部, 教授 (40271605)
OGAWA Koichi 福岡大学, 医学部, 准教授 (60078780)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 超音波照射 / 癌細胞皮膚 |
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| Research Abstract |
8週齢の雌のヘアレスマウスの背部にマイクロバブルと遺伝子の混合溶液0.05mlを複数箇所皮内投与した(SonoVue、Bracco社製、GFP(1μg/ml))。超音波発振素子画径6mmのプローベを用いて麻酔下の皮膚表面から照射した(2143kHz, 50% duty cycle, 3Hz Burst rate)。超音波照射後48時間後観察で、超音波強度0.5W/cm2、照射時間2と3minの群でGFPの発現が認められた。
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Report
(4 results)
Research Products
(15 results)
