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Mechanism of the beneficial effects of exercise training and lipid lowering drug therapy

Research Project

Project/Area Number 18500395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTohoku University

Principal Investigator

ITO Osamu  Tohoku University, Tohoku University Hospital, Lecturer (00361072)

Co-Investigator(Kenkyū-buntansha) KANAZAWA Masayuki  TOHOKU UNIVERSITY, Graduate School of Medicine, Associate Professor (60282050)
KOHZUKI Masahiro  TOHOKU UNIVERSITY, Graduate School of Medicine, Professor (70234698)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsexercise training / HMG-CoA reductase inhibitor / glucose and lipid metabolism / hepatic steatosis / antihypertensive effect / pleiotropic effect / kidney / nitric oxide / 高血圧自然発症ラット / 降圧作用 / 一酸化窒素 / Zucker肥満ラット / アディポサイトカイン
Research Abstract

Effects of a combination therapy of the exercise training (Ex) and HMG-CoA reductase inhibitor, statin were determined. Male Zucker-fatty-rats were divided into four groups; a control, an atorvastatin (ATV), an Ex and a combination therapy (ATV+Ex) groups. After 10 weeks, the plasma glucose was not different in the ATV or the. Ex group, but it was lower in the ATV+Ex group than in the control group. The plasma total cholesterol was lower in the Ex and the ATV+Ex groups. The plasma triglyceride was lower in all three experimental groups. The plasma insulin, leptin and adiponectin were not significantly different among the four groups.-The hepatic triglyceride was lower in the Ex and the ATV+Ex groups, and the minimum levels were observed in the Ex group. The combination therapy has beneficial effects on reduction of the plasma. glucose and lipids and improvement of hepatic steatosis without the change of the plasma adipocytokines in Zucker fatty rats.
Effects of ATV and Ex on: blood pressure and the expression of endothelial and neuronal NO synthase (eNOS, nNOS) in spontaneously hypertensive rats (SHR) were determined. Male <SHR were divided randomly into four groups; a control group, an ATV group, an Ex group, and a ATV+ Ex group. After 8 weeks, systolic blood pressure (SBP) was significantly lower in the ATV, Ex and ATV +Ex groups, compared with the control group. ATV induced eNOS protein in the renal cortex, medulla and thoracic. aorta, and nNOS protein in the renal medulla and thoracic aorta. Ex-induced eNOS protein specifically in the renal medulla, and nNOS protein in the renal cortex, medulla and thoracic aorta. ATV and Ex prevents the development of hypertension in SHR in part through the induction of NOS proteins, which is regulated by Ex and ATV in a different manner.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (62 results)

All 2008 2007 2006

All Journal Article (16 results) (of which Peer Reviewed: 4 results) Presentation (46 results)

  • [Journal Article] Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle.2007

    • Author(s)
      Minami N, Li Y, Guo Q, Kawamura T, Mori N, Nagasaka M, Ogawa M, Ito O, Kurosawa H, Kanazawa M, Kohzuki M
    • Journal Title

      Journal of Hypertension 25

      Pages: 1241-1248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats.2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M.
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine

      Pages: 625-627

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine

      Pages: 621-623

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 高血圧自然発症ラットの血圧、腎NO産生系に対するatorvastatin長期投与の効果2007

    • Author(s)
      伊藤大亮, 伊藤修, 曹鵬宇, 金澤雅之, 尾股健, 上月正博
    • Journal Title

      Therapeutic Research 28

      Pages: 1925-1926

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 高血圧自然発症ラットのandrogen依存性P4504A誘導と高血圧への関与.2007

    • Author(s)
      米城淑子, 森建文, 伊藤修, 石塚恒夫, 遠藤聡, 尾股健, 伊藤貞嘉.
    • Journal Title

      Therapeutic Research 28

      Pages: 1927-1928

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle2007

    • Author(s)
      Minami N, Li Y, Guo Q, Kawamura T, Mori N, Nagasaka M, Ogawa M, Ito O, Kurosawa H, Kanazawa M, Kohzuki M.
    • Journal Title

      J Hypertens 25

      Pages: 1241-1248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocvtokine in Zucker fattv rats2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M.
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine

      Pages: 625-627

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito 0, Cao P, Kanazawa M, Kohzuki M.
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine

      Pages: 621-623

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of chronic treatment of atorvastatin on blood pressure and renal nitric oxide synthases in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito 0, Cao P, Kanazawa M, Omata K, Kohzuki M.
    • Journal Title

      Therapeutic Research 28

      Pages: 1925-1926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of androgen-induced P4504A in development of hypertension in spontaneously hypertensive rats2007

    • Author(s)
      Yoneki Y, Mori T, Ito O, Ishizuka T, Endo S, Omata K, Ito S.
    • Journal Title

      Therapeutic Research 28

      Pages: 1925-1926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Journal Title

      Proceedings of the 4th World Congress of the Internatio nal Society of Physical and Rehabilitation Medicine

      Pages: 621-623

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Disability prevention of metabolic syndrome : Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats.2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine 印刷中

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Disability prevention of cardiovascular and chronic kidney diseases : Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M
    • Journal Title

      Proceedings of the 4th World Congress of the International Society of Physical and Rehabilitation Medicine 印刷中

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mechanism behind augumentation in baroreflex sensitivity after acute exercise in spontaneously hepertensive rats.2006

    • Author(s)
      Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M, et. al.
    • Journal Title

      Hypertension Research 29

      Pages: 117-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mechanism behind augumentation in baroreflex sensitivity after acute exercise in spontaneously hepertensive rats2006

    • Author(s)
      Minami N, Mori N, Nagasaka M, Ito 0, Kurosawa H, , Kanazawa M, et. al.
    • Journal Title

      Hypertension Res 29

      Pages: 117-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mechanism behind augumentation in baroreflex sensitivity after acute exercise in spontaneously hepertensive rats.2006

    • Author(s)
      Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M et al.
    • Journal Title

      Hypertension Research 29

      Pages: 117-122

    • Related Report
      2006 Annual Research Report
  • [Presentation] 高血圧自然発症ラットの血圧と腎nitric Oxide合成酵素に対する長期的運動の影響.2008

    • Author(s)
      伊藤大亮, 伊藤修, 森信芳, 長坂誠, 金澤雅之, 上月正博.
    • Organizer
      第23回日本リハビリテーション医学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2008-03-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training or blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats2008

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Organizer
      23th Tohoku Area Meeting of Japanese Association of Rehabilitation Medicine
    • Place of Presentation
      Sendai
    • Year and Date
      2008-03-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高血圧自然発症ラットの血圧と腎nitric oxide合成酵素に対する長期的運動の影響.2008

    • Author(s)
      伊藤大亮, 伊藤修, 森信芳, 長坂誠, 金澤雅之, 上月正博.
    • Organizer
      第23回日本リハビリテーション医学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2008-03-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高血圧自然発症ラットの大動脈と腎組織におけるNO合成酵素に対するatorvastatin長期投与の効果.2008

    • Author(s)
      伊藤大亮, 伊藤修, 曹鵬宇, 室谷嘉一、高島健太, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第37回日本心脈管作動性物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Effects of atorvastatin on NO synthases in the aorta and the kidney of spontaneously hypertensive rats2008

    • Author(s)
      Ito D, Ito O, Cao P, Muroya Y, Takashima K, Kanazawa M, Omata K, Kohzuki M
    • Organizer
      37th Scientific Meeting of Japanease Society of Cardiovascular substances
    • Place of Presentation
      Sendai
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高血圧自然発症ラットの血圧と腎NO合成酵素に対するatorvastatin長期投与の効果.2007

    • Author(s)
      伊藤大亮, 伊藤修, 曹鵬宇, 室谷嘉一, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第30回日本高血圧学会
    • Place of Presentation
      那覇
    • Year and Date
      2007-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Effects of atorvastatin on blood pressure and renal NO synthases in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito O, Cao P, Muroya Y, Kanazawa M, Omata K, Kohzuki M
    • Organizer
      30th Scientific Meeting of Japanease Society of Hypertension
    • Place of Presentation
      Naha
    • Year and Date
      2007-10-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of exercise training on blood pressure and renal nitric oxide system in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Organizer
      68th Annual Assembly of American Academy of Physical Medicine and Rehabilitation
    • Place of Presentation
      Boston
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Effects of exercise training on blood pressure and renal nitric oxide system in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Organizer
      68th Annual Assembly of American Academy of Physical Medicine and Rehabilitation
    • Place of Presentation
      Boston
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atorvastatin prevents development of hypertension with upregulation of nitric oxide synthases in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Muroya Y, Cao P, Nagasaka M, Kanazawa M, Kohzuki M
    • Organizer
      8th World Congress for Microcirculation
    • Place of Presentation
      Milwaukee
    • Year and Date
      2007-08-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Atorvastatin prevents development of hypertension with upregulation of nitric oxide synthases in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito O, Muroya Y, Cao P, Nagasaka M, Kanazawa M, Kohzuki M
    • Organizer
      8th World Congress for Microcirculation
    • Place of Presentation
      Milwaukee
    • Year and Date
      2007-08-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of metabolic syndrome : Effects of a combination therapy of exercise training and HMG-GoA reductase inhibitor on plasma lipid and hepatic steatosis in Zucker fatty rats.2007

    • Author(s)
      Ito O, Tan L, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M.
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats.2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and HMG-CoA reductase inhibitor on plasma lipid and hepatic steatosis in Zucker fatty2007

    • Author(s)
      Ito O, Tan L, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and HMG-CoA reductase inhibitor on plasma lipid and hepatic steatosis in Zucker fatty rats.2007

    • Author(s)
      Ito O, Tan L, Ito D, Mori N, Nag asaka M, Kanazawa M, Kohzuki M.
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Disability prevention of metabolic syndrome: Effects of a combination therapy of exercise training and atorvastatin on plasma glucose and adipocytokine in Zucker fatty rats.2007

    • Author(s)
      Tan L, Ito O, Niu K, Ito D, Mori N, Nagasaka M, Kanazawa M, Kohzuki M.
    • Organizer
      4tn World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats.2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M.
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Disability prevention of cardiovascular and chronic kidney diseases: Effect of exercise training on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats2007

    • Author(s)
      Ito D, Ito O, Cao P, Kanazawa M, Kohzuki M
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2007-06-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 長期的運動とスタチンの併用効果(その4)-肥満ラットの運動耐容能と心臓リモデリングへの効果.2007

    • Author(s)
      伊藤修, 森信芳, 伊藤大亮, 長坂誠, 黒澤一, 金澤雅之, 上月正博.
    • Organizer
      第44回日本リハビリテーション医学会
    • Place of Presentation
      神戸
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Effects of a combination therapy of exercise training and statin on exercise tolerance and cardiac remodeling in Zucker fatty rats2007

    • Author(s)
      Ito O, Mori N, Ito D, Nagasaka M, Kurosawa H, Kanazawa M, Kohzuki M
    • Organizer
      44th Scientific Meeting of Japanese Association of Rehabilitation Medicine
    • Place of Presentation
      Kobe
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高血圧自然発症ラットの血圧とNO合成酵素に対するatorvastatin長期投与の効果.2007

    • Author(s)
      伊藤修, 伊藤大亮, 曹鵬宇, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第50回日本腎臓学会
    • Place of Presentation
      浜松
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of atorvastatin on blood pressure and nitric oxide synthases in spontaneously hypertensive rats2007

    • Author(s)
      Ito O, Ito D, Cao P, Kanazawa M, Omata K, Kohzuki M.
    • Organizer
      50th Scientific Meeting of Japanease Society of Nephrology
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高血圧自然発症ラットの血圧と腎NO合成酵素に対するatorvastatin長期投与の効果.2007

    • Author(s)
      伊勝修, 伊藤大亮, 曹鵬宇, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第50回日本腎臓学会
    • Place of Presentation
      浜松
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高血圧自然発症ラットの血圧とNO合成酵素に対するatorvastatin長期投与の効果.2007

    • Author(s)
      伊藤修, 伊藤大亮, 曹鵬宇, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第14回日本内分泌学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2007-04-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of atorvastatin on blood pressure and nitric oxide synthases in spontaneously hypertensive rats2007

    • Author(s)
      Ito O, Ito D, Cao P, Kanazawa M, Omata K, Kohzuki M.
    • Organizer
      14th Tohoku Area Meeting of Japan Endocrine Society
    • Place of Presentation
      Sendai
    • Year and Date
      2007-04-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of chronic exercise combined statins on development of hypertension in spontaneously hypertensive rats.2006

    • Author(s)
      Ito D, Ito O, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      International Symposium The Kidney and Hypertension 2006 Sendai
    • Place of Presentation
      Sendai
    • Year and Date
      2006-10-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of chronic exercise combined statin on development of hypertension in spontaneously hypertensive rats2006

    • Author(s)
      Ito D, Ito O, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      International Symposium The Kidney and Hypertension 2006 Sendai
    • Place of Presentation
      Sendai
    • Year and Date
      2006-10-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of cytochrome P-450 4A and 4F in human tissues.2006

    • Author(s)
      Ito O, Nakamura Y, Ito D, Minami N, Kanazawa M, Ito S, Sasano H, Kohzuki M.
    • Organizer
      21st Scientific Meeting of International Society of Hypertension
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of the combination therapy of atorvastatin and exercise training on blood Pressure in spontaneously hypertensive rats.2006

    • Author(s)
      Ito D, Ito O, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      21st Scientific Meeting of International Society of Hypertension
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of cytochrome P-450 4A and 4F in human tissues2006

    • Author(s)
      Ito O, Nakamura Y, Ito D, Minami N, Kanazawa M, Ito S, Sasano H, Kohzuki M.
    • Organizer
      21st. Scientific Meeting of International Society of Hypertension
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of the combination therapy of atorvastatin and exercise training on blood pressure in spontaneously hypertensive rats2006

    • Author(s)
      Ito D, Ito O, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      21st Scientific Meeting of International Society of Hypertension
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Brattleboro尿崩症ラットの腎機能、オキシトシン分泌へのチトクロ-ムP-450阻害薬の効果.2006

    • Author(s)
      伊藤修, 森建文, Albert Sarkis, Richard J. Roman, Allen W. Cowley, 伊藤貞嘉, 上月正博.
    • Organizer
      第49回日本腎臓学会
    • Place of Presentation
      東京
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a CYP inbitor on renal function and plasma oxitocin in Brattleboro rats2006

    • Author(s)
      Ito O, Mori T, Sarkis A, Roman RJ, Cowley AW, Ito S, Kohzuki M
    • Organizer
      49th Scientific Meeting of Japanease Society of Nephrology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 長期的運動とスタチンの併用効果(その1)-肥満ラットの脂質代謝への影響.2006

    • Author(s)
      伊藤修, 森信芳, 新里純子, 山川麻貴, 長坂誠, 小川美歌, 南尚義, 黒澤一, 金澤雅之, 上月正博.
    • Organizer
      第43回日本リハビリテーション医学会
    • Place of Presentation
      東京
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 長期的運動とスタチンの併用効果(その2)-肥満ラットの糖代謝と血中アディポサイトカインへの影響.2006

    • Author(s)
      伊藤修, 森信芳, 新里純子, 山川麻貴, 長坂誠, 小川美歌, 南尚義, 黒澤一, 金澤雅之, 上月正博.
    • Organizer
      第43回日本リハビリテーション医学会
    • Place of Presentation
      東京
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 長期的運動とスタチンの併用効果(その3)-肥満ラットの脂肪肝への影響.2006

    • Author(s)
      伊藤修, 森信芳, 新里純子, 山川麻貴, 長坂誠, 小川美歌, 南尚義, 黒澤一, 金澤雅之, 上月正博.
    • Organizer
      第43回日本リハビリテーション医学会
    • Place of Presentation
      東京
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a combination therapy of exercise training and statin on lipid metabolism in Zucker fatty rats2006

    • Author(s)
      Ito O, Mori N, Nisato J, Yamakawa M, Nagasaka M, Ogawa M, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      43rd Scientific Meeting of Japanese Association of Rehabilitation Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a combination therapy of exercise training and statin on glucose metabolism in Zucker fatty rats2006

    • Author(s)
      Ito O, Mori N, Nisato J, Yamakawa M, Nagasaka M, Ogawa M, Minami N, Kanazawa M, Kohzuki M.
    • Organizer
      43rd Scientific Meeting of Japanese Association of Rehabilitation Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a combination therapy of exercise training and statin hepatic steatosis in Zucker fatty rats2006

    • Author(s)
      Ito O, Mori N, Nisato J, Yamakawa M, Nagasaka M, Ogawa M, Minami N, Kanazawa M, Kohzuki M
    • Organizer
      43rd Scientific Meeting of Japanese Association of Rehabilitation Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of cvtochrome P-450 4A and 4F subfamilies in human tissues.2006

    • Author(s)
      Ito O, Nakamura Y, Tan L, Ito D, Minami N, Kanazawa M, Sasano H, Kohzuki M.
    • Organizer
      21st Annual Scientific Meeting of American Society of Hypertension
    • Place of Presentation
      New York
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of cytochrome P-450 4A and 4F subfamilies in human tissues2006

    • Author(s)
      Ito O, Nakamura Y, Tan L, Ito. D, Minami N, Kanazawa M, Sasano H, Kohzuki M.
    • Organizer
      21st Annual Scientific Meeting of American Society of Hypertension
    • Place of Presentation
      New York
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Zucker肥満ラットの糖・脂質代謝への長期的運動とHMG-CoA還元阻害薬の併用効果.2006

    • Author(s)
      伊藤大亮, 譚麗萍, 伊藤修, 牛凱軍, 佐々木裕子, 森信芳, 南尚義, 金澤雅之, 尾股健, 上月正博.
    • Organizer
      第12回日本内分泌学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2006-04-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アラキドン酸ω水酸化酵素CYP4AとCYP4Fのヒト心臓・血管系における発現.2006

    • Author(s)
      伊藤修, 中村保宏, 譚麗萍, 伊藤大亮, 南尚義, 金澤雅之, 伊藤貞嘉, 笹野公伸, 上月正博.
    • Organizer
      第12回日本内分泌学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2006-04-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a combination therapy of exercise training and atorvastatin on glucose and lipid metabolism in Zucker fatty rats2006

    • Author(s)
      Ito D, Tan L, Ito O, Niu K, Sasaki Y, Mori N, Minami N, Kanazawa M, Omata, K, Kohzuki M.
    • Organizer
      11th Tohoku Area Meeting of Japan Endocrine Society
    • Place of Presentation
      Sendai
    • Year and Date
      2006-04-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of cytochrome P-450 4A and 4F in human tissues2006

    • Author(s)
      Ito O, Nakamura Y, Tan L, Ito D, Minami N, Kanazawa M, Ito S, Sasano H, Kohzuki M.
    • Organizer
      11th Tohoku Area Meeting of Japan Endocrine Society
    • Place of Presentation
      Sendai
    • Year and Date
      2006-04-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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