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Effects of physicul stimulation and some growth factors on peripheral nerve regeneration and muscle strophy.

Research Project

Project/Area Number 18500403
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKobe University

Principal Investigator

MIKI Akinori  Kobe University, School of Medicine, Professor (20144561)

Co-Investigator(Kenkyū-buntansha) ANDO Keiji  Kobe University, School of Medicine, Professor (30144562)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsmuscle atrophy / hindlimb suspension / immobilization / myosin heavy chain isoform / electromagnetic stimulation / erinheral nerve / nerve regeneration / nerve growth factor / 末梢神経再生 / 筋再生 / 物理刺激 / 褥瘡 / 末梢血液循環
Research Abstract

1) Effects of fixed muscle length during hindlimb suspension were examined. Animals were divided into 3 groups; 1: hindlimb suspension (HS), 2: hindlimb suspension with dorsal flexion (HSD), 3: hindlimb suspension with plantar flexion (HDP). In the tibias anterior, muscle atrophy occurred more severer in the shortened position than in the expanded position. While in the soleus muscle, it occurred more severer in the HS rather than HSP. These findings suggested that muscle atrophy might be depend not only on fixed muscle length but also on some other factors, such as contractile manner.
2) Changes of myosin heavy chain (MHC) isoform during the hindlimb suspension were examined in the rat skeletal mus- cle. In he tibialis anterior, MHC isoforms did not change during the hindlimb suspension. In the normal soleus muscle. most of MHC was type I, but after the hindlimb suspension, rate of type I reduced and type IIx, IIa, and IIb appeared. When the electromagnetic stimulation was applied every day during the hindlimb suspension, decrease of type I and ap- pearance of type IIx, IIa and IIb was reduced. These findings suggested that in the soleus muscle, electromagnetic sti- mulation might lighten not only muscle strophy but also immaturelization of myosin heavy chain isoformes.
3) Expression of nerve growth factor (NGF) in the peripheral nerve during regeneration was immunohistochemically examined. In the normal nerve, NGF was not noted, but in the crushed nerve. NGF immunoreaction became to be found.
When the electromagnetic stimulation was applied to the regenerating nerve, the immunoreaction became stronger. It was said that, the electromagnetic stimulation accelerate the nerve regeneration. One of the reasons for the effect of the stimulation might be the enhancement of the expression of NGF through electromagnetic stimulation.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (16 results)

All 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Repairing process in the transected muscle fibers in the mouse tibialis anterior.2007

    • Author(s)
      M. Matsumoto. A. Miki
    • Journal Title

      J. Jpn. Phys. Ther. Assoc. 10

      Pages: 1-10

    • NAID

      130004431316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Two anatomical autopsy cases of direct communication between a persi-stent primitive trigeminal artery and anterior inferior cerebellar artery.2007

    • Author(s)
      T. Arakawa. M. Koizumi, et. al.
    • Journal Title

      Ann. Anat. 189

      Pages: 489-498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of exercise and heat stress before hindlimb suspension on pre-vention of the skeletal muscle atrophy.2007

    • Author(s)
      H. Tasaki. T. Matsubara. A. Miki
    • Journal Title

      Bull. Health Sci. Kobe 23

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Repairing process in the transected muscle fibers in the mouse tibialis anterior2007

    • Author(s)
      M. Matsumoto, A. Mild
    • Journal Title

      J. Jim. Phys. Ther 10

      Pages: 1-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two anatomical autopsy cases of direct communication unication bet ween a persistent primitive trigeminal artery and anterior inferior cere- bellar artery2007

    • Author(s)
      T. Aralmwa. M. Roizumi. T. Terashima. S. Homma. K. Kawai. K. Kodanna, A. Mild
    • Journal Title

      Ann. Ant 189

      Pages: 489-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of exercise and heat stress before hindlimb suspension on prevention of the skeletal muscle atrophy2007

    • Author(s)
      H. Tassad. T. Matsubara, A. Mild
    • Journal Title

      Bull. Health Sci. Robe 23

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Repairing process in the transected muscle fibers in the mouse tibial anterior.2007

    • Author(s)
      M. Matsumoto. A. Miki
    • Journal Title

      J. Jpn. Phys. Ther. Assoc. 10

      Pages: 1-10

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of exercise and heat stress before hindlimb suspension on pre-vention of the skeletal muscle atrophy.2007

    • Author(s)
      H. Tasaki, T. Matsubara, A, Miki
    • Journal Title

      Bull. Health Sciences Kobe 23

      Pages: 1-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repairing process in the transacted muscle fibers in the mouse tibial anterior.2007

    • Author(s)
      M.Matsumoto, A.Miki
    • Journal Title

      J. Physical Therapy (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of electrical stimulation applied to the para- spinal tissue on peripheral blood circulation2006

    • Author(s)
      H. Terao, A. Miki
    • Journal Title

      Bull. Health Sci. Robe 22

      Pages: 47-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] マウスの坐骨神経切断後に生じる足底踵部の褥瘡様皮膚損傷2006

    • Author(s)
      小形晶子, 栢原哲郎, 三木明徳
    • Journal Title

      神戸学院総合リハビリテーション研究 2

      Pages: 59-67

    • NAID

      110006484954

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of electrical stimulation applied to paraspinal tissue on peripheral blood circulation.2006

    • Author(s)
      H.Terao, A.Miki
    • Journal Title

      Bull. Health Sci. Kobe 22

      Pages: 47-55

    • NAID

      110006483307

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nerve communication between the glossoph:lyngeal nerve. external carotid plexus and surface cervical ansa: human autopsy case

    • Author(s)
      T. Amkawa. T. Terashima, A. Mild
    • Journal Title

      Anat. Sci. htt (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コメディカル教育における人体解部学実習の意義2007

    • Author(s)
      三木明徳
    • Organizer
      日本医学会総会
    • Place of Presentation
      ホテルニューオータニ
    • Year and Date
      2007-04-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コメディカル教育における人体解剖学実習の意義2007

    • Author(s)
      三木 明徳
    • Organizer
      日本医学会総会
    • Place of Presentation
      ホテルニューオータニ
    • Year and Date
      2007-04-08
    • Related Report
      2007 Annual Research Report
  • [Book] カラーリングで覚える神経解剖学2007

    • Author(s)
      三木明徳, 三木雪子
    • Total Pages
      299
    • Publisher
      西村書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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