| Budget Amount *help |
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
Since visceral fat tissue is known to release various pro- and anti-inflammatory cytokines, abdominal obesity may play a key role in the inflammation associated with metabolic syndrome (MetS). However, few studies have determined precise relationships of abdominal obesity with inflammatory markers in MetS. This study elucidated the significance of abdominal obesity on the inflammatory network in MetS in apparently healthy subjects.
Subjects with abdominal obesity (waist circumference ≧ 85 cm) showed higher serum hs-CRP and IL-6 levels and a lower adiponectin level than those without abdominal obesity. Serum levels of hs-CRP and IL-6 significantly increased in association with clustering of MetS components in the subjects with abdominal obesity, but not in those without abdominal obesity. Significant negative correlation between adiponectin and hs-CRP was observed in the subjects with abdominal obesity, however this correlation was not detected in obese subjects defined by body mass inde
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x ≧ 25. Therefore, inflammatory status is not exaggerated by clustering of MetS components in the subjects without abdominal obesity.
In the next series of the study, we evaluated the relative contribution of inflammation and MetS on subclinical atherosclerosis in healthy subjects. Increase in number of clustering MetS components was more clearly associated with worsening of carotid intima-media thickness (IMT) and pulse wave velocity (PWV) in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a "high" IL-6 or hs-CRP, or a "low" adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation. Components of MetS present profound effects on early arterial alterations in women rather than in men. While serum IL-6 and adiponectin levels are important factors for these alterations in men.
To summarize, abdominal obesity may exhibit distinct effect on pro- and anti-inflammatory proteins and modulate inflammatory network in MetS and exaggerate atherosclerosis. Less
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