| Project/Area Number |
18500561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kurume University |
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Principal Investigator |
YOSHIDA Noriko Kurume University, The Institute of Health and Sport Science, Associate Professor (10210709)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hisao Kurume University, School of Medicine, Professor (50168134)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | oxidative stress / life-style related disease / exercise / physical training / 運動トレーニング / 運動強度 |
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| Research Abstract |
Objective: The effects of exercise training on oxidative stress were examined in patients with life-style related diseases. Method: Subjects were 29 patients with life-style related diseases those were hypertension, diabetes or hyperlipidemia. 1) The acute effect of one exercise session: Patients took fixed load (50% estimated VO2 max) exercise by bicycle ergometor for 30 minutes. Blood samplings were performed at rest, the end of exercise session during exercise, 7 minutes and 15 minutes after exercise. Free radical analytical system (Diacron Co. Italy) was used to measure the reactive oxygen metabolites (ROMs) and the biological antioxidant potential (BAP). ROMs/BAP was defined as index of oxidative stress. 2) The effect of exercise training: patients performed exercise (50% estimated VO2 max) training by bicycle ergometor more than three times per week for 12 weeks. The duration time of one exercise session was 30 minutes or more. Result: there were no significant changes in ROMs/BAP during and after fixed load (50% estimated VO2 max) exercise. After 12 weeks exercise, although ROMs unchanged, BAP increased at rest, during exercise and after exercise. Accordingly, ROMs/BAP decreased significantly at rest, during exercise and after exercise.
Conclusion : patients with life-style related diseases could perform 50% estimated VO2 max exercise without increased oxidative stress. Aerobic exercise training may decrease oxidative stress in patients with life-style related diseases.
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