Combined effect of sawa-wasabi and green tea to H. pylori and the related epidemiological study
| Project/Area Number |
18500625
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
KINAE Naohide University of Shizuoka, School of Food and Nutritional Sciences, Professor (00046286)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Shuichi University of Shizuoka, School of Food and Nutritional Sciences, Assistant Professor (40336657)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Wasabi / green tea / H. pylori / bactericidal / Mongolian gerbils / epidemiological stud / Stomach cancer |
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| Research Abstract |
In previously, we reported several functional properties containing antibacterial potency of Sawa-wasabi (Wasabia japonica), a traditional spice and a special product of our prefecture. We also studied on antioxidative and antimutagenic effects of green tea (Camelia sinenses) a traditional beverage of Japan.
In this paper, our purpose was to elucidate the combined preventive effect of wasabi and green tea to Helicobacter pylori induced stomach cancer. The epidemiological data between incidence of stomach cancer and intake of wasabi and/or green tea was required in this experiments.
We obtained this following results from this study.
(1) The ether extracts and water soluble fraction of wasabi leaves showed strong antioxdative activity.
(2) The rhizomes and leaves of wasabi showed growth inhibition and disinfection to H.pylori.
(3) Wasabi leaf extract showed strong radical scavenging activity.
(4) The mixture of wasabi and green tea extracts exhibited bactericidal effect to H.pylori. additively.
(5) By oral administration of wasabi leaf extract to H.pylori. injected Mongolian gerbils, the number of bacteria, injury and petechial hemorrhange scores of gastric mucosa was significantly decreased.
(6) By epidemiological studies, the producing areas of wasabi and green tea stomach cancer SMR was lower than those of control areas. These experimental data demonstrates that the combined preventive effect between wasabi and green tea to H.pylori. infection might be expected.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.2006
Author(s)
Nishikawa A, Sai K, Okazaki K, Son HY, Kanki K, Nakajima M, Kinae N, Nohmi T, Trosko JE, Inoue T, Hirose M
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Journal Title
Environ Mol Mutagen 47(1)
Pages: 48-55
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[Journal Article] Genotoxicity of acrylamide and glycidemide in human lymphoblastoid TK6 cells.2006
Author(s)
Koyama N, Sakamoto H, Sakuraba M, Koizumi T, Takashima Y, Hayashi M, Matsufuji H, Yamagata K, Masuda S, Kinae N, Honma M
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Journal Title
Mutat Res 603(2)
Pages: 151-8
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[Journal Article] Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitrite.2006
Author(s)
Masuda S, Terashima Y, Sano A, Okada M, Deguchi Y, Toyoizumi T, Sugiyama C, Kumazawa S, Kamihira M, Yoshioka H, Terao Y, Kinae N
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Journal Title
Biosci Biotechnol Biochem 70(4)
Pages: 890-6
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[Journal Article] Effect of Green Tea on the Formation of Nitrosamines, and Cancer Mortality.2006
Author(s)
Masuda S, Uchida S, Terashima Y, Kuramoto H, Serizawa M, Deguchi Y, Yanai K, Sugiyama C, Oguni I, Kinae N
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Journal Title
Journal of Health Science 52(3)
Pages: 211-220
NAID
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