Preventive effect of powdered green tea and exercise on Postmenopausal osteoporosis

• Project/Area Number: 18500631
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Gifu Women's University
• Principal Investigator: HASEGAWA Noboru Gifu Women's University, 家政学部, 教授 (10156317)
• Co-Investigator(Kenkyū-buntansha): MOCHIZUKI Miyako 岐阜女子大学, 家政学部, 助手 (20367858)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
• Keywords: 粉末緑茶 / カテキン / 更年期 / 骨粗鬆症 / 運動負荷 / 緑茶 / 骨強度 / 運動療法 / 骨訴訟症

Research Abstract

We studied the protective effect of EGCG on bone loss in ovariectomized (OVX) rats. Ovariectomy significantly decreased femur bone strength. Supplementation of EGCG suppressed bone loss induced by OVX and osteoclastogenesis in RAW264.7. We recruited eleven postmenopausal women, age 60-80. These women were given a daily EGCG tablet for 3 months. At 56 days, the SOS rate tended to increase as expected in the supplemented group. These observations confirmed that EGCG can prevent postmenopausal bone loss.

Research Products

• [Journal Article] (-)Epigallocatechin-3-gallate reduces experimental colon injury in rats by regulating macrophage and mast cell. (2010)
  • Author(s): Mochizuki M., Hasegawa N.
  • Journal Title: Phytother. Res. 24
  • Peer Reviewed
• [Journal Article] Improved effect of Pycnogenol on impaired spatial memory function in partial androgen deficiency rat model. (2009)
  • Author(s): Hasegawa N., Mochizuki M.
  • Journal Title: Phytother. Res. 23 Pages: 840-843
  • Peer Reviewed
• [Journal Article] Improved effect of Pycnogenol on impaired spatial memory function in partial androgen deficiency rat model. (2009)
  • Author(s): N.Hasegawa, M.Mochizuki
  • Journal Title: Phytother.Res. 23 Pages: 840-843
  • Peer Reviewed
• [Presentation] 持久的トレーニングと緑茶カテキン投与が更年期モデルラットの体組成に及ぼす影響 (2008)
  • Author(s): 望月美也子、長谷川昇
  • Organizer: 日本薬学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] 持久的トレーニングと緑茶カテキン投与が更年期モデルラットの体組成に及ぼす影響 (2008)
  • Author(s): 望月 美也子、長谷川 昇
  • Organizer: 日本薬学会第128年回
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-27
• [Presentation] 持久的トレーニンと緑茶カテキン投与が更年期モデルラットの体組成に及ぼす影響 (2008)
  • Author(s): 望月美也子、長谷川昇
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Book] Chemo-preventiveaction of tea against obesity (2008)
  • Author(s): Noboru Hasegawa
  • Publisher: Economic Crisis in TeaIndustry, Eds NK Jain, F Rahman, P Beker, Studium Press