| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
To investigate the novel candidate molecules involved in the cause of diabetic angiopathy, we used cultured human umbilical vein endothelial cells (HUVEC). In living HUVEC that was exposed to high glucose, antioxidant ability via the GSH cycle was remarkably reduced. The possibility was suggested that glycation of glutathione is responsible for this reduction. Two glycated glutathiones, whose N-position and S-position was respectively modified, were synthesized, and their coenzyme activities for antioxidative enzyme via GSH system were decreased. Further studies in this line would contribute to actual medical treatment in future.
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